JP2010248238A - 乱用が可能な物質の剤形における乱用可能性の減少 - Google Patents
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- A62D3/00—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
- A62D3/00—Processes for making harmful chemical substances harmless or less harmful, by effecting a chemical change in the substances
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/0075—Disposal of medical waste
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/14—Linings or internal coatings
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62D—CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
- A62D2101/00—Harmful chemical substances made harmless, or less harmful, by effecting chemical change
- A62D2101/20—Organic substances
- A62D2101/26—Organic substances containing nitrogen or phosphorus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B2101/00—Type of solid waste
- B09B2101/65—Medical waste
- B09B2101/68—Transdermal patches
Abstract
【解決手段】(a)薬物を不動化する結合剤、該薬物と共に溶媒中に溶解可能な該薬物に対する拮抗物質、刺激物質、及びそれらの組み合わせから選択される該薬物に対する抗乱用物質を含有する、抗乱用層と;(b)該抗乱用層から離間して配設された、該薬物を含有する層と;(c)該抗乱用層と該薬物を含有する層との間に存在してそれらの接触を防いでいる分離膜と;(d)該分離膜に連結され、該パッチデバイスを皮膚に適用した際に、該皮膚に粘着する粘着部分を有する連結除去装置とを備え、該パッチデバイスが該皮膚から剥がされることにより、該パッチデバイスから該分離膜が引き抜かれ、これにより抗乱用層及び薬物を含有する層の接触が生じる、経皮パッチデバイス。
【選択図】なし
Description
本発明により、最初の使用者からパッチデバイスが取り除かれた後乱用可能物質の残量を含有する皮膚貼付経皮パッチデバイスにおける物質の乱用の可能性を減少させるためのシステム及び方法が提供される。本発明は、接触して乱用可能物質を不動化し不活化することにより乱用の可能性を減少させる結合剤などの離間して存する抗乱用物質の使用に関する。抗乱用物質は、拮抗物質又は刺激化合物又は、ある場合には、後述するような拮抗物質又は刺激化合物も含有することができる。本発明の乱用防止システムは一般的に、皮膚貼付パッチの除去と処理に関し、任意の各種形態をとることができる。
図1は、オピオイドのような乱用可能物質の経皮投与に使用される種類の皮膚貼付パッチ10を示す。このパッチは、通常10で示され、皮膚に固定する接着剤含有層12及び14において皮膚に接触するように設計されたオピオイド含有層を含む。皮膚貼付パッチ10に付随するように設計された処理容器又は袋は一般的に参照数字16によって示され、矢印20により示されているように、オピオイド層14が吸収物質18に面するように使用済み皮膚貼付パッチ10を挿入することにより層14と18の間の接触が生じて層14のオピオイドの吸収と不活化を確実にするように、容器16の一つの側面に接着した吸収物質18の層を含む。容器16には、容器の両側に付けられた接着テープ22で例示されるようなパッチ14を内部に密封する手段も用意されている。このようにして、皮膚貼付パッチ10の層14に含有されるオピオイド物質は層18中の吸収物質により効果的に不活化されたという理解の上で、使用済みパッチ14を入れた容器16を廃棄することができる。オピオイドの場合には、活性炭が好ましい。
Claims (6)
- 残存する薬物の乱用の可能性を減少させる皮膚貼付経皮パッチデバイスにおいて、
(a) 該薬物を不動化する結合剤、該薬物と共に溶媒中に溶解可能な該薬物に対する拮抗物質、該薬物と共に溶媒中に溶解可能な刺激物質、及びそれらの組み合わせから選択される該薬物に対する抗乱用物質を含有する、抗乱用層と;
(b) 該抗乱用層から離間して配設された、該薬物を含有する層と;
(c) 該抗乱用層と該薬物を含有する層との間に存在してそれらの接触を防いでいる分離膜と;
(d) 該分離膜に連結され、該パッチデバイスを皮膚に適用した際に、該皮膚に粘着する粘着部分を有する連結除去装置とを備え、
該パッチデバイスが該皮膚から剥がされることにより、該パッチデバイスから該分離膜が引き抜かれ、これにより抗乱用層及び薬物を含有する層の接触が生じる、経皮パッチデバイス。 - 前記抗乱用物質が、
(a)前記結合剤、或いは
(b) 該結合剤と、該乱用可能物質と共に溶媒中に溶解可能な、拮抗物質及び/又は刺激物質との組合せである、請求項1に記載の皮膚貼付経皮パッチデバイス - 前記結合剤が、水、エタノール及びそれらの組み合わせから選択される溶媒を使用して前記薬物を抽出するのを防止することができる物質である、請求項1又は2に記載のシステム。
- 前記結合剤が、活性炭を含む請求項1から3の何れか1項に記載の皮膚貼付経皮パッチデバイス。
- 前記抗乱用物質が、刺激物質又は拮抗物質を含む請求項1から4の何れか1項に記載の皮膚貼付経皮パッチデバイス。
- 乱用可能物質が残存する皮膚貼付経皮パッチデバイス中の該物質の乱用の可能性を減少させる方法であって、
請求項1から5の何れか1項に記載の経皮パッチデバイスを用い、
該パッチを取り去ることにより前記分離膜の引き抜きを生じさせて、前記乱用可能物質と該抗乱用物質との接触を生じさせる、方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/763,628 US7867511B2 (en) | 2004-01-23 | 2004-01-23 | Abuse potential reduction in abusable substance dosage form |
US10/763,628 | 2004-01-23 |
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JP2006551380A Division JP4642784B2 (ja) | 2004-01-23 | 2005-01-20 | 乱用が可能な物質の剤形における乱用可能性の減少 |
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JP2010248238A true JP2010248238A (ja) | 2010-11-04 |
JP5248555B2 JP5248555B2 (ja) | 2013-07-31 |
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JP2006551380A Active JP4642784B2 (ja) | 2004-01-23 | 2005-01-20 | 乱用が可能な物質の剤形における乱用可能性の減少 |
JP2010156607A Active JP5248555B2 (ja) | 2004-01-23 | 2010-07-09 | 乱用が可能な物質の剤形における乱用可能性の減少 |
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JP2006551380A Active JP4642784B2 (ja) | 2004-01-23 | 2005-01-20 | 乱用が可能な物質の剤形における乱用可能性の減少 |
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US (9) | US7867511B2 (ja) |
EP (1) | EP1720498B8 (ja) |
JP (2) | JP4642784B2 (ja) |
WO (1) | WO2005070003A2 (ja) |
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JP4642784B2 (ja) | 2011-03-02 |
US20150352390A1 (en) | 2015-12-10 |
US10413768B2 (en) | 2019-09-17 |
JP2007518819A (ja) | 2007-07-12 |
WO2005070003A2 (en) | 2005-08-04 |
JP5248555B2 (ja) | 2013-07-31 |
US20130233748A1 (en) | 2013-09-12 |
US20050163717A1 (en) | 2005-07-28 |
US8445010B2 (en) | 2013-05-21 |
US20150352011A1 (en) | 2015-12-10 |
EP1720498A4 (en) | 2012-08-22 |
US8329212B2 (en) | 2012-12-11 |
US20110092926A1 (en) | 2011-04-21 |
US20200289863A1 (en) | 2020-09-17 |
US10406394B2 (en) | 2019-09-10 |
WO2005070003A3 (en) | 2006-01-05 |
EP1720498A2 (en) | 2006-11-15 |
US20110066130A1 (en) | 2011-03-17 |
EP1720498B1 (en) | 2016-09-21 |
US7867511B2 (en) | 2011-01-11 |
US20100068250A1 (en) | 2010-03-18 |
EP1720498B8 (en) | 2016-11-09 |
US20180185686A1 (en) | 2018-07-05 |
US10391346B2 (en) | 2019-08-27 |
US11305144B2 (en) | 2022-04-19 |
US8475837B2 (en) | 2013-07-02 |
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