JP2010234308A - Jig for filling and method for manufacturing fluid treatment container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a jig for filling which is capable of controlling the amount of a sealing agent to be used while controlling the amount of a filler to be used. <P>SOLUTION: The jig 30 for filling is fitted to the end of a tubular part 10 in filling the opening end of a hollow fiber membrane bundle A stored at the tubular part 10 of a fluid treatment vessel 1 with a filling agent E when the fluid treatment vessel 1 is prepared. The jig 30 for filling is tubularly formed and a groove 41 opened in one direction of the axis direction is formed along the outer peripheral wall 40 at the inside of the tubular and outer peripheral wall 40. The jig 30 for filling has an outer tube 50, an inner tube 51, a bottom part 52 and an insertion part 53. The end of the outer tube 50 is more protruded than the end of the inner tube 51. The groove 41 is formed between the outer tube 50 and the inner tube 51. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention provides an eye attached to the end of the tubular portion when the ends of the hollow fiber membrane bundle accommodated in the tubular portion of the fluid treatment device are sealed with a sealant during the manufacture of the fluid treatment device. The present invention relates to a stopping jig and a method for manufacturing a fluid treatment device using the sealing jig.

  In recent years, fluid treatment devices using hollow fiber membranes have been widely used in industrial fields such as water treatment and gas separation, and medical fields such as blood treatment, especially as water purifiers, artificial kidneys, artificial lungs, etc. Demand is extremely increasing.

  Generally, in the manufacture of the fluid treatment device, after the hollow fiber membrane bundle is loaded inside the cylindrical portion of the fluid treatment device, both ends of the tubular portion are fixed while fixing the tubular portion and both ends of the hollow fiber membrane bundle. Is sealed with a sealant, and further, a potting step is performed in which the cured sealed portion is cut to form an opening of the hollow fiber membrane bundle. Specifically, with several thousand to several tens of thousands of hollow fiber membrane bundles inserted into the cylindrical portion, a sealing agent (potting of a thermosetting resin such as polyurethane or epoxy is applied to both ends of the cylindrical portion. Agent) is injected and cured between the hollow fiber membranes and between the tubular part and the hollow fiber membrane bundle, and both ends of the tubular part are sealed. After sealing, both ends of the hollow fiber membrane bundle are cut at the position of the sealant to form an open end of the hollow fiber membrane bundle. Thereafter, a header cap serving as a fluid inlet / outlet is attached to the opening of the cylindrical portion.

  In the potting process, a centrifugal molding method is generally used. In the centrifugal molding method, both ends of the cylindrical part loaded with the hollow fiber membrane bundle are temporarily closed with an end cap or the like, and the cylindrical part is set horizontally, and then the cylindrical part is moved to the vertical central axis. The sealant is injected into the cylindrical portion while rotating around (for example, Patent Documents 1 and 2). The sealing agent moves to both ends of the cylindrical portion by centrifugal force and is cured there. However, in such a potting process, a part of the sealing agent may enter the inside from the open end of the hollow fiber membrane. When the distance of the sealant increases, for example, even if the hollow fiber membrane is cut at the position of the hardened sealant after that, the open end of the hollow fiber membrane cannot be formed, and the fluid flows appropriately in the hollow fiber membrane. It may disappear.

  Therefore, as a method for preventing the sealing agent from entering the hollow fiber membrane during the potting process by centrifugation, the open ends at both ends of the hollow fiber membrane are blocked in advance (sealed) before performing the potting process. A method has been proposed. For example, there is a method in which injection of the sealing agent is divided into two times, and sealing is performed by the first injection and curing (see Patent Document 3).

  When performing the above-described sealing, for example, both ends of the cylindrical portion are closed with an existing end cap or the like in the potting process, and a thermosetting resin sealant is injected into the cylindrical portion. It can be considered that the sealing agent is moved to the end of the hollow fiber membrane by centrifugal force or the like. However, in this case, there is originally a distance between the end cap and the open end of the hollow fiber membrane, and the volume of the space between them is relatively large. Therefore, the sealing agent accumulates in order from the end cap side by centrifugal molding. A large amount of sealant is required until it reaches the open end of the hollow fiber membrane. Most of the sealant is wasted because it is discarded by the subsequent cutting. In particular, in a fluid treatment device having a large diameter or a fluid treatment device for hemodialyzer that performs mass production even if the diameter is small, the amount of the sealant used cannot be ignored, which may increase the production cost.

JP 2008-279374 A Japanese Patent No. 271987 Japanese Patent Publication No.56-3772

  Therefore, for example, when performing sealing as shown in FIG. 14, a ring-shaped sealing jig 102 is connected to the end 101 a of the cylindrical portion 101 of the fluid processing device 100, and the sealing jig 102 It is conceivable to seal the opening end of the hollow fiber membrane bundle A by filling the sealing agent E inside and curing it. In this case, since the sealing agent E is supplied only around the open end of the hollow fiber membrane bundle A, the amount of the sealing agent E used can be reduced. And the potting process in this case supplies sealing agent in the cylindrical part 101 inside sealing agent E after sealing, and seals the sealing agent by the centrifugal force etc. at the end of the cylindrical part 101 It is performed by moving to the part side.

  However, in this case, for example, as shown in FIG. 15, when the sealing agent E is cured, the sealing agent E contracts inward due to thermal contraction. For this reason, it is conceivable that a gap is formed between the inner peripheral surface of the sealing jig 102 and the sealing agent E. If a gap is formed between the sealing jig 102 and the sealing agent E, it is considered that the sealing agent leaks to the outside through the gap during the potting process. In this case, a part of the sealant is wasted and the amount of sealant used is increased.

  The present invention has been made in view of such points, and includes a sealing jig that can suppress the amount of sealant used while suppressing the amount of sealing agent used, and the sealing jig. It is an object of the present invention to provide a method for manufacturing the fluid treatment device used.

As a result of intensive studies, the present inventors have found that when a sealing jig having a specific structure is used, the sealing agent does not leak at all even if the sealing agent cures and contracts, leading to the present invention. It was.
That is,
The present invention is attached to the end portion of the tubular portion when the opening end of the hollow fiber membrane bundle accommodated in the tubular portion of the fluid treatment device is sealed with a sealant during the manufacture of the fluid treatment device. A sealing jig that is formed in a cylindrical shape, and that a groove that opens in one axial direction is formed along the outer peripheral wall on the inner side of the cylindrical outer peripheral wall. Features.

  According to the present invention, since the sealing agent enters the groove at the time of sealing, even if the sealing agent is thermally contracted inward, the sealing agent in the groove is in close contact with the wall surface of the groove in the shrinking direction. The airtightness between the sealing agent and the sealing jig is ensured. For this reason, the sealing agent is prevented from leaking outside through the gap between the sealing agent and the sealing jig during the potting process. As a result, it is possible to reduce the amount of sealant used while reducing the amount of sealant used using the sealing jig.

  Further, the sealing jig according to the present invention includes a cylindrical outer cylinder portion that forms the outer peripheral wall, a cylindrical inner cylinder portion that is disposed inside the outer cylinder portion, and the outer cylinder portion. A bottom part that connects the inner cylinder part in the radial direction; and a fitting part that is connected to the opposite side of the bottom part in the one direction and can be fitted to the end part of the cylindrical part of the fluid treatment device. The end portion on the one direction side of the outer tube portion protrudes from the end portion on the one direction side of the inner tube portion, and the groove is formed between the outer tube portion and the inner tube portion. It may be formed between.

  The inner cylinder portion may have a step portion that makes the width of the groove on the bottom side narrow. The inner corner portion of the step portion may be curved.

  Further, the shift between the end surfaces on the one direction side of the outer cylinder part and the inner cylinder part may be 2.0 mm or more and 15.0 mm or less.

  The widest portion of the groove may be 2.0 mm or more and 6.0 mm or less.

  The fluid treatment device may be a blood treatment device.

  According to another aspect of the present invention, there is provided a method of manufacturing a fluid processing device using the sealing jig, wherein the sealing jig is attached to an end of a cylindrical portion of the fluid processing device; In a state where the hollow fiber membrane bundle is accommodated in the cylindrical portion, a sealing agent is supplied to the inside including the groove in the sealing jig to solidify the sealing agent, and the hollow fiber membrane bundle is solidified. Sealing the opening end of the sealing member, supplying a sealing agent into the cylindrical part closer to the center than the sealing agent, moving the sealing agent to the end part of the cylindrical part, and sealing agent Solidifying and sealing the end of the cylindrical portion, and cutting the solidified sealing agent to form an open end at the end of the hollow fiber membrane. Features.

  In the manufacturing method of the fluid treatment device, when the opening end of the hollow fiber membrane bundle is sealed, the opening end of the hollow fiber membrane bundle is connected to the end surface of the inner cylinder portion and the outer cylinder portion of the sealing jig. It may be located between the end faces.

  You may make it the edge of the said hollow fiber membrane bundle protrude in the range of 0.1 mm or more and 13.0 mm or less from the end surface of the said inner cylinder part.

  The sealing agent may be a thermoplastic resin.

  The resin viscosity of the sealing agent may be 100 mPa · s or more and 100,000 mPa · s or less.

  According to the present invention, the amount of both the sealant and the sealant used can be suppressed, so that the production cost of the fluid processor can be reduced.

It is explanatory drawing which shows the outline of a composition of a fluid processing device. It is explanatory drawing of the longitudinal cross-section which shows the outline of a structure of the jig | tool for sealing. It is a top view of the jig | tool for sealing. It is explanatory drawing which shows the state which attached the jig | tool for sealing to the both ends of the cylindrical part of a fluid processing device. It is explanatory drawing of the longitudinal cross-section which shows the state by which the sealing agent was supplied to the jig | tool for sealing. It is explanatory drawing which shows the state which the sealing agent contracted. It is explanatory drawing which shows the state by which the sealing agent was supplied to the cylindrical part. It is explanatory drawing of the longitudinal cross-section which shows the outline of a structure of the jig | tool for sealing which has a step part in a groove | channel. 9A to 9F are schematic views showing variations in the structure of the outer cylinder portion of the sealing jig. 10A to 10F are schematic views showing variations in the structure of the inner cylinder portion of the sealing jig. FIGS. 11A to 11F are schematic views showing variations in the structure of the groove portion of the sealing jig. 12A to 12F are schematic views showing variations in the structure of the fitting portion of the sealing jig. It is explanatory drawing of the jig | tool for sealing without a groove | channel. It is explanatory drawing of the longitudinal cross-section which shows the state in which the sealing agent was supplied to the cylindrical sealing jig without a groove | channel. It is explanatory drawing which shows the state which the sealing agent shrink | contracted in the jig | tool for sealing of FIG.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a schematic diagram showing an outline of a configuration of a fluid processing device 1 in which a sealing jig according to the present embodiment is used during manufacturing. In addition, in this specification and drawing, about the component which has the substantially same function structure, duplication description is abbreviate | omitted by attaching | subjecting the same code | symbol.

  For example, as shown in FIG. 1, the fluid treatment device 1 includes a tubular portion 10 in which the hollow fiber membrane bundle A is accommodated in the longitudinal direction (axial direction), and a header cap 11 that closes both ends of the tubular portion 10. ing.

  The hollow fiber membrane bundle A is formed of about 5000 to 16000 hollow fiber membranes. The hollow fiber membrane is porous and formed in a tubular shape.

  Both end portions of the cylindrical portion 10 are sealed with a sealant B. The sealant B is hardened in a disc shape, and is filled between the hollow fiber membranes and between the hollow fiber membrane bundle A and the inner wall of the tubular portion 10, and the hollow fiber membrane bundle A and the tubular portion 10. Is fixed. Note that both ends of each hollow fiber membrane of the hollow fiber membrane bundle A are open to the outside of the sealant B.

  A fluid passage portion 20 that communicates from the outside of the fluid processing device 1 to the inside of the tubular portion 10 is formed on the outer peripheral surface in the vicinity of both ends of the tubular portion 10. The fluid passage portion 20 is formed on the center side of the position of the sealant B and communicates with the outer peripheral space C of the hollow fiber membrane bundle A inside the tubular portion 10. A fluid passage 21 that communicates with the outside of the fluid processor 1 is formed at the center of each header cap 11, and the end space D in the header cap 11 communicates with the outside of the fluid processor 1. Yes. The open end of the hollow fiber membrane bundle A is open to this end space D. Therefore, for example, the fluid flowing in from one fluid passage portion 21 of the header cap 11 passes through the end space D and flows into the hollow fiber membrane bundle A, and passes through the hollow fiber membrane bundle A to the opposite end space. It flows out to D and flows out from the other fluid passage part 21 to the outside. When passing through the hollow fiber membrane bundle A, the specific component that has passed through the fine holes in the side walls of each hollow fiber membrane flows out into the outer peripheral space C and out of the fluid passage portion 20 to the outside.

  Next, the structure of the sealing jig 30 used when manufacturing the fluid treatment device 1 will be described.

  The sealing jig 30 is formed in a cylindrical shape, for example, as shown in FIGS. 2 and 3, and a groove 41 that opens toward one direction X <b> 1 in the axial direction X is formed inside the cylindrical outer peripheral wall 40. Is formed. The groove 41 is formed in an annular shape along the outer peripheral wall 40.

  As shown in FIG. 2, the sealing jig 30 includes, for example, a cylindrical outer cylinder portion 50 that forms an outer peripheral wall 40, a cylindrical inner cylinder portion 51 disposed inside the outer cylinder portion 50, A bottom portion 52 that connects the cylindrical portion 50 and the inner cylindrical portion 51 in the radial direction, and is formed on the opposite side of one direction X1 of the bottom portion 52, and can be fitted to the end portion 10a of the cylindrical portion 10 of the fluid treatment device 1. A fitting portion 53 is provided.

  An end portion on the one direction X1 side of the outer cylinder portion 50 protrudes from an end portion on the one direction X1 side of the inner cylinder portion 51. For example, the shift H1 between the end faces on one side X1 of the outer cylinder part 50 and the inner cylinder part 51 is set to 2.0 mm or more and 15.0 mm or less. In addition, the jig | tool for sealing so that the edge of the hollow fiber membrane bundle A may protrude from the end surface of the inner cylinder part 51 in the range of 0.10 mm or more and 13.0 mm or less, More preferably, 1.0 mm or more and 5.0 mm or less. 30 is configured.

  The groove 41 is formed between the outer cylinder part 50 and the inner cylinder part 51. The widest portion T1 of the groove 41 is set to 2.0 mm or more and 6.0 mm or less, preferably 2.5 mm or more and 5.0 mm or less.

  The fitting portion 53 is formed in a cylindrical shape having a slightly larger diameter than the end portion 10 a of the tubular portion 10, and can be fitted in an airtight manner outside the end portion 10 a of the tubular portion 10.

  Next, a manufacturing method of the fluid processing device 1 using the sealing jig 30 configured as described above will be described.

  First, the hollow fiber membrane bundle A is loaded into the cylindrical portion 10 to which the header cap 11 has not yet been attached, and in this state, as shown in FIG. It is attached to the part. The hollow fiber membrane bundle A may be loaded in the tubular portion 10 in a state where the sealing jig 30 is attached to both ends of the tubular portion 10 in advance. At this time, both ends of the hollow fiber membrane bundle A are positioned between the end surface of the outer cylinder portion 50 and the end surface of the inner cylinder portion 51 of the sealing jig 30 as shown in FIG.

  Next, as shown in FIG. 5, for example, a melted thermosetting resin sealing agent E from above the sealing jig 30 is used for sealing in a state where the cylindrical portion 10 is erected in the vertical direction. It is poured into the jig 30. Thereby, the sealing agent E is filled in the groove 41 and the inside of the sealing jig 41 including the inside of the inner cylinder portion 51. The resin viscosity of the sealant E is set to, for example, 100 mPa · s to 100,000 mPa · s, more preferably 1000 mP · s to 10,000 mP · s.

  The sealing agent E is poured into the sealing jig 30 and then cooled and hardened. Thereby, the opening end of the hollow fiber membrane bundle A is closed and sealed. At this time, as shown in FIG. 6, the sealant E is entirely thermally contracted toward the central axis P, but at least the sealant E in the groove 41 is in close contact with the inner cylinder portion 51. It is prevented that the center side and the outer side of the cylindrical part 10 communicate with each other. This sealing is performed on both sides of the hollow fiber membrane bundle A.

  Next, the cylindrical part 10 is arrange | positioned in a centrifugal molding machine so that a center axis may become horizontal, and the cylindrical part 10 is rotated around the vertical axis which passes along the center of the cylindrical part 10 in the state. And in the state where the cylindrical part 10 was rotated, the sealing agent B of a thermosetting resin, for example, flows into the cylindrical part 10 from the fluid passage part 20, for example. As shown in FIG. 7, the sealing agent B that has flowed into the cylindrical portion 10 is caused to flow outward by centrifugal force and is stored on the center side of the sealing agent E. In this state, the sealant B is cured, and at both ends of the hollow fiber membrane bundle A, the sealant B is between the hollow fiber membranes and between the hollow fiber membrane bundle A and the inner wall of the tubular portion 10. It solidifies, the hollow fiber membrane bundle A and the cylindrical part 10 are fixed, and the both ends of the cylindrical part 10 are sealed (potting).

  After that, for example, the sealing jig 30 is removed or attached, and both ends of the hollow fiber membrane bundle A are perpendicular to the axial direction X at the portion where the sealant B is present (cut line Q in FIG. 7). Disconnected. Thereby, the open end of the hollow fiber membrane bundle A is formed. Thereafter, header caps 11 are attached to both end portions of the cylindrical portion 10 to complete the fluid processing device 1.

  According to the above embodiment, the groove 41 that opens toward the one direction X <b> 1 is formed along the outer peripheral wall 40 inside the outer peripheral wall 40 of the sealing jig 30. For this reason, when the sealing agent E is cured and thermally contracted, the sealing agent E in the groove 41 is in close contact with the inner wall surface of the groove 41, and the gap between the sealing agent E and the sealing jig 30 is between the sealing agent E and the sealing jig 30. It is possible to prevent a gap from being formed on the surface. Thereby, it can prevent that the sealing agent B supplied in the cylindrical part 10 leaks through the clearance gap between the sealing jig | tool 30 and the sealing agent E by a post process. Thereby, the usage-amount of the sealing agent B can be reduced.

  In addition, when the groove 41 is formed in the sealing jig 30, the distance between the hollow fiber membrane bundle A and the outer peripheral wall 40 of the sealing jig 30 is larger than when the groove is not formed. For this reason, it can suppress that the sealing agent E supplied to the outer peripheral side periphery of the hollow fiber membrane bundle A is cooled by the low temperature outer wall surface 40, and hardens | cures at an early stage. Thereby, the melted sealing agent E is sufficiently supplied also to the outer peripheral side of the hollow fiber membrane bundle A, and the outer peripheral side of the hollow fiber membrane bundle A can be sufficiently sealed.

  The sealing jig 30 has an outer cylinder part 50, an inner cylinder part 51, a bottom part 52, and a fitting part 53. One end of the outer cylinder part 50 on the side X1 is The cylindrical portion 51 protrudes from one end on the direction X1 side, and the groove 41 is formed between the outer cylindrical portion 50 and the inner cylindrical portion 51. Thereby, the sealing jig 30 having a simple configuration can be realized.

  The deviation H1 between the end faces on the one side X1 side of the outer cylinder part 50 and the inner cylinder part 51 is set to 2.0 mm or more and 15.0 mm or less. By setting the displacement H1 to be 2.0 mm or more, it is possible to prevent the sealing agent E from leaking to the outside of the outer cylindrical portion 50 when supplying the sealing agent E. Further, by setting the deviation H1 to 15.0 mm or less, it is possible to prevent bubbles from being mixed into the sealing agent E due to, for example, an impact caused by dropping the sealing agent E in the sealing jig 30 or the like. Moreover, it can prevent that the sealing agent E cools and hardens | cures until it reaches the opening end of the hollow fiber membrane bundle A, and the hollow fiber membrane bundle A is not sufficiently sealed.

 In the above embodiment, when the open end of the hollow fiber membrane bundle A is sealed, the open end of the hollow fiber membrane bundle A is connected to the end surface of the inner cylindrical portion 51 of the sealing jig 30 and the outer cylindrical portion 50. It is located between the end faces and protrudes from the end face of the inner cylinder portion 51 within a range of 0.10 mm to 13.0 mm. For this reason, the sealing agent E is efficiently supplied to the open end of the hollow fiber membrane bundle A, and the sealing is effectively performed with the minimum amount of the sealing agent E.

  Since the widest portion T1 of the groove 41 is 2.0 mm or more and 6.0 mm or less, the sealing agent E properly enters the groove 41.

  In the said embodiment, the resin viscosity of the sealing agent E is set to 100 mPa * s or more and 100,000 mPa * s or less. When the viscosity of the sealing agent E applied or immersed is too high, the sealing agent E may not enter the hollow fiber membrane even if it reaches the opening end face of the hollow fiber membrane. Thus, since the sealing agent E having an appropriate viscosity is used, the sealing agent E enters the hollow fiber membrane appropriately.

  Moreover, the manufacturing method of the fluid treatment device 1 of the above embodiment includes the step of attaching the sealing jig 30 to the end portion 10a of the tubular portion 10 of the fluid treatment device 1, and the hollow fiber in the tubular portion 10. In a state where the membrane bundle A is accommodated, the sealing agent E is supplied to the inside including the groove 41 in the sealing jig 30, and the sealing agent E is solidified to open the open end of the hollow fiber membrane bundle A. The sealing agent B is supplied into the cylindrical portion 10 on the center side from the sealing agent E, and the sealing agent B is moved to the end portion of the cylindrical portion 10. Solidifying and sealing the end of the cylindrical portion 10. With this manufacturing method, the manufacturing cost of the fluid processing device 1 can be reduced.

  As shown in FIG. 8, a step portion 60 is formed on the surface of the inner cylinder portion 51 of the groove 41 in the above-described embodiment on the outer cylinder portion 50 side so that the width of the groove 41 on the bottom portion 52 side becomes narrower. Also good. For example, the inner corner portion 60a of the step portion 60 is smoothly curved. Further, the bottom surface of the groove 41, that is, the inner surface of the bottom portion 52 may be curved in a concave shape. In this case, the widest portion T <b> 1 of the groove 41 becomes the upper end portion of the cylindrical portion 51.

  In this case, since the inner cylinder part 51 has the step part 60, it can suppress that the sealing agent E reaches | attains the bottom of the groove | channel 41, for example. Thereby, the consumption of the sealing agent E can be reduced. Further, since the inner corner portion 60a of the step portion 60 is curved, the sealing agent E is supplied to the inner corner portion 60a of the step portion 60 without any gap. Thereby, the adhesiveness of the sealing agent E and the inner cylinder part 51 improves, and the leak of the sealing agent B is prevented more reliably.

  The hollow fiber membrane bundle A may be packaged with a film so that the hollow fiber membrane does not deform or vary. Examples of hollow fiber membrane materials include polysulfone polymers, regenerated cellulose, cellulose acetate, polyamide polymers, polyacrylonitrile polymers, polyvinyl alcohol polymers, polymethyl methacrylate polymers, polyolefin polymers, and polyvinylidene fluoride polymers. Is used.

  Further, the fluid processor 1 may be any of a water processor, a gas separator, a blood processor, and the like. Since the fluid treatment device 1 manufactured by the above method is also excellent in sealing performance of the hollow fiber membrane, it is more preferable when the fluid treatment device 1 is a blood treatment device. In other words, when clogging occurs due to the penetration of the sealant into the hollow fiber membrane of the fluid treatment device, blood or blood components remain in the fluid treatment device (residual blood), and psychologically and to the subject (patient). This is because a physical burden may occur, but according to the present invention, there is no such fear. Examples of the blood treatment device include an artificial kidney, an artificial liver, an artificial lung, a plasma separator, a blood component separator, and the like.

  The sealant B used in the potting process is preferably a resin that is cured after being injected in a molten state, and for example, a urethane-based resin, an epoxy-based resin, a silicon-based resin, or the like is used.

  The resin of the sealing agent E used for sealing the open end of the hollow fiber membrane is preferably a resin whose viscosity can be easily changed, and optimally contains a thermoplastic resin. The thermoplastic resin is preferably an olefin resin. By including the thermoplastic resin, the process of solidifying the sealant after the supply of the sealant is facilitated.

  In the above embodiment, mounting of the sealing jig 30 and the cylindrical portion 10 of the fluid processing device 1 is performed by fitting, but other adhesive methods using an adhesive or ultrasonic waves are used. Also good.

  9A to 9F are schematic views showing variations of the structure of the outer cylinder portion 50 of the sealing jig 30 according to the present invention. 10A to 10F are schematic views showing variations of the structure of the inner cylinder portion 51 of the sealing jig 30 according to the present invention. 11A to 11F are schematic views showing variations of the structure of the groove 41 of the sealing jig 30 according to the present invention. 12A to 12F are schematic views showing variations of the structure of the fitting portion 53 of the sealing jig 30 according to the present invention. Any combination may be used.

  Next, the present invention will be described more specifically with reference to examples, but the present invention is not limited to the following examples. First, the measurement method used in the examples will be described.

(Opening ratio of hollow fiber membrane)
By determining the opening ratio of the end face of the final hollow fiber membrane bundle, the degree of clogging due to the penetration of the sealing agent into the hollow fiber membrane was quantitatively evaluated. First, a fluid processing device manufactured by each predetermined manufacturing method was prepared, and the entire opening end of the hollow fiber membrane bundle was colored with a dark oil-based pen. By doing so, the sealing agent entering the open end of the clogged hollow fiber membrane is colored, and the distinction from the normally opened hollow fiber membrane becomes clear, so the accuracy is high. Observation becomes possible. Next, while observing the open end of the hollow fiber membrane bundle with a magnifying glass or a microscope, the numerical aperture and non-open numerical aperture of the hollow fiber membrane were counted, and the numerical aperture of the hollow fiber membrane bundle was calculated by the formula (2).
Opening ratio (%) of hollow fiber membrane bundle = (numerical aperture of hollow fiber membrane / number of hollow fiber membranes) × 100 (2)

(Minimum thickness of resin layer)
After using the same size container and injecting the same amount of sealant to form the resin layer part, create a sample by cutting the resin layer part at the same position, and the resin layer part formed by the sealant The amount of sealant used (the amount of loss) was evaluated by comparing the thicknesses of the sealants. The thickness of the resin layer was measured with several calipers and the minimum thickness was recorded. In this case, the smaller the minimum thickness, the more the injected sealing agent leaked from the lid of the sealing agent.
In this embodiment, the sealing jig 30 having the step portion 60 in the groove 41 as shown in FIG. 8 is used.

<Example 1>
Ten thousand (± 500) polysulfone hollow fiber membranes having an outer diameter of 255 μm were bundled to prepare a hollow fiber membrane bundle having a diameter of 45 mm and a length of 305 mm. As the cylindrical portion, two nozzles (fluid passage portions) for inflow / outflow of fluid were provided near both ends, and a container made of polystyrene resin having a total length of 286 mm was prepared. Made of polypropylene, the displacement H1 between the end surfaces of the inner cylinder part and the outer cylinder part is 8.0 mm (the height from the bottom of the groove to the end face of the outer cylinder part is 11.0 mm, and the height from the end face of the inner cylinder part is 3 0.0 mm), and a fixing jig having a maximum groove width T1 of 3.0 mm is mounted on both ends of the cylindrical portion as shown in FIG. Was loaded into a cylindrical part to which was attached. At that time, the both ends of the hollow fiber membrane bundle were adjusted so as to protrude 2.0 mm from the end face of the inner cylinder part. Next, 10 g of a molten resin having a viscosity of 2000 mmPa · s mainly composed of a polypropylene-based polymer was poured into a sealing jig as a sealing agent. At this time, the sealing agent covered the entire end surface of the hollow fiber membrane bundle, and further covered to the groove of the sealing jig, and then allowed to stand at room temperature and solidified. Similarly, the opposite end face was also sealed. Next, centrifugal molding was performed while injecting 50 (g / piece) of polyurethane resin as a sealant from two nozzles (fluid passages) provided in the cylindrical part to form a resin layer part. The cured resin layer was cut to a position where a cap can be attached.
Both ends of the hollow fiber membrane after cutting were visually observed with a magnifying glass to obtain the opening ratio of the hollow fiber membrane bundle, and the minimum thickness of the resin layer portion was measured with a caliper.

<Example 2>
A sample was prepared under the same conditions as in Example 1 except that the protruding distance from the end face of the inner cylinder at both ends of the hollow fiber membrane bundle was 1.0 mm or more and the viscosity of the filler was 8000 mmPa · s.

<Example 3>
Except that the protruding distance from the end face of the inner cylinder part at both ends of the hollow fiber membrane bundle is 1.0 mm or more, the viscosity of the sealing agent is 3000 mmPa · s, and the maximum value T1 of the groove width is 4.0 mm Prepared a sample under the same conditions as in Example 1.

<Example 4>

Except that the protruding distance from the end face of the inner cylinder part at both ends of the hollow fiber membrane bundle is 1.0 mm or more, the viscosity of the sealing agent is 3000 mmPa · s, and the maximum value T1 of the groove width is 6.0 mm Prepared a sample under the same conditions as in Example 1.

<Example 5>
The protruding distance from the end face of the inner cylinder part at both ends of the hollow fiber membrane bundle is 1.0 mm or more, the viscosity of the sealing agent is 8000 mmPa · s, the maximum value T1 of the groove width is 3.0 mm, A sample was prepared under the same conditions as in Example 1, except that the deviation H1 between the end surface of the outer cylinder portion and the outer cylinder portion was 14.0 mm and the height from the bottom surface of the groove to the end surface of the outer cylinder portion was 17.0 mm. .

<Example 6>
The protruding distance from the end face of the inner cylinder part at both ends of the hollow fiber membrane bundle is 1.0 mm or more, the viscosity of the sealing agent is 8000 mmPa · s, the maximum value T1 of the groove width is 3.0 mm, A sample was prepared under the same conditions as in Example 1 except that the displacement H1 between the end surface of the outer cylinder portion and the outer cylinder portion was 4.0 mm, and the height from the bottom surface of the groove to the end surface of the outer cylinder portion was 7.0 mm. .

<Comparative Example 1>
Ten thousand (± 500) polysulfone hollow fiber membranes having an outer diameter of 255 μm were bundled to prepare a hollow fiber membrane bundle having a diameter of 45 mm and a length of 305 mm. As the cylindrical portion, two nozzles (fluid passage portions) for inflow / outflow of fluid were provided near both ends, and a container made of polystyrene resin having a total length of 286 mm was prepared. Made of polypropylene, the displacement H1 between the end surfaces of the inner cylinder part and the outer cylinder part is 8.0 mm (the height from the bottom of the groove to the end face of the outer cylinder part is 11.0 mm, and the height from the end face of the inner cylinder part is 3 0.0 mm), and a fixing jig having a maximum groove width T1 of 3.0 mm is mounted on both ends of the cylindrical portion as shown in FIG. Was loaded into a cylindrical part to which was attached. At that time, the both ends of the hollow fiber membrane bundle were adjusted so as to protrude −1.0 mm from the end surface of the inner cylinder portion (retracted 1.0 mm). Next, 10 g of a molten resin having a viscosity of 3000 mmPa · s mainly composed of a polypropylene-based polymer was poured into a sealing jig as a sealing agent. At this time, the sealing agent covered the entire end surface of the hollow fiber membrane bundle, and further covered to the groove of the sealing jig, and then allowed to stand at room temperature and solidified. Similarly, the opposite end face was also sealed. Next, centrifugal molding was performed while injecting 50 (g / piece) of polyurethane resin as a sealant from two nozzles (fluid passages) provided in the cylindrical part to form a resin layer part. The cured resin layer was cut to a position where a cap can be attached.
Both ends of the hollow fiber membrane after cutting were visually observed with a magnifying glass to obtain the opening ratio of the hollow fiber membrane bundle, and the minimum thickness of the resin layer portion was measured with a caliper.

<Comparative example 2>
Except for the length of the hollow fiber membrane bundle being 305 mm, the protruding distance from the end surface of the inner cylinder at both ends of the hollow fiber membrane bundle being 1.0 mm or more, and the maximum value T1 of the groove width being 1.0 mm Prepared a sample under the same conditions as in Comparative Example 1.

<Comparative Example 3>
Except that the length of the hollow fiber membrane bundle is 305 mm, the protruding distance from the end surface of the inner cylinder part at both ends of the hollow fiber membrane bundle is 1.0 mm or more, and the viscosity of the sealant is 1000000 mmPa · s. Samples were prepared under the same conditions as in Example 1.

<Comparative example 4>
The length of the hollow fiber membrane bundle is 305 mm, the protruding distance from the end surface of the inner cylinder portion at both ends of the hollow fiber membrane bundle is 1.0 mm or more, the viscosity of the sealant is 3000 mmPa · s, A sample was prepared under the same conditions as in Comparative Example 1 except that the deviation H1 of the end surface of the outer cylinder portion was 17.0 mm and the height from the bottom surface of the groove to the end surface of the outer cylinder portion was 20.0 mm.

<Comparative Example 5>
The length of the hollow fiber membrane bundle is set to 305 mm, the protruding distance from the end surface of the inner cylinder portion at both ends of the hollow fiber membrane bundle is set to 1.0 mm or more, the viscosity of the sealing agent is set to 3000 mmPa · s, A sample was prepared under the same conditions as in Comparative Example 1 except that the deviation H1 of the end surface of the outer cylinder portion was 1.0 mm and the height from the bottom surface of the groove to the end surface of the outer cylinder portion was 4.0 mm.

<Comparative Example 6>
As a sealing jig, the difference in height between the end surface of the outer tube portion and the end surface of the inner tube portion (in this figure, it is precisely the difference in height between the end surface of the outer tube portion and the step between the inner wall portion) As shown in FIG. 13 having a polypropylene property of 8.0 mm, a shape having no groove is used.
A sample was prepared under the same conditions as in Comparative Example 1 except that the length of the hollow fiber membrane bundle was 305 mm, and the deviation H1 between the inner cylinder portion (step of the inner wall portion) and the end surface of the outer cylinder portion was 8.0 mm.

  Table 1 shows the specifications of the sealing jig used in the examples and the application conditions of the sealing agent (sealing resin), and Table 2 shows the specifications of the sealing jig used in the comparative example and the sealing agent (mesh). The application conditions of the (stopping resin) are shown. Table 3 shows the measurement results of the aperture ratio (%) of the hollow fiber membrane bundle of the example and the minimum thickness (mm) of the resin layer portion, and Table 4 shows the aperture ratio (%) of the hollow fiber membrane bundle of the comparative example and the resin layer portion. Shows the minimum thickness measurement result

  As is clear from the comparison between Examples 1 to 6 and Comparative Examples 1, 3, and 4, the parameters of the shape of each part of the sealing jig, the viscosity of the sealing agent, and the end face of the inner cylinder part of the hollow fiber membrane bundle It was found that the protruding distance had an effect on the aperture ratio of the hollow fiber membrane bundle. In Comparative Example 1, the outer periphery of the end portion of the hollow fiber membrane is in contact with the vicinity of the top of the inner cylinder, the sealant contacts the top of the inner cylinder at the time of applying the sealing resin, and heat is taken away. It is considered that it means that the sealing agent did not reach the outer peripheral portion of the end portion of the hollow fiber membrane and solidified without solidifying. Comparative Example 3 is considered to mean that the resin did not penetrate into the hollow fiber membrane even when the seal resin reached the opening end of the hollow fiber membrane because the viscosity of the seal resin was too high. In Comparative Example 4, since the height of the outer cylinder portion is high, the idle running distance to the end surface of the hollow fiber membrane bundle of the sealant is increased, which means that the seal resin has poor sealing due to entrapment of bubbles in the seal resin. It is thought that.

As is clear from the comparison between Examples 1 to 6 and Comparative Examples 2, 3, and 6, the parameters of the shape of each part of the sealing jig and the viscosity of the sealing resin are the minimum thickness of the resin layer, that is, the sealing agent. It turns out that it is affecting the leak. In Comparative Examples 2, 3, and 6, the maximum width of the groove is too narrow (no groove) and the viscosity of the sealant is too high, so the sealant does not immerse in the groove and is near the top of the inner cylinder due to solidification shrinkage It is considered that the sealant leaked due to the lack of physical contact, and the minimum thickness of the resin layer portion was thinner than in the examples. When the workpiece after potting was actually confirmed, leakage of the sealant was confirmed in the workpieces of Comparative Examples 2, 3, and 6.
In Comparative Example 5, when the sealant was applied, the swelling of the sealant and the protrusion of the sealant from the end surface of the outer cylinder portion were confirmed. This is considered to be caused by a short difference in height between the end surface of the outer tube portion and the end surface of the inner tube portion.

  It should be noted that the same effect can be obtained with respect to the reduction of the leakage of the sealant when a sealing jig for the groove 41 without the stepped portion 60 as shown in FIG. 2 is used.

  INDUSTRIAL APPLICABILITY The present invention is useful for suppressing the amount of sealant used and the amount of sealant used when a fluid processing device is manufactured using a sealing jig.

DESCRIPTION OF SYMBOLS 1 Fluid processor 10 Cylindrical part 11 Header cap 30 Sealing jig 40 Outer peripheral wall 41 Groove 50 Inner cylindrical part 51 Outer cylindrical part A Hollow fiber membrane bundle B Sealant E Sealant

Claims (12)

When manufacturing the fluid treatment device, when the opening end of the hollow fiber membrane bundle accommodated in the cylindrical portion of the fluid treatment device is sealed with a sealing agent, the sealing treatment attached to the end portion of the cylindrical portion is used. Tools,
A sealing jig characterized in that a groove is formed along the outer peripheral wall, which is formed in a cylindrical shape, and is open inside the cylindrical outer peripheral wall in one axial direction. . A cylindrical outer cylinder part forming the outer peripheral wall;
A cylindrical inner cylinder disposed inside the outer cylinder; and
A bottom portion connecting the outer tube portion and the inner tube portion in a radial direction;
A fitting portion that is connected to the opposite side of the one direction of the bottom portion and can be fitted to an end portion of the cylindrical portion of the fluid treatment device,
An end portion on the one direction side of the outer cylinder portion protrudes from an end portion on the one direction side of the inner cylinder portion,
The sealing jig according to claim 1, wherein the groove is formed between the outer tube portion and the inner tube portion.   The said inner cylinder part has the step part which the width | variety of the said groove | channel on the said bottom part side becomes narrow, The jig | tool for sealing of Claim 2 characterized by the above-mentioned.   4. The sealing jig according to claim 3, wherein an inner corner portion of the step portion is curved.   The eye stop according to any one of claims 2 to 4, wherein a shift of an end face of said one direction side of said outer cylinder part and said inner cylinder part is 2.0 mm or more and 15.0 mm or less. Jig.   The jig for sealing according to any one of claims 1 to 5, wherein the widest portion of the groove is 2.0 mm or more and 6.0 mm or less.   The sealing jig according to claim 1, wherein the fluid processing device is a blood processing device. A method for producing a fluid treatment device using the sealing jig according to claim 1,
Attaching a sealing jig to the end of the cylindrical portion of the fluid treatment device;
In a state where the hollow fiber membrane bundle is accommodated in the cylindrical portion, a sealing agent is supplied to the inside including the groove in the sealing jig to solidify the sealing agent, and the hollow fiber membrane bundle is solidified. A step of closing the open end of
The sealing agent is supplied into the cylindrical portion on the center side from the sealant, the sealing agent is moved to the end of the cylindrical portion, the sealing agent is solidified, and the cylindrical portion Sealing the end,
And cutting the solidified sealing agent to form an open end at the end of the hollow fiber membrane.   When the opening end of the hollow fiber membrane bundle is sealed, the opening end of the hollow fiber membrane bundle is located between the end surface of the inner cylinder portion and the end surface of the outer cylinder portion of the sealing jig. The method for manufacturing a fluid processing device according to claim 8, wherein:   10. The method of manufacturing a fluid treatment device according to claim 9, wherein an end of the hollow fiber membrane bundle protrudes from an end surface of the inner cylinder portion in a range of 0.1 mm to 13.0 mm.   The method for manufacturing a fluid treatment device according to claim 8 or 9, wherein the sealing agent is a thermoplastic resin.   The method for manufacturing a fluid treatment device according to any one of claims 8 to 11, wherein the resin viscosity of the sealing agent is 100 mPa · s or more and 100,000 mPa · s or less.