JP2010210603A - Local in-brain temperature measuring sensor for small animal - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a temperature measuring sensor for sufficiently measuring temperature in a living body. <P>SOLUTION: A thermistor chip 5 is covered with a reinforcing resin 3 of high bending elastic modulus, and stress to a wire 2 and a connection section 4 between the thermistor chip 5 and the wire 2 can be suppressed. The reinforcing resin 3 is made of resin of low thermal expansion coefficient, so that stress by temperature variation to the wire 2 and the connection section 4 between the thermistor chip 5 and the wire 2 can be suppressed. A glass layer 1 is formed on the formed insulating resin 3. The thickness of the glass layer 1 is 200 μm or smaller, and the glass layer 1 can be made flexible. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a temperature sensor capable of accurately measuring a temperature in a living body accurately for a long period of time.

  Conventionally, the temperature sensor is protected by a metal cover or a structure sealed with glass or resin, and there has been a problem in using it in a living body in such a state.

Conventional temperature sensors have the following drawbacks.
(B) In the temperature sensor of the protective cover made of metal, the outflow of metal ions may occur in the living body, which may affect the biological reaction.

  (B) The required high bending elastic modulus could not be obtained with a protective cover made of metal having a diameter of 1 mm or less.

  (C) A thermistor chip that is as large as possible is good in temperature accuracy, but it is very difficult to protect it with a metal case and further insulate it to a diameter of 1 mm or less.

  (D) A temperature sensor with a thermistor chip protected only by glass and having a diameter of 1 mm or less and a length of 3 mm or more was embedded in the living brain. .

(D) In the case of resin sealing, there is a possibility that thermistor chip, joint portion or wiring may be deteriorated due to outflow of resin ions, moisture absorption due to long-term use of the resin in the living body, or intrusion of substances.
The present invention has been made to eliminate the above drawbacks.

In measuring the temperature in the living body.
In order to eliminate the disadvantages of the conventional technology, thermistor chip, wiring connection part, and wiring are prevented from stress on the body by resin formation to ensure performance.

  In addition, the resin ion is prevented from flowing out into the living body, and further, it is formed of a reinforcing resin, a thermistor chip and a wiring connection portion, and a glass layer that prevents moisture absorption and substance intrusion into the wiring, thereby obtaining long-term reliability.

  In the present invention, the composite structure of these resin and glass is the most main feature and exhibits the effect.

  According to the above invention, it has become possible to continuously measure the mouse brain temperature in a stable state for one month.

  It is sectional drawing of this invention.

  In order to measure the temperature in the living body in a stable state over a long period of time, it can be attached to the living body with the minimum number of parts, and the body diameter excluding wiring is 1mm or less and the overall length is 3.5mm or more. .

In measuring the temperature in the living body.
In order to ensure stable insulation of the thermistor chip, the wiring connection portion, and the wiring, a temperature sensor is formed with an insulating resin.

  Creating a shape with a diameter of 1 mm or less was a difficult task with the conventional method of filling an insulating material in a metal cover, but molding with a resin mold became possible and manufacturing became easy.

  In addition, the metal cover method did not provide sufficient rigidity, but it became possible to obtain a high flexural modulus with the resin reinforced structure.

  Even in a living body where movement occurs due to the use of a reinforcing resin having a high flexural modulus, it is possible to suppress the occurrence of stress on the internal temperature measurement component, the connection between the component and the wiring, and the wiring.

  By using a reinforced resin having a small coefficient of thermal expansion, it is possible to suppress the generation of stress on the thermistor chip, the wiring connection portion, and the wiring due to temperature changes in the living body.

  Create a glass layer on the formed insulating resin

  The glass layer was formed by a method that does not adversely affect the thermistor chip, its junction, wiring, and reinforcing resin by using a method that is possible at a temperature of 150 ° C. or less.

  The glass layer was formed with a layer of 200 microns or less, which made it possible to have flexibility in the glass layer and to prevent cracking from stress due to the movement of the living body.

  It is used for research to prove the relationship between living body temperature and life activity. Furthermore, it is considered to be used for research on therapeutic methods for diseases.

1 Glass layer 2 Wiring 3 Resin 4 Wiring connection part 5 Thermistor chip

Claims (1)

  A temperature measurement sensor part in which the temperature detection part such as the thermistor chip, the wiring connection part, and the wiring are reinforced with resin and protected by glass.

Images