JP2010184875A - Anti-obestic agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicine, food or the like which is excellent in safety, and is effective for preventing or improving obesity, fatty liver, and various developed diseases caused by or related to them. <P>SOLUTION: The anti-obestic agent is characterized by containing the dry powder and/or extract of a genus Bidens plant as an active ingredient. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an anti-obesity agent comprising as an active ingredient a dried product or extract of a plant belonging to the genus Sendangsa.

  Conventionally, as a method of preventing or improving obesity, there are known methods such as glucomannan that swell with moisture in the stomach when eaten to give the stomach a feeling of fullness and reduce the amount of meal, but there are shortcomings that do not last long enough At present, it is not possible to obtain a good effect. The present invention relates to providing pharmaceuticals or foods that are excellent in safety and effective in preventing or ameliorating obesity, fatty liver, and various diseases caused by or related to these.

  It is an object of the present invention to provide a pharmaceutical or food product that is excellent in safety and effective in preventing or ameliorating obesity, fatty liver, and various diseases caused or caused by these.

As a result of studying the usefulness of bidenspirosa, the present inventors have recognized the effectiveness in preventing or improving obesity, and have completed the present invention.
That is, the present invention is as follows.
(1)
An anti-obesity agent comprising a dried product or extract of a plant belonging to the genus Sendangsa as an active ingredient.
(3)
The antiobesity agent according to (1) above, which is in an aqueous solution or a solid form.
(4)
The antiobesity agent according to (1) or (2) above, wherein the plant of the genus Sendungusa is bidenspirosa.

As shown in the results of Examples described later, the dried or extract of Sendangsa plant is extremely effective as an anti-obesity agent, that is, a prophylactic or ameliorating agent for obesity. The effect of preventing or improving obesity seems to be largely due to the effect of increasing the concentration of adiponectin in the blood and the effects of organic substances contained in Sendangusa plants and minerals contained in large amounts.
The plant of the genus Sendangsa used in the present invention, in particular, a dry powder tablet of bidenspirosa or a tea or extract extract of boiled tea or an extract tablet is taken by humans and has no safety problem, and is used as an agent for preventing or improving obesity. Very useful.

The Sendangusa plant used in the present invention is a group of plants referred to as the genus Bidens in scientific name. There are many kinds of varieties because they cross each other in various ways, and there is confusion in botany, and the correspondence of scientific names, Japanese names, and Chinese names is also mixed and it is extremely difficult to identify, but it is used in the present invention The plant of the genus Sendangusa includes those listed below.
Bidens pilosa L. (Kosendangusa, Koshirono Sendangusa, Sakai Toyokusa)
Bidens pilosa L. var. Minor (Blume) Sherff (Shirobanasendangusa, Shironosendangusa, Koshironosendangusa, Kosendangususa, Sakai Toyokusa)
Bidens pilosa L. var. Bisetosa Ohsani et S. Suzuki
Bidens pilosa Lf decumbens Scherff
Bidens pilosa L. var. Radiata Scherff (may also include Tachiawayukisendangusa and Hiawayukisendangusa)
Bidens pilosa L.var. Radiata Schultz Bipontinus
Bidens biternata Lour.Merrill et Sherff (Sendangsa)
Bidens bipinnata L. (Kobano Sendangsa, Sendangsa)
Bidens cernua L.
Bidens frndosa L. (American Sendangsa, Seitakatakogi )
Bidens parviflora Willd
Bidens radiate Thuill.var. Pinnatifida (Turcz. ) Kitamura ( Ezonotaukogi)
Bidens tripartita L.
This plant is mainly called 咸咸 草 in China / Taiwan, but it has many synonyms, such as Jigyo, Ogre, Tsubasa, Tsubasa, Tsubasa, Tsubame, Tsubame, Hakuhana There are names such as “grass”, “signou”, “red check”, “weather”, “south”, etc., and it is not clear which scientific name each corresponds to.

  The flower is a unique form of the Asteraceae, with 5 to 8 petal-like tongue-shaped flowers with rounded white or yellow, and several tens of yellow-brown tubular flowers in the center. The stem has square and light purple colored nodes. The leaves that are divided into three or five feathers have a handle, and the edges are jagged and opposite each other. In Japan, it is found in the southern part of Honshu, and is an annual grass of 25-85 cm in height, distributed in Taiwan, China, and tropical regions. When blessed with mild climatic conditions, flowers bloom one after another. There is a needle with a reverse spine on the top of the dark brown seed that is carried on the clothes of animals and humans.

In the present invention, among the above-mentioned plants of the genus Sendangsa, it is particularly preferable to use a group of plants called Bidence Pilosa. More specifically, Bidens pilosa L. , Bidens pilosa L. var.minor (Blume) Sherff , Bidens pilosa L. var. Bisetosa Ohtani et S. Suzuki , Bidens pilosa Lfdecumbens Scherff , Bidens pilosa L. var . Radiata Scherff , And Bidens pilosa L. var . Radiata Schultz Bipontinus .

The dried product and extract of the Sendangusa plant of the present invention can be prepared as follows.
The use part of the above-mentioned Sendangsa plant may be any part of the root, the above-ground part (stem, leaf, flower, etc.) or the whole plant. In particular, the use of leaf and stem portions is preferred in terms of efficacy.

  The drying of the plants of the genus Sendungusa is carried out using sun drying or ventilation drying. In the latter case, the temperature may be at a level that does not burn, but it is preferably 80 ° C. or lower for safety. In the case of sun drying, it is necessary to prevent it from being applied to the rain during drying. As a standard for drying, it is desirable to dry until the water content is 10% or less. Moreover, you may produce a dry powder by grind | pulverizing after drying.

As an extract, you may use the thing extracted by adding water or a hydrous solvent to normal temperature or a warm thing to a Sendangusa genus plant or its dried material. As an extraction method, for example, it is possible to obtain an extract by dipping and leaving still, or using an extraction device such as a Soxhlet extractor. Depending on the type of extraction solvent, the extract may be used as it is, or juice or extraction. The product may be dried to form a solid and then used. Examples of the extraction solvent include water, organic solvents such as methanol, ethanol, methyl acetate, ethyl acetate, ethylene glycol, and butylene glycol, and mixed solvents thereof. Water (or hot water) is particularly preferable during extraction. The temperature can usually be from room temperature to the boiling point. The extraction time depends on the temperature and the solvent, but when extraction is performed at room temperature to about boiling point, it can be performed over a range of about 1 to 300 hours.
When the juice or extract is used after being dried, it may be used as a dry powder by spray drying, freeze drying or the like. Moreover, you may mix and use a small amount of paste components as an adhesive agent in drying.

The anti-obesity agents of the present invention can be in aqueous solution or solid form. The solid form may be a powder, and can take various forms such as tablets, capsules, pellets, lozenges, granules, pills and the like.
The anti-obesity agent in the form of an aqueous solution of the present invention can be prepared by dissolving an aqueous solution of Sendangusa plant with water, or dissolving an extract of Sendangusa plant with water. In addition to water, a solvent such as ethanol or an aqueous xylitol solution may be added. Moreover, it can also be various liquid forms, such as a dispersion liquid, emulsion, and a syrup agent.

  The solid anti-obesity agent of the present invention can be prepared, for example, by mixing Sendangusa plant extract with crystalline cellulose and pressing.

The anti-obesity agent of the present invention is preferably taken at about 0.10 to 1.0 g / kg (body weight) a day when administering a dried product of the genus Sendangsa, 0.09 to 0.75 g / It is more preferable to take about kg (body weight), and it is more preferable to take about 0.27 to 0.45 g / kg (body weight) per day. Moreover, since the effect is easily exhibited by taking for at least 30 days, it is preferable to take for 90 days.
In addition, when administering a dried extract of the plant of the genus Sendangsa, it is preferable to take about 0.01 to 0.30 g / kg (body weight) per day, and 0.03 to 0.25 g / kg (body weight per day). It is more preferable to take about 0.09 to 0.15 g / kg (body weight) per day. Moreover, since the effect is easily exhibited by taking for at least 30 days, it is preferable to take for 90 days.

Adiponectin is produced in adipocytes and has been reported to suppress monocyte adhesion, smooth muscle cell proliferation / migration, and macrophage fat accumulation, and has an anti-atherogenic effect. In addition, it has been reported that there is an insulin sensitivity enhancing action, and this action suppresses arteriosclerosis, myocardial infarction, obesity, and fat accumulation.
It was found that the concentration of adiponectin in the blood was significantly increased by continuously taking the hot water extract of bidenspirosa, a plant of the genus Sendunga.
Therefore, it is thought that the increase in the adiponectin concentration is one cause of the obesity preventing or ameliorating action of bidenspirosa which is a plant of the genus Sendangsa. However, increasing adiponectin concentration does not necessarily have a correlation with obesity prevention or improvement. Since Bidenspirosa contains a large amount of minerals, this obesity prevention or amelioration action can be achieved by the metabolism-promoting action of this mineral or by the synergistic effect of the mineral-promoting action and the action of increasing the adiponectin concentration. It is speculated that it is being demonstrated.
Examples are shown below, but the present invention is not limited to these examples.

[Production Example 1] Dry powder of biden spirosa The whole above-ground grass of biden spirosa is cut into 1-5 cm, dried and pulverized to a particle size of 10-100 μm.

[Production Example 2] Hot water extract of biden spirosa 50 g dry product of the above-ground whole plant of biden spirosa was added to 1,000 g of water, extracted at 80-100 ° C. for 5 hours, cooled and filtered to 600 g of hot water extract ( A pure content of 3.1% by mass) was obtained.

[Production Example 3] Hot water extract dried product of bidenspirosa 100 g of the hot water extract obtained in Production Example 2 was freeze-dried to obtain 3 g of a dry powder.

[Example 1]
1,000 g of water was mixed with 5 g of the dry powder of bidenspirosa (BP) obtained in Production Example 1, and the mixture was boiled for 15 minutes, followed by a drinking test as boiled tea, and the change in body weight was measured. In addition, the meal was as usual, and tea was drunk 1,000 to 2,000g per person per day. Five people were tested. The results after 3 months are summarized in Table 1.

表１の通り、効果が出ている。 Table 1 Changes in body weight by drinking BP dry powder tea

As shown in Table 1, the effect is achieved.

[Example 2]
The BP dry powder obtained in Production Example 1 was used as tea in the same manner as in Example 1. The amount of adiponectin, etc. in the blood before the drink was obtained in an amount of 1,000 g per day for 14 people to drink for 1 month. And measured 1 month after the beverage. The results are shown in Table 2.

n：14、M±SEM ＊＊：ｐ＜0.01（飲用前と比較） ＊：ｐ＜0.05（飲用前と比較） Table 2 Changes in adiponectin in blood by drinking BP dry powder tea

n: 14, M ± SEM **: p <0.01 (compared to before drinking) *: p <0.05 (compared with before drinking)

Adiponectin is produced in adipocytes and has been reported to suppress monocyte adhesion, smooth muscle cell proliferation / migration, and macrophage fat accumulation, and has an anti-atherogenic effect. In addition, it has been reported that there is an insulin sensitivity enhancing action, and this action suppresses arteriosclerosis, myocardial infarction, obesity, and fat accumulation.
TNF-α (Tumor Necrosis Factor) is one of tumor necrosis factors, and is a cytokine secreted mainly by monocyte macrophages and used as an index of damage to blood vessel walls.
BUN (Blood Urea Nitrogen) is urea nitrogen in the blood, and it increases with decreased renal function.
SCr (Serum Creatinin) means blood creatinine. Increased due to decreased renal function.

The results in Table 2 indicate that the adiponectin concentration in the blood of subjects who took BP dry powder tea for 1 month has increased significantly, and that there is no change in renal function.
The decrease in body weight in Example 1 seems to be caused by the improvement in obesity due to the increasing action of adiponectin.

[Example 3]
The Bidenspirosa (BP) extract powder obtained in Production Example 3 was converted into a 0.25g tablet, and 21 tablets a day were divided into three times and taken before meals. It was summarized in 3.

表３から明らかなように、BP抽出物錠の飲用でも、明らかに体重の減少が見られ、効果は確認された。 Table 3 21 BP extract tablets / weight change due to daily intake

As is clear from Table 3, even when the BP extract tablet was taken, a decrease in body weight was clearly observed, and the effect was confirmed.

Claims (3)

  An anti-obesity agent comprising a dried product or extract of a plant belonging to the genus Sendangsa as an active ingredient.   The antiobesity agent according to claim 1, which is in an aqueous solution or a solid form.   The anti-obesity agent according to claim 1 or 2, wherein the plant of the genus Sendungusa is bidenspirosa.