JP2010172365A - Apparatus and program for diagnosing autonomic nerve function - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To diagnose the presence/absence of abnormality of an autonomic nerve function with high accuracy. <P>SOLUTION: Electrocardiographic data of a person to be measured is measured by an electrocardiogram monitor, and a sympathetic nerve activity index (LF/HF), CVRR (electrocardiogram R-R interval variation coefficient) and a heart rate (HR) are calculated on the basis of the measured electrocardiographic data. Then, the relation between the calculated LF/HF and the calculated CVRR is two-dimensionally displayed to a display device, and the relation between the calculated heart rate and the calculated CVRR is two-dimensionally displayed to the display device. Then, a controller divides respective two-dimensional planes into 9 areas and performs display by setting two thresholds for the respective values respectively. By making general determination on the basis of the two two-dimensional graphs, the autonomic nerve function is diagnosed. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an autonomic nerve function diagnostic apparatus and program for evaluating whether or not an autonomic nerve function is functioning normally.

  In modern society, various stresses based on the social environment are increasing. Therefore, in recent years, an increase in patients with mental illnesses such as depression and autonomic dysfunction has become a major social problem. And when it falls into such a mental illness, the functional disorder which an autonomic nerve does not function normally generate | occur | produces.

  In order to diagnose a patient having such a mental illness, a diagnosis by a specialist doctor with sufficient experience and knowledge is required. However, in order to receive a diagnosis by a doctor, the patient himself / herself must be aware of the symptoms and visit the doctor, or a surrounding person must bring the patient to the doctor.

  In addition, the degree of such mental illness varies widely, and there may be a slight degree that no abnormality is seen at first glance. For this reason, there are many cases where the patient himself / herself is aware of the symptoms and the surrounding people cannot always recognize the patient's morbidity. Therefore, a method for objectively diagnosing whether or not an autonomic nerve dysfunction has occurred is desired. If the presence or absence of abnormality of the autonomic nerve function can be diagnosed by a simple method, for example, it can be applied to a medical examination such as a medical examination that is simultaneously received by many humans. It becomes possible to detect mild depression and autonomic disorder early and take appropriate measures.

  Various methods have been proposed for objectively diagnosing such autonomic nervous function (see, for example, Patent Documents 1 and 2).

  Patent Documents 1 and 2 disclose a method for evaluating autonomic nervous function based on a patient's pulse and blood pressure value. However, this method does not directly evaluate the autonomic nervous function, but only evaluates the autonomic nervous function indirectly from the pulse and blood pressure values. In the case of a patient, it is not always possible to accurately grasp the state of autonomic nerve function. In addition, if the patient has received temporary mental stress or physical load before receiving the diagnosis, the autonomic nerve function may not be accurately diagnosed.

JP 2003-235817 A JP 2006-102265 A

  With the above-described conventional technology, when diagnosing autonomic nerve function, the autonomic nerve function is highly accurate because it is affected by circulatory function and brain function diseases, temporary mental stress, and physical load. There was a problem that it could not be evaluated.

  An object of the present invention is to provide an autonomic nervous function diagnostic apparatus and program capable of diagnosing the presence or absence of abnormality in autonomic nervous function with high accuracy.

[Autonomic nerve function diagnosis device]
In order to achieve the above object, an autonomic nervous function diagnostic apparatus according to the present invention includes an electrocardiogram measuring means for measuring an electrocardiogram of a living body,
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
Display means for displaying biological information;
Control means for controlling the display means so as to two-dimensionally display the relationship between the heart rate calculated by the heart rate calculation means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means.

  According to the present invention, the electrocardiogram RR interval variation coefficient and the heart rate are calculated based on the electrocardiogram data measured from the patient, and the relationship between the electrocardiogram RR interval variation coefficient and the heart rate is displayed two-dimensionally. Therefore, when diagnosing the autonomic nerve function, it is possible to determine whether or not the diagnosis result is affected by temporary mental stress or physical load.

In addition, another autonomic nervous function diagnostic apparatus of the present invention includes an electrocardiogram measuring means for measuring the electrocardiogram of a living body,
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed two-dimensionally, and a plurality of values are displayed for each value. Control means for controlling the display means so as to divide and display the two-dimensional plane into a plurality of areas by setting threshold values.

  According to the present invention, when the relationship between the electrocardiogram RR interval variation coefficient calculated based on the electrocardiogram data measured from the patient and the sympathetic nerve activity index is displayed two-dimensionally, the electrocardiogram RR interval variation coefficient. Since the two-dimensional plane is divided into a plurality of areas by setting a plurality of threshold values for each value of the sympathetic nerve activity index, the electrocardiogram RR interval variation coefficient and the sympathy It becomes easy to quantitatively grasp the relationship between the nerve activity index.

In addition, another autonomic nervous function diagnostic apparatus of the present invention includes an electrocardiogram measuring means for measuring the electrocardiogram of a living body,
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed in a two-dimensional manner and calculated by the heart rate calculating means. Control means for controlling the display means so as to two-dimensionally display the relationship between the heart rate and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means.

  In the present invention, the relationship between the electrocardiogram RR interval variation coefficient calculated based on the electrocardiographic data measured from the patient and the sympathetic nerve activity index are secondarily displayed, and the electrocardiographic data measured from the patient is displayed. The relationship between the electrocardiogram RR interval variation coefficient calculated based on this and the heart rate is secondarily displayed. Therefore, according to the present invention, it is possible to diagnose the autonomic nervous function based on the relationship between the electrocardiogram RR interval variation coefficient and the sympathetic nerve activity index, and the relationship between the electrocardiogram RR interval variation coefficient and the heart rate. Thus, it can be determined whether or not the diagnosis result of the autonomic nerve function is affected by temporary mental stress or physical load, and the autonomic nerve function can be diagnosed with high accuracy.

  Furthermore, in the autonomic nervous function diagnostic apparatus of the present invention, the control means sets a plurality of threshold values for each value of the sympathetic nerve activity index, the electrocardiogram RR interval variation coefficient, and the heart rate. Each two-dimensional plane may be divided into a plurality of areas for display.

  According to the present invention, it becomes easy to quantitatively grasp the relationship between the electrocardiogram RR interval variation coefficient and the sympathetic nerve activity index, and the relationship between the electrocardiogram RR interval variation coefficient and the heart rate.

In addition, another autonomic nervous function diagnostic apparatus of the present invention includes an electrocardiogram measuring means for measuring the electrocardiogram of a living body,
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means, the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means, and the heart rate calculated by the heart rate calculating means And a control means for controlling the display means to display based on a relationship with a plurality of threshold values set for each value.

In addition, another autonomic nervous function diagnostic apparatus of the present invention includes a receiving unit that receives electrocardiographic data measured by the electrocardiographic measuring unit,
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
A heart rate calculating means for calculating a heart rate based on the electrocardiogram data received by the receiving means;
CVRR calculating means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data received by the receiving means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed in a two-dimensional manner and calculated by the heart rate calculating means. Control means for controlling the display means so as to display two-dimensionally the relationship between the heart rate and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means.

[program]
Further, the program of the present invention includes a step of measuring an electrocardiogram of a living body by an electrocardiogram measuring means,
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating a heart rate based on the electrocardiogram data measured by the electrocardiograph means;
Calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
The relationship between the calculated sympathetic nerve activity index and the calculated electrocardiogram RR interval variation coefficient is displayed two-dimensionally, and the relationship between the calculated heart rate and the calculated electrocardiogram RR interval variation coefficient is 2 Causing the computer to execute the step of displaying dimensions.
Furthermore, another program of the present invention includes a step of receiving electrocardiographic data measured by an electrocardiographic measurement means;
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a heart rate based on the received electrocardiogram data;
Calculating an electrocardiogram RR interval variation coefficient based on the received electrocardiogram data;
The relationship between the calculated sympathetic nerve activity index and the calculated electrocardiogram RR interval variation coefficient is displayed two-dimensionally, and the relationship between the calculated heart rate and the calculated electrocardiogram RR interval variation coefficient is 2 Causing the computer to execute the step of displaying dimensions.

  As described above, according to the present invention, it is possible to obtain an effect that it is possible to diagnose the presence or absence of abnormality of the autonomic nerve function with high accuracy.

It is a block diagram which shows the structure of the autonomic nerve function diagnostic apparatus of one Embodiment of this invention. It is a flowchart which shows operation | movement of the autonomic-nervous function diagnostic apparatus of one Embodiment of this invention. It is a flowchart for demonstrating the LF / HF calculation method in the autonomic-nervous function diagnostic apparatus of one Embodiment of this invention. It is a figure which shows the heart rate fluctuation | variation measuring method in the case of LF / HF calculation. It is a figure which shows an example which spectrum-analyzed in the case of LF / HF calculation. It is a figure which shows an example of the display shown by the display apparatus 22 in FIG. It is a figure for demonstrating the content of each area at the time of dividing the two-dimensional display in the display apparatus 22 into 9 parts. It is a figure which shows the example of a display at the time of displaying as percentage what measurement data are classified into. It is the example of a display which showed the measurement data of a certain to-be-measured person simply. It is the example of a display which showed the measurement data of another to-be-measured person simply. It is the example of a display which showed the measurement data of another to-be-measured person simply. It is a figure which shows an example at the time of displaying simply the relationship of three values, LF / HF, CVRR, and a heart rate. It is a figure which shows an example at the time of displaying the graph shown in FIG. 12 in time series.

  Next, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing a configuration of an autonomic nervous function diagnostic apparatus according to an embodiment of the present invention.

  As shown in FIG. 1, the autonomic nervous function diagnostic apparatus of the present embodiment displays an electrocardiogram monitor 14 for acquiring electrocardiographic data of a measurement subject, a control device 18, a storage device 20, and biological information. Display device 22, autonomic nerve activity calculation unit 24, and CVRR (Coefficient of Variation of RR intervals) calculation unit 25.

  The electrocardiogram monitor 14 attaches a minus electrode, for example, to the measurement subject's throat, a plus electrode on the left flank, and a body ground on the right flank, obtains heart movement as an electrical signal and records it as electrocardiographic data.

  The autonomic nerve activity calculation unit 24 calculates a sympathetic nerve activity index (LF / HF) indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram monitor 14. A specific method for calculating LF / HF will be described later.

  The CVRR calculation unit 25 calculates CVRR (electrocardiogram RR interval variation coefficient) based on the electrocardiogram data measured by the electrocardiogram monitor 14. A specific method for calculating the CVRR will also be described later.

  The heart rate calculator 26 calculates a heart rate (HR: Heart Rate) based on the electrocardiogram data measured by the electrocardiogram monitor 14. Here, the heart rate is the number of heart beats within a predetermined period such as 1 minute.

  The control device 18 includes, for example, a computer, processes the biological information obtained by the autonomic nerve activity calculation unit 24, the CVRR calculation unit 25, and the heart rate calculation unit 26, and stores the processed information in the storage device 20. Alternatively, it is displayed on the display device 22. The control device 18 displays biological information on the display device 22 for each heartbeat of the electrocardiogram obtained by the electrocardiogram monitor 14.

  Then, the control device 18 determines the relationship between the sympathetic nerve activity index (LF / HF) calculated by the autonomic nerve activity calculation unit 24 and the CVRR calculated by the CVRR calculation unit 25 with respect to the display device 22. In addition to the two-dimensional display, the relationship between the heart rate calculated by the heart rate calculation unit 26 and the CVRR calculated by the CVRR calculation unit 25 is two-dimensionally displayed on the display device 22.

  At this time, the control device 18 sets two threshold values for each value of the sympathetic nerve activity index (LF / HF), CVRR, and heart rate, respectively, so that each two-dimensional plane is divided into nine areas ( Area). In the present embodiment, the description will be made using a case where the two-dimensional plane is divided into nine parts. However, by setting one threshold value or setting three or more threshold values for each value, the two-dimensional plane is changed. It is also possible to display by dividing into 4, 6 and 12 parts.

  Further, the control device 18 may set each threshold value in accordance with patient information input in advance such as the patient's past history, age, and sex.

  Next, the operation of the autonomic nervous function diagnosis apparatus of this embodiment will be described in detail with reference to FIG. FIG. 2 is a flowchart showing the operation of the autonomic nervous function diagnostic apparatus of this embodiment.

  First, the operation of the autonomic nervous function diagnostic apparatus of this embodiment will be described with reference to FIG.

  First, as an initial setting, before the examination is started, patient information such as the name, age, ID number, sex, medical history (diabetes, vascular disorder, etc.) of the person to be measured is input to the control device 18 (S201). .

  When the treatment is started, the electrocardiogram data of the living body is measured by the electrocardiogram monitor 14 (step S202). Then, the heart rate calculation unit 26 calculates the heart rate (HR) of the measurement subject. Then, the autonomic nerve activity calculation unit 24 performs LF / HF calculation to calculate a sympathetic nerve activity index (LF / HF) indicating the activity level of the sympathetic nerve (step S203). Then, the CVRR calculation unit 25 performs CVRR calculation to calculate CVRR that is an index indicating the degree of variation in the RR interval (step S204). The calculation result calculated by the heart rate calculation unit 26, the calculation result calculated by the autonomic nerve activity calculation unit 24, and the calculation result calculated by the CVRR calculation unit 25 are stored in the storage device 20 by the control device 18. And two-dimensionally displayed on the display device 22 (step S205).

  Then, it is determined whether or not an instruction to end the examination has been performed (step S206), and the processes of steps S202 to S205 are performed for each heartbeat until an instruction to end the examination is given.

  Next, details of the LF / HF calculation method shown in step S203 of FIG. 2 are shown in FIGS.

  First, in step S <b> 301, the autonomic nerve activity calculation unit 24 calculates heartbeat variability from electrocardiographic data input from the electrocardiogram monitor 14. The heart rate variability was calculated as shown in FIGS. 4A and B by measuring the RR interval by taking the interval between the R wave and the next R wave, and then measuring as shown in FIGS. 4C and D. The R-R interval data is plotted at the time position of the rear R-wave, and after interpolation, data is resampled at equal intervals (dotted line in FIG. 4C). In the next step S302, spectrum analysis (frequency conversion) is performed on the data obtained in step S301. An example of the spectrum analysis in step S302 is shown in FIG. In the next step S303, a low frequency component LF is obtained. Here, the low frequency component LF is an integral value of the power spectrum component of 0.04 to 0.15 Hz. In the next step S304, a high frequency component HF is obtained. Here, the high frequency component HF is an integral value of the power spectrum component of 0.15 to 0.40 Hz. In step S305, the ratio between the LF obtained in step S303 and the HF obtained in step S304 is calculated as LF / HF.

  In this way, the autonomic nerve activity calculation unit 24 calculates the sympathetic nerve activity index (LF / HF) from the electrocardiogram data measured by the electrocardiogram monitor 14.

Next, details of the CVRR calculation method shown in step S204 of FIG. 2 will be described.
CVRR is an index indicating the degree of variation in heart rate variability, and is a coefficient indicating the degree of variation in the RR interval (interval of the apex of the R wave in the electrocardiogram waveform) shown in FIG. 4A. Specifically, this CVRR is calculated by the following equation.
CVRR = R−R interval standard deviation / R−R interval average × 100 (%)

  Here, the RR interval standard deviation is, for example, the standard deviation of the RR interval in a predetermined period of 1 minute or a predetermined number of heartbeats such as 100 beats. The RR interval average is, for example, an average of RR intervals in a predetermined period or a predetermined number of heartbeats.

  The CVRR calculation unit 25 calculates CVRR from the electrocardiogram data measured by the electrocardiogram monitor 14 based on the above formula.

  Next, FIG. 6 shows an example of display on the display device 22 in the autonomic nervous function diagnostic apparatus of the present embodiment.

  In the display example shown in FIG. 6, the sympathetic nerve activity index (LF / HF) is set on the horizontal axis, and CVRR is set on the vertical axis. The sympathetic nerve activity index (LF / The relationship between (HF) and CVRR is displayed two-dimensionally. Further, the relationship between the heart rate and CVRR is two-dimensionally displayed with the heart rate (HR) as the horizontal axis and CVRR as the vertical axis. In the display example shown in FIG. 6, the past measurement values are indicated by black circles, and the latest measurement values are indicated by white circles.

  In the two two-dimensional displays, since the CVRR is set to the vertical axis in common, the two two-dimensional displays arranged on the left and right can be easily compared.

  In the two two-dimensional displays, each two-dimensional plane is divided into nine areas (regions) by setting two threshold values for each value. Specifically, in the display example shown in FIG. 6, 0.1 and 5.0 are set as threshold values for LF / HF, and 2.0 and 5.0 are set as threshold values for CVRR. Yes. Further, 60 (bpm: beats per minute) and 100 (bpm) are set as the heart rate threshold.

  The threshold is set as described above. When LF / HF is 5.0 or more, it can be determined that the function of the sympathetic nerve is enhanced. In this case, it can be determined that the function of the sympathetic nerve is normal, and when it is 0.1 or less, it can be determined that the function of the sympathetic nerve is lowered.

  CVRR is used as an index indicating whether the parasympathetic nerve is increased or decreased in function. Therefore, when CVRR is 5.0 or more, it can be determined that the function of the parasympathetic nerve is enhanced, and when 2.0 to 5.0, the function of the parasympathetic nerve is normal. If it is 2.0 or less, it can be determined that the function of the parasympathetic nerve is lowered.

  When the heart rate is 100 (bpm) or more, it is determined to be tachycardia, when 60 to 100 (bpm) is normal, and when it is 60 (bpm) or less, it is determined to be bradycardia. Can do.

  Note that the present invention is not limited to the threshold values shown here, and various values can be set for each threshold value depending on the situation.

The meaning of each area when the two-dimensional plane is divided into nine in this way will be described with reference to FIG.
In the left graph showing the relationship between LF / HF and CVRR, each of the nine areas shows a state of a combination of enhancement / normality / decrease of sympathetic nerve function and enhancement / normality / decrease of parasympathetic nerve. In FIG. 6, “↑” means that the function is enhanced, “−” means that the function is normal, and “↓” means that the function is lowered. . Thus, according to the autonomic nerve function diagnostic apparatus of this embodiment, it becomes possible to evaluate the autonomic nerve function by a combination of enhancement / normality / decrease of sympathetic nerve function and enhancement / normality / decrease of parasympathetic nerve.

  In the graph on the right, which shows the relationship between heart rate (HR) and CVRR, whether the current state of the autonomic nerve is transient due to physical or mental external stress, etc. It is shown whether it is chronic due to.

  Normally, when the subject is at rest, the parasympathetic nerve is dominant, the sympathetic nerve activity index (LF / HF) is a relatively small value, the RR interval is stable, and the value of CVRR Is also a small value. Then, when any physical stress or mental stress is applied to the measurement subject, the value of this CVRR increases. And when a to-be-measured person receives some physical stress and mental stress, a heart rate also becomes large with CVRR. For example, when a standing test is performed, when a standing test is performed, or when the person being measured is in tension, heart rate variability increases due to tachycardia, so both heart rate (HR) and CVRR are large. Become.

  Therefore, in the graph on the right, which shows the relationship between heart rate (HR) and CVRR, when the measured value is moving upward or downward to the left, It can be determined that the condition is external stress or cerebral anemia. In other words, if the measured values are concentrated in the direction of the upper right area and the lower left area centering on the normal area in the middle of the nine areas, there may be a major cause that is particularly problematic. It can be judged that the nature is low.

  On the other hand, when CVRR is a small value but only the heart rate is large, or when CVRR is a large value and only the heart rate is small. Is expected to have some problem with the health condition of the subject. In particular, when CVRR is small but only heart rate is large, such as myocardial infarction, angina pectoris, ventricular arrhythmia, sudden cardiac death, coronary artery disease, congestive heart failure, etc. There may be some impairment in cardiac function and it is highly suspected that there is a serious impairment in the subject.

  According to the autonomic nerve function diagnostic apparatus of the present embodiment, the state of autonomic nerve function (balance between sympathetic nerve function and parasympathetic nerve function) is determined from the graph showing the relationship between LF / HF and CVRR, and the heart rate and CVRR are also determined. It is possible to determine whether the condition of the subject is transient and mild or severe and has a chronic disorder.

  Further, since the two-dimensional display is divided into nine parts, it is easy to quantitatively grasp the relationship between CVRR and LF / HF and the relationship between heart rate and CVRR. Further, after the measurement for a certain period is completed, as shown in FIG. 8, it is possible to further quantitatively grasp the measurement result by displaying in which area the measurement value is classified as a percentage. .

  In the autonomic nervous function diagnosis apparatus according to the present embodiment, the case where two graphs are displayed side by side has been described. However, each graph can be used alone. For example, even when only the graph showing the relationship between LF / HF and CVRR shown in FIG. 6 is used, the balance between the sympathetic nerve function and the parasympathetic nerve function is obtained because the two-dimensional plane is divided into nine areas. It is possible to quantitatively grasp what state is. In addition, even when only the graph showing the relationship between the heart rate and CVRR is used, it is possible to grasp the state of the autonomic nerve function from the relationship between the subject's accessory switching function and the heart function, It is possible to determine whether the measurement subject is transient and has no problem or whether there is any serious disability.

  Next, display examples simply showing measurement results obtained by actually measuring the electrocardiographic data of a measurement subject will be described with reference to FIGS.

  In the display example shown in FIG. 9, referring to the graph on the left side, it can be seen that the parasympathetic nerve function is enhanced and the exchange nerve function is slightly enhanced. Then, referring to the graph on the right side, it can be seen that the heart rate is a slightly large value, indicating tachycardia. As a result, when comprehensively determined, the person to be measured can be determined to be in a tension state due to temporary anxiety and can be determined to be particularly unnecessary for some kind of examination.

  In the display example shown in FIG. 10, referring to the graph on the left side, it can be seen that the parasympathetic nerve function is lowered and the exchange nerve function is normal. Then, referring to the graph on the right side, it can be seen that the heart rate is a slightly large value and the CVRR is lowered despite the tachycardia. As a result, when judged comprehensively, it is suspected that the subject has some kind of disease in the heart function or the like although not serious yet.

  In the display example shown in FIG. 11, referring to the graph on the left side, it can be seen that the parasympathetic nerve function is increased and the exchange nerve function is decreased. Then, referring to the graph on the right side, it can be seen that the heart rate is normal, but CVRR is a large value. As a result, when judged comprehensively, the subject is suspected of having an abnormal autonomic nerve function. Actually, the measurement data shown in FIG. 11 is a case of a patient who has been diagnosed as having not recovered autonomic nerve function since only about two months have passed since the operation of the intraspinal tumor (brain stem). is there.

  Thus, according to the autonomic nervous function diagnostic apparatus of the present embodiment, referring to two graphs, a graph showing the relationship between LF / HF and CVRR, and a graph showing the relationship between heart rate and CVRR, By determining, the state of the autonomic nerve function can be diagnosed with high accuracy.

  In the present embodiment, the relationship between the three values of LF / HF, CVRR, and heart rate is displayed by two two-dimensional graphs. For simplicity, these three values are represented for each value. If the display is made based on the relationship between the two set threshold values, a similar diagnosis can be performed. For example, as shown in FIG. 12, two threshold values are set for each of LF / HF, CVRR, and heart rate (HR), and the relationship between the measured values is displayed in a line graph. Good. In the example shown in FIG. 12, only the average value of a plurality of measured values in the graph shown in FIG. 6 is shown, and what position this average value is with respect to the set threshold value. It is shown. In the display example shown in FIG. 12, it is impossible to indicate in what range each measurement value varies, but what is the relationship between the average values of the measurement values of LF / HF, CVRR, and HR? Can be grasped visually.

  Then, if the graph shown in FIG. 12 is displayed in time series as shown in FIG. 13, it is possible to easily grasp the change in the autonomic nervous function of the measurement subject.

  In addition, by performing such measurement before and after a load test such as a standing test, it is possible to grasp whether the autonomic nerve responds normally to an external load.

[Modification]
In the above embodiment, the electrocardiogram monitor 14 is provided, and the sympathetic nerve activity index (LF / HF), CVRR, and heart rate are calculated based on the electrocardiogram data measured by the electrocardiogram monitor 14. However, the present invention is not limited to such a configuration. Without providing the electrocardiogram monitor 14, a receiving means for receiving external electrocardiographic data is provided, and a sympathetic nerve activity index (LF / HF), CVRR, and heart rate are calculated based on the electrocardiographic data received by the receiving means. It can also be set as the structure which performs. By adopting such a configuration, the autonomic nervous function diagnosis apparatus does not need to be provided with an electrocardiogram measurement means such as the electrocardiogram monitor 14.

14 ECG Monitor 18 Control Device 20 Storage Device 22 Display Device 24 Autonomic Nervous Activity Level Calculation Unit 25 CVRR Calculation Unit 26 Heart Rate Calculation Unit S201 to S207 Steps S301 to S305 Steps

Claims (8)

An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
Display means for displaying biological information;
Control means for controlling the display means to two-dimensionally display the relationship between the heart rate calculated by the heart rate calculation means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means;
An autonomic nervous function diagnostic apparatus comprising: An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed two-dimensionally, and a plurality of values are displayed for each value. Control means for controlling the display means so as to divide and display a two-dimensional plane into a plurality of areas by setting respective threshold values;
An autonomic nervous function diagnostic apparatus comprising: An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed in a two-dimensional manner and calculated by the heart rate calculating means. Control means for controlling the display means so as to two-dimensionally display the relationship between the calculated heart rate and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means;
An autonomic nervous function diagnostic apparatus comprising:   The control means divides each two-dimensional plane into a plurality of areas by setting a plurality of threshold values for each value of the sympathetic nerve activity index, the electrocardiogram RR interval variation coefficient, and the heart rate. The autonomic function diagnosis apparatus according to claim 3. An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Heart rate calculating means for calculating a heart rate based on the electrocardiographic data measured by the electrocardiogram measuring means;
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means, the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means, and the heart rate calculated by the heart rate calculating means. Control means for controlling the display means to display based on a relationship with a plurality of threshold values set for each value;
An autonomic nervous function diagnostic apparatus comprising: Receiving means for receiving electrocardiogram data measured by the electrocardiogram measuring means;
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
A heart rate calculating means for calculating a heart rate based on the electrocardiogram data received by the receiving means;
CVRR calculating means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data received by the receiving means;
Display means for displaying biological information;
The relationship between the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means is displayed in a two-dimensional manner and calculated by the heart rate calculating means. Control means for controlling the display means so as to two-dimensionally display the relationship between the calculated heart rate and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculation means;
An autonomic nervous function diagnostic apparatus comprising: Measuring the electrocardiogram of a living body by means of electrocardiogram measuring means;
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating a heart rate based on the electrocardiogram data measured by the electrocardiograph means;
Calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
The relationship between the calculated sympathetic nerve activity index and the calculated electrocardiogram RR interval variation coefficient is displayed two-dimensionally, and the relationship between the calculated heart rate and the calculated electrocardiogram RR interval variation coefficient is 2 A step of displaying dimensions;
A program that causes a computer to execute. Receiving the electrocardiogram data measured by the electrocardiograph means;
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a heart rate based on the received electrocardiogram data;
Calculating an electrocardiogram RR interval variation coefficient based on the received electrocardiogram data;
The relationship between the calculated sympathetic nerve activity index and the calculated electrocardiogram RR interval variation coefficient is displayed two-dimensionally, and the relationship between the calculated heart rate and the calculated electrocardiogram RR interval variation coefficient is 2 A step of displaying dimensions;
A program that causes a computer to execute.

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