JP4516623B1 - Autonomic nerve function diagnosis apparatus and program - Google Patents

Abstract

An object of the present invention is to easily determine the presence or absence of abnormality in autonomic nerve function with high accuracy.
An autonomic nerve total activity index (LH + HF) indicating an overall activity amount of autonomic nerve activity and CVRR (electrocardiogram RR interval variation coefficient) based on electrocardiogram data measured by an electrocardiogram monitor. calculate. Then, the relationship between the calculated autonomic nerve total activity index (LF + HF) and CVRR is displayed two-dimensionally on the display device. Further, the relationship between LF + HF and CVRR is approximated by a linear function, and a straight line based on this linear function is displayed. If there is measurement data that deviates significantly from the correlation between LF + HF and CVRR, it can be determined that there is an abnormality in the autonomic nerve function.
[Selection] Figure 6

Description

  The present invention relates to an autonomic nerve function diagnostic apparatus and program for evaluating whether or not an autonomic nerve function is functioning normally.

  In modern society, various stresses based on the social environment are increasing. Therefore, in recent years, an increase in patients with mental illnesses such as depression, autonomic dysfunction, and orthostatic dysregulation has become a major social problem. And when it falls into such a mental illness, the functional disorder which an autonomic nerve does not function normally generate | occur | produces.

  Autonomic nerves include sympathetic nerves that function mainly in an active state and parasympathetic nerves that function mainly in a resting state. When the living body is in a resting state, the state of the autonomic nerve becomes parasympathetic dominant, and the blood pressure value and the pulse rate decrease. When the living body is in a tension / active state, the state of the autonomic nerve becomes a sympathetic dominant state, and the blood pressure value and the pulse rate increase.

  When the autonomic nerve function is normal, switching between the sympathetic nerve dominant state and the parasympathetic nerve dominant state is performed while maintaining a balance between the sympathetic nerve and the parasympathetic nerve. However, when the autonomic nerve function becomes abnormal, the sympathetic nerve overreacts and increases abnormally, or the parasympathetic nerve overreacts and abnormally increases. Thus, if either the sympathetic nerve or the parasympathetic nerve is abnormally increased, the balance of the autonomic nerve is lost, and various symptoms such as headache, nausea, dizziness, palpitation and standing dizziness are caused.

  Various methods have been proposed as methods for diagnosing such autonomic nervous function (see, for example, Patent Documents 1 and 2).

JP 2003-235817 A JP 2006-102265 A

  Patent Documents 1 and 2 disclose a method for evaluating autonomic nervous function based on a patient's pulse and blood pressure value. However, in the method disclosed in Cited Document 1, the upper and lower limbs of a living body are compressed with a cuff, and after starting the compression, the autonomic nervous function is based only on the change amount or change rate of dispersion indicating the degree of variation in heart rate. It is not considered that the response to the pressure on the upper limb and the lower limb varies in each living body, and the autonomic nervous function cannot be accurately diagnosed.

  In addition, the method described in the cited document 2 does not directly evaluate the autonomic nervous function, but only evaluates the autonomic nervous function indirectly from the pulse and blood pressure values. In the case of a patient having a disease or the like, it may not always be possible to accurately grasp the state of autonomic nerve function. In addition, if the patient has received temporary mental stress or physical load before receiving the diagnosis, the autonomic nerve function may not be accurately diagnosed.

  An object of the present invention is to provide an autonomic nervous function diagnostic apparatus and program that can easily determine whether there is an abnormality in autonomic nervous function with high accuracy.

[Autonomic nerve function diagnosis device]
In order to achieve the above object, an autonomic nervous function diagnostic apparatus according to the present invention includes an electrocardiogram measuring means for measuring an electrocardiogram of a living body,
Based on the electrocardiogram data measured by the electrocardiogram measurement means, an autonomic nerve activity degree calculating means for calculating an autonomic nerve total activity amount index indicating an overall activity amount of the autonomic nerve activity,
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
Control means for controlling the display means to two-dimensionally display the relationship between the autonomic nerve activity activity index calculated by the autonomic nerve activity degree calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means. And.

  According to the present invention, an electrocardiogram RR interval variation coefficient and an autonomic nerve total activity index are calculated based on electrocardiogram data measured from a patient, and the electrocardiogram RR interval variation coefficient and autonomic nerve total activity amount are calculated. Since the relationship with the index is displayed two-dimensionally, the correlation between the electrocardiogram RR interval variation coefficient and the autonomic nerve total activity amount index can be easily grasped, and the autonomic nerve is based on this correlation. It is possible to easily determine whether there is a malfunction in the function.

Moreover, the autonomic nervous function diagnostic apparatus of the present invention includes an accepting means for accepting electrocardiogram data measured by the electrocardiogram measuring means,
Based on the electrocardiogram data received by the receiving means, an autonomic nerve activity degree calculating means for calculating an autonomic nerve total activity amount index indicating an overall amount of autonomic nerve activity,
CVRR calculating means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data received by the receiving means;
Display means for displaying biological information;
Control means for controlling the display means to two-dimensionally display the relationship between the autonomic nerve activity activity index calculated by the autonomic nerve activity degree calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means. And.

The autonomic nervous function diagnostic apparatus of the present invention includes a plurality of autonomic nerve activity level indexes calculated by the autonomic nerve activity calculating unit, and a plurality of electrocardiogram RR interval variation coefficients calculated by the CVRR calculating unit. And a correlation calculating means for calculating a relationship between the autonomic nerve total activity index and the electrocardiogram RR interval variation coefficient by a linear function,
The control unit controls the display unit to display a straight line based on the linear function calculated by the correlation calculation unit.

  According to the present invention, the relationship between the autonomic nerve total activity index and the electrocardiogram RR interval variation coefficient is calculated by a linear function, and a straight line based on the calculated linear function is displayed. It becomes easier to grasp the correlation between the RR interval variation coefficient and the autonomic nerve total activity amount index, and it is possible to more easily determine whether there is an abnormality in the autonomic nerve function based on the correlation.

  Further, the autonomic nervous function diagnostic apparatus of the present invention is based on a measurement result deviating a predetermined amount or more from the relationship between the autonomic nerve total activity index calculated by the correlation calculating means and the electrocardiogram RR interval variation coefficient, It further comprises a determination means for determining whether there is an abnormality in the autonomic nerve function.

  According to the present invention, since the determination means automatically determines the presence or absence of abnormality of the autonomic nerve function, even if the user cannot diagnose the autonomic nerve function only by the display content, the autonomic nerve function is objectively detected. It becomes possible to perform diagnosis.

[program]
The program of the present invention includes a step of measuring an electrocardiogram of a living body by an electrocardiogram measuring means,
Based on the electrocardiogram data measured by the electrocardiogram measurement means, calculating an autonomic nerve total activity amount index indicating an overall activity amount of autonomic nerve activity;
Calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Causing the computer to execute a step of two-dimensionally displaying a relationship between the calculated autonomic nerve total activity amount index and the calculated electrocardiogram RR interval variation coefficient.

Further, the program of the present invention receives the electrocardiogram data measured by the electrocardiogram measuring means,
Calculating an autonomic nerve total activity index indicating an overall activity amount of autonomic nerve activity based on the received electrocardiogram data;
Calculating an electrocardiogram RR interval variation coefficient based on the received electrocardiogram data;
Two-dimensionally displaying a relationship between the calculated autonomic nerve total activity amount index and the calculated electrocardiogram RR interval variation coefficient;
Is executed on the computer.

  As described above, according to the present invention, it is possible to obtain an effect that it is possible to diagnose the presence or absence of abnormality of the autonomic nerve function with high accuracy.

It is a block diagram which shows the structure of the autonomic nerve function diagnostic apparatus of one Embodiment of this invention. It is a flowchart which shows operation | movement of the autonomic-nervous function diagnostic apparatus of one Embodiment of this invention. It is a flowchart for demonstrating the LF + HF calculation method in the autonomic-nervous function diagnostic apparatus of one Embodiment of this invention. It is a figure which shows the heart rate fluctuation | variation measuring method in the case of LF + HF calculation. It is a figure which shows an example which carried out the spectrum analysis in the case of LF + HF calculation. It is a figure which shows the example of a pattern of the display shown on the display apparatus 22, when an autonomic nerve function is normal. It is a figure which shows the example of the pattern of the display shown on the display apparatus 22, when the excessive reaction of the sympathetic nerve has occurred. It is a figure which shows the example of the pattern of the display shown on the display apparatus 22, when the parasympathetic nerve excessive reaction has occurred. It is the figure which showed the actual measurement data when the excessive reaction of a sympathetic nerve occurred. It is a figure which shows the change with time passage of HF, HR (heart rate), L / H, and CVRR at the time of measuring the data shown in FIG. FIG. 10 is a diagram illustrating a display example when the measurement data illustrated in FIG. 9 is two-dimensionally displayed in a relationship between CVRR and LF + HF. It is the figure which showed the actual measurement data when the excessive reaction of a parasympathetic nerve occurred.

  Next, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing a configuration of an autonomic nervous function diagnostic apparatus according to an embodiment of the present invention.

  As shown in FIG. 1, the autonomic nervous function diagnostic apparatus of the present embodiment displays an electrocardiogram monitor 14 for acquiring electrocardiographic data of a measurement subject, a control device 18, a storage device 20, and biological information. Display device 22, autonomic nerve activity calculation unit 24, and CVRR (Coefficient of Variation of RR intervals) calculation unit 25.

  The electrocardiogram monitor 14 attaches a minus electrode, for example, to the measurement subject's throat, a plus electrode on the left flank, and a body ground on the right flank, obtains heart movement as an electrical signal and records it as electrocardiographic data.

  The autonomic nerve activity degree calculation unit 24 calculates an autonomic nerve total activity amount index (LH + HF) indicating the overall activity amount of the autonomic nerve activity based on the electrocardiogram data measured by the electrocardiogram monitor 14. A specific method for calculating the autonomic nerve total activity index (LF + HF) will be described later.

  The CVRR calculation unit 25 calculates CVRR (electrocardiogram RR interval variation coefficient) based on the electrocardiogram data measured by the electrocardiogram monitor 14. A specific method for calculating the CVRR will also be described later.

  The control device 18 includes, for example, a computer, processes the biological information obtained by the autonomic nerve activity calculation unit 24 and the CVRR calculation unit 25, stores the processed information in the storage device 20, or displays it on the display device 22. To do. The control device 18 displays biological information on the display device 22 for each heartbeat of the electrocardiogram obtained by the electrocardiogram monitor 14.

  Then, the control device 18 two-dimensionally displays the relationship between the autonomic nerve activity amount index (LF + HF) calculated by the autonomic nerve activity calculation unit 24 and the CVRR calculated by the CVRR calculation unit 25 with respect to the display device 22. Display.

  Next, the operation of the autonomic nervous function diagnosis apparatus of this embodiment will be described in detail with reference to FIG. FIG. 2 is a flowchart showing the operation of the autonomic nervous function diagnostic apparatus of this embodiment.

  First, as an initial setting, before the examination is started, patient information such as the name, age, ID number, sex, medical history (diabetes, vascular disorder, etc.) of the person to be measured is input to the control device 18 (S201). .

  When the examination is started, the electrocardiogram data of the living body is measured by the electrocardiogram monitor 14 (step S202). Then, the autonomic nerve activity degree calculation unit 24 performs LF + HF calculation, and calculates an autonomic nerve total activity amount index (LH + HF) indicating the overall activity amount of the autonomic nerve activity (step S203). Then, the CVRR calculation unit 25 performs CVRR calculation to calculate CVRR that is an index indicating the degree of variation in the RR interval (step S204). Then, the calculation result calculated by the autonomic nerve activity calculation unit 24 and the calculation result calculated by the CVRR calculation unit 25 are stored in the storage device 20 by the control device 18 and two-dimensionally displayed on the display device 22 ( Step S205).

  While the processes in steps S202 to S205 are repeated, it is confirmed whether or not the autonomic nerve is normally switched by performing a load test such as a standing test and a deep breath on the subject.

  Then, it is determined whether or not an instruction to end the examination has been performed (step S206), and the processing of steps S202 to S205 is performed for each heartbeat until an instruction to end the examination is given.

  Next, details of the LF + HF calculation method shown in step S203 of FIG. 2 are shown in FIGS.

  First, in step S <b> 301, the autonomic nerve activity calculation unit 24 calculates heart rate variability from electrocardiogram data input from the electrocardiogram monitor 14. The heart rate variability was calculated as shown in FIGS. 4A and B by measuring the RR interval by taking the interval between the R wave and the next R wave, and then measuring as shown in FIGS. 4C and D. The R-R interval data is plotted at the time position of the rear R-wave, and after interpolation, data is resampled at equal intervals (dotted line in FIG. 4C). In the next step S302, spectrum analysis (frequency conversion) is performed on the data obtained in step S301. An example of the spectrum analysis in step S302 is shown in FIG. In the next step S303, a low frequency component LF is obtained. Here, the low frequency component LF is an integral value of the power spectrum component of 0.04 to 0.15 Hz. In the next step S304, a high frequency component HF is obtained. Here, the high frequency component HF is an integral value of the power spectrum component of 0.15 to 0.40 Hz. In step S305, the sum of the LF obtained in step S303 and the HF obtained in step S304 is calculated as LF + HF.

  In this way, the autonomic nerve activity degree calculation unit 24 calculates the autonomic nerve total activity amount index (LH + HF) from the electrocardiogram data measured by the electrocardiogram monitor 14.

Next, details of the CVRR calculation method shown in step S204 of FIG. 2 will be described.
CVRR is an index that indicates the degree of variation in heart rate variability, and is a coefficient that indicates the degree of variation in the RR interval (interval of the apex of the R wave in the electrocardiogram waveform) shown in FIG. 4A. Specifically, this CVRR is calculated by the following equation.
CVRR = R−R interval standard deviation / R−R interval average × 100 (%)

  Here, the RR interval standard deviation is, for example, the standard deviation of the RR interval in a predetermined period of 1 minute or a predetermined number of heartbeats such as 100 beats. The RR interval average is, for example, an average of RR intervals in a predetermined period or a predetermined number of heartbeats.

  The CVRR calculation unit 25 calculates CVRR from the electrocardiogram data measured by the electrocardiogram monitor 14 based on the above formula.

  Next, FIG. 6 shows an example of display on the display device 22 in the autonomic nervous function diagnostic apparatus of the present embodiment.

  In the display example shown in FIG. 6, the autonomic nerve activity index (LH + HF) calculated by the autonomic nerve activity calculation unit 24 with the autonomic nerve activity index (LH + HF) as the horizontal axis and CVRR as the vertical axis. And the relationship with CVRR are two-dimensionally displayed.

  Here, based on the plurality of autonomic nerve activity amount indexes (LF + HF) calculated by the autonomic nerve activity degree calculation unit 24 and the plurality of CVRRs calculated by the CVRR calculation unit 25, the control device 18 calculates LF + HF and You may make it function as a correlation calculation means which calculates the relationship of CVRR by a linear function. Then, the control device 18 displays a straight line based on the calculated linear function on the display device 22. Here, the control device 18 approximates the relationship between LF + HF and CVRR to a linear function by, for example, the least square method.

  Furthermore, the control device 18 may function as a determination unit that determines whether there is an abnormality in the autonomic nervous function based on a measurement result that deviates by a predetermined amount or more from the calculated relationship between LF + HF and CVRR. For example, the distance from the direct by the calculated linear function is calculated, and if the distance is greater than or equal to a predetermined value, it is determined that the correlation between LF + HF and CVRR is out of the correlation. The presence / absence of abnormality of the autonomic nerve function may be determined based on the number of measurement results being present and the distance from the primary straight line.

  Here, LF + HF which is the sum of the high frequency component (HF) and the low frequency component (LF) in the spectrum analysis result of the RR interval indicates the overall size of the autonomic nerve activity and the total power of the autonomic nerve. ing. Therefore, in this embodiment, this LF + HF is used as an autonomic nerve total activity amount index indicating the overall activity amount of autonomic nerve activity.

  Next, FIG. 7 shows an example of a display pattern when the sympathetic nerve overreacts, and FIG. 8 shows an example of a display pattern when the parasympathetic nerve overreacts.

  In the display example shown in FIG. 7, a large number of measurement data is seen at locations far away from the straight line indicating the correlation between LF + HF and CVRR, and it is determined that there is a high possibility that the autonomic nervous function is abnormal. In the display example shown in FIG. 8 as well, a large number of measurement data are seen at locations far away from the straight line indicating the correlation between LF + HF and CVRR, and it is determined that there is a high possibility of an abnormality in the autonomic nervous function. .

  In general, the high frequency component HF in the spectrum analysis result of the RR interval indicates the activity level of the parasympathetic nerve, and the low frequency component LF indicates the activity level of the sympathetic nerve and the parasympathetic nerve. Therefore, LF / HF is generally used as an index of the degree of sympathetic nerve activity, and HF is used as an index of the degree of parasympathetic nerve activity. In general, whether the sympathetic nerve is dominant or the parasympathetic nerve is dominant is determined based on the sympathetic nerve activity index LF / HF.

  However, since the index LF / HF is the ratio of LF to HF, it is not possible to grasp the overall amount of autonomic nerve activity. For example, if both LF and HF increase, the value of LF / HF remains unchanged, and even if LF does not change, the value of LF / HF increases if HF decreases. That is, the index LF / HF is not an index indicating the overall amount of autonomic nerve activity.

  CVRR is known to increase with an increase in the overall activity of autonomic nerve function. Also, CVRR is a variation coefficient of the heartbeat interval (RR interval), and naturally increases in proportion to the variation amount (ΔHR) of the heart rate (HR). As a result, the CVRR is proportional to the autonomic nerve total activity index (LF + HF) × ΔHR (heart rate fluctuation).

  That is, CVRR is proportional to the autonomic nerve total activity index (LF + HF) indicating the total power of autonomic nerve activity, and is also proportional to the heart rate fluctuation ΔHR. Therefore, when the sympathetic nerve overreacts and LF + HF increases due to an increase in LF and the heart rate increases, CVRR rapidly increases in a square manner due to two factors.

  When sympathetic excessive reaction occurs, HF generally tends to be smaller. Therefore, the value of LF + HF is not so large as compared with that before the occurrence of excessive sympathetic nerve reaction.

  Therefore, the data measured when the sympathetic overreaction occurs is different from the case where the correlation between LF + HF and CVRR is normal.

  When an excessive reaction of the parasympathetic nerve occurs, both LF and HF increase and LF + HF also increases. If the heart rate decreases due to excessive reaction of the parasympathetic nerve, the heart rate fluctuation ΔHR also increases. In this case, CVRR rapidly increases squarely due to two factors. Since the increase in CVRR is a square sudden increase compared to the increase in LF + HF, the data measured when the parasympathetic nerve overreaction occurs is also the case where the correlation between LF + HF and CVRR is normal. It will be off.

  Next, display examples simply showing the measurement results obtained by actually measuring the electrocardiographic data of a certain measurement subject will be described with reference to FIGS.

  The display example shown in FIG. 9 shows actual measurement data when an excessive reaction of the sympathetic nerve occurs. In the display example shown in FIG. 9, the data in the range surrounded by a circle is data that deviates greatly from the correlation indicated by the straight line. By measuring a large number of data surrounded by the circle, it can be determined that there is a high possibility that the subject's autonomic function is abnormal.

  FIG. 10 shows changes with time in HF, HR (heart rate), L / H (LF / HF), and CVRR when the data shown in FIG. 9 is measured.

  In the data shown in FIG. 10, it can be seen that HR is increased, HF is decreased, L / H is increased, and CVRR is rapidly increased due to excessive reaction of the sympathetic nerve. In FIG. 10, LF is not shown, but LF increases with the excessive reaction of the sympathetic nerve.

  Furthermore, FIG. 11 shows a display example when the measurement data shown in FIG. 9 is two-dimensionally displayed in the relationship between CVRR and LF / HF. Also in the display example shown in FIG. 11, the range of data that is considered to have an abnormality in the autonomic nerve function is surrounded by a circle. However, in the display example shown in FIG. 11, it is difficult to grasp the difference between the data in which an abnormality occurs in the autonomic nerve function and the data in which the abnormality does not occur, and it is determined that the autonomic nerve function is abnormal at first glance. Difficult to do.

  The reason for this is that when the sympathetic nerve undergoes an excessive reaction, HF decreases as shown in FIG. 10, so that LF / HF also increases rapidly as LF increases. As a result, even if CVRR increases rapidly, the correlation between CVRR and LF / HF does not change so clearly, and it becomes difficult to grasp the abnormality of the autonomic nerve only from the displayed measurement data.

  Referring to FIGS. 9 and 11, according to the autonomic nerve function diagnostic apparatus of the present embodiment, the abnormality of the autonomic nerve function can be easily compared with the case where the relationship between CVRR and LF / HF is displayed two-dimensionally. It can be seen that the abnormality of the autonomic nerve function can be determined with higher accuracy.

  FIG. 12 shows actual measurement data when an excessive reaction occurs in the parasympathetic function. In FIG. 12, the data in the range surrounded by the ellipse is data that deviates greatly from the correlation indicated by the straight line. Referring to FIG. 12, it can be easily understood that an abnormality has occurred in the autonomic nerve.

  Further, as can be seen by comparing FIG. 9 and FIG. 12, the data pattern differs between when the sympathetic nerve is overreacting and when the parasympathetic nerve is overreacting. Therefore, according to the autonomic nerve function diagnostic apparatus of this embodiment, it is possible to determine whether the sympathetic nerve is overreacting or the parasympathetic nerve is overreacting due to the difference in the data pattern.

[Modification]
In the above embodiment, the electrocardiogram monitor 14 is provided, and the autonomic nervous activity index (LH + HF) and CVRR are calculated based on the electrocardiogram data measured by the electrocardiogram monitor 14. Is not limited to such a configuration. Without receiving the electrocardiogram monitor 14, a receiving means for receiving external electrocardiographic data is provided, and the autonomic nerve activity index (LH + HF) and CVRR are calculated based on the electrocardiographic data received by the receiving means. It can also be configured. By adopting such a configuration, the autonomic nervous function diagnosis apparatus does not need to be provided with an electrocardiogram measurement means such as the electrocardiogram monitor 14.

  In the above embodiment, the relationship between the autonomic nervous activity index (LH + HF) and CVRR is displayed two-dimensionally on the display device 22. It is also possible to automatically determine only the determination result and output only the determination result.

14 ECG monitor 18 Control device 20 Storage device 22 Display device 24 Autonomic nerve activity level calculation unit 25 CVRR calculation unit S201 to S206 Steps S301 to S305 Steps

Claims (5)

An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Based on the electrocardiogram data measured by the electrocardiogram measurement means, an autonomic nerve activity degree calculating means for calculating an autonomic nerve total activity amount index indicating an overall activity amount of the autonomic nerve activity,
CVRR calculation means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Display means for displaying biological information;
Control means for controlling the display means to two-dimensionally display the relationship between the autonomic nerve activity activity index calculated by the autonomic nerve activity degree calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means. When,
Based on a plurality of autonomic nerve activity index calculated by the autonomic nerve activity calculating means and a plurality of electrocardiogram RR interval variation coefficients calculated by the CVRR calculating means, Correlation calculating means for calculating the relationship of electrocardiogram RR interval variation coefficients by a linear function;
Determination means for determining the presence or absence of abnormality of the autonomic nerve function based on the measurement result deviating from a predetermined amount from the relationship between the autonomic nerve total activity index calculated by the correlation calculating means and the electrocardiogram RR interval variation coefficient When,
An autonomic nervous function diagnostic apparatus comprising: Receiving means for receiving electrocardiogram data measured by the electrocardiogram measuring means;
Based on the electrocardiogram data received by the receiving means, an autonomic nerve activity degree calculating means for calculating an autonomic nerve total activity amount index indicating an overall amount of autonomic nerve activity,
CVRR calculating means for calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data received by the receiving means;
Display means for displaying biological information;
Control means for controlling the display means to two-dimensionally display the relationship between the autonomic nerve activity activity index calculated by the autonomic nerve activity degree calculating means and the electrocardiogram RR interval variation coefficient calculated by the CVRR calculating means. When,
Based on a plurality of autonomic nerve activity index calculated by the autonomic nerve activity calculating means and a plurality of electrocardiogram RR interval variation coefficients calculated by the CVRR calculating means, Correlation calculating means for calculating the relationship of electrocardiogram RR interval variation coefficients by a linear function;
Determination means for determining the presence or absence of abnormality of the autonomic nerve function based on the measurement result deviating from a predetermined amount from the relationship between the autonomic nerve total activity index calculated by the correlation calculating means and the electrocardiogram RR interval variation coefficient When,
An autonomic nervous function diagnostic apparatus comprising:   The autonomic nervous function diagnosis apparatus according to claim 1, wherein the control unit controls the display unit to display a straight line based on the linear function calculated by the correlation calculation unit. Measuring the electrocardiogram of a living body by means of electrocardiogram measuring means;
Based on the electrocardiogram data measured by the electrocardiogram measurement means, calculating an autonomic nerve total activity amount index indicating an overall activity amount of autonomic nerve activity;
Calculating an electrocardiogram RR interval variation coefficient based on the electrocardiogram data measured by the electrocardiogram measurement means;
Two-dimensionally displaying a relationship between the calculated autonomic nerve total activity amount index and the calculated electrocardiogram RR interval variation coefficient;
Based on the calculated plurality of autonomic nerve total activity index and the calculated plurality of electrocardiogram RR interval variation coefficients, the relationship between the autonomic nerve total activity index and the electrocardiogram RR interval variation coefficient is a linear function. A step of calculating by
A step of determining the presence or absence of abnormality of the autonomic nerve function based on the measurement result deviated by a predetermined amount or more from the relationship between the calculated autonomic nerve total activity amount index and the electrocardiogram RR interval variation coefficient;
A program that causes a computer to execute. Receiving the electrocardiogram data measured by the electrocardiograph means;
Calculating an autonomic nerve total activity index indicating an overall activity amount of autonomic nerve activity based on the received electrocardiogram data;
Calculating an electrocardiogram RR interval variation coefficient based on the received electrocardiogram data;
Two-dimensionally displaying a relationship between the calculated autonomic nerve total activity amount index and the calculated electrocardiogram RR interval variation coefficient;
Based on the calculated plurality of autonomic nerve total activity index and the calculated plurality of electrocardiogram RR interval variation coefficients, the relationship between the autonomic nerve total activity index and the electrocardiogram RR interval variation coefficient is a linear function. A step of calculating by
A step of determining the presence or absence of abnormality of the autonomic nerve function based on the measurement result deviated by a predetermined amount or more from the relationship between the calculated autonomic nerve total activity amount index and the electrocardiogram RR interval variation coefficient;
A program that causes a computer to execute.