JP4091972B1 - Vascular function diagnosis system and program - Google Patents

Abstract

Detailed diagnosis of vascular function is performed more accurately without using a complicated method.
A blood pressure value of a patient is measured and a sympathetic nerve activity index (LF / HF) is calculated based on electrocardiographic data. The vascular function is determined based on the change patterns of the systolic blood pressure value (SYS), the diastolic blood pressure value (DIA), and the mean blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). When the degree of change of the mean blood pressure (MAP) with respect to the sympathetic nerve activity index (LF / HF) is small, it is determined that the peripheral blood vessel resistance is increased due to a hardening phenomenon in the peripheral blood vessel. When the degree of change of the minimum blood pressure (DIA) with respect to the sympathetic nerve activity index (LF / HF) is small, it is determined that a sclerosis phenomenon has occurred in the aorta.
[Selection] Figure 8

Description

  The present invention relates to a vascular function diagnostic system for diagnosing a vascular function of a living body such as the degree of progression of arteriosclerosis.

  In recent years, arteriosclerosis is increasing due to changes in eating habits, unexpected movements, aging, and the like. In order to prevent such arteriosclerosis, it is necessary to diagnose how much arteriosclerosis is progressing. As a method for diagnosing the degree of arteriosclerosis, a method of measuring the degree of arterial sclerosis using pulse wave velocity (hereinafter abbreviated as PWV (Pulse Wave Velocity)) is known (for example, patents). Reference 1). The PWV is a speed at which a pulse wave generated when the heart ejects blood propagates through the blood vessel wall.

  A blood vessel in which arteriosclerosis has progressed is hard, so the PWV is fast, and a blood vessel in which arteriosclerosis has not progressed is very flexible, so the PWV is slow. Therefore, it is possible to diagnose the degree of progression of arteriosclerosis by measuring the measurement subject's PWV.

  However, the method of measuring the degree of arterial stiffness using the pulse wave velocity cannot determine whether the aorta is cured or the peripheral blood vessels are cured. Further, it cannot be distinguished whether the blood vessels are cured by the action of the smooth muscles of the blood vessels due to mental stress or the like, or whether the blood vessels themselves are actually cured. Furthermore, in the method of measuring the degree of arterial stiffness using the pulse wave velocity, there is a restriction that measurement in a resting state must be performed in the supine position.

JP 2003-250769 A

  The above-described conventional techniques have a problem in that it is difficult to distinguish between hardening of the aorta and increase in peripheral vascular resistance, and it is difficult to accurately diagnose vascular function by eliminating factors such as mental state.

  An object of the present invention is to provide a vascular function diagnosis system and program capable of more accurately diagnosing a detailed vascular function without using a complicated method.

[Vascular function diagnosis system]
In order to achieve the above object, the vascular function diagnostic system of the present invention comprises a blood pressure measuring means for measuring a blood pressure value of a living body,
An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Calculating means for calculating the degree of change in blood pressure value relative to the sympathetic nerve activity index based on the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the blood pressure value measured by the blood pressure measuring means;
Determination means for determining the vascular function based on the degree of change in blood pressure value relative to the sympathetic nerve activity index calculated by the calculation means.

  According to the present invention, since the blood vessel function is determined based on the degree of change in the blood pressure value with respect to the sympathetic nerve activity index, detailed diagnosis of the blood vessel function is performed more accurately without using a complicated method. It becomes possible.

Further, the blood vessel function diagnosis system of the present invention includes a receiving means for receiving the blood pressure value of the living body measured by the blood pressure measuring means and the electrocardiographic data measured by the electrocardiographic measuring means,
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
Calculating means for calculating the degree of change in blood pressure value relative to the sympathetic nerve activity index based on the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the blood pressure value received by the receiving means;
Determination means for determining a vascular function based on the degree of change in blood pressure value with respect to the sympathetic nerve activity index calculated by the calculation means.

Preferably, the blood pressure measurement means measures the maximum blood pressure and the minimum blood pressure of the living body,
The determination means determines the vascular function based on a change pattern of the maximum blood pressure and the minimum blood pressure with respect to the sympathetic nerve activity index.

Preferably, the blood pressure measurement means measures the maximum blood pressure, the minimum blood pressure and the average blood pressure of the living body,
The determination means determines the vascular function based on a change pattern of the maximum blood pressure, the minimum blood pressure, and the average blood pressure with respect to the sympathetic nerve activity index.

Preferably, the determination means determines that the vascular function is normal when the maximum blood pressure, the average blood pressure, and the minimum blood pressure increase as the sympathetic nerve activity index increases.
If the systolic activity index increases and the systolic blood pressure and mean blood pressure increase but the diastolic blood pressure does not change or decreases, it is determined that the vascular function is somewhat abnormal,
It is determined that the vascular function is abnormal when the systolic blood pressure, the mean blood pressure, and the diastolic blood pressure do not change or decrease as the sympathetic activity index increases.

  According to the present invention, the presence or absence of hardening of the aorta is determined based on the change pattern of minimum blood pressure, and the presence or absence of increase in peripheral vascular resistance is determined based on the change pattern of average blood pressure. The vascular function can be diagnosed in more detail without using.

Preferably, the blood pressure measuring means measures a minimum blood pressure of the living body,
The determination means determines the vascular function based on the rate of change in the minimum blood pressure relative to the sympathetic nerve activity index.

Preferably, the blood pressure measurement means measures a pulse pressure that is a difference between the highest blood pressure and the lowest blood pressure of the living body,
The determination means determines the vascular function based on the magnitude of the pulse pressure that changes with respect to the sympathetic nerve activity index.

[program]
The program of the present invention includes a step of measuring a blood pressure value of a living body by a blood pressure measuring means,
Measuring the electrocardiogram of a living body by means of electrocardiogram measuring means;
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating the degree of change in blood pressure value relative to the sympathetic nerve activity index based on the calculated sympathetic nerve activity index and the blood pressure value measured by the blood pressure measuring means;
And causing the computer to execute a step of determining the vascular function based on the degree of change in blood pressure value with respect to the calculated sympathetic nerve activity index.

Further, the program of the present invention receives a blood pressure value of the living body measured by the blood pressure measuring means and electrocardiographic data measured by the electrocardiographic measuring means,
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a degree of change in blood pressure value relative to the sympathetic nerve activity index based on the calculated sympathetic nerve activity index and the received blood pressure value;
And causing the computer to execute a step of determining the vascular function based on the degree of change in the blood pressure value with respect to the calculated sympathetic nerve activity index.

  As described above, according to the present invention, it is possible to obtain an effect that a detailed vascular function diagnosis can be performed more accurately without using a complicated method.

  Next, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing a configuration of a vascular function diagnosis system according to an embodiment of the present invention.

  As shown in FIG. 1, the vascular function diagnosis system of the present embodiment includes a manchette (or cuff) 8, a blood pressure measuring device 12 that measures a blood pressure value of a living body, an electrocardiogram monitor 14, a control device 18, and a memory. The apparatus 20 is comprised from the display apparatus 22 for displaying biometric information, and the autonomic nerve activity calculation part 24. FIG.

  The blood pressure measuring device 12 pressurizes and depressurizes the manchette 8 wound around the upper arm of the living body to systolic blood pressure (SYS) and diastolic blood pressure (DIA). ) And mean arterial pressure (MAP) are automatically measured.

  Here, the mean blood pressure is a blood pressure value at which the area on the highest blood pressure side and the area on the lowest blood pressure side are the same when the measured pulse pressure waveform is divided between the highest blood pressure and the lowest blood pressure. In simple terms, it can be calculated by the formula: average blood pressure = minimum blood pressure + pulse pressure / 3. Here, the pulse pressure is the difference between the highest blood pressure and the lowest blood pressure.

  The electrocardiogram monitor 14 attaches a minus electrode to the measurement subject's throat, for example, a plus electrode on the left flank, and a body earth on the right flank, and obtains heart movement as an electrical signal and records it as electrocardiographic data.

  The autonomic nerve activity calculation unit 24 calculates a sympathetic nerve activity index (LF / HF) indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram monitor 14. A specific method for calculating LF / HF will be described later.

  The control device 18 includes, for example, a computer, processes the biological information obtained by the blood pressure measuring device 12 and the autonomic nerve activity calculation unit 24, and stores the processed information in the storage device 20 or displays it on the display device 22. To do.

  Further, the control device 18 includes the sympathetic nerve activity index (LF / HF) calculated by the autonomic nerve activity calculating unit 24, the maximum blood pressure value (SYS) and the minimum blood pressure value (DIA) measured by the blood pressure measuring device 12. ) And the mean blood pressure value (MAP) and the degree of change of the systolic blood pressure value (SYS), the lowest blood pressure value (DIA), and the mean blood pressure value (MAP) with respect to the sympathetic nerve activity index (LF / HF) . Then, the control device 18 determines the vascular function based on the degree of change in the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). Determine.

  Specifically, the control device 18 is based on the change pattern of the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). Determine vascular function.

  Further, the control device 18 displays on the display device 22 the degree of change in the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). At the same time, the determination result of the obtained blood vessel function is displayed on the display device 22.

  Next, the operation of the vascular function diagnosis system of this embodiment will be described in detail with reference to the drawings.

  First, the overall operation of the vascular function diagnosis system of this embodiment will be described with reference to the flowchart of FIG.

  When diagnosing vascular function by the vascular function diagnostic system of the present embodiment, first, the patient's biological state is measured by the blood pressure measuring device 12 and the electrocardiogram monitor 14 in the patient's state (step S201). Then, the control device 18 performs a display for prompting the patient to perform abdominal breathing via the display device 22 or the like (step S202), and then the patient's biological condition is again measured by the blood pressure measuring device 12 and the electrocardiogram monitor 14. Is measured (step S203).

  Then, after a display for prompting the patient to take a shallow breath in the mouth via the display device 22 or the like (step S204), the patient's biological state is measured again by the blood pressure measuring device 12 and the electrocardiogram monitor 14. (Step S205).

  The reason why the biological state is measured after the abdominal breathing is performed is to measure a value when a load is applied to the patient. The reason why the biological state is measured after the shallow mouth breathing is performed is to measure the value when the patient is in a resting state.

  In this case, abdominal breathing is used as an operation to load the patient, and shallow breathing (shallow mouth breathing) is used as an operation not to load the patient. May be any action. For example, an upright test may be used as an operation for applying a load to the patient.

  After such measurement of the biological state is performed, the control device 18 determines the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the sympathetic nerve activity index (LF / HF). The degree of change is calculated and displayed on the display device 22 (step S206).

  Then, the control device 18 determines the vascular function based on the degree of change in the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). Is determined (step S207).

  Next, the operation of the vascular function diagnosis system of the present embodiment during treatment will be described with reference to FIG.

  During the treatment, the blood pressure value of the living body is measured by the blood pressure measuring device 12, and the electrocardiographic data is measured by the electrocardiogram monitor 14 (S201). Then, the autonomic nerve activity degree calculation unit 24 performs LF / HF calculation, and performs a sympathetic nerve activity index (LF / HF) indicating the degree of sympathetic nerve activity and a parasympathetic nerve activity index (ie, the degree of parasympathetic nerve activity). HF) is calculated (S202). The measurement results measured by the blood pressure measuring device 12 and the pulse measuring device 13 and the calculation results calculated by the autonomic nerve activity calculating unit 24 are stored in the storage device 20 by the control device 18 and displayed on the display device 22. (S203).

Next, details of the biological state measurement processing (steps S201, S203, and S205) in FIG. 2 will be described with reference to the flowchart of FIG.
In this biological state measurement process, the blood pressure measuring device 12 measures the patient's systolic blood pressure value (SYS), the diastolic blood pressure value (DIA), and the mean blood pressure value (MAP), and the electrocardiogram monitor 14 captures the patient's electrocardiographic data. Measurement is performed (step S301).

  The autonomic nerve activity calculation unit 24 calculates a sympathetic nerve activity index (LF / HF) indicating the degree of sympathetic nerve activity based on the electrocardiogram data measured by the electrocardiogram monitor 14 (step S302).

  Then, the control device 18 stores the blood pressure value measured by the blood pressure measuring device 12 and the sympathetic nerve activity index (LF / HF) calculated by the autonomic nerve activity calculating unit 24 in the storage device 20 (step S303).

  Next, details of the LF / HF calculation process shown in step S302 of FIG. 3 will be described with reference to FIGS.

  First, in step S401, the autonomic nerve activity calculation unit 24 calculates heart rate variability from the electrocardiogram data input from the electrocardiogram monitor 14. As shown in FIGS. 5A and 5B, the heart rate variability was calculated by measuring the RR interval by taking an interval between the R wave and the next R wave, and then measuring as shown in FIGS. 5C and D. The R-R interval data is plotted at the time position of the backward R wave, and after interpolation, data is resampled at equal intervals (dotted line in FIG. 6C). In the next step S402, spectrum analysis (frequency conversion) is performed on the data obtained in step S401. An example of the spectrum analysis in step S402 is shown in FIG. In the next step S403, a low frequency component LF is obtained. Here, the low frequency component LF is an integral value of the power spectrum component of 0.04 to 0.15 Hz. In the next step S404, a high frequency component HF is obtained. Here, the high frequency component HF is an integral value of the power spectrum component of 0.15 to 0.40 Hz. In step S405, the ratio obtained in step S403 and the ratio obtained in step S404 are calculated to obtain LF / HF.

  In this manner, the autonomic nerve activity calculation unit 24 calculates the sympathetic nerve activity index (LF / HF) from the electrocardiogram data measured by the electrocardiogram monitor 14.

Next, an example of display on the display device 22 in the vascular function diagnosis system of the present embodiment is shown in FIG.
In the vascular function diagnosis system of the present embodiment, as shown in FIG. 7, the control device 18 includes a sympathetic nerve activity index (LF / HF), a maximum blood pressure value (SYS), a minimum blood pressure value (DIA), and The relationship of the mean blood pressure value (MAP) is shown by approximating it to a linear function.

  In FIG. 7, the expression “Y = 2.2.52 + 132.8” shown in the vicinity of the linear function indicating the degree of change in the systolic blood pressure value (SYS) is a sympathetic nerve activity index (LF) with the blood pressure as the Y axis. / HF) is an approximated linear function when the X-axis is used, and the slope is 2.52 and the Y-axis intercept is 132.8 (mmHg).

  The control device 18 in the vascular function diagnosis system of the present embodiment determines the state of the vascular function of the patient based on the change pattern as shown in FIG. A specific determination method used when the control device 18 determines the state of the blood vessel function will be described with reference to FIG.

  Specifically, as shown in FIG. 8A, the control device 18 increases the sympathetic nerve activity index (LF / HF) and increases the systolic blood pressure (SYS), the mean blood pressure (MAP), and the diastolic blood pressure (MAP). When DIA) increases, it is determined that the vascular function is normal. Specifically, it is determined that no problem such as arteriosclerosis has occurred in both the aorta and the peripheral blood vessels.

  Further, as shown in FIG. 8 (B), the control device 18 increases the sympathetic nerve activity index (LF / HF) and increases the systolic blood pressure (SYS) and the mean blood pressure (MAP). If the blood pressure (DIA) does not change or decreases, it is determined that the vascular function is somewhat abnormal. Specifically, it is determined that there is a possibility of arteriosclerosis in the aorta, but no problem such as arteriosclerosis has occurred in the peripheral blood vessel.

  Furthermore, as shown in FIG. 8C, the control device 18 increases the sympathetic nerve activity index (LF / HF), so that the systolic blood pressure (SYS), the mean blood pressure (MAP), and the diastolic blood pressure (DIA) If there is no change or a decrease, it is determined that the vascular function is abnormal. Specifically, it is determined that there may be a problem such as arteriosclerosis in both the aorta and the peripheral blood vessels.

  When the degree of change of the mean blood pressure (MAP) with respect to the sympathetic nerve activity index (LF / HF) is small, it is considered that the peripheral blood vessel resistance is increased due to a hardening phenomenon in the peripheral blood vessels. Further, when the degree of change of the minimum blood pressure (DIA) with respect to the sympathetic nerve activity index (LF / HF) is small, it is considered that a sclerosis phenomenon has occurred in the aorta.

  Furthermore, when the degree of change of the systolic nerve activity index (LF / HF) of the systolic blood pressure (SYS) is small, there is an abnormality in the adjustment function of the brain and coronary arteries, which may cause cerebral infarction and myocardial infarction. It is thought that it is getting higher.

  Therefore, as in the vascular function diagnosis system of the present embodiment, the degree of change in the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the sympathetic nerve activity index (LF / HF) is determined. By observing, it is possible to diagnose blood vessel function.

  In particular, the vascular function diagnostic system according to the present embodiment has a sympathetic nerve activity as compared with a case where a vascular function is diagnosed by only one measurement in a case where the patient is in a certain state as in the conventional vascular function diagnostic method. Since the blood vessel function is diagnosed based on the measured values in a plurality of states with different degree indices (LF / HF), it is possible to make a more accurate diagnosis. In addition, it is possible to estimate not only whether or not arteriosclerosis is occurring but also in which part of the artery the arteriosclerosis is occurring, so that a more detailed diagnosis result can be obtained.

  Furthermore, according to the vascular function diagnostic system of the present embodiment, the vascular function can be diagnosed only by measuring blood pressure and electrocardiographic data, and therefore compared with a method using pulse wave velocity (PWV). Diagnosis can be made by a simple method.

  In this embodiment, the blood pressure measurement and the sympathetic nerve activity index (LF / HF) are measured in three states having different sympathetic nerve activity indices (LF / HF), but the accuracy is higher. When a diagnosis is desired, the biological state may be measured in more states.

  In the above description, the control device 18 determines the degree of change in the maximum blood pressure value (SYS), the minimum blood pressure value (DIA), and the average blood pressure value (MAP) with respect to the calculated sympathetic nerve activity index (LF / HF). However, it is also possible to determine the vascular function based on other values.

  For example, the control device 18 can determine the vascular function based on the rate of change in the diastolic blood pressure (DIA) with respect to the sympathetic nerve activity index (LF / HF).

  As described above, when the degree of change of the minimum blood pressure (DIA) with respect to the sympathetic nerve activity index (LF / HF) is small, it is considered that a sclerosis phenomenon has occurred in the aorta. Therefore, it is possible to determine the degree of hardening of the aorta by performing a more detailed diagnosis of the vascular function using the degree of change in the minimum blood pressure (DIA).

  For example, as shown in FIG. 9, the control device 18 determines that the blood vessel function is normal when the slope of the diastolic blood pressure (DIA) is 1 or more, and 1 when the slope of the diastolic blood pressure (DIA) is 0 or more. If it is less than that, it is determined that the vascular function is somewhat abnormal, and if the slope of the diastolic blood pressure (DIA) is less than 0, it is determined that the vascular function is abnormal.

  The control device 18 may determine the vascular function based on the magnitude of the pulse pressure that changes with respect to the sympathetic nerve activity index (LF / HF).

  When such a blood vessel function is diagnosed, the blood pressure measuring device 12 measures the pulse pressure from the patient's systolic blood pressure (SYS) and the systolic blood pressure (DIA).

As described above, the pulse pressure is a difference between the systolic blood pressure (SYS) and the diastolic blood pressure (DIA), and is a value calculated by the following equation.
Pulse pressure = systolic blood pressure (SYS)-diastolic blood pressure (DIA)

  As the degree of aortic stiffness increases and flexibility is lost, systolic blood pressure (SYS) increases and diastolic blood pressure (DIA) decreases. As a result, the pulse pressure that is the difference between the systolic blood pressure (SYS) and the diastolic blood pressure (DIA) also increases. Therefore, it becomes possible to determine the degree of hardening of the aorta by making a more detailed diagnosis of the vascular function based on pulse pressure values in a plurality of states having different sympathetic nerve activity index (LF / HF).

  For example, as shown in FIG. 10, the control device 18 determines that the blood vessel function is normal when the pulse pressure is less than 60 mmHg, and the aorta is hardened when the pulse pressure is 60 mmHg or more. Judge that there is a possibility.

  In addition, the diagnosis of the vascular function by the change pattern described above, the diagnosis of the vascular function by the diastolic blood pressure (DIA), and the diagnosis of the vascular function by the pulse pressure may be performed individually or in combination with a plurality of diagnosis methods. It is also possible to diagnose blood vessel function.

  In the present embodiment, the vascular function diagnosis system including the electrocardiogram monitor 14 and the blood pressure measurement device 12 is described. However, the electrocardiogram monitor 14 and the blood pressure measurement device 12 are independent of the vascular function diagnosis system. The blood pressure value of the patient measured by the blood pressure measuring device 12 and the electrocardiogram data measured by the electrocardiogram monitor 14 may be included. In such a configuration, the blood vessel function is diagnosed using the blood pressure value and electrocardiogram data received by the receiving means.

  Furthermore, in the vascular function diagnosis system of the present embodiment, the blood pressure measuring device 12 is described as measuring three blood pressure values of the patient's maximum blood pressure, minimum blood pressure, and intermediate blood pressure. It may be calculated from the minimum blood pressure. Alternatively, only the maximum blood pressure and the minimum blood pressure may be measured by the blood pressure measuring device 12, and the blood vessel function may be determined based on the change pattern of the maximum blood pressure and the minimum blood pressure with respect to the sympathetic nerve activity index.

It is a block diagram which shows the structure of the vascular function diagnostic system of one Embodiment of this invention. It is a flowchart which shows operation | movement of the vascular function diagnostic system of one Embodiment of this invention. It is a flowchart which shows the detail of the biological condition measurement process (step S201, S203, S205) in FIG. It is a flowchart which shows the detail of the LF / HF calculation process (step S302) in FIG. It is a figure which shows the heart rate fluctuation | variation measuring method in the case of LF / HF calculation. It is a figure which shows an example which spectrum-analyzed in the case of LF / HF calculation. It is a figure which shows an example of the display shown by the display apparatus 22 in FIG. It is a figure for demonstrating an example of the determination method of the vascular function in the control apparatus. It is a figure for demonstrating the other example of the determination method of the vascular function in the control apparatus. It is a figure for demonstrating the other example of the determination method of the vascular function in the control apparatus.

Explanation of symbols

8 Manchette 12 Blood pressure measuring device 14 ECG monitor 18 Control device 20 Storage device 22 Display device 24 Autonomic nerve activity calculation unit S201 to S207 Step S301 to S303 Step S401 to S405 Step

Claims (9)

Blood pressure measuring means for measuring a blood pressure value of a living body;
An electrocardiogram measuring means for measuring the electrocardiogram of a living body;
Autonomic nerve activity calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data measured by the electrocardiogram measuring means;
Calculating means for calculating the degree of change in blood pressure value relative to the sympathetic nerve activity index based on the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the blood pressure value measured by the blood pressure measuring means;
Determining means for determining vascular function based on the degree of change in blood pressure value relative to the sympathetic nerve activity index calculated by the calculating means;
A vascular function diagnostic system comprising: Receiving means for receiving the blood pressure value of the living body measured by the blood pressure measuring means and the electrocardiographic data measured by the electrocardiographic measuring means;
Autonomic nerve activity degree calculating means for calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the electrocardiographic data received by the receiving means;
Calculating means for calculating the degree of change in blood pressure value relative to the sympathetic nerve activity index based on the sympathetic nerve activity index calculated by the autonomic nerve activity calculating means and the blood pressure value received by the receiving means;
Determining means for determining vascular function based on the degree of change in blood pressure value relative to the sympathetic nerve activity index calculated by the calculating means;
A vascular function diagnostic system comprising: The blood pressure measurement means measures the maximum blood pressure and the minimum blood pressure of the living body,
The vascular function diagnosis system according to claim 1, wherein the determination unit determines a vascular function based on a change pattern of a maximum blood pressure and a minimum blood pressure with respect to a sympathetic nerve activity index. The blood pressure measuring means measures the maximum blood pressure, the minimum blood pressure and the average blood pressure of the living body,
The vascular function diagnosis system according to claim 1, wherein the determination unit determines a vascular function based on a change pattern of a maximum blood pressure, a minimum blood pressure, and an average blood pressure with respect to a sympathetic nerve activity index. The determination means determines that the vascular function is normal when the maximum blood pressure, the average blood pressure and the minimum blood pressure increase with an increase in the sympathetic nerve activity index,
If the sympathetic activity index increases and the systolic blood pressure and mean blood pressure increase but the diastolic blood pressure does not change or decreases, it is determined that the vascular function is somewhat abnormal,
The vascular function diagnosis system according to claim 4, wherein the vascular function is determined to be abnormal when the systolic blood pressure, the average blood pressure, and the diastolic blood pressure do not change or decrease as the sympathetic nerve activity index increases. The blood pressure measuring means measures the minimum blood pressure of the living body,
The vascular function diagnosis system according to claim 1, wherein the determination unit determines the vascular function based on a rate of change in the minimum blood pressure with respect to the sympathetic nerve activity index. The blood pressure measuring means measures a pulse pressure that is a difference between the highest blood pressure and the lowest blood pressure of the living body,
The vascular function diagnosis system according to claim 1, wherein the determination unit determines a vascular function based on a magnitude of a pulse pressure that changes with respect to a sympathetic nerve activity index. Measuring the blood pressure value of the living body with the blood pressure measuring means;
Measuring the electrocardiogram of a living body by means of electrocardiogram measuring means;
Based on the electrocardiographic data measured by the electrocardiogram measuring means, calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity;
Calculating a degree of change in blood pressure value with respect to the sympathetic nerve activity index based on the calculated sympathetic nerve activity index and the blood pressure value measured by the blood pressure measuring means;
A program for causing a computer to execute a step of determining a vascular function based on a degree of change in blood pressure value with respect to a calculated sympathetic nerve activity index. Receiving the blood pressure value of the living body measured by the blood pressure measuring means and the electrocardiographic data measured by the electrocardiographic measuring means;
Calculating a sympathetic nerve activity index indicating the degree of sympathetic nerve activity based on the received electrocardiogram data;
Calculating a degree of change in blood pressure value relative to the sympathetic nerve activity index based on the calculated sympathetic nerve activity index and the received blood pressure value;
A program for causing a computer to execute a step of determining vascular function based on a degree of change in blood pressure value with respect to a calculated sympathetic nerve activity index.

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