JP2010162376A - 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 - Google Patents
漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 Download PDFInfo
- Publication number
- JP2010162376A JP2010162376A JP2010092239A JP2010092239A JP2010162376A JP 2010162376 A JP2010162376 A JP 2010162376A JP 2010092239 A JP2010092239 A JP 2010092239A JP 2010092239 A JP2010092239 A JP 2010092239A JP 2010162376 A JP2010162376 A JP 2010162376A
- Authority
- JP
- Japan
- Prior art keywords
- polyurethane
- modulus
- disc
- artificial
- mold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002635 polyurethane Polymers 0.000 title claims description 121
- 239000004814 polyurethane Substances 0.000 title claims description 121
- 238000004519 manufacturing process Methods 0.000 title abstract description 34
- 239000007943 implant Substances 0.000 title description 6
- 239000000463 material Substances 0.000 claims abstract description 112
- 238000000034 method Methods 0.000 claims abstract description 54
- 230000008859 change Effects 0.000 claims description 32
- 229920000642 polymer Polymers 0.000 claims description 25
- 230000008569 process Effects 0.000 claims description 24
- 239000007787 solid Substances 0.000 claims description 3
- 230000001747 exhibiting effect Effects 0.000 claims description 2
- 239000002861 polymer material Substances 0.000 claims 3
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000002156 mixing Methods 0.000 description 81
- 238000006243 chemical reaction Methods 0.000 description 63
- 238000002347 injection Methods 0.000 description 56
- 239000007924 injection Substances 0.000 description 56
- 239000011162 core material Substances 0.000 description 37
- 239000000203 mixture Substances 0.000 description 34
- 239000000047 product Substances 0.000 description 29
- 238000009826 distribution Methods 0.000 description 26
- 229920005862 polyol Polymers 0.000 description 25
- 150000003077 polyols Chemical class 0.000 description 25
- 239000004970 Chain extender Substances 0.000 description 24
- 239000002994 raw material Substances 0.000 description 23
- 239000000376 reactant Substances 0.000 description 23
- 239000012948 isocyanate Substances 0.000 description 21
- 150000002513 isocyanates Chemical class 0.000 description 21
- 238000006116 polymerization reaction Methods 0.000 description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 13
- 238000001125 extrusion Methods 0.000 description 13
- -1 polymethylene Polymers 0.000 description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 10
- 210000001503 joint Anatomy 0.000 description 9
- 210000000988 bone and bone Anatomy 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 7
- 239000003054 catalyst Substances 0.000 description 6
- 150000002009 diols Chemical class 0.000 description 6
- 230000035882 stress Effects 0.000 description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 5
- 238000001746 injection moulding Methods 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 238000011882 arthroplasty Methods 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
- 229940043375 1,5-pentanediol Drugs 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- XXKOQQBKBHUATC-UHFFFAOYSA-N cyclohexylmethylcyclohexane Chemical compound C1CCCCC1CC1CCCCC1 XXKOQQBKBHUATC-UHFFFAOYSA-N 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 125000005442 diisocyanate group Chemical group 0.000 description 2
- CZZYITDELCSZES-UHFFFAOYSA-N diphenylmethane Chemical compound C=1C=CC=CC=1CC1=CC=CC=C1 CZZYITDELCSZES-UHFFFAOYSA-N 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000005056 polyisocyanate Substances 0.000 description 2
- 229920001228 polyisocyanate Polymers 0.000 description 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 125000004815 1,2-dimethylethylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([*:2])C([H])([H])[H] 0.000 description 1
- ALQLPWJFHRMHIU-UHFFFAOYSA-N 1,4-diisocyanatobenzene Chemical compound O=C=NC1=CC=C(N=C=O)C=C1 ALQLPWJFHRMHIU-UHFFFAOYSA-N 0.000 description 1
- SBJCUZQNHOLYMD-UHFFFAOYSA-N 1,5-Naphthalene diisocyanate Chemical compound C1=CC=C2C(N=C=O)=CC=CC2=C1N=C=O SBJCUZQNHOLYMD-UHFFFAOYSA-N 0.000 description 1
- 229940008841 1,6-hexamethylene diisocyanate Drugs 0.000 description 1
- AQJBTVUWDXWSGQ-UHFFFAOYSA-N 2,2-dihexylpropane-1,3-diol Chemical compound CCCCCCC(CO)(CO)CCCCCC AQJBTVUWDXWSGQ-UHFFFAOYSA-N 0.000 description 1
- OPAGRXOXGAGKCM-UHFFFAOYSA-N 2,2-dipentylpropane-1,3-diol Chemical compound CCCCCC(CO)(CO)CCCCC OPAGRXOXGAGKCM-UHFFFAOYSA-N 0.000 description 1
- HYQIPEBBTROHDG-UHFFFAOYSA-N 2,4-di(propan-2-yl)pentane-1,5-diol Chemical compound CC(C)C(CO)CC(CO)C(C)C HYQIPEBBTROHDG-UHFFFAOYSA-N 0.000 description 1
- GYQSCXOHRLAKNJ-UHFFFAOYSA-N 2,4-dibutylpentane-1,5-diol Chemical compound CCCCC(CO)CC(CO)CCCC GYQSCXOHRLAKNJ-UHFFFAOYSA-N 0.000 description 1
- OJRJDENLRJHEJO-UHFFFAOYSA-N 2,4-diethylpentane-1,5-diol Chemical compound CCC(CO)CC(CC)CO OJRJDENLRJHEJO-UHFFFAOYSA-N 0.000 description 1
- COFDRIMTTUANRX-UHFFFAOYSA-N 2,4-dihexylpentane-1,5-diol Chemical compound CCCCCCC(CO)CC(CO)CCCCCC COFDRIMTTUANRX-UHFFFAOYSA-N 0.000 description 1
- ZJWDJIVISLUQQZ-UHFFFAOYSA-N 2,4-dimethylpentane-1,5-diol Chemical compound OCC(C)CC(C)CO ZJWDJIVISLUQQZ-UHFFFAOYSA-N 0.000 description 1
- ZKCMAOCUXXAPQI-UHFFFAOYSA-N 2,4-dipentylpentane-1,5-diol Chemical compound CCCCCC(CO)CC(CO)CCCCC ZKCMAOCUXXAPQI-UHFFFAOYSA-N 0.000 description 1
- OMMFUUKPSANWIL-UHFFFAOYSA-N 2,4-dipropylpentane-1,5-diol Chemical compound CCCC(CO)CC(CO)CCC OMMFUUKPSANWIL-UHFFFAOYSA-N 0.000 description 1
- UEQSTOOLOFRXQP-UHFFFAOYSA-N 2-ethyl-4-methylpentane-1,5-diol Chemical compound CCC(CO)CC(C)CO UEQSTOOLOFRXQP-UHFFFAOYSA-N 0.000 description 1
- XTPRQBATIUTKMZ-UHFFFAOYSA-N 2-ethyl-4-propan-2-ylpentane-1,5-diol Chemical compound CCC(CO)CC(CO)C(C)C XTPRQBATIUTKMZ-UHFFFAOYSA-N 0.000 description 1
- QMUHKDYJFFYPNU-UHFFFAOYSA-N 2-ethyl-4-propylpentane-1,5-diol Chemical compound CCCC(CO)CC(CC)CO QMUHKDYJFFYPNU-UHFFFAOYSA-N 0.000 description 1
- UCVOCQOLKXXBRN-UHFFFAOYSA-N 2-methyl-4-propan-2-ylpentane-1,5-diol Chemical compound CC(C)C(CO)CC(C)CO UCVOCQOLKXXBRN-UHFFFAOYSA-N 0.000 description 1
- BNMHDPZDANSITP-UHFFFAOYSA-N 2-methyl-4-propylpentane-1,5-diol Chemical compound CCCC(CO)CC(C)CO BNMHDPZDANSITP-UHFFFAOYSA-N 0.000 description 1
- KZEKCWYLGPCTCW-UHFFFAOYSA-N 2-propan-2-yl-4-propylpentane-1,5-diol Chemical compound CCCC(CO)CC(CO)C(C)C KZEKCWYLGPCTCW-UHFFFAOYSA-N 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 239000005058 Isophorone diisocyanate Substances 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 229920001730 Moisture cure polyurethane Polymers 0.000 description 1
- IXQBIOPGDNZYNA-UHFFFAOYSA-N N=C=O.N=C=O.CC1=CC=CC=C1C1=CC=CC=C1C Chemical compound N=C=O.N=C=O.CC1=CC=CC=C1C1=CC=CC=C1C IXQBIOPGDNZYNA-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 235000005545 Veronica americana Nutrition 0.000 description 1
- 240000005592 Veronica officinalis Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- IAQRGUVFOMOMEM-UHFFFAOYSA-N butene Natural products CC=CC IAQRGUVFOMOMEM-UHFFFAOYSA-N 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000007809 chemical reaction catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000000968 fibrocartilage Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 210000003035 hyaline cartilage Anatomy 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
- YPQKTLPPOXNDMC-UHFFFAOYSA-N isocyanic acid;methylcyclohexane Chemical compound N=C=O.CC1CCCCC1 YPQKTLPPOXNDMC-UHFFFAOYSA-N 0.000 description 1
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000004629 polybutylene adipate terephthalate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920005906 polyester polyol Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920006389 polyphenyl polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000909 polytetrahydrofuran Polymers 0.000 description 1
- 229920006295 polythiol Polymers 0.000 description 1
- 229920003009 polyurethane dispersion Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 229920003226 polyurethane urea Polymers 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 210000001032 spinal nerve Anatomy 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 1
- RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/0895—Manufacture of polymers by continuous processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/389—Tibial components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
- A61F2002/30112—Rounded shapes, e.g. with rounded corners
- A61F2002/30133—Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30795—Blind bores, e.g. of circular cross-section
- A61F2002/30807—Plurality of blind bores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0015—Kidney-shaped, e.g. bean-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/20—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. moulding inserts or for coating articles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2120/00—Compositions for reaction injection moulding processes
Abstract
【解決手段】ポリマー製品の少なくとも一部を通してモジュラスの漸進的な変化を有するポリマー製品の作製方法を、その方法を用いて形成された人工椎間板と合わせて開示する。
【選択図】なし
Description
(a)多官能イソシアナートと、ポリオールと、任意選択により鎖伸長剤とを反応させるステップであって、イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を強く混合して所定の化学量論比と熱履歴を有する第1のポリウレタンを形成させるステップ;
(b)多官能イソシアナートと、ポリオールと、任意選択により鎖伸長剤とを反応させるステップであって、イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を強く混合して第1のポリウレタンの化学量論比および熱履歴とは異なった所定の化学量論比と熱履歴を有する第2のポリウレタンを形成させるステップ;および
(c)上記第1のポリウレタンと第2のポリウレタンの製造に関わる重合反応が完了する前に、ポリマー製品の形を定める鋳型中に第1のポリウレタンと第2のポリウレタンを射出し、それによって鋳型中で第1ポリウレタンと第2のポリウレタンとの重合反応が起こるステップ、
を含む方法が提供される。
(a)多官能イソシアナートと、ポリオールと、任意選択で鎖伸長剤とを反応させるステップであって、イソシアナート、ポリオール、鎖伸長剤、その任意の混合物およびこれらから形成される任意のプレポリマーから選択される少なくとも2つの反応原料を強く混合して所定の化学量論比と熱履歴を有するポリウレタンを形成させるステップ、
(b)上記反応の過程の間に、少なくとも2つの反応原料の相対量を変化させて、形成されるポリウレタンのモジュラスを連続的に変化させるステップ、および
(c)そのポリウレタンの製造に関わる重合反応が完了する前に、上記ポリマー製品の形を定める鋳型中にポリウレタンを射出し、それによって鋳型中での重合を続行させるステップ、
を含む方法を提供する。
(a)イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を定量的に分配するための第1の供給系;前記少なくとも2つの反応原料を強く混合して所定の化学量論比を有する第1のポリウレタンを形成させるための混合手段、
(b)イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を定量的に分注するための第2の供給系;前記少なくとも2つの反応原料を強く混合するための混合手段、および第1のポリウレタンとは異なる所定の化学量論比を有する第2のポリウレタンを形成させるための、反応を伴う押出手段と、および
(c)上記第1のポリウレタンと第2のポリウレタンの形成に関わる重合反応が完了する前に、鋳型中に第1のポリウレタンと第2のポリウレタンを射出し、それによって鋳型中で第1のポリウレタンと第2のポリウレタンの間に重合反応を起こさせる手段、
を含む装置を提供する。
(a)イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を定量的に分配するための供給系;前記少なくとも2つの反応原料を強く混合して所定の化学量論比を有する第1のポリウレタンを形成させるための混合手段、
(b)イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマー、から選択される少なくとも2つの反応原料を定量的に分配するために供給系を使用している間に、第1のポリウレタンをその中に導入する中間容器;前記少なくとも2つの反応原料を強く混合するための混合手段、および第1のポリウレタンとは異なる所定の化学量論比を有する第2のポリウレタンを形成させるための、反応を伴う押出手段、および
(c)上記第1のポリウレタンと第2のポリウレタンの形成に関わる重合反応が完了する前に、鋳型中に第1のポリウレタンと第2のポリウレタンを射出し、それによって鋳型中で第1のポリウレタンと第2のポリウレタンとの間に重合反応を起こさせる手段、
を含む装置を提供する。
用途のためには、多官能イソシアナートおよびポリオールを、鎖伸長剤と反応させないことがある。しかし、ほとんどの場合、ウレタン結合プレポリマーの鎖伸長または架橋を実施するために、それを形成させるときに鎖伸長剤を含めることになる。この目的のために適した、適切な任意のポリオール、ポリチオール、またはポリアミン、あるいはその混合物を使用することができる。例えば、2,4-ジアルキル-1,5-ペンタンジオールおよび2,2-ジアルキル-1,3-プロパンジオールを含む混合ジオール。2,4-ジアルキル-1,5-ペンタンジオールの具体的な例には、2,4-ジメチル-1,5-ペンタンジオール、2-エチル-4-メチル-1,5-ペンタンジオール、2-メチル-4-プロピル-1,5-ペンタンジオール、2,4-ジエチル1,5-ペンタンジオール、2-エチル-4-プロピル-1,5-ペンタンジオール、2,4-ジプロピル-1,5-ペンタンジオール、2-イソプロピル-4-メチル-1,5-ペンタンジオール、2-エチル-4-イソプロピル-1,5-ペンタンジオール、2,4-ジイソプロピル-1,5-ペンタンジオール、2-イソプロピル-4-プロピル-1,5-ペンタンジオール、2,4-ジブチル-1,5-ペンタンジオール、2,4-ジペンチル-1,5-ペンタンジオール、2,4-ジヘキシル1,5-ペンタンジオール等が含まれる。2,2-ジアルキル-1,3-プロパンジオールの具体的な例には、2,2-ジペンチル-1,3-プロパンジオール、2,2-ジヘキシル1,3-プロパンジオール等が含まれる。特に好ましい鎖伸長剤には、1,4-ブタンジオール、1,2-エチレンジアミン、ヒドラジン、およびトリエチルアミンが含まれる。しかし、当分野の技術者に知られている多くの他の適切なポリオールおよびアミンの部類も含まれる。本発明の文脈では、「強く混合された」という用語は一般に、イソシアナート、ポリオール、鎖伸長剤、それらの任意の混合物、およびこれらから形成される任意のプレポリマーから選択される2種以上の反応原料が分子レベルで密に混合されることを意味する。好ましい実施形態では、2種以上の反応原料を渦巻状にして強く混合し、それによって2種以上の反応原料ストリームを同時に起こさせ、旋回状に一緒に流動させる。別の実施形態では、2種以上の反応原料を斜板ポンプまたはギヤポンプで輸送する。2種以上の反応原料は、従来のRIMまたはSRIMプロセスで用いられている種類の反応的射出加工技術で強く混合することが最も好ましい。好ましい実施形態では、本発明の合成技術は、RIM設備で使用されるものと同様で、かつ2種以上の反応原料ストリームに適している衝突混合ヘッドを使用する。それぞれの異なるストリームは、現在のRIMまたはREX技術と関連しないが、必要量の反応原料を連続的にかつ高い精度で供給するようにプログラムを組むことができる。さらに、反応原料が分子レベルで強く混合されるにしたがって、一般に反応が自発的に開始し、それによって、反応触媒を含める必要性がまったく回避されるか、またはそうした必要触媒量が著しく削減される。このような反応で通常使用される触媒の多くは、潜在的にインビボで毒性が強いので、本発明の方法はインプラント化のためのポリウレタンの医療用デバイスを作製するのに特に適している。それぞれを使用した後に装置を清浄化させることを回避するために、混合ヘッドは自己清浄化型が好ましい。一実施形態では、2種以上の反応原料を、好ましくは1つまたは複数の射出ランス(lance)を通して圧力下で混合ヘッドに供給する。例えば、第1の射出ランスはイソシアナートを含み、第2の射出ランスはポリオールおよび鎖伸長剤を含むことができる、あるいは、第1の射出ランスは第1のイソシアナートを含み、第2の射出ランスはエンドキャッピングをもたらすために一定分量の第1のポリオールと混合されている第2のイソシアナートを含み、第3の射出ランスは第2のポリオールを含み、第4の射出ランスは鎖伸長剤を含むことができる。種々の反応原料の多くの組合せと変形が可能であることは明らかであり、これらの組合せはすべて本発明の範囲に包含されるものとする。混合ステップは実質的に瞬間的に、最も好ましくは1秒からせいぜい数秒の間に起こることが好ましい。混合直後は得られる混合物が実質的に均一であるが、重合が進行するにしたがって後続する混合物の組成がはっきり変化することが特に望ましい。本発明の文脈では、「反応を伴って押出される」という用語は、好ましくは従来のREX法に関して上記の様々な変更の形態のうちの少なくとも1つにより、ポリウレタン混合物の物理的および化学的特性を、連続流混合型の反応器(CSTR)または押出機中で改変することを意味するものと理解されたい。
応を伴う押出手段中のポリウレタン混合物の温度を制御するための手段;反応を伴う押出の間のポリウレタン混合物の特性を検出し、検出器信号を発生するように適合させるための手段;並びに、前記検出器信号に応答して前記第1、第2および第3の制御信号を発生するように適合されたプロセッサー、を備えることができる。これによって、本発明のプロセスを自動化し、よく規定されているかまたは所定の化学量論比および熱履歴のポリウレタンを製造するために要求される任意の必要な調整を正確に制御することが可能となる。この最後に述べた実施形態では、制御および検出手段はプログラミング可能な手段であって、それによってその動作を、コンピュータ操作のプログラムによって制御できることが好ましい。
1.材料特性-粘度、材料の接触角。
2.射出速度-椎間板を参照すると、正しい分布を得るためには、環状部および中心核材料の射出速度は異なっている。
3.射出ポート形状-これは、材料の鋳型中への流れに影響を与えることになる。椎間板を参照すると、射出ポートの形状は中心核材料の分布に影響を及ぼすことになる。
粘度材料A=5000cP
粘度材料B=15000cP
材料の鋳型表面との接触角=60°
射出速度=0.100ml/s及び0.010ml/s
6 混合ヘッド
7 鋳型
8 油圧シリンダ
9 ランスポンプ
10 入口管
11 逆止弁
13 出口管
14 シリンダ状の混合ピン
Claims (17)
- モジュラスの漸進的な変化を有する少なくとも一部分を示すポリマー材料からなる固形物体を含む人工椎間板。
- 前記部分を通じて、前記モジュラスがほぼ線形で変化する、請求項1に記載の人工椎間板。
- 環状部領域で囲まれた核を含み、前記部分が、前記核と前記環状部領域との間の領域に位置している、請求項1または2に記載の人工椎間板。
- 一組の一体のポリマー終板であって、前記終板と前記椎間板の残部との間に界面結合がないように構成された終板を含む、請求項1〜3のいずれか一項に記載の人工椎間板。
- 請求項1〜17のいずれか一項に記載の方法によって製造された、請求項1〜4のいずれか一項に記載の人工椎間板。
- 前記環状部領域のモジュラスよりも前記核領域のモジュラスが小さい、請求項3に記載の人工椎間板。
- 前記固体物体が、第1の化学量論比を有する第1のポリウレタン材料と、第2の化学量論比を有する第2のポリウレタン材料とを含む、請求項1に記載の人工椎間板。
- 核領域と単一の環状部領域とを含むポリマー材料構造を含み、前記核領域のモジュラスが前記環状部領域のモジュラスよりも小さい、人工椎間板。
- 前記物体とともに提供される第1の終板と、前記物体とともに提供される第2の終板とをさらに含む、請求項8に記載の人工椎間板。
- 前記第1及び第2の終板と、前記物体との間に明確な境界がない、請求項9に記載の人工椎間板。
- 前記物体の所定の部分がモジュラスの漸進的な変化を有する請求項8記載の人工椎間板。
- 前記所定の部分を横切って前記核領域からの距離の増加とともにモジュラスが増加する、請求項11に記載の人工椎間板。
- 前記ポリマー材料の構造が単一である、請求項8に記載の人工椎間板。
- 上側表面と下側表面とを有し、ポリマー材料を含む物体;
前記物体の上側表面で前記ポリマー材料と共有結合で結合されたポリマー材料を含む第1の終板;
前記物体の下側表面で前記ポリマー材料と共有結合で結合されたポリマー材料を含む第2の終板、を含む人工椎間板。 - 前記終板の少なくとも1つの外表面が溝を備えている、請求項14に記載の人工椎間板。
- 前記第1及び第2の終板と、前記物体との間に明確な境界がない、請求項14に記載の人工椎間板。
- 上側表面と、下側表面と、前記上側表面と前記下側表面との間の側壁とを有し、ポリマー材料を含む物体であって、核領域と環状部領域とを含み、前記環状部領域が、前記上側表面及び前記下側表面から前記核領域を分離している物体;
前記物体とともに提供され、ポリマー材料を含む第1の終板;及び
前記物体とともに提供され、ポリマー材料を含む第2の終板、
を含む人工椎間板。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223327.8 | 2002-10-08 | ||
GBGB0223327.8A GB0223327D0 (en) | 2002-10-08 | 2002-10-08 | Artificial spinal disc |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004542630A Division JP4828122B2 (ja) | 2002-10-08 | 2003-10-08 | 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010162376A true JP2010162376A (ja) | 2010-07-29 |
JP5544211B2 JP5544211B2 (ja) | 2014-07-09 |
Family
ID=9945504
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004542630A Expired - Fee Related JP4828122B2 (ja) | 2002-10-08 | 2003-10-08 | 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 |
JP2010092239A Expired - Fee Related JP5544211B2 (ja) | 2002-10-08 | 2010-04-13 | 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004542630A Expired - Fee Related JP4828122B2 (ja) | 2002-10-08 | 2003-10-08 | 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 |
Country Status (9)
Country | Link |
---|---|
US (4) | US8353960B2 (ja) |
EP (1) | EP1554325B1 (ja) |
JP (2) | JP4828122B2 (ja) |
AU (2) | AU2003271913B8 (ja) |
BR (1) | BR0315090B1 (ja) |
CA (1) | CA2499645C (ja) |
ES (1) | ES2394278T3 (ja) |
GB (1) | GB0223327D0 (ja) |
WO (1) | WO2004033516A1 (ja) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006201583B2 (en) * | 2000-08-03 | 2008-01-24 | Ranier Limited | Precision polyurethane manufacture |
GB0019074D0 (en) * | 2000-08-03 | 2000-09-27 | Ranier Ltd | Precision polyurethane manufacture |
GB0223327D0 (en) * | 2002-10-08 | 2002-11-13 | Ranier Ltd | Artificial spinal disc |
US20070027547A1 (en) * | 2003-06-27 | 2007-02-01 | Advanced Bio Surfaces, Inc. | System and method for ankle arthroplasty |
US7383164B2 (en) * | 2004-03-05 | 2008-06-03 | Depuy Products, Inc. | System and method for designing a physiometric implant system |
EP1838249B1 (en) | 2005-01-19 | 2012-03-14 | Nexgen Spine, Inc. | Fixation of elastomer to rigid structures |
US7591853B2 (en) * | 2005-03-09 | 2009-09-22 | Vertebral Technologies, Inc. | Rail-based modular disc nucleus prosthesis |
EP1948041A2 (en) | 2005-10-24 | 2008-07-30 | Nexgen Spine, Inc. | Intervertebral disc replacement and associated instrumentation |
US20070276492A1 (en) * | 2006-05-09 | 2007-11-29 | Ranier Limited | Artificial spinal disc implant |
US20080071379A1 (en) * | 2006-05-10 | 2008-03-20 | Mark Rydell | Intervertebral disc replacement |
US9011542B2 (en) | 2006-09-26 | 2015-04-21 | K2M, Inc. | Intervertebral prosthesis endplate having double dome and surgical tools for implanting same |
US9737414B2 (en) | 2006-11-21 | 2017-08-22 | Vertebral Technologies, Inc. | Methods and apparatus for minimally invasive modular interbody fusion devices |
US8715352B2 (en) | 2006-12-14 | 2014-05-06 | Depuy Spine, Inc. | Buckling disc replacement |
US20100320639A1 (en) * | 2007-02-08 | 2010-12-23 | Christopher Reah | Medical Implants with Pre-Settled Cores and Related Methods |
US20080255664A1 (en) * | 2007-04-10 | 2008-10-16 | Mdesign International | Percutaneously deliverable orthopedic joint device |
US8292925B2 (en) | 2007-06-19 | 2012-10-23 | Zimmer Spine, Inc. | Flexible member with variable flexibility for providing dynamic stability to a spine |
US10821003B2 (en) | 2007-06-20 | 2020-11-03 | 3Spline Sezc | Spinal osteotomy |
US20090093846A1 (en) * | 2007-10-04 | 2009-04-09 | Zimmer Spine Inc. | Pre-Curved Flexible Member For Providing Dynamic Stability To A Spine |
US20090099606A1 (en) * | 2007-10-16 | 2009-04-16 | Zimmer Spine Inc. | Flexible member with variable flexibility for providing dynamic stability to a spine |
US8118873B2 (en) * | 2008-01-16 | 2012-02-21 | Warsaw Orthopedic, Inc. | Total joint replacement |
US20090270988A1 (en) * | 2008-04-24 | 2009-10-29 | Ranier Limited | Artificial spinal disc implant |
US8114156B2 (en) * | 2008-05-30 | 2012-02-14 | Edwin Burton Hatch | Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints |
US9364338B2 (en) | 2008-07-23 | 2016-06-14 | Resspond Spinal Systems | Modular nucleus pulposus prosthesis |
CA2731048C (en) * | 2008-07-23 | 2016-11-29 | Marc I. Malberg | Modular nucleus pulposus prosthesis |
US8187333B2 (en) * | 2008-09-18 | 2012-05-29 | Mayer Peter L | Intervertebral disc prosthesis and method for implanting and explanting |
US8814937B2 (en) | 2008-09-18 | 2014-08-26 | Peter L. Mayer | Intervertebral disc prosthesis, method for assembling, method for implanting prosthesis, and method for explanting |
CN102341131A (zh) * | 2009-03-05 | 2012-02-01 | 帝斯曼知识产权资产管理有限公司 | 脊柱融合器 |
US9549820B2 (en) * | 2009-06-25 | 2017-01-24 | Zimmer, Inc. | Glenoid implant with synthetic labrum |
US20110012280A1 (en) * | 2009-07-14 | 2011-01-20 | Doctors Research Group, Inc. | Method for fabricating a multi-density polymeric interbody spacer |
US20110015743A1 (en) * | 2009-07-14 | 2011-01-20 | Doctors Research Group, Inc. | Multi-density polymeric interbody spacer |
WO2011032043A1 (en) * | 2009-09-11 | 2011-03-17 | Articulinx, Inc. | Disc-shaped orthopedic devices |
JP5607744B2 (ja) | 2009-10-29 | 2014-10-15 | エイオーテック インターナショナル パブリック リミティド カンパニー | 埋め込み可能な電気装置上に直接形成されたポリウレタンヘッダ |
US9510953B2 (en) | 2012-03-16 | 2016-12-06 | Vertebral Technologies, Inc. | Modular segmented disc nucleus implant |
US9393126B2 (en) | 2012-04-20 | 2016-07-19 | Peter L. Mayer | Bilaterally placed disc prosthesis for spinal implant and method of bilateral placement |
US9364339B2 (en) | 2012-04-30 | 2016-06-14 | Peter L. Mayer | Unilaterally placed expansile spinal prosthesis |
EP3389570B1 (en) * | 2015-12-16 | 2024-04-17 | Nuvasive, Inc. | Porous spinal fusion implant |
EP3195833B1 (en) | 2016-01-19 | 2022-01-12 | K2M, Inc. | Surgical instrument |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02224660A (ja) * | 1988-08-18 | 1990-09-06 | Johnson & Johnson Orthopedics Inc | 椎間スペーサ及びその製法 |
US5545229A (en) * | 1988-08-18 | 1996-08-13 | University Of Medicine And Dentistry Of Nj | Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759829A (fr) * | 1969-12-03 | 1971-06-03 | Upjohn Co | Preparation de polyurethanes |
CA992255A (en) | 1971-01-25 | 1976-07-06 | Cutter Laboratories | Prosthesis for spinal repair |
IT971855B (it) | 1972-12-14 | 1974-05-10 | Afros Srl | Testata per lo stampaggio di materiali espansi |
US4834757A (en) | 1987-01-22 | 1989-05-30 | Brantigan John W | Prosthetic implant |
US4911718A (en) | 1988-06-10 | 1990-03-27 | University Of Medicine & Dentistry Of N.J. | Functional and biocompatible intervertebral disc spacer |
CA1318469C (en) | 1989-02-15 | 1993-06-01 | Acromed Corporation | Artificial disc |
JPH0748513B2 (ja) | 1990-06-22 | 1995-05-24 | 株式会社東芝 | 接合部の検査方法 |
EP0464886A3 (en) | 1990-07-06 | 1992-09-02 | General Motors Corporation | Self-reinforcing polyurethane compositions |
DE4106699A1 (de) * | 1991-03-02 | 1992-09-03 | Kopp Gerhard Gmbh | Kunststoffmanschette oder -scheibe sowie verfahren und vorrichtung zu deren herstellung |
IT1252680B (it) | 1991-11-13 | 1995-06-23 | Sviluppo Settori Impiego Srl | Procedimento per la realizzazione di corpi di materiale polimerico comprendenti un nucleo di materiale espanso racchiuso da un guscio esterno, e dispositivo utilizzato in tale procedimento |
US5258023A (en) * | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
GB9204263D0 (en) | 1992-02-28 | 1992-04-08 | Limbs & Things Ltd | Artificial spinal disc |
US5306309A (en) | 1992-05-04 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant and implantation kit |
JP2746024B2 (ja) * | 1992-10-30 | 1998-04-28 | 豊田合成株式会社 | Rimポリウレタン二色成形方法 |
US5628944A (en) * | 1992-10-30 | 1997-05-13 | Toyoda Gosei Co., Ltd. | Method and apparatus for molding two-color polyurethane parts by RIM |
EP0610837B1 (en) | 1993-02-09 | 2001-09-05 | Acromed Corporation | Spine disc |
DE4318700C1 (de) | 1993-06-04 | 1994-11-17 | S & G Implants Gmbh | Implantat zum Versteifen benachbarter Wirbelknochen |
DE4423826B4 (de) | 1993-07-07 | 2007-01-04 | Pentax Corp. | Keramische Wirbelprothese |
US5514180A (en) | 1994-01-14 | 1996-05-07 | Heggeness; Michael H. | Prosthetic intervertebral devices |
US5391397A (en) * | 1994-04-05 | 1995-02-21 | Motorola, Inc. | Method of adhesion to a polyimide surface by formation of covalent bonds |
US6248131B1 (en) * | 1994-05-06 | 2001-06-19 | Advanced Bio Surfaces, Inc. | Articulating joint repair |
US5674296A (en) * | 1994-11-14 | 1997-10-07 | Spinal Dynamics Corporation | Human spinal disc prosthesis |
US5676670A (en) | 1996-06-14 | 1997-10-14 | Beth Israel Deaconess Medical Center | Catheter apparatus and method for creating a vascular bypass in-vivo |
AU7178698A (en) * | 1996-11-15 | 1998-06-03 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
US6641614B1 (en) * | 1997-05-01 | 2003-11-04 | Spinal Concepts, Inc. | Multi-variable-height fusion device |
US5824094A (en) | 1997-10-17 | 1998-10-20 | Acromed Corporation | Spinal disc |
US20010016773A1 (en) | 1998-10-15 | 2001-08-23 | Hassan Serhan | Spinal disc |
US6139579A (en) | 1997-10-31 | 2000-10-31 | Depuy Motech Acromed, Inc. | Spinal disc |
US6162252A (en) | 1997-12-12 | 2000-12-19 | Depuy Acromed, Inc. | Artificial spinal disc |
US6679915B1 (en) | 1998-04-23 | 2004-01-20 | Sdgi Holdings, Inc. | Articulating spinal implant |
US6302916B1 (en) | 1998-12-24 | 2001-10-16 | Biopro, Inc. | Polyurethane and so forth containing joints |
ES2238290T3 (es) | 1999-06-04 | 2005-09-01 | Sdgi Holdings, Inc. | Implante de disco artificial. |
US7201776B2 (en) | 1999-10-08 | 2007-04-10 | Ferree Bret A | Artificial intervertebral disc replacements with endplates |
US7060100B2 (en) | 1999-10-08 | 2006-06-13 | Ferree Bret A | Artificial disc and joint replacements with modular cushioning components |
US6592624B1 (en) | 1999-11-24 | 2003-07-15 | Depuy Acromed, Inc. | Prosthetic implant element |
US20030040800A1 (en) | 2000-04-26 | 2003-02-27 | Li Lehmann K. | Apparatus and method for replacing the nucleus pulposus of an intervertebral disc or for replacing an entire intervertebral disc |
US6482234B1 (en) | 2000-04-26 | 2002-11-19 | Pearl Technology Holdings, Llc | Prosthetic spinal disc |
GB0019107D0 (en) | 2000-08-03 | 2000-09-27 | Ranier Ltd | Balloon-free uninary catheter |
GB0019074D0 (en) * | 2000-08-03 | 2000-09-27 | Ranier Ltd | Precision polyurethane manufacture |
AU2001281166B2 (en) * | 2000-08-08 | 2006-07-20 | Warsaw Orthopedic, Inc. | Implantable joint prosthesis |
US20020026244A1 (en) * | 2000-08-30 | 2002-02-28 | Trieu Hai H. | Intervertebral disc nucleus implants and methods |
US6620196B1 (en) | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
US6468660B2 (en) * | 2000-12-29 | 2002-10-22 | St. Jude Medical, Inc. | Biocompatible adhesives |
US20030069639A1 (en) * | 2001-04-14 | 2003-04-10 | Tom Sander | Methods and compositions for repair or replacement of joints and soft tissues |
US6987136B2 (en) | 2001-07-13 | 2006-01-17 | Vita Special Purpose Corporation | Bioactive spinal implant material and method of manufacture thereof |
US7179294B2 (en) * | 2002-04-25 | 2007-02-20 | Warsaw Orthopedic, Inc. | Articular disc prosthesis and method for implanting the same |
US6723097B2 (en) | 2002-07-23 | 2004-04-20 | Depuy Spine, Inc. | Surgical trial implant |
US20040054413A1 (en) | 2002-09-16 | 2004-03-18 | Howmedica Osteonics Corp. | Radiovisible hydrogel intervertebral disc nucleus |
GB0223327D0 (en) | 2002-10-08 | 2002-11-13 | Ranier Ltd | Artificial spinal disc |
US20040133278A1 (en) | 2002-10-31 | 2004-07-08 | Marino James F. | Spinal disc implant |
US7201779B2 (en) * | 2003-06-16 | 2007-04-10 | L'oreal S.A. | Dye composition comprising at least one direct dye containing mixed chromophores |
US7008452B2 (en) | 2003-06-26 | 2006-03-07 | Depuy Acromed, Inc. | Dual durometer elastomer artificial disc |
US20040267367A1 (en) | 2003-06-30 | 2004-12-30 | Depuy Acromed, Inc | Intervertebral implant with conformable endplate |
US20050015150A1 (en) | 2003-07-17 | 2005-01-20 | Lee Casey K. | Intervertebral disk and nucleus prosthesis |
US7250060B2 (en) | 2004-01-27 | 2007-07-31 | Sdgi Holdings, Inc. | Hybrid intervertebral disc system |
AU2006206560A1 (en) | 2005-01-19 | 2006-07-27 | Nexgen Spine, Inc. | Elastomeric intervertebral disc prosthesis |
US20060241759A1 (en) | 2005-04-25 | 2006-10-26 | Sdgi Holdings, Inc. | Oriented polymeric spinal implants |
JP4754903B2 (ja) * | 2005-08-19 | 2011-08-24 | 富士通株式会社 | 半導体装置、及び半導体装置における制御方法 |
US20070050032A1 (en) | 2005-09-01 | 2007-03-01 | Spinal Kinetics, Inc. | Prosthetic intervertebral discs |
US20070276492A1 (en) | 2006-05-09 | 2007-11-29 | Ranier Limited | Artificial spinal disc implant |
-
2002
- 2002-10-08 GB GBGB0223327.8A patent/GB0223327D0/en not_active Ceased
-
2003
- 2003-10-08 AU AU2003271913A patent/AU2003271913B8/en not_active Ceased
- 2003-10-08 WO PCT/GB2003/004352 patent/WO2004033516A1/en active Application Filing
- 2003-10-08 CA CA2499645A patent/CA2499645C/en not_active Expired - Fee Related
- 2003-10-08 BR BRPI0315090-9A patent/BR0315090B1/pt not_active IP Right Cessation
- 2003-10-08 ES ES03753751T patent/ES2394278T3/es not_active Expired - Lifetime
- 2003-10-08 EP EP03753751A patent/EP1554325B1/en not_active Expired - Lifetime
- 2003-10-08 JP JP2004542630A patent/JP4828122B2/ja not_active Expired - Fee Related
- 2003-10-08 US US10/530,919 patent/US8353960B2/en not_active Expired - Fee Related
-
2006
- 2006-08-17 US US11/505,629 patent/US20070043443A1/en not_active Abandoned
- 2006-08-17 US US11/505,633 patent/US8882837B2/en not_active Expired - Fee Related
- 2006-08-17 US US11/505,632 patent/US20070050037A1/en not_active Abandoned
-
2010
- 2010-04-13 JP JP2010092239A patent/JP5544211B2/ja not_active Expired - Fee Related
-
2011
- 2011-02-11 AU AU2011200572A patent/AU2011200572A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02224660A (ja) * | 1988-08-18 | 1990-09-06 | Johnson & Johnson Orthopedics Inc | 椎間スペーサ及びその製法 |
US5171281A (en) * | 1988-08-18 | 1992-12-15 | University Of Medicine & Dentistry Of New Jersey | Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness |
US5545229A (en) * | 1988-08-18 | 1996-08-13 | University Of Medicine And Dentistry Of Nj | Functional and biocompatible intervertebral disc spacer containing elastomeric material of varying hardness |
Also Published As
Publication number | Publication date |
---|---|
AU2003271913A1 (en) | 2004-05-04 |
CA2499645C (en) | 2012-03-27 |
GB0223327D0 (en) | 2002-11-13 |
AU2003271913B8 (en) | 2011-03-17 |
JP5544211B2 (ja) | 2014-07-09 |
BR0315090A (pt) | 2005-09-06 |
AU2011200572A1 (en) | 2011-03-03 |
CA2499645A1 (en) | 2004-04-22 |
EP1554325A1 (en) | 2005-07-20 |
US20070050038A1 (en) | 2007-03-01 |
WO2004033516A1 (en) | 2004-04-22 |
BR0315090B1 (pt) | 2014-07-01 |
JP2006502274A (ja) | 2006-01-19 |
AU2003271913B2 (en) | 2010-11-18 |
US20060167550A1 (en) | 2006-07-27 |
EP1554325B1 (en) | 2012-08-08 |
JP4828122B2 (ja) | 2011-11-30 |
US8353960B2 (en) | 2013-01-15 |
US20070043443A1 (en) | 2007-02-22 |
US20070050037A1 (en) | 2007-03-01 |
ES2394278T3 (es) | 2013-01-30 |
US8882837B2 (en) | 2014-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5544211B2 (ja) | 漸進的なモジュラスの変動を有する椎間板インプラントなどのポリウレタン製品の高精度な製造 | |
JP4374188B2 (ja) | 人工椎間円板 | |
US20070276492A1 (en) | Artificial spinal disc implant | |
US7713301B2 (en) | Intervertebral disc prosthesis | |
US8038718B2 (en) | Multi-composite disc prosthesis | |
AU2013206000A1 (en) | Method of Manufacturing a Polymeric Product | |
NL2027199B1 (en) | Method of manufacturing a non-biodegradable plug-shaped implant for the replacement and regeneration of biological tissue | |
CN101267783A (zh) | 多元复合椎间盘假体 | |
CA2243154A1 (en) | Biomaterial system for in situ tissue repair |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100507 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120821 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121121 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130221 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130423 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130719 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130724 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131023 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140414 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140512 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5544211 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |