JP2010155827A5 - - Google Patents
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- Publication number
- JP2010155827A5 JP2010155827A5 JP2009275269A JP2009275269A JP2010155827A5 JP 2010155827 A5 JP2010155827 A5 JP 2010155827A5 JP 2009275269 A JP2009275269 A JP 2009275269A JP 2009275269 A JP2009275269 A JP 2009275269A JP 2010155827 A5 JP2010155827 A5 JP 2010155827A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- alkyl group
- group
- compound
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001424 substituent group Chemical group 0.000 claims 21
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229940123730 Orexin receptor antagonist Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108050000742 Orexin Receptor Proteins 0.000 claims 1
- 102000008834 Orexin receptor Human genes 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- -1 phenyl 4-[(4-fluorophenyl) sulfonyl] -1-oxa-4,8-diazaspiro [4.5] decane-8-carboxylate Chemical compound 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009275269A JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008310301 | 2008-12-04 | ||
| JP2009275269A JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010155827A JP2010155827A (ja) | 2010-07-15 |
| JP2010155827A5 true JP2010155827A5 (fi) | 2013-01-17 |
Family
ID=42574021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009275269A Ceased JP2010155827A (ja) | 2008-12-04 | 2009-12-03 | スピロ環化合物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2010155827A (fi) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7106659B2 (ja) | 2018-02-13 | 2022-07-26 | 上海 インスティテュート オブ オーガニック ケミストリー、チャイニーズ アカデミー オブ サイエンシーズ | インドール－２、３－ジオキシゲナーゼ阻害剤としてのスピロ化合物 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2506266C2 (ru) * | 2009-01-26 | 2014-02-10 | Израэл Инститьют Фо Байолоджикал Рисерч | Бициклические гетероциклические спиросоединения |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| EP2811997B1 (en) | 2012-02-07 | 2018-04-11 | Eolas Therapeutics Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| JP6453216B2 (ja) * | 2013-07-23 | 2019-01-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ縮合環化合物 |
| TW201613864A (en) * | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| JP6663909B2 (ja) | 2014-08-13 | 2020-03-13 | エオラス セラピューティクス， インコーポレイテッド | オレキシンレセプターモジュレーターとしてのジフルオロピロリジン |
| AU2017217931B2 (en) | 2016-02-12 | 2020-10-22 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| CN105859726B (zh) * | 2016-05-18 | 2018-07-13 | 南京富润凯德生物医药有限公司 | 一种嘧啶并环中选择性脱卤素的方法 |
| MX2022006422A (es) * | 2019-11-27 | 2022-08-25 | Sumitomo Pharma Co Ltd | Derivado de cicloalquilurea. |
| JPWO2022250108A1 (fi) * | 2021-05-26 | 2022-12-01 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812768A1 (de) * | 1967-12-11 | 1969-07-03 | Yoshitomi Pharmaceutical | Neue Benzodioxanderivate |
| AU2006282955A1 (en) * | 2005-08-26 | 2007-03-01 | Merck & Co., Inc. | Diazaspirodecane orexin receptor antagonists |
-
2009
- 2009-12-03 JP JP2009275269A patent/JP2010155827A/ja not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7106659B2 (ja) | 2018-02-13 | 2022-07-26 | 上海 インスティテュート オブ オーガニック ケミストリー、チャイニーズ アカデミー オブ サイエンシーズ | インドール－２、３－ジオキシゲナーゼ阻害剤としてのスピロ化合物 |
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