JP2010143894A5

JP2010143894A5 -

Info

Publication number: JP2010143894A5
Application number: JP2008325880A
Authority: JP
Filing date: 2008-12-22
Publication date: 2012-11-08
Anticipated expiration: 2028-12-22

Description

すなわち、本発明は、ビタミンＢ₁を１μｇ／ｍｌ以上、及び二酸化炭素をガス内圧で１．０〜４．０ｋｇ／ｃｍ ^２含有するビタミンＢ₁に由来する不快な味および臭いが低減された内服液剤を提供するものである。
また、本発明は、ビタミンＢ₁を１μｇ／ｍｌ以上含有する内服液剤に、二酸化炭素をガス内圧で１．０〜４．０ｋｇ／ｃｍ ^２含有せしめる、ビタミンＢ₁内服液のビタミンＢ₁に由来する不快な味および臭いの低減方法を提供するものである。 That is, the present invention has reduced unpleasant taste and odor derived from vitamin B ₁ containing ₁ μg / ml or more of vitamin B ₁ and 1.0 to 4.0 kg / cm ² of carbon dioxide at the gas internal pressure. An internal liquid is provided.
The present invention also vitamin B ₁ in oral liquid preparation containing more than 1 [mu] g / ml, carbon dioxide 1.0 to 4.0 kg / cm ² allowed to contain a gas pressure, to vitamin B ₁ Vitamin B ₁ oral solution The present invention provides a method for reducing the unpleasant taste and odor derived therefrom.

本発明において、二酸化炭素の含有量は、内服液全体に対するガス内圧（単位体積中に溶解しているガス量）として、１．０〜４．０ｋｇ／ｃｍ ^２であるが、２．２〜３．７ｋｇ／ｃｍ ^２が好ましく、２．５〜３．５ｋｇ／ｃｍ ^２がより好ましく、３．０〜３．４ｋｇ／ｃｍ ^２がさらに好ましい。
ガス内圧力が１．０ｋｇ／ｃｍ ^２を下回ると、ビタミンＢ₁に由来する不快な味や臭いの低減作用が十分得られない点で、好ましくない。 In the present invention, the content of carbon dioxide is 1.0 to 4.0 kg / cm ² as gas internal pressure (the amount of gas dissolved in a unit volume) with respect to the entire internal liquid, but 2.2 to 3.7 kg / cm ² is preferable, 2.5 to 3.5 kg / cm ² is more preferable, and 3.0 to 3.4 kg / cm ² is more preferable.
When the gas internal pressure is less than 1.0 kg / cm ² , it is not preferable in that the effect of reducing the unpleasant taste and odor derived from vitamin B ₁ cannot be obtained sufficiently.

実施例１
ビタミンＢ₁を含有する内服液剤および比較液剤の製造：ビタミンＢ₁（硝酸塩）０．４ｇ、１ｇ、２ｇ、１０ｇそれぞれを精製水４０Ｌに溶解し、脱気処理を行った。次に、得られたそれぞれの溶液、または、脱気を行った精製水の８Lを耐圧容器に取り、二酸化炭素をガス内圧でそれぞれ、１．２ｋｇ／ｃｍ ^２、２．２ｋｇ／ｃｍ ^２、３．２ｋｇ／ｃｍ ^２になるように調整して圧入した。この液を洗浄した褐色ガラスビンに充填し、キャッピングしたものを内服液剤とした。 Example 1
Manufacture of internal solution and comparative solution containing vitamin B ₁ : 0.4 g, 1 g, 2 g, and 10 g of vitamin B ₁ (nitrate) were dissolved in 40 L of purified water and subjected to deaeration treatment. Next, 8 L of each of the obtained solutions or purified water that has been degassed is placed in a pressure vessel, and carbon dioxide is 1.2 kg / cm ² and 2.2 kg / cm ² , respectively, at the gas internal pressure. The pressure was adjusted to 3.2 kg / cm ² and press-fitted. The solution was filled into a washed brown glass bottle and capped to obtain an internal solution.

実施例２
ビタミンＢ₁及びＢ₂を含有する内服液剤および比較液剤の製造：ビタミンＢ₁（硝酸塩）とビタミンＢ₂（リン酸エステル）それぞれを０．４ｇづつ合計０．８ｇ、１ｇづつ合計２ｇ、２ｇづつ合計４ｇ、１０ｇづつ合計２０ｇを精製水４０Ｌに溶解し、脱気処理を行った。次に、得られたそれぞれの溶液、または、脱気を行った精製水の８Lを耐圧容器に取り、二酸化炭素を、ガス内圧が３．２ｋｇ／ｃｍ ^２になるように調整して圧入した。この液を洗浄した褐色ガラスビンに充填し、キャッピングしたものを内服液剤とした。 Example 2
Manufacture of internal solutions and comparative solutions containing vitamins B ₁ and B ₂ : 0.4 g of each of vitamin B ₁ (nitrate) and vitamin B ₂ (phosphate ester) in total 0.8 g, 1 g in total 2 g, 2 g in each A total of 20 g in total of 4 g and 10 g was dissolved in 40 L of purified water and subjected to deaeration treatment. Next, 8 L of each of the obtained solutions or degassed purified water was placed in a pressure vessel, and carbon dioxide was adjusted and injected so that the internal pressure of the gas was 3.2 kg / cm ² . . The solution was filled into a washed brown glass bottle and capped to obtain an internal solution.

ビタミンＢ₁及びＢ₆を含有する内服液剤および比較液剤の製造：ビタミンＢ₁（硝酸塩）とビタミンＢ₆（塩酸塩）それぞれを０．４ｇづつ合計０．８ｇ、１ｇづつ合計２ｇ、２ｇづつ合計４ｇ、１０ｇづつ合計２０ｇを精製水４０Ｌに溶解し、脱気処理を行った。次に、得られたそれぞれの溶液、または、脱気を行った精製水の８Lを耐圧容器に取り、二酸化炭素をガス内圧を３．２ｋｇ／ｃｍ ²になるように調整して圧入した。この液を洗浄した褐色ガラスビンに充填し、キャッピングしたものを内服液剤とした。 Manufacture of internal solutions and comparative solutions containing vitamins B ₁ and B ₆ : 0.4 g total for each of vitamin B ₁ (nitrate) and vitamin B ₆ (hydrochloride), 2 g for each 2 g, 2 g for each total A total of 20 g of 4 g and 10 g was dissolved in 40 L of purified water and subjected to deaeration treatment. Next, 8 L of each of the obtained solutions or purified water that had been degassed was placed in a pressure vessel, and carbon dioxide was injected by adjusting the internal pressure of the gas to 3.2 kg / cm ² . The solution was filled into a washed brown glass bottle and capped to obtain an internal solution.

ビタミンＢ₁、Ｂ₂及びＢ₆を含有する内服液剤および比較液剤の製造：ビタミンＢ₁（硝酸塩）、ビタミンＢ₂（リン酸エステル）、ビタミンＢ₆（塩酸塩）それぞれを０．４ｇづつ合計１．２ｇ、１ｇづつ合計３ｇ、２ｇづつ合計６ｇ、１０ｇづつ合計３０ｇを精製水４０Ｌに溶解し、脱気処理を行った。次に、得られたそれぞれの溶液、または、脱気を行った精製水の８Lを耐圧容器に取り、二酸化炭素を、ガス内圧が３．２ｋｇ／ｃｍ ²になるように調整して圧入した。この液を洗浄した褐色ガラスビンに充填し、キャッピングしたものを内服液剤とした。 Manufacture of internal solutions and comparative solutions containing vitamin B ₁ , B ₂ and B ₆ : 0.4g each of vitamin B ₁ (nitrate), vitamin B ₂ (phosphate ester), vitamin B ₆ (hydrochloride) 1.2 g, 1 g in total 3 g, 2 g in total 6 g, 10 g in total 30 g in total were dissolved in 40 L of purified water, and degassed. Next, 8 L of each of the obtained solutions or purified water that had been degassed was placed in a pressure vessel, and carbon dioxide was adjusted and adjusted so that the gas internal pressure was 3.2 kg / cm ² . . The solution was filled into a washed brown glass bottle and capped to obtain an internal solution.

Claims

An oral liquid preparation with reduced unpleasant taste and odor derived from vitamin B ₁ containing ₁ μg / ml or more of vitamin B ₁ and 1.0 to 4.0 kg / cm ² of carbon dioxide at the gas internal pressure.

Vitamin B ₁ in oral liquid preparation containing more than 1 [mu] g / ml, carbon dioxide allowed to 1.0 to 4.0 kg / cm ² containing a gas pressure, unpleasant taste derived from vitamin B ₁ Vitamin B ₁ oral solution and Odor reduction method.