JP7279328B2 - drinking composition - Google Patents

Description

The present invention relates to a drinkable composition containing vitamin B2 or a derivative thereof or a salt thereof and a polyhydric phenol compound, which does not cause sedimentation in a liquid preparation, and can be applied to the fields of medicine and food.

Vitamin B2 or derivatives thereof or salts thereof are effective in relieving various symptoms such as angular stomatitis, stomatitis, glossitis, cheilitis, conjunctivitis, keratitis, acute/chronic eczema, seborrheic dermatitis, etc., and physical fatigue. It is used to supplement vitamin B2 during pregnancy, lactation, and when physical strength is weakened during or after illness.
Polyphenolic compounds are known to have antioxidant properties, and so far, the stability of oral solutions and triptan compounds in which gallic acids, which are polyphenolic compounds, have been added to improve the photostability of thioctic acid has been investigated. Oral liquid preparations that suppress the decrease have been disclosed (Patent Documents 1 to 3). It is also known that gallic acids are useful for reducing the unpleasant odor of vitamin B1s (Patent Document 4).
On the other hand, gallic acids, which are polyhydric phenol compounds, have been reported to produce by-products with low solubility in water upon irradiation with light (Non-Patent Document 1), which may cause precipitation.

JP 2004-305089 JP 2012-36166 JP 2012-36167 Japanese Patent Application Laid-Open No. 2004-321178

J. Phys. Chem. A., 112, 1188-94 (2008).

The present inventors have found that a drinking composition containing vitamin B2 or a derivative thereof or a salt thereof and gallic acid, a derivative thereof, or a salt thereof, which is a polyphenol compound, has a high photostability of gallic acid, a derivative thereof, or a salt thereof. I got the knowledge that it greatly decreases.

Accordingly, an object of the present invention is to provide a drink composition that suppresses photodegradation of polyhydric phenol compounds in the drink composition and suppresses the formation of by-products that cause precipitation.

As a result of intensive studies to solve the above problems, the present inventors found that photodecomposition of gallic acid, a derivative thereof, or a salt thereof, which is a polyhydric phenol compound, is suppressed when carbon dioxide is contained. , completed the present invention.

That is, the present invention
(1) a) vitamin B2 or its derivative or its salt, b) 0.02 to 2.5 parts by mass of a polyhydric phenol compound per 1 part by mass of vitamin B2 or its derivative or its salt, and c) dioxide A drinking composition containing carbon at an internal gas pressure of 1.0 to 4.0 kg/cm ² ,
(2) The beverage composition according to (1), wherein the vitamin B2 or a derivative thereof or a salt thereof is at least one selected from the group consisting of riboflavin, riboflavin phosphate, riboflavin butyrate, flavin adenine nucleotides and salts thereof;
(3) The drinking composition according to (1), wherein the polyhydric phenol compound is propyl gallate;
(4) The drinking composition according to any one of (1) to (3) filled in a container having a light transmittance of 0.1% or more at 449 nm,
is.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a drinking composition that suppresses precipitation in liquid by adding carbon dioxide to a drinking composition containing vitamin B2 or a derivative thereof or a salt thereof and a polyhydric phenol compound. Became.

Vitamin B2 or derivatives thereof or salts thereof used in the present invention refer to edible ones, and specific examples thereof include riboflavin, riboflavin phosphate, riboflavin butyrate, flavin adenine nucleotide and salts thereof. . The content of vitamin B2 or a derivative thereof or a salt thereof in the present invention is not particularly limited. Preferably, 2 to 30 mg is more preferable. The content of riboflavin in the drink composition is preferably 0.00001 to 1 w/v%, more preferably 0.00033 to 0.3 w/v%, even more preferably 0.002 to 0.3 w/v%.

The polyhydric phenol compound used in the present invention generally refers to edible compounds and is not particularly limited, but gallic acid, derivatives thereof, or salts thereof are preferred. Gallic acid, methyl gallate, ethyl gallate, propyl gallate, butyl gallate and salts thereof are more preferred, and methyl gallate, ethyl gallate, propyl gallate and butyl gallate are more preferred. The content of the polyhydric phenol in the present invention is 0.02 to 2.5 parts by mass with respect to 1 part by mass of vitamin B2 or its derivative or its salt from the viewpoint of ensuring the photostability of vitamin B2 or its derivative or its salt. parts, preferably 0.06 to 2.0 parts by mass, more preferably 0.06 to 1.3 parts by mass.

The carbon dioxide used in the present invention refers to those commonly used in foods and pharmaceuticals. As carbon dioxide, carbon dioxide may be used alone, or a mixture of two or more kinds of carbon dioxide and other gases such as oxygen, hydrogen, nitrogen, etc. may be used. It is preferable to use it alone. The content of carbon dioxide is 1.0 to 4.0 kg/cm ² , but 1.3 to 3.8 kg/cm as an internal gas pressure (the amount of gas dissolved in a unit volume) of the entire drinking composition. cm ² is more preferred.

The container used in the present invention preferably has a light transmittance of 0.1% or more at 449 nm, more preferably 0.2% or more. Specifically, transparent glass bottles, brown or brownish glass bottles, and the like can be used. The material of the container is not particularly limited, and examples thereof include glass and plastic.

The pH of the drink composition according to the present invention is not particularly limited, and is, for example, 2.0 to 7.0. From the standpoint of flavor, the pH is preferably low, more preferably 2.5 to 5.5. A commonly used pH adjuster can be used to adjust the pH of the drink composition of the present invention. Specific pH adjusters include organic acids such as citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid, glutamic acid, and fumaric acid, salts thereof, and hydrochloric acid. and inorganic bases such as sodium hydroxide.

Other ingredients such as vitamins, minerals, amino acids and their salts, other herbal medicines and herbal extracts, caffeine, etc., are appropriately blended in the beverage composition of the present invention as long as they do not impair the effects of the present invention. can do.

Additives such as sweeteners, acidulants, thickeners, antioxidants, coloring agents, flavors, corrigents, preservatives, seasonings, bittering agents, enhancers, solubilizers, emulsifiers, etc. can be appropriately blended within a range that does not impair the effects of the present invention.

The drink composition of the present invention can be prepared by a conventional method, and the method is not particularly limited. Usually, each component is taken and dissolved in an appropriate amount of purified water, then the pH is adjusted, the remaining purified water is added to adjust the volume, filtered and sterilized as necessary, and the resulting beverage concentrate is cooled, It can be produced by a process of charging carbon dioxide gas into a container so that the gas pressure is in a predetermined range, for example, 1.0 to 4.0 kg/cm ² , and filling the container. There are a premix method and a postmix method for producing carbonated beverages, and either method may be employed in the present invention.

The drinkable composition of the present invention can be applied to, for example, pharmaceuticals such as syrups and drinks, various formulations such as quasi-drugs, and various beverages such as health drinks.

The present invention will be described in more detail below with reference to examples, comparative examples and test examples.

(Examples 1-3, Comparative Examples 1-2)
5 mg of sodium riboflavin phosphate, 2 mg of propyl gallate, 60 mg of sodium benzoate, and 500 mg of citric acid were dissolved in purified water, and carbon dioxide was added at internal gas pressures of 1.3 kg/cm ² , 2.4 kg/cm ² , and 3, respectively. Carbonated water adjusted to 0.8 kg/cm ² was added to bring the total volume to 100 mL. This solution was filled into a washed brown glass bottle having a light transmittance of 0.1% at 449 nm and capped to prepare an internal solution.
Comparative Examples 1 and 2 below were prepared in the same manner as in Examples 1 to 3 except that the carbonated water was changed to purified water. Each formulation is shown in Table 1.

(Examples 4-12, Comparative Examples 3-8)
In the same manner as in Examples 1-3 and Comparative Examples 1-2, oral solutions of Examples 4-12 and Comparative Examples 3-8 were prepared according to the formulations in Tables 2-7.

(Test Example 1: Photostability test of propyl gallate)
The oral solutions obtained in Examples 1 to 3, 6 to 12, Comparative Examples 1 and 2, and Comparative Examples 5 to 8 were exposed to light of 3000 Lux for 200 hours. The oral liquid preparations obtained in Examples 4 and 5 and Comparative Examples 3 and 4 were exposed to light for 3000 Lux×60 hours. The residual ratio of propyl gallate in these oral solutions was measured by liquid chromatography (column: ODS-80TS (Tosoh), mobile phase: water: acetonitrile: acetic acid = 800: 170: 30, flow rate: 1 mL/min, detection wavelength: 280 nm). Tables 1 to 7 show the propyl gallate residual rate (%) after exposure to 3000 Lux×200 hours or after exposure to 3000 Lux×60 hours compared to immediately after preparation.

As is clear from Table 1, compared to Comparative Examples 1 and 2, the photostability of propyl gallate in the presence of sodium riboflavin phosphate was greatly reduced. Examples 1-3 had improved photostability of propyl gallate compared to Comparative Example 2.
Example 4 had improved photostability of propyl gallate compared to Comparative Example 3. Example 5 had improved photostability of propyl gallate compared to Comparative Example 4. Example 6 had improved photostability of propyl gallate compared to Comparative Example 5. Examples 7 and 8 had improved photostability of propyl gallate compared to Comparative Example 6. Examples 9 and 10 had improved photostability of propyl gallate compared to Comparative Example 7. Examples 11 and 12 had improved photostability of propyl gallate compared to Comparative Example 8.
From these results, it was clarified that the inclusion of carbon dioxide can improve the decrease in photostability of propyl gallate that occurs when riboflavin phosphate is included.

According to the present invention, it is possible to obtain a liquid preparation for internal use that stably contains vitamin B2 and does not cause precipitation, and can be used for pharmaceuticals, foods, health drinks, foods for specified health uses, and the like.

Claims (2)

a) vitamin B2 or a derivative thereof or a salt thereof, which is at least one selected from the group consisting of riboflavin, riboflavin phosphate, riboflavin butyrate, and flavin adenine nucleotides ; b) per 1 part by mass of vitamin B2 or a derivative thereof or a salt thereof A drinking composition containing 0.02 to 2.5 parts by mass of propyl gallate and c) carbon dioxide at an internal gas pressure of 1.0 to 4.0 kg/cm 2 and packed in a capping container. 2. The drinking composition according to claim 1, packed in a container having a light transmittance of 0.1% or more at 449 nm.