JP3460089B2 - Internal liquids that prevent off-flavor generation - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a water-soluble vitamin-containing internal liquid preparation capable of preventing an offensive odor produced during storage, and a method for preventing an offensive odor produced during storage thereof.

[0002]

2. Description of the Related Art Liquids for internal use containing water-soluble vitamins include syrups and drinks. Examples of vitamins include vitamins B ₁ , B ₂ , B ₆ , B ₁₂ and other vitamin B groups, vitamins. Various combinations of C, nicotinic acid, nicotinic acid amide, biotin and the like are contained. In particular, there are many examples of formulations in which vitamins B ₁ , B ₂ , B ₆ and nicotinic acid amide coexist, but these are unstable in solution, and it is often difficult to ensure stability during formulation. In particular, vitamin B ₁ is _one of the very unstable substances that are easily affected by heat, light, oxygen, pH, and coexisting substances.

As a stabilizing method for formulation, for example, a general treatment such as adjusting pH to an acidic range, avoiding contact with oxygen as much as possible, avoiding high temperature and light is taken. Further, addition of sulfur compounds such as amino acids and thiourea and thioglycerin as stabilizers is known. Further, as a countermeasure against a kind of so-called vitamin odor decomposer, flavoring by flavouring, addition of fumaric acid and its salts, addition of cinnamic aldehyde and the like have been carried out.

[0004]

However, by adjusting the pH and adding a stabilizer such as an amino acid, it is not possible to prevent the generation of a so-called vitamin odor, which is a kind of decomposition product odor. However, there is a quality control defect that it becomes a negative factor to the product value.

It is said that this is caused by a sulfur-containing compound produced by decomposition of vitamin B ₁ itself or a compound produced by mutual reaction of vitamins.

[0006] The odor (off-flavor) of these decomposition products is vitamin B.
Even if a small amount of ₁ is decomposed, it is generated, and in the stability test, even if the content is maintained within a certain range over time, the generation of offensive odor cannot be avoided.

[0007] Flavoring methods often use flavors with strong habits such as strawberry, vanilla, chocolate, cocoa, and cola, but they are not persistent and the masking effect diminishes according to changes in the flavor itself. I often end up doing it. Chocolate, cocoa, and cola have a relatively long life, but they are naturally limited in terms of the taste of the product and are not commonly used.

The addition of fumaric acid and its salts has a remarkable effect on the masking of offensive odors and can be said to be an excellent additive. However, in a system containing nicotinic acid amide, it has been confirmed that the production of fumaric acid-nicotinic acid molecular compound causes a decrease in the content of nicotinic acid amide, which is not preferable.

As a result of earnest studies, the present inventors have found that
The present invention has been completed by finding out that the above-mentioned problems can be solved by the following structure.

[0010]

The present invention is a method for preventing the off-flavor production of vitamin B ₁ characterized by containing a polyhydric phenol compound in the formulation of a water-soluble vitamin-containing aqueous liquid preparation.

The aqueous liquid preparation containing the water-soluble vitamin according to the present invention has little offensive odor even during long-term storage or storage under severe conditions such as high temperature, and has good quality control and good commerciality. it can. It is an object of the present invention to prevent the generation of this offensive odor.

The polyvalent phenol compound in the present invention means a compound in which two or more hydroxyl groups are bonded to an aromatic ring such as a benzene ring or a naphthalene ring, and specifically, gallic acid or alkali metal gallate. Examples thereof include salt, gallic acid ester, tannic acid, tannin and the like.

Further, the gallic acid used in the present invention includes not only its free acid itself but also acid derivatives such as methyl, ethyl, propyl, butyl esters of gallic acid and alkali metal salts of gallic acid such as sodium and potassium. To be The above compounds can be used alone or in any combination of two or more, and usually 0.001 to 0.2% by weight, preferably 0.01 to 0.
1% by weight is added.

Examples of the water-soluble vitamin used in the present invention include vitamins B ₁ , B ₂ , B ₆ , B ₁₂ , vitamin C, nicotinic acid amide, biotin, etc., which are appropriately selected depending on the purpose. There is no particular limitation as long as they are selected and combined. Also, the amount used is not particularly limited.

In the production of the aqueous liquid, a flavoring agent, a coloring agent, a buffering agent, a preservative and the like which are usually used can be used if necessary.

The water-soluble vitamin-containing aqueous liquid in the present invention can be produced by a usual method. For example, thiamine nitrate, sodium riboflavin phosphate, pyridoxine hydrochloride, nicotinic acid amide, citric acid, sodium citrate, and sodium benzoate are sequentially dissolved in purified water. Separately, ethanol or propyl gallate dissolved in a surfactant (HCO-60, etc.) is dissolved in the above-mentioned purified aqueous solution, flavor is added, and purified water is further added to produce a total volume of 30 ml per bottle. it can.

Effect The liquid preparation for internal use according to the present invention has less commercial odor during storage and has high commercial properties. Although the mechanism for preventing the production of off-flavors is not always clear, the off-flavor substances produced by the decomposition of sulfur-containing compounds such as vitamin B ₁ or the off-flavor substances produced by the mutual reaction of vitamins chemically react with polyvalent phenol. It is considered that one of the mechanisms is binding and deodorization.

Confirmation of the degree of offensive odor is performed by a sensory odor test. Immediately after production, there is no offensive odor, so
Based on this. Then, the quality of the product as an internal-use liquid agent is controlled by assigning a ranking (grade) according to the degree of generation of off-flavor with storage.

[0019]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples.

Example 1 Thiamine nitrate 1000 mg, riboflavin sodium phosphate 200 mg, pyridoxine hydrochloride 500 mg, nicotinic acid amide 2000 mg, and appropriate amounts of citric acid, sodium citrate, sodium benzoate, and sucrose are sequentially dissolved in purified water.

Separately, a solution of 300 mg of propyl gallate dissolved in ethanol was prepared, added to the above-mentioned purified aqueous solution, further strawberry flavor was added, and purified water was added to make a total volume of 3000 ml. 30 ml of this was dispensed into 100 bottles to obtain an aqueous solution containing a water-soluble vitamin.

Example 2 Thiamine nitrate 1000 mg, riboflavin sodium phosphate 200 mg, pyridoxine hydrochloride 500 mg, nicotinic acid amide 2000 mg, and appropriate amounts of citric acid, sodium citrate, sodium benzoate, and sucrose were sequentially dissolved in purified water.

300 mg gallic acid separately dissolved in HCO-60
Was prepared, added to the above-mentioned purified aqueous solution, strawberry flavor was further added, and then purified water was added to make a total amount of 3000 ml. 30 ml of this was dispensed into 100 bottles to obtain an aqueous solution containing a water-soluble vitamin.

Experimental Example Comparative Example Other than not using the propyl gallate solution,
An aqueous liquid preparation containing a water-soluble vitamin was obtained in the same manner as in Example 1.

For Examples 1 and 2 and Comparative Example, immediately after production and stored at 40 ° C. for 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, and at 60 ° C. The generation of the offensive odor and the degree of the offensive odor were checked for the samples stored for 3 months, 2 months, 3 months. The results are shown in Table 1.

In these tables, the grade of the degree of offensive odor is as follows.

−: No offensive odor ±: Slight offensive odor +: Offensive ++ +++: Outstanding offensive odor

[0028]

[Table 1]

As is clear from Table 1, it is demonstrated that the aqueous liquid preparation of the present invention is prevented from producing an offensive odor.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI // A61K 31/375 A61K 31/375 31/455 31/455 31/525 31/525 (72) Inventor Toshio Kurobe Kumagaya, Saitama Prefecture City Kaji 1000-7 (72) Inventor Shoji Kaneko 244-4 Nishitomita, Honjo City, Saitama Prefecture (72) Inventor Norito Koyama 2272-2 Suehiro-cho, Honjo City, Saitama Prefecture (72) Shigemitsu Osawa Honjo City, Saitama Prefecture 2286-12 Suehirocho (56) Reference JP-A-2-202581 (JP, A) J. Agric. Food Chem m. , 1981, vol. 29, no. 1, 183-5 J. Agric. Food Chem m. , 1984, vol. 32, no. 5, 1015-18 (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 9/08 A61K 47/10 A61K 47/12 A61K 47/14 A61K 31/375 A61K 31/455 A61K 31/51 A61K 31/525 CAPLUS (STN) REGISTRY (STN)

Claims (2)

(57) [Claims] 1. A vitamin B characterized in that an aqueous liquid preparation containing a water-soluble vitamin contains a polyhydric phenol compound.
_1. A method for preventing the generation of a nasty smell. 2. The off-odor production of vitamin B _{1 according to} claim 1, wherein the polyhydric phenol compound is at least one of gallic acid, alkali metal gallate, gallic acid ester, tannic acid and tannin. Method.