JP2010120880A - Oral composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral composition exhibiting a good feeling of use by improving astringency, particularly a creaking feeling of teeth, of an oral composition containing phytic acid. <P>SOLUTION: The oral composition contains the following components (A) and (B): (A) 0.01-10 mass% of phytic acid or a salt thereof; (B) 3-60 mass% of erythritol, and the mass ratio of the component (B) to the component (A), (B/A), is 5-1,000. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a composition for oral cavity having a good feeling when used in the oral cavity.

It is known that phytic acid has effects such as removal of tobacco crabs, tartar-inhibiting effect, and stabilization of tin fluoride, and cleaning agents and dentifrices containing phytic acid have been reported (Patent Literature). 1). Moreover, in order to improve the astringency when the composition containing phytic acid is applied to the oral cavity, amphoteric electrolytes such as amino acids and proteins (Patent Document 2) and specific perfume ingredients (Patent Document 3) are improved. ), Chain hydrocarbon compounds (Patent Document 4), polyvinyl alcohol, polyvinylpyrrolidone (Patent Document 5), and the like are known. There is also a technique of blending an alkali metal sulfate salt to improve the convergence of polyphosphate (Patent Document 6).
Japanese Patent Laid-Open No. 56-18913 Japanese Patent Publication No.61-23768 JP-A-62-198611 Japanese Patent Laid-Open No. 10-87458 JP 2000-26259 A JP-A-7-285839

However, the conventional technique has a problem of astringency, that is, action on the skin and oral mucosa, and the squeaky sensation of the phytic acid-containing oral composition has not been known. In addition, depending on the components to be blended, new problems such as bitterness and oiliness occur, and the usability is not necessarily improved.
Therefore, the present invention relates to an oral composition that improves the squeaky sensation of teeth of the phytic acid-containing oral composition and has a good feeling of use.

  Therefore, the present inventor has made various studies to improve the squeaking feeling of phytic acid. Unexpectedly, when erythritol is added in a certain amount or more, the squeaking feeling of phytic acid is remarkably improved and refreshed. It was found that a composition for oral cavity having a good usability was obtained.

That is, the present invention includes the following components (A) and (B):
(A) Phytic acid or a salt thereof 0.01 to 10% by mass
(B) Erythritol 3-60 mass%
The composition for oral cavity in which the mass ratio (B / A) of a component (B) and a component (A) is 5-1000 is contained.

  ADVANTAGE OF THE INVENTION According to this invention, the squeaky feeling peculiar to a phytic acid can be improved, and the composition for oral cavity with a favorable refreshing feeling can be provided. Here, the squeaky feeling of the teeth refers to the feeling when the teeth are brought into contact with each other or rubbed together, and is a physical discomfort. ADVANTAGE OF THE INVENTION According to this invention, the usability | use feeling felt with a tooth | gear can be provided and the composition for oral cavity which improved the texture of the tooth | gear surface can be provided.

  The composition for oral cavity of the present invention contains phytic acid as a whitening component of teeth. Phytic acid is also called myo-inositol hexaphosphate and is a phosphate compound. Examples of the salt include alkali metal salts such as sodium and potassium, ammonium salts, and the like, and alkali metal salts are preferable from the viewpoint of taste and odor.

  The composition for oral cavity of this invention contains 0.01-10 mass% of phytic acid or its salt (A) in the said composition. Phytic acid or a salt thereof (A) is preferably contained in an amount of 0.05% by mass or more, more preferably 0.1% by mass or more from the viewpoint of teeth whitening action and gloss imparting action. The salt (A) is preferably contained in the composition in an amount of 5% by mass or less, and more preferably 2% by mass or less. When the oral composition of the present invention is a mouthwash, phytic acid or a salt thereof (A) is preferably 3% by mass or less, more preferably 1% by mass or less. In addition, the content of phytic acid or a salt thereof in the present invention is measured by neutralizing with potassium hydroxide or sodium hydroxide, and the total amount is converted to an acid.

  The oral composition of the present invention contains 3 to 60% by mass of erythritol (B). By blending erythritol within this range, the squeaking feeling of phytic acid is improved and a good feeling of use is obtained. A more preferable content of erythritol is 4 to 50% by mass, and more preferably 5 to 45% by mass. When the oral composition of the present invention is a mouthwash, erythritol is preferably 30% by mass or less, more preferably 20% by mass or less.

  The mass ratio (B / A) of the component (B) to the component (A) in the present invention is important in terms of the effect of improving the squeakiness of teeth and the feeling of use due to phytic acid, and is 5 to 1000, more preferably 10 to 800, Furthermore, 15-500, especially 20-500 are preferable. Moreover, when the composition for oral cavity of this invention is a mouthwash, mass ratio (B / A) of a component (B) and a component (A) is 5-300, Furthermore, 10-300, Furthermore, 15-300, Especially 20-300 is preferable.

  As mentioned above, phytic acid is a kind of phosphoric acid compound, and other phosphoric acid compounds such as polyphosphoric acid also have a squeaky sensation of teeth, but the squeaking sensation of phytic acid is peculiar. Even if erythritol is blended, the squeaky feeling of the teeth due to polyphosphoric acid is not improved, so the action of the present invention is considered to be peculiar to the combination of phytic acid and erythritol.

In the composition for oral cavity of the present invention, the pH when diluted to 30% by mass with water is preferably 5.5 or more and 8 or less, and more preferably 7 or less, in terms of the effect of improving the squeakiness of teeth by phytic acid. Moreover, it is preferable that it is 6.5 or less from a viewpoint of the whitening of the tooth | gear by phytic acid, and glossiness provision.
Since the pH cannot be accurately measured in the case of a highly viscous oral composition such as toothpaste, the pH of the composition is determined by diluting the composition to 30% by mass with water. . What was diluted to 30% by mass with water was assumed to be applied to the oral cavity of the composition.
In order to adjust the pH of the composition to the above range, it is preferable to use a pH adjusting agent, and as the pH adjusting agent, the whitening effect and the gloss imparting effect by phytic acid are not inhibited, and tooth decalcification is suppressed. As long as it is possible, and does not cause a squeaky feeling or damage to the teeth, organic acid salts such as acetic acid, fumaric acid, malic acid, lactic acid, gluconic acid, tartaric acid, phosphoric acid other than phytic acid (for example, Orthophosphoric acid), inorganic acid salts such as hydrochloric acid and sulfuric acid, hydroxides such as sodium hydroxide, ammonia or aqueous ammonia, lower alkanolamines, basic amino acids such as arginine and lysine, etc. Two or more kinds may be used in combination.

  In the composition for oral cavity of the present invention, it is preferable to keep the content of polyvalent cation low. This is because the polyvalent cation makes phytic acid insoluble and thus prevents a decrease in its effect. The total content is preferably less than 0.1 mole times that of phytic acid as measured by ICP emission spectrometry (ICP emission analyzer: Optima 5300 DV from Perkin Elmer). That is, it is desirable not to add an agent that mainly supplies polyvalent cations such as aluminum, calcium, magnesium, iron, and zinc, and those that substantially do not contain polyvalent cations are preferable. In addition, adsorbents such as cationic bactericides, zeolites or activated carbons bind to phytic acid or adsorb phytic acid, so that the effect is reduced. It is preferable that it is less than 0.001 mass% in a thing, Furthermore, it is preferable that it is 0.0001 mass% or less, and the thing which does not contain substantially is preferable.

  Further, the oral composition of the present invention does not contain fluorides (fluorine ion supply compounds) such as sodium fluoride, potassium fluoride, ammonium fluoride, sodium monofluorophosphate, or inhibits the effect of phytic acid. You may mix | blend in the range which does not. The fluoride is preferably less than 500 ppm in terms of fluorine atoms, further preferably contains 300 ppm or less, and preferably contains no fluoride.

  In addition to the above components, the oral composition of the present invention includes, for example, a foaming agent, a foaming aid, an abrasive, a wetting agent, a thickening agent, a gelling agent, a binder, a bulking agent, a sweetener, a preservative, Bactericides, medicinal components, pigments, dyes, fragrances and the like can be appropriately contained, and the composition can be produced by methods according to various dosage forms. Moreover, combined use, such as polyethyleneglycol which is a whitening component used conventionally, is not restrict | limited.

The oral composition of the present invention is prepared, for example, in a dosage form such as a solution, gel, or paste, and can be made into a dentifrice, a moisturizing dentifrice, a toothpaste, a liquid dentifrice, a mouthwash, and the like. it can.
In any of these dosage forms, polyethylene glycol, propylene glycol, glycerin, sorbitol, maltitol, xylitol, lactitol and the like can be contained for the purpose of a wetting agent or a thickening agent.

Further, as a thickening agent for a solution-like composition or a gelling agent for a gel-like composition, and as a binder for a paste-like composition, sodium carboxymethylcellulose, hydroxyethylcellulose, carboxyvinyl polymer, xanthan gum, carrageenan, alginic acid Sodium, hydroxypropyl cellulose, guar gum, sodium chondroitin sulfate and the like can be contained alone or in combination. Among these, it is preferable to select a binder other than sodium alginate from the viewpoint of sufficiently exerting the whitening effect and gloss forming effect of phytic acid or a salt thereof.
In particular, in the case of a high salt concentration due to the buffer system, one or more kinds of nonionic polymers, that is, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose and the like can be contained.

  In order to apply the composition for oral cavity of the present invention to teeth, it may be applied as it is, or includes both cases in which the composition is diluted to about 30% by mass with water or saliva. That is, in the case of a mouthwash, it is applied to teeth without dilution. On the other hand, in the case of a toothpaste, etc., it is applied to the teeth in a state diluted to about 30% by mass with saliva.

  In the following examples,% means mass%.

Test example 1
The mouthwashes shown in Tables 1 and 2 were prepared, and the squeaky feeling of the teeth was evaluated.
The mouth was rinsed with mouthwash for 20 seconds and the mouthwash was discharged, and then the teeth were rubbed together to evaluate the feeling of squeezing. The evaluation was performed in the following four stages, and an evaluation common to two or more of the three subjects was adopted.
AA: I don't feel any squeaky teeth.
A: I hardly feel any squeaky teeth.
B: Slightly squeaky teeth and good.
C: I feel squeaky teeth.
The evaluation results are also shown in Table 1.

  As shown in Comparative Example 5 in Table 1, the mouthwash having a pH of 6 and containing 0.3% by mass of phytic acid felt (C) a tooth squeak. On the other hand, as shown in Table 1, the mouthwash of Comparative Example 1 in which glycerin was blended with 0.3% by mass of phytic acid did not improve the squeaking feeling of the teeth, and conversely, the squeaking feeling of the teeth was strong. became. In addition, in Comparative Examples 2 and 3 in which the same amounts of sorbitol and xylitol as erythritol were blended, the squeakiness of teeth was not improved. Furthermore, the squeaky feeling of the teeth was not improved in Comparative Example 4 in which sorbitol was blended with 0.1% by mass of phytic acid. In addition, sorbitol blended had a sweet taste but low refreshing feeling, and xylitol blended had a sweet taste but a refreshing refreshing feeling was not obtained.

  On the other hand, Example 1 which mix | blended erythritol acquired the improvement effect of the squeakiness of a tooth | gear by phytic acid. Furthermore, as shown in Table 2, when the ratio of erythritol / phytic acid is 5 or more, the effect of improving the squeaking feeling of the tooth is obtained, and when it is 15 or more, the effect of improving the squeaking of the tooth is excellent. It was found that the effect of the squeaky teeth was even better. Moreover, the feeling of use of the obtained mouthwash was good because the squeakiness of the teeth was improved and the refreshing feeling was excellent.

Test example 2
Table 2 shows the result of measuring the change in b ^* as an evaluation of the whitening effect of the teeth and the result of measuring the luminance (Δ luminance) as an evaluation of the gloss or gloss of the teeth. The whitening effect and the gloss of the teeth are evaluated with the removed human teeth, and the whitening is performed by brushing with a toothbrush (Puora Habrush Compact hair hardness: normal) made in ion-exchanged water for 2 minutes. Thus, human teeth from which the enamel surface was removed were used, and human teeth without brushing treatment were used for gloss evaluation. For the evaluation of whitening effect and gloss, human teeth were immersed in each mouthwash at room temperature for 48 hours, and b ^* change (Δb ^* ) and luminance change (Δ luminance) before and after the immersion were measured. Three human teeth were used, and Δb ^* and Δ luminance were evaluated based on the average value of the three data.

B * change [Delta] b ^* is the human teeth before and after immersion in each mouthrinse, (after immersion b ^* - before immersion b ^*)
I asked for it. This b ^* value is an image taken using a digital camera D1x, Ai AF Zoom Micro Nikkor ED 70-180mm F4.5-F5.6D (all manufactured by Nikon) and a white flash light source (manufactured by Konica Minolta). Was expressed in the L ^* a ^* b ^* color system using Adobe Photoshop CS3 (manufactured by Adobe Systems). As the value of b ^* is a positive value and close to 0, it means that the whiteness increases with less yellowness, and as the value of −Δb ^* (Δb ^* absolute value) increases, the whiteness increases. Among Examples 1 to 10, Examples 8 and 9 having a high pH have a small absolute value of Δb ^* .

The change in luminance (Δ luminance) of human teeth before and after immersion in each mouthwash was determined from (luminance after immersion-luminance before immersion). As a luminance measurement method, a method of measuring the surface reflected light intensity from image analysis using polarized light was used. Nikon D70 digital SLR camera, Ai AF micro Nikkor 105mm F2.8D lens, wireless remote speedlight SB-R200 (both made by Nikon) for strobe lighting The installed one was used. Photographs were taken with a plastic polarizing plate (manufactured by Edmond) placed in front of the light emitting part of the speedlight and the lens so that the transmission axes intersected 30 degrees. The average brightness of the highlight portion of the captured image was obtained using Adobe Photoshop CS3 (manufactured by Adobe System). The larger the numerical value, the higher the gloss, and the higher the numerical value of Δ, the higher the gloss.

The formulas of the mouthwash and toothpaste of the present invention are shown below. The evaluation of the mouthfeel of the mouthwash was performed under the same conditions as in Test Example 1, and the whitening evaluation and gloss evaluation were performed under the same conditions as in Test Example 2. Evaluation of toothpaste of toothpaste was performed on 3 subjects, brushed with toothpaste for 2 minutes, rinsed mouth, then rubbed into teeth and evaluated for squeaky feeling. Evaluation was adopted. The whitening effect and gloss evaluation of the toothpaste were performed by immersing human teeth in a solution obtained by diluting the toothpaste twice, and the evaluation was performed under the same conditions as in Test Example 2.
Example 11 (Mouth Wash)
Phytic acid (50% aqueous solution) 0.5
Erythritol 6
Glycerin 6
Ethanol 4
Polyglycerin laurate 0.5
Saccharin sodium 0.01
Fragrance 0.2
Potassium hydroxide aqueous solution (48% aqueous solution) Adjust to pH 6
Purified water remaining
Total 100 (%)
Erythritol / phytic acid (mass ratio) 24
Teeth squeak evaluation AA
Whitening evaluation Δb * = − 5.4, gloss evaluation Δluminance = 7.4

Example 12 (Toothpaste)
Phytic acid (50% aqueous solution) 1
Erythritol 40
Sorbitol solution (70% aqueous solution) 25
Sodium carboxymethylcellulose 0.8
Xanthan gum 0.1
Polyethylene glycol 5
Saccharin sodium 0.1
Abrasive silica 11
Sodium lauryl sulfate 1.5
Sodium hydroxide solution (48% aqueous solution) Adjusted fragrance to pH 6 1
Purified water remaining
Total 100 (%)
Erythritol / phytic acid (mass ratio) 80
Teeth squeak evaluation AA
Whitening evaluation Δb * = − 5.6, gloss evaluation Δluminance = 7.6

Claims (4)

The following components (A) and (B):
(A) Phytic acid or a salt thereof 0.01 to 10% by mass
(B) Erythritol 3-60 mass%
The composition for oral cavity which contains 5 and 1000 by mass ratio (B / A) of a component (B) and a component (A).   The composition for oral cavity according to claim 1, which has a pH of 5.5 to 8 when diluted to 30% by mass with water. (A) Content of phytic acid or its salt is 0.05-5 mass%, The composition for oral cavity of Claim 1 or 2.   The composition for oral cavity according to any one of claims 1 to 3, which has a pH of 5.5 to 6.5 when diluted to 30% by mass with water.