JP2010059155A - Agent for improving exercise function - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an agent for improving exercise function, agent for improving endurance, fatigue-resisting agent, agent for improving muscular strength, agent for promoting glycogen reserve and agent for improving muscular pumping ability which are safe, easily obtained and excellent in processability. <P>SOLUTION: There are provided the agent for improving exercise function, agent for improving endurance, fatigue-resisting agent, agent improving for muscular strength, agent for promoting glycogen reserve and agent for improving muscular pumping ability that have a fat globule membrane component as an active ingredient. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to pharmaceuticals, foods, and the like that exhibit an effect of improving motor function.

  In general, exercise training and well-balanced nutrition are considered important for improving athletic ability such as muscle strength. In recent years, exercise enthusiasts and athletes have attempted to use nutrition supplements such as supplements in addition to training to improve muscle strength more efficiently (Patent Document 1).

However, there is a concern that training with excessive intake of some proteins and amino acids may cause adverse effects on renal function and the like (Non-patent Document 1).
On the other hand, even for non-exercise enthusiasts and athletes, due to an unreasonable diet, there is a shortage of nutritional components in the body, skeletal muscle loss, and motor functions such as muscle strength and endurance decline, and motor functions Fatigue associated with decline is regarded as a problem.
Therefore, not only exercise enthusiasts and athletes aiming at performance improvement, but also general people aiming at alleviating obesity, an efficient method for improving motor function is desired.

  From such a point of view, a component having a motor function improving action is searched, and for example, endurance improving action by tea catechin (Patent Document 2) and polymer fruit polyphenol (Patent Document 3) are reported. ing.

  The fat globule membrane component is a film that coats milk fat globule secreted from the mammary gland and has not only the function of dispersing fat in milk but also has many physiological functions as food for newborn animals. is doing. For example, it is known to have physiological functions such as blood adiponectin increase and / or decrease inhibitory effect (Patent Document 4), learning ability improving effect (Patent Document 5), sialomucin secretion promoting effect and the like (Patent Document 6). .

  However, the effect of fat globule membrane components on endurance and other motor functions and fatigue has never been known.

Japanese Patent Laid-Open No. 2002-065212 JP 2005-89384 A International Publication No. 2005/07496 Pamphlet JP 2007-320901 A JP 2007-246404 A JP 2007-112793 A

Anderson, JAMA, 223, 1973

  The present invention is a medicinal product or pharmaceutical having rich dietary experience and high safety and having excellent motor function improving action, endurance improving action, anti-fatigue action, muscle strength improving action, glycogen accumulation promoting action, or muscle pump function improving action It relates to providing quasi-drugs, food and feed.

  As a result of searching for an effective component in improving the body function, the present inventors, as a result of the milk-derived component, the fat globule film component, the motor function improving action, endurance improving action, anti-fatigue action, muscle strength improving action, It has been found that there is an effect of promoting the accumulation of glycogen or the function of improving the muscle pump function, which is useful as a pharmaceutical, a quasi-drug, a food and a feed that can exhibit the effect.

That is, the present invention relates to the following (1) to (6).
(1) A motor function improver comprising a fat globule membrane component as an active ingredient.
(2) Endurance improver comprising a fat globule membrane component as an active ingredient.
(3) An anti-fatigue agent comprising a fat globule film component as an active ingredient.
(4) A muscle strength improver comprising a fat globule membrane component as an active ingredient.
(5) A glycogen accumulation promoter comprising a fat globule membrane component as an active ingredient.
(6) A muscle pump function improver comprising a fat globule membrane component as an active ingredient.

  The motor function improver, endurance improver, anti-fatigue agent, muscle strength improver, glycogen accumulation promoter and muscle pump function improver of the present invention are exercises in a broad sense including exercise and daily movements and labor. It is useful as a food, pharmaceutical, quasi-drug or feed for improving function, endurance, anti-fatigue, muscle strength, promoting glycogen accumulation, or improving muscle pump function.

The graph which shows transition of spontaneous exercise amount. Cont represents a standard food intake group, and MFGM represents a 3.5% milk fat globule membrane component food intake group. The graph which shows the muscular strength of the isolated soleus. Cont represents a standard food intake group, and MFGM represents a 3.5% milk fat globule membrane component food intake group. The graph which shows swimming endurance. Ex represents a standard food intake + exercise (exercise control) group, ML represents a 1% milk fat globule membrane component food intake + exercise group, and MH represents a 3.5% milk fat globule membrane component food intake + exercise group. The graph which shows a gastrocnemius glycogen content. Cont is a standard diet intake (control) group, MF is a 1% milk fat globule membrane component diet intake group, Ex is a standard diet intake + exercise (exercise control) group, MF-Ex is a 1% milk fat globule membrane component diet intake + Indicates an exercise group. The graph which shows the gene expression level of Na ⁺ -K ⁺ pump (beta) 1 (Na pump) and SERCA2 (Ca pump) in a soleus muscle. Cont is a standard diet intake (control) group, MF is a 1% milk fat globule membrane component diet intake group, Ex is a standard diet intake + exercise (exercise control) group, MF-Ex is a 1% milk fat globule membrane component diet intake + Indicates an exercise group. Relative mRNA (/ 36B4) indicates the relative mRNA expression level obtained by correcting the obtained gene expression level with the expression level of the housekeeping gene 36B4.

Examples of the fat globule membrane component in the present invention include a component that coats a fat globule in milk and a membrane component mixture derived therefrom.
The fat globule membrane component is known to be contained in a large amount in milk complex lipid-rich fractions such as buttermilk and buttersarum, and about half of the dry amount of the fat globule membrane component is composed of lipids (Miura Aoi, FOOD STYLE21, 2009). As the lipid, it is known that many triglycerides and phospholipids (for example, sphingophospholipids, glycerophospholipids, etc.) are included, and in addition, glycosphingolipids (for example, glucosylceramide, ganglioside, etc.) are included ( Keenan, Applied Sci, 1983). In addition, it is known that components other than lipids include proteins such as glycoprotein called milk mucin (Mather, Biochim Biophys Acta, 1978).

  Examples of the phospholipid contained in the fat globule membrane component in the present invention include glycerophospholipids such as phosphatidylcholine and phosphatidylethanolamine in addition to sphingophospholipids such as sphingomyelin. Of these, sphingomyelin, which is a characteristic phospholipid derived from milk, is preferably contained in the fat globule membrane component.

Although content of the lipid in the fat globule membrane component in the present invention is not particularly limited, it is preferably 20 to 100% by mass, more preferably 50 to 90% by mass in terms of dry matter.
The content of the phospholipid in the fat globule membrane component in the present invention is not particularly limited, but is preferably 10 to 100% by mass, more preferably 15 to 85% by mass, and further preferably 20 to 70% by mass in terms of dry matter. .
The content of each phospholipid in the fat globule membrane component is not particularly limited. For example, the content of sphingomyelin is 1 to 50 mass% in terms of dry matter in the fat globule membrane component, and more 2 to 30 mass%. %, 3 to 25% by mass, and more preferably 4 to 20% by mass.

  As the fat globule membrane component of the present invention, those obtained by preparing various fat globule membrane components such as a centrifugal separation method or an organic solvent extraction method from a milk raw material or the like may be used. Furthermore, you may use what improved purity by refine | purifying with methods, such as a dialysis, an ammonium sulfate fraction, gel filtration, isoelectric precipitation, ion-exchange chromatography, and a solvent fraction.

Examples of the milk raw material for the fat globule membrane component of the present invention include milk and goat milk, but among milk, the fat globule membrane component derived from milk has abundant food experience, and high purity and inexpensive products are also marketed. It is particularly preferable.
In addition to milk such as raw milk, skim milk and processed milk, dairy products include dairy products. Examples of dairy products include buttermilk, butter oil, buttersarum, whey protein concentrate (WPC) and the like. Can be mentioned.

Preparation of the fat globule membrane component of the present invention is, for example, a method of extracting dairy products such as milk, whey protein concentrate (WPC), buttermilk and skim milk powder with ether or acetone (JP-A-3-47192), It is performed by a method (patent No. 3103218) or the like that removes proteins produced by adjusting buttermilk to an acidic region and performing isoelectric precipitation and drying the concentrate obtained by microfiltration membrane treatment of the supernatant. be able to.
Further, a method of filtering and concentrating the protein after removing the protein from the buttersarum and drying it (Japanese Patent Application Laid-Open No. 2007-89535) can also be used. According to this production method, for example, a fat globule membrane component containing 20% by mass or more of milk-derived complex lipid in the dried product can be prepared. The form of the fat globule membrane component is not particularly limited, and may be any of liquid, semi-solid, solid, powder, etc., and these may be used alone or in combination of two or more.

Moreover, a commercial item can also be used as a fat globule membrane component. Examples of such commercial products include Megre Japan Co., Ltd. “BSCP”, Snow Brand Milk Products Co., Ltd. “Milk Ceramide MC-5”, New Zealand Milk Products Co., Ltd. “Phospholipid Concentrate Series (500, 700)”, and the like.
Further, since the fat globule membrane component is contained in a large amount in butter milk obtained when producing butter granules from a cream obtained by centrifuging milk or the like, butter milk may be used as it is. Similarly, since the fat globule membrane component is contained in a large amount in the butter serum produced when producing the butter oil, the butter serum may be used as it is.

The fat globule membrane component of the present invention, as shown in the examples below, significantly improved the amount of spontaneous exercise and significantly increased the muscle strength of the soleus muscle in mice. Moreover, since it has improved swimming endurance, it has endurance improvement action and anti-fatigue action. In addition, the fat globule membrane component of the present invention significantly increases the glycogen content in skeletal muscle and significantly increases the expression level of genes related to muscle pump function in mice. Has an effect of improving the pump function.
Therefore, the fat globule membrane component is an exercise function improver, endurance improver, anti-fatigue agent, muscle strength improver, glycogen accumulation promoter, muscle pump function improver (hereinafter referred to as “motor function improver”). And can be used to produce these agents as well. In this case, the motor function improver and the like are acceptable in the later-described objects to be blended, such as a carrier, a stabilizer, and the like, which are appropriately selected as necessary, in addition to the fat globule membrane component. You may use what is done. In addition, the said formulation can be manufactured by a conventional method according to the target object which should be mix | blended.

  Motor function improvers and the like are drugs or quasi drugs for humans or animals that exhibit the effects of motor function improvement, endurance improvement, anti-fatigue, muscle strength improvement, glycogen accumulation promotion, or muscle pump function improvement. It can be used as an active ingredient in foods or feeds. In addition, fat globule membrane components are required for the concept of improving exercise function, endurance, anti-fatigue, muscle strength, promoting glycogen accumulation, or improving muscle pump function in people with exercise deficiency, middle-aged and elderly people, bed rest persons, or athletes. It can be applied to foods, functional foods, foods for the sick, and foods for specified health use.

  Examples of the dosage form when the motor function improver of the present invention is used as an active ingredient of pharmaceuticals and quasi-drugs include oral administration or injections such as tablets, capsules, granules, powders, and syrups. Parenteral administration such as an agent, an inhalation agent, a transdermal absorption agent, and an external preparation. In order to prepare such various dosage forms, the motor function improver of the present invention alone or other pharmaceutically acceptable excipients, binders, extenders, disintegrants. , Surfactants, lubricants, dispersants, buffers, preservatives, flavoring agents, fragrances, coating agents, carriers, diluents, medicinal components other than fat globule film components, and the like can be used in appropriate combinations. Of these dosage forms, the preferred form is oral administration, and when an oral liquid preparation is prepared, it can be produced by a conventional method by adding a flavoring agent, a buffering agent, a stabilizer and the like.

  As the form when the motor function improver of the present invention is used as an active ingredient of food, milk, processed milk, milk drink, yogurt, soft drink, tea-based drink, coffee drink, fruit drink, carbonated drink, juice In addition to foods and drinks such as jelly, wafers, biscuits, bread, noodles, sausages and various foods such as nutritional foods, nutritional supplements in the same form (tablets, capsules, syrups, etc.) as the above-mentioned oral preparations Composition for use.

  To prepare various forms of food, the motor function improver of the present invention alone, or other food materials, solvents, softeners, oils, emulsifiers, preservatives, fragrances, stabilizers, colorants , Antioxidants, moisturizers, thickeners, active ingredients other than fat globule membrane components, etc., in combination as appropriate, food for improving motor function, food for improving endurance, food for anti-fatigue, food for improving muscle strength, pet food, etc. It is possible to blend in.

  In addition, the motor function improver of the present invention can be blended in the form of a nutritional composition such as an enteral nutrient in elderly people who are difficult to supplement with an appropriate amount of nutrition or in bed-rested patients. is there.

  When the motor function improver or the like of the present invention is used as an active ingredient in feed, it can be used in the same form as the food.

  The content of the fat globule membrane component (in terms of dry matter) for the beverages such as milk beverages, soft drinks, tea beverages, etc. is usually 0.001 to 3.0% by mass, and further 0.01 to 2 in the beverage. It is preferably 0.0% by mass, particularly 0.1 to 1.0% by mass.

  In the case of foods and feeds other than the above, and pharmaceuticals such as oral solid preparations such as tablets, granules and capsules, and oral liquid preparations such as oral liquids and syrups, foods, feeds or pharmaceuticals other than those described above The content of the fat globule film component (in terms of dry matter) in the total amount is usually 0.02 to 80% by mass, more preferably 0.2 to 75% by mass, and particularly preferably 2 to 50% by mass. In addition, the fat globule membrane component may be in a dissolved state or a dispersed state, and the presence state thereof does not matter.

  The intake of the motor function improver and the like of the present invention varies depending on the dosage form and use, but it is 10 to 10,000 mg / 60 kg body weight per day for adults as a fat globule membrane component (in terms of dry matter). Particularly preferred is 100 to 5000 mg / 60 kg body weight, more preferably 500 to 5000 mg / 60 kg body weight.

  The typical test examples and examples of the present invention are shown below.

Test example 1
We investigated the effects of fat globule membrane components on spontaneous exercise and muscle strength. As the fat globule film component, BSCP manufactured by Megre Japan was used (Table 1: Composition of feed).
BSCP contains 49% by mass of protein (hereinafter referred to as “%”) and 39% of lipid, 3.7% of sphingomyelin as sphingophospholipid, and 2.4% of glucosylceramide as glycosphingolipid in terms of dry matter. , And 0.4% ganglioside.

Proteins and lipids in fat globule membrane components are analyzed by the Kjeldahl method (Makoto Kateri, latest food analysis method, the same documentary institute) and the Rosette Gottlieb method (edited by the Japan Food Industry Association, food analysis method, Korin). It was.
The analysis of phospholipids in the fat globule membrane component was performed by LC-MS method. That is, the lipid fraction was extracted from the fat globule membrane component using chloroform / methanol (= 2: 1), dried in a nitrogen stream, and then dissolved in hexane / isopropanol (= 95: 5). This sample was subjected to the following LC-MS analysis to quantify phospholipids.
As specific analysis means, the following were used.
Column: Inertsil SIL 100A-3 (GL Science, 1.5mm x 150mm)
Column temperature: 40 ° C
Flow rate: 0.1 mL / min
Detector: Agilent, 1100 LC / MSD
Mobile phase: Gradient separation of liquid A (hexane: isopropanol: formic acid = 95: 5: 0.1) and liquid B (hexane: isopropanol: 50 mM ammonium formate = 25: 65: 10)

After pre-breeding for 1 week, divided into 2 groups so that they are equal based on body weight and voluntary exercise amount, respectively, the Cont (standard diet intake) group and the MFGM (milk fat globule membrane component 1 intake) group, respectively. (N = 6 for each group). For 4 weeks after grouping, the mouse's spontaneous momentum was measured using a rotating basket type spontaneous momentum measuring device SW-15 (Melquest). After breeding for 4 weeks, it was subjected to dissection and the muscle strength of the soleus was measured. The muscle strength of the isolated muscle was measured according to the method of Cannon et al. (Biomed Sci Instrum, 2005). That is, the soleus muscle was removed from the mouse, fixed to the transducer (WPI, FORT100) using a suture (# 5-0 silk), and in Krebs solution at 37 ° C. (95% -O ₂ , 5% -CO ₂ Dipped in aeration). Electrical stimulation was performed from two platinum electrodes. For stimulation, after applying a single pulse (twitch), 40Hz, 330ms (1 / s) stimulation is repeated for 2 minutes (120 seconds) (tetanic), and the signal (g / mg muscle) obtained from the transducer is used as muscle strength. It was measured. The significant difference test between the Cont group and the MFGM group was performed by repeated measure ANOVA (spontaneous exercise amount) or student's t-test (muscle strength).

As a result, in the MFGM group, the amount of spontaneous exercise during the period was significantly higher than that in the Cont group (FIG. 1). In addition, the muscle strength of the MFGM group was significantly higher than the Cont group (FIG. 2).
Spontaneous exercise amount is the sum of motor functions including endurance and muscle strength, and it is considered that resistance to physical fatigue is improved by improving motor functions. In this test, the fat globule membrane component increased the amount of spontaneous exercise and the muscle strength of the extracted muscle, and thus was found to be effective in improving motor function, endurance, muscle strength, and anti-fatigue.

Test example 2
The effect of fat globule membrane components on endurance was examined. As the fat globule membrane component, Phospholipid Concentrate 700 manufactured by New Zealand Milk Products was used (Table 2: Composition of feed).
Phospholipid Concentrate 700 contained 85% lipid and 16.5% sphingomyelin in terms of dry matter.
After 1 week of pre-breeding, 7-week-old male BALB / c mice were divided into 3 groups so that the body weight and limit swimming time (= swimming endurance) were equal, and each group was Ex (standard food intake + exercise) ) Group, ML (1% fat globule membrane component diet 2 intake + exercise) group, and MH (3.5% fat globule membrane component diet 3 intake + exercise) group. For swimming endurance, swimming time to the limit was measured in a running water pool for mice (Kyoto Daimatsu Momentum Measuring Water Tank). After grouping, the test meal was fed and swimming training (5 L / min, 30 min) was performed twice a week. Moreover, the limit swimming time was measured at the time of breeding for 12 weeks, and the effect of fat globule membrane components on endurance was verified.
FIG. 3 shows the results of swimming endurance at the time of grouping and at 12 weeks. The swimming time in the ML and MH groups was significantly higher than that in the Ex group.

  From these results, it was revealed that the fat globule membrane component is effective in improving exercise endurance. Furthermore, since the improvement of exercise endurance means the improvement of physical fatigue resistance, it became clear that the fat globule membrane component is effective for anti-fatigue.

Test example 3
The effects of fat globule membrane components on skeletal muscle glycogen content and gene expression were examined. As a fat globule membrane component, Milk Ceramide MC-5 manufactured by Snow Brand Milk Products Co., Ltd. was used (Table 3: Composition of feed). Milk ceramide MC-5 contained 21.2% protein and 59.3% lipid and 6.9% sphingomyelin in terms of dry matter.

After 1 week of preliminary breeding, 7-week-old male BALB / c mice were divided into 4 groups so that the body weight and limit swimming time (= swimming endurance) were equal, and each group was divided into Cont (standard food intake) groups. MF (1% milk fat globule membrane component diet 4 intake + exercise) group, Ex (standard diet intake + exercise) group, MF-Ex (1% milk fat globule membrane component diet 4 intake + exercise) group. After grouping, the test meal was fed. For Ex group and MF-Ex group, twice a week swimming training (5 L / min, 30 min) was given, and for Cont group and MF group, no swimming training was given.
The limit swimming time was measured when each group was raised for 12 weeks. Thereafter, the animals were dissected for 13 weeks, and the muscle strength of the soleus was measured. After dissection, quantitative PCR of gastrocnemius glycogen content according to the method of Xu et al. (J Cell Mol Med, 942-54, 2008) and Na ⁺ -K ⁺ pumpβ1 and SERCA2 gene expression levels in soleus and gastrocnemius muscle Measured by the method (Murase et al, Biogerontology, 2009). Table 4 shows the primers (SEQ ID NOs: 1 to 6) used in measuring the gene expression level related to the muscle pump function. Na ⁺ -K ⁺ pump β1 is a gene related to Na pump function, and SERCA2 (sarcoplasmic / endoplasmic reticulum Ca ²⁺ ATPase) is known as a gene related to Ca pump.

As a result, the limit swimming time in the 12-week breeding period was significantly higher in the MF-Ex group (52.6 (4.5 min) than in the Ex group (40.1 (3.8 min)), and the endurance due to intake of milk fat globule membrane component foods In addition, the soleus muscle strength at 13 weeks of breeding was 1.90 (0.08 for the MF-Ex group, 1.73 (0.07 for the Ex group, 1.64 (0.07 (g / mg muscle) for the Cont group), The muscle strength was improved by the intake of milk fat globule membrane component food.
FIG. 4 shows the gastrocnemius glycogen content at the time of dissection. In the MF group and MF-Ex group, muscle glycogen showed a significantly high value. Therefore, it has been clarified that the milk fat globule membrane component has an action of promoting the accumulation of muscle glycogen. Since glycogen in muscle is an important energy source for muscle contraction, an increase in the amount of muscle glycogen due to intake of milk fat globule membrane component is considered to contribute to improvement of motor function.

FIG. 5 shows the results of gene expression levels related to the muscle pump function in the soleus at the time of dissection. The expression levels of Na ⁺ -K ⁺ pumpβ1 (Na pump) and SERCA2 (Ca pump) were higher in the MF group than in the Cont group and in the MF-Ex group compared to the Ex group, respectively. In particular, the expression levels of Na ⁺ -K ⁺ pumpβ1 (Na pump) and SERCA2 (Ca pump) were significantly higher in the MF-Ex group than in the Cont group. Na pump is known to be involved in maintaining excitability of muscle cell membranes through action potential retention, and Ca pump is known to be involved in calcium uptake into the sarcoplasmic reticulum. Have a role. Therefore, it has been clarified that the milk fat globule membrane component is effective as a muscle pump function improving agent and acts on improvement of motor functions such as endurance and muscle strength through improvement of the muscle contraction related pump function.

Formulation example Formulation example 1 Jelly food for improving motor function Carrageenan and locust bean gum mixed gelling agent 0.65%, grapefruit 50% concentrated fruit juice 5.0%, citric acid 0.05%, vitamin C 0.05% , And fat globule membrane components (Phospholipid Concentrate 700: New Zealand Milk Products, Inc .: 85% lipid, 16.5% sphingomyelin) were mixed to adjust to 100% with water and dissolved at 65 ° C. . Further, a small amount of grapefruit flavor was added and kept at 85 ° C. for 5 minutes, sterilized, and dispensed into a 100 mL container. A jelly food containing a fat globule film component that has a good mouth meltability, a fruit flavor, and a good texture when left in the mouth and cooled to 5 ° C. while gradually cooling, gelled and included in the mouth. Got.

Formulation Example 2 Motor Function Improvement Tablet Ascorbic acid 180 mg, citric acid 50 mg, aspartame 12 mg, magnesium stearate 24 mg, crystalline cellulose 120 mg, lactose 274 mg, and fat globule membrane component (MSCPRE BSCP: 49% protein, 39% lipid, Sphingomyelin 3.7%, Glucosylceramide 2.4%, Ganglioside 0.4%) 440mg prescription (2200mg / day), manufactured according to the Japanese Pharmacopoeia (general drug “Tablet”), containing fat globule membrane component To obtain a tablet.

Formulation Example 3 Vitamin oral solution for improving motor function Taurine 800 mg, sucrose 2000 mg, caramel 50 mg, sodium benzoate 30 mg, vitamin B1 nitrate 5 mg, vitamin B2 20 mg, vitamin B6 20 mg, vitamin C 2000 mg, vitamin E 100 mg, vitamin D3 2000 IU, Add nicotinamide 20mg, fat globule membrane component (Snow Brand Milk Products Co., Ltd. Milk Ceramide MC-5: Protein 21.2%, Lipid 59.3%, Sphingomyelin 6.9%) 1000mg, Leucine 200mg, Isoleucine 100mg, Valine 100mg to the appropriate amount of purified water After the solution was dissolved and adjusted to pH 3 with an aqueous phosphoric acid solution, purified water was added to make the total volume 50 mL. This was sterilized at 80 ° C. for 30 minutes to obtain a drink for improving exercise function containing fat globule membrane components and amino acids.

Formulation Example 4 Milk Beverage for Improvement of Motor Function Milk Casein 3.4 g, Isolated Soy Protein 1.67 g, Dextrin 14.86 g, Sucrose 1.3 g, Soybean Oil 1.75 g, Perilla Oil 0.18 g, Soybean Phospholipid 0 .14 g, 0.07 g of glycerin fatty acid ester, 0.60 g of minerals, 0.06 g of vitamins, fat globule membrane component (New Zealand Milk Products Phospholipid Concentrate 500: 89% lipid, 7.8% sphingomyelin) purified to 1.0 g Water was added and sterilized by retort according to a conventional method to obtain a beverage for improving motor function (100 mL) containing a fat globule membrane component.

Claims (6)

  Motor function improver comprising fat globule membrane component as an active ingredient.   Endurance improver containing fat globule membrane component as an active ingredient.   Anti-fatigue agent containing fat globule membrane component as an active ingredient.   Muscle strength improver containing fat globule membrane component as an active ingredient.   Glycogen accumulation promoter containing fat globule membrane component as an active ingredient.   Muscle pump function improver comprising fat globule membrane component as an active ingredient.

Images