JP2010018525A - Improving agent for ozostomia, body odor and excreta odor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a food or a cosmetic that is safe and exhibits excellent improving effects for bad breath, body odor and excreta odor. <P>SOLUTION: Screening of functional raw materials by evaluation of bad breath, body odor and excreta odor by a questionnaire was carried out in order to find out a functional raw material that exhibits excellent improving effects for bad breath, body odor and excreta odor when combined with iron chlorophyllin. The result reveals that combination of extracts from pine bark with iron chlorophyllin exhibits excellent improving effects for bad breath, body odor and excreta odor. In other words, the combination of extracts from pine bark with iron chlorophyllin exhibits excellent improving effects for bad breath, body odor and excreta odor and can be used in the form of foods or cosmetics. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to the improvement of bad breath, body odor and excrement odor containing pine bark extract and iron chlorophyllin.

Improving bad odors related to the human body such as bad breath, body odor and manure odor is an important issue in order to lead a comfortable daily life. It is widely known that iron chlorophyllin and its derivatives are effective as materials showing an effect of improving bad odor such as bad breath, body odor and manure odor. In addition to iron chlorophyllin, pine bark extract can improve bad breath, and can be found in the followings: Body odor prevention action of plants and fungi selected from Hamamelis or its extract, prevention of bad breath of parsley and carrot, odor generation suppression action of asteraceae plant extract, iron chlorophyllin sodium and tamarind, houji tea, yucca, champignon, green tea, Improvement of halitosis, body odor and manure odor by combining plant extracts selected from twilight tea, pear, licorice and lemon balm, deodorizing action of halitosis, body odor and manure odor of tea dry distillate, champignon and persimmon extract (Patent Documents 1 to 6) are known.
JP 2001-335501 A WO2005 / 088784 JP 2002-255776 A JP-A-9-59138 JP 2002-114660 A Japanese Patent No. 3560904

  As described above, iron chlorophyllin is known to be effective in improving bad odor such as bad breath, body odor and manure odor, but on the other hand, when the amount is large, the solution becomes black and the color tone becomes poor. There was a problem of causing bitterness. However, if the amount of iron chlorophyllin is small, it does not show a sufficient bad odor improving action such as bad breath, body odor and manure odor. Therefore, it has been desired to develop foods or cosmetics in which the amount of iron chlorophyllin has an effect of improving bad odor such as bad breath, body odor and manure odor by combining other food materials and iron chlorophyllin.

The present invention relates to a mouth odor, body odor and manure odor improving agent containing a pine bark extract and iron chlorophyllin, and more preferably to a mouth odor, body odor and manure odor improving agent containing a tea extract. Moreover, said bad breath, body odor, and manure odor improving agent are related with a foodstuff or cosmetics.

  ADVANTAGE OF THE INVENTION According to this invention, the bad breath, body odor, and manure odor improving agent containing a pine bark extract and iron chlorophyllin can be provided.

  Hereinafter, embodiments of the present invention will be described. In addition, this invention should not be limited and interpreted by description of the following embodiment, A various change is possible within the range of description in a claim.

  Pine bark extracts used in the present invention include Pinus Martina, larch, Japanese black pine, Japanese red pine, Japanese pine, Japanese pine, Korean pine, Japanese pine, Ryukyu pine, Utsukushima, Japanese pine, white pine, Canadian Quebec region A bark extract of a plant belonging to the order of Pinae such as Aneda is preferably used. Among them, the bark extract of French maritime pine (Pinus Martina) is preferable.

  French coastal pine is a marine pine that grows on the Atlantic coast of southern France. This French coastal pine bark contains proanthocyanidins, organic acids, and other physiologically active ingredients, and it is known that proanthocyanidins, which are the main ingredients, have a strong antioxidant action to remove active oxygen. Yes.

  Proanthocyanidins refer to a group of compounds composed of a condensation polymer having a degree of polymerization of 2 or more and having flavan-3-ol and / or flavan-3,4-diol as a structural unit. It is a powerful antioxidant produced by plants and is intensively contained in the leaves, bark, fruit peel and seeds of plants. This proanthocyanidin is a substance that cannot be produced in the human body.

  The pine bark extract contains a condensed polymer having a polymerization degree of 2 or more as proanthocyanidins, and further contains catechin and the like. In particular, proanthocyanidins containing a large amount of a condensation polymer having a low degree of polymerization are preferably used. The condensation polymer having a low polymerization degree is preferably a condensation polymer having a polymerization degree of 2 to 30 (2 to 30 mer), more preferably a condensation polymer having a polymerization degree of 2 to 10 (2 to 10 mer). Further, a condensation polymer (2 to 4 mer) having a polymerization degree of 2 to 4 is more preferable. Proanthocyanidins that are condensation polymers having a degree of polymerization of 2 to 4 (2 to 4 mer) are particularly easily absorbed into the body. In the present specification, the polymer having a degree of polymerization of 2 to 4 is referred to as an oligomeric proanthocyanidin (hereinafter referred to as “OPC”).

  The pine bark extract contains 15% by weight, preferably 20% by weight or more, more preferably 30% by weight of a condensation polymer having a degree of polymerization of 2 to 4 (2 to 4 mer; that is, OPC). An extract containing a pentamer or more proanthocyanidins in a proportion of 10% by weight or more, preferably 15% by weight or more is preferable.

  The pine bark extract is obtained by extracting pine bark with water or an organic solvent. When water is used, warm water or hot water is preferably used. As the organic solvent used for extraction, organic solvents that are acceptable for the production of foods or drugs are used. For example, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, hexane, cyclohexane , Propylene glycol, hydrous ethanol, hydrous propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible fats and oils, 1,1,1,2-tetrafluoroethane, and 1,1,2- Trichloroethene is mentioned. These water and organic solvent may be used alone or in combination. In particular, hot water, hydrous ethanol, and hydrous propylene glycol are preferably used.

  The pine bark extract preferably contains 5% by weight or more of catechins together with proanthocyanidins, particularly OPC. Catechin is a general term for polyhydroxyflavan-3-ol. As catechins, (+)-catechin, (−)-epicatechin, (+)-gallocatechin, (−)-epigallocatechin, epigallocatechin gallate, epicatechin gallate and the like are known. In addition to (+)-catechin, which is said to be a catechin in the narrow sense, gallocatechin, afzelekin, and (+)-catechin or 3-galloyl derivatives of gallocatechin are isolated from extracts derived from raw material plants such as pine bark. Has been. For catechins, bad breath prevention action, carcinogenesis improvement action, arteriosclerosis prevention action, fat metabolism abnormality improvement action, blood pressure increase improvement action, platelet aggregation improvement action, antiallergic action, antiviral action, antibacterial action, caries prevention action, It is known to have an intestinal flora normalizing action, an active oxygen and free radical scavenging action, an antioxidant action, and the like. Catechins have the property of activating OPC while increasing water solubility in the presence of OPC.

  The catechins are preferably contained in an amount of 0.1 parts by weight or more with respect to 1 part by weight of proanthocyanidins in order to improve the solubility and function of OPC. More preferably, the pine bark extract containing 20% by weight or more of OPC is prepared so that catechins are contained by 5% by weight or more. For example, when the catechin content of the pine bark extract is less than 5% by weight, the catechins may be added so as to be 5% by weight or more. It is most preferable to use a pine bark extract containing 5% by weight or more of catechins and 20% by weight or more of OPC.

  The mouth odor, body odor and manure odor improving agent of the present invention contains 0.00001% by weight or more of a pine bark extract. Preferably, the composition contains 0.00001-20% by weight of pine bark extract, more preferably 0.00001-15% by weight, most preferably 0.00001-10% by weight.

  The iron chlorophyllin used in the present invention is not particularly limited as long as it is iron chlorophyllin or a derivative of iron chlorophyllin. Examples of the iron chlorophyllin derivative include iron chlorophyllin sodium, iron chlorophyllin potassium, and a conjugate of iron chlorophyllin and a polymer.

  The mouth odor, body odor and manure odor improving agent of the present invention contains 0.00001% by weight or more of iron chlorophyllin. Preferably, iron chlorophyllin is contained in the composition in an amount of 0.00001 to 20% by weight, more preferably 0.00001% to 15% by weight, and most preferably 0.00001% to 10% by weight.

  The tea pulverized product or extract used in the present invention is not particularly limited, and specific examples thereof include pulverized products or extracts of green tea, white tea, blue tea, yellow tea, black tea and the like.

  In the present invention, the method for pulverizing tea is not particularly limited, and can be pulverized by a conventional method.

  In the present invention, the tea extraction method is not particularly limited, and can be extracted by a conventional method.

  The tea varieties used in the tea pulverized product or extract are not particularly limited. For example, Yabukita, Benifuuki, Benihore, Asatsuyu, Miyoshi, Tamami Midori, Saya Midori, Makino Harayase, Koyani, Rokuro, Yamato Midori, Takachiho, Indo, Hatsumomiji, Benetachi, Akane, Natsumi, Yaeho, Asagiri, Kyomidori, Hatsumidori, Benikaori, Beni Fuji, Himemidori, Izumi , Satsumabe, Okumusashi, Yamanami, Benihikari, Yunkai, Kanaya Midori, Sayaka Kaori, Okumidori, Toyoka, Okuyutaka, Meiko, Fukumidori, Shunmei, Minekaori, Minami Kaori , Samidori, Fushun, Minami Sayaka, Hokumei, Ryofu, Musashikaori, Saki Midori, Harumi Midori, etc.

  The mouth odor, body odor and manure odor improving agent of the present invention contains 0.00001% by weight or more of a tea ground product or an extract. Preferably, the composition contains 0.00001 to 20% by weight, more preferably 0.00001 to 15% by weight, and most preferably 0.00001 to 10% by weight of the tea ground or extract.

  The mouth odor, body odor and manure odor improving agent of the present invention is appropriately prepared by known methods in the form of solids or solutions such as tablets, pills, capsules, granules, powders, powders, softeners, gels, gels, and liquids. be able to. That is, a solid preparation or a liquid preparation useful as the preparation of the present invention is produced by mixing a pine bark extract and iron chlorophyllin and, if desired, an additive and using a well-known conventional preparation method. The Examples of additives include excipients, pH adjusting agents, cooling agents, suspending agents, diluents, antifoaming agents, thickeners, solubilizers, disintegrating agents, binders, lubricants, antioxidants. Agents, coating agents, coloring agents, flavoring agents, surfactants, plasticizers or fragrances.

The food of the present invention is produced by blending a pine bark extract and iron chlorophyllin into a food material during food production. For example, solid foods such as bread, chewing gum, cookies, chocolate and cereals, jams, ice cream, yogurt, jelly and other jam foods, cream or gel foods, juices, coffee, cocoa, tea and other foods It can be in the form. Moreover, it can also mix | blend with a seasoning, a food additive, etc.

  The cosmetics of the present invention can be prepared by mixing pine bark extract and iron chlorophyllin with other components by a commonly used method, and can be used as pharmaceuticals, quasi drugs, cosmetics, and toiletries. For example, lotion, cosmetic cream, milky lotion, cream, pack, shampoo, hair rinse, treatment, body shampoo, facial cleanser, soap, hair conditioner, hair restorer, aqueous ointment, oily ointment, ship, gel and the like. In addition, it can be locally administered for a long time by a method such as holding or absorbing in a carrier such as ship or gel or a cross-linking agent and applying it to a local area.

  In addition to the pine bark extract and iron chlorophyllin, the cosmetic product of the present invention may contain other components usually used in quasi-drugs, cosmetics and the like as long as the effects of the cosmetic product are not impaired. Examples of such components include water, other medicinal ingredients, other oils, moisturizers, surfactants, ultraviolet absorbers, absorption accelerators, fragrances, dyes, preservatives, thickeners, chelating agents, antiseptics A glaze etc. can be mentioned. Examples of other medicinal ingredients include active oxygen scavengers, antioxidants, anti-inflammatory analgesics, antihistamines, antipruritics, bactericides, vitamins, and hormonal agents.

  Moreover, you may add antioxidant in order to improve the stability of a pine bark extract. Thereby, the oxidation of skin protein and fats and oils can be prevented, and the effect which improves and protects skin quality can be acquired.

  Examples of the antioxidant include carotenoids such as vitamin A, vitamin Bs, ascorbic acid, vitamin E, and derivatives or salts thereof.

  Examples of the excipient include sugar alcohols such as D-sorbitol, D-mannitol or xylitol, sugars such as glucose, sucrose, lactose or fructose, crystalline cellulose, carmellose sodium, calcium hydrogen phosphate, wheat starch, rice Examples thereof include starch, corn starch, potato starch, dextrin, β-cyclodextrin, light anhydrous silicic acid, titanium oxide, and magnesium aluminate metasilicate.

  Examples of the pH adjuster include citric acid, malic acid, sodium hydrogen phosphate, and dipotassium phosphate.

  Examples of the refreshing agent include l-menthol or mint water.

  Examples of the suspending agent include kaolin, carmellose sodium, xanthan gum, methylcellulose, and tragacanth.

Examples of the diluent include purified water, ethanol, vegetable oil, and emulsifier.

  Examples of the antifoaming agent include dimethylpolysiloxane or silicon antifoaming agent.

  Examples of the thickener include xanthan gum, tragacanth, methylcellulose, and dextrin.

  Examples of the solubilizer include ethanol, sucrose fatty acid ester, and macrogol.

  Examples of the disintegrant include low-substituted hydroxypropylcellulose, carboxymethylcellulose calcium, croscarmellose sodium, hydroxypropyl starch, or partially pregelatinized starch.

  Examples of the binder include methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatin, gum arabic, ethylcellulose, polyvinyl alcohol, pullulan, pregelatinized starch, agar, tragacanth, sodium alginate or propylene glycol alginate. Can be mentioned.

  Examples of the lubricant include stearic acid, magnesium stearate, calcium stearate, polyoxyl stearate, cetanol, talc, hydrogenated oil, sucrose fatty acid ester, dimethylpolysiloxane, beeswax and white beeswax.

  Examples of the antioxidant include ascorbic acid, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), and citric acid.

  Examples of the coating agent include hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose, cellulose acetate phthalate, polyvinyl acetal diethylaminoacetate, aminoalkyl methacrylate copolymer. , Hydroxypropyl methylcellulose acetate succinate, methacrylic acid copolymer, polyvinyl acetate diethylaminoacetate or shellac.

  Examples of the colorant include turmeric extract, riboflavin, and titanium oxide.

  Examples of the flavoring agent include citric acid, adipic acid, fructose, D-sorbitol, glucose, sodium saccharin, simple syrup, sucrose, honey, amacha, licorice, citric acid, adipic acid, orange oil, spruce tincture, fennel oil, mint Or menthol.

  Examples of the surfactant include polyoxyethylene hydrogenated castor oil, glyceryl monostearate, sorbitan monostearate, sorbitan monolaurate, polyoxyethylene polyoxypropylene, polysorbates, sodium lauryl sulfate, macrogol or sucrose. Examples include fatty acid esters.

  Examples of the plasticizer include triethyl citrate, polyethylene glycol, triacetin, and cetanol.

  As said fragrance | flavor, synthetic fragrance | flavors, such as natural fragrance | flavors, such as an animal fragrance | flavor or a vegetable fragrance | flavor, or an isolated fragrance | flavor etc. are mentioned, for example.

  Examples of the present invention will be described below. It should be noted that the present invention should not be construed as being limited to the following examples, and various modifications can be made within the scope of the claims.

  The dried parsley powder was extracted with 50% ethanol / water and dried to obtain a powdered parsley extract.

  Carrot dry powder was extracted with 50% ethanol / water and dried to obtain powdered carrot extract.

  The dried chrysanthemum powder was extracted with 50% ethanol / water and dried to obtain a dried chrysanthemum extract.

  The dried koji powder was extracted with 50% ethanol / water, and dried to obtain a dried koji extract.

  The tea dry powder was extracted with 50% ethanol / water and dried to obtain a powdered tea extract.

  Gardenia dry powder was extracted with 50% ethanol / water and dried to obtain powdered gardenia extract.

  The armature dry powder was extracted with 50% ethanol / water, and dried to obtain a powdered armature extract.

  The dried cordyceps powder was extracted with 50% ethanol / water and dried to obtain a powdered cordyceps extract.

  The dried licorice powder was extracted with 50% ethanol / water and dried to obtain a powdered licorice extract.

  The tamarind dry powder was extracted with 50% ethanol / water and dried to obtain a powdered tamarind extract.

(Preparation Example 1)
Preparation Example 1 was prepared as 100 ml of an aqueous solution prepared such that the concentration of pine bark extract (Toyo Shinyaku Co., Ltd.) was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 2)
Preparation Example 2 was prepared as 100 ml of an aqueous solution prepared so that the concentration of the parsley extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 3)
Preparation Example 3 was prepared as 100 ml of an aqueous solution prepared so that the carrot extract concentration was 0.0001 wt% and the iron chlorophyllin concentration was 0.0001 wt%.

(Preparation Example 4)
Preparation Example 4 was prepared as 100 ml of an aqueous solution prepared such that the concentration of chrysanthemum extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 5)
Preparation Example 5 was prepared as 100 ml of an aqueous solution prepared so that the soot extract concentration was 0.0001 wt% and the iron chlorophyllin concentration was 0.0001 wt%.

(Preparation Example 6)
Preparation Example 6 was prepared as 100 ml of an aqueous solution prepared so that the concentration of ground tea or extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 7)
Preparation Example 7 was prepared as 100 ml of an aqueous solution prepared so that the concentration of gardenia extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 8)
Preparation Example 8 was prepared as 100 ml of an aqueous solution prepared so that the concentration of the armature extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 9)
Preparation Example 9 was 100 ml of an aqueous solution prepared so that the concentration of Cordyceps extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 10)
Preparation Example 10 was prepared as 100 ml of an aqueous solution prepared so that the concentration of licorice extract was 0.0001 wt% and the concentration of iron chlorophyllin was 0.0001 wt%.

(Preparation Example 11)
Preparation Example 11 was 100 ml of an aqueous solution prepared so that the concentration of the tamarind extract was 0.0001% by weight and the concentration of iron chlorophyllin was 0.0001% by weight.

(Preparation Example 12)
Preparation Example 12 was prepared as 100 ml of an aqueous solution prepared so that the concentration of pine bark extract was 0.00001 wt% and the concentration of iron chlorophyllin was 0.00001 wt%.

(Preparation Example 13)
Preparation Example 13 was prepared as 100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.01% by weight and the concentration of iron chlorophyllin was 0.01% by weight.

(Preparation Example 14)
Preparation Example 14 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 1% by weight and the concentration of iron chlorophyllin was 1% by weight.

(Preparation Example 15)
Preparation Example 15 was prepared as 100 ml of an aqueous solution prepared such that the concentration of pine bark extract was 5% by weight and the concentration of iron chlorophyllin was 5% by weight.

(Preparation Example 16)
Preparation Example 16 was 100 ml of an aqueous solution prepared so that the concentration of pine bark extract was 10% by weight and the concentration of iron chlorophyllin was 10% by weight.

(Preparation Example 17)
Preparation Example 17 was 100 ml of an aqueous solution prepared so that the concentration of pine bark extract was 15% by weight and the concentration of iron chlorophyllin was 15% by weight.

(Preparation Example 18)
Preparation Example 18 was prepared as 100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 20 wt% and the concentration of iron chlorophyllin was 20 wt%.

(Preparation Example 19)
Preparation Example 19 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of parsley extract was 0.0001% by weight.

(Preparation Example 20)
Preparation Example 20 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of carrot extract was 0.0001% by weight.

(Preparation Example 21)
Preparation Example 21 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of chrysanthemum extract was 0.0001% by weight.

(Preparation Example 22)
Preparation Example 22 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of the pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of the straw extract was 0.0001% by weight.

(Preparation Example 23)
Preparation Example 23 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of tea extract was 0.0001% by weight.

(Preparation Example 24)
Preparation Example 24 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of gardenia extract was 0.0001% by weight.

(Preparation Example 25)
Preparation Example 25 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of armature extract was 0.0001% by weight.

(Preparation Example 26)
Preparation Example 26 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of Cordyceps extract was 0.0001% by weight.

(Preparation Example 27)
Preparation Example 27 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of licorice extract was 0.0001% by weight.

(Preparation Example 28)
Preparation Example 28 was prepared as 100 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.0001% by weight, the concentration of iron chlorophyllin was 0.0001% by weight, and the concentration of tamarind extract was 0.0001% by weight.

(Preparation Example 29)
Preparation Example 29 was 30 ml of an aqueous solution prepared so that the concentration of pine bark extract was 0.00001 wt% and the concentration of iron chlorophyllin was 0.00001 wt%.

(Preparation Example 30)
Preparation Example 30 was prepared as 30 ml of an aqueous solution adjusted so that the concentration of pine bark extract was 0.00001 wt%, the concentration of iron chlorophyllin was 0.00001 wt%, and the concentration of tea extract was 0.00001 wt%.

(Comparative Example 1)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.0002% by weight was used as Comparative Example 1.

(Comparative Example 2)
100 ml of an aqueous solution prepared so that the concentration of the parsley extract was 0.0002% by weight was used as Comparative Example 2.

(Comparative Example 3)
100 ml of an aqueous solution prepared so that the concentration of the carrot extract was 0.0002% by weight was used as Comparative Example 3.

(Comparative Example 4)
100 ml of an aqueous solution prepared so that the concentration of chrysanthemum extract was 0.0002% by weight was used as Comparative Example 4.

(Comparative Example 5)
100 ml of an aqueous solution prepared so that the concentration of the koji extract was 0.0002% by weight was used as Comparative Example 5.

(Comparative Example 6)
100 ml of an aqueous solution prepared so that the concentration of the tea extract was 0.0002% by weight was used as Comparative Example 6.

(Comparative Example 7)
100 ml of an aqueous solution prepared so that the concentration of gardenia extract was 0.0002% by weight was used as Comparative Example 7.

(Comparative Example 8)
Comparative Example 8 was 100 ml of an aqueous solution adjusted so that the concentration of the armature extract was 0.0002 wt%.

(Comparative Example 9)
100 ml of an aqueous solution prepared so that the concentration of Cordyceps extract was 0.0002% by weight was used as Comparative Example 9.

(Comparative Example 10)
100 ml of an aqueous solution adjusted so that the concentration of licorice was 0.0002% by weight was used as Comparative Example 10.

(Comparative Example 11)
100 ml of an aqueous solution prepared so that the concentration of the tamarind extract was 0.0002% by weight was used as Comparative Example 11.

(Comparative Example 12)
100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 0.0002% by weight was used as Comparative Example 12.

(Comparative Example 13)
100 ml of water was used as Comparative Example 13.

(Comparative Example 14)
Comparative Example 14 was 100 ml of an aqueous solution adjusted so that the concentration of iron chlorophyllin was 0.00002 wt%.

(Comparative Example 15)
Comparative Example 15 was 100 ml of an aqueous solution adjusted so that the concentration of iron chlorophyllin was 0.02 wt%.

(Comparative Example 16)
100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 2% by weight was used as Comparative Example 16.

(Comparative Example 17)
100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 10% by weight was used as Comparative Example 17.

(Comparative Example 18)
Comparative Example 18 was 100 ml of an aqueous solution adjusted so that the concentration of iron chlorophyllin was 20% by weight.

(Comparative Example 19)
100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 30% by weight was used as Comparative Example 19.

(Comparative Example 20)
100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 40% by weight was used as Comparative Example 20.

(Comparative Example 21)
Comparative Example 21 was 100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.00002 wt%.

(Comparative Example 22)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.02% by weight was used as Comparative Example 22.

(Comparative Example 23)
Comparative Example 23 was 100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 2% by weight.

(Comparative Example 24)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 10% by weight was used as Comparative Example 24.

(Comparative Example 25)
100 ml of an aqueous solution adjusted to a pine bark extract concentration of 20% by weight was used as Comparative Example 25.

(Comparative Example 26)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 30% by weight was used as Comparative Example 26.

(Comparative Example 27)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 40% by weight was used as Comparative Example 27.

(Comparative Example 28)
100 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.0003 wt% was used as Comparative Example 28.

(Comparative Example 29)
100 ml of an aqueous solution prepared so that the concentration of the parsley extract was 0.0003 wt% was used as Comparative Example 29.

(Comparative Example 30)
100 ml of an aqueous solution adjusted so that the concentration of carrot extract was 0.0003 wt% was used as Comparative Example 30.

(Comparative Example 31)
100 ml of an aqueous solution prepared so that the concentration of chrysanthemum extract was 0.0003 wt% was used as Comparative Example 31.

(Comparative Example 32)
100 ml of an aqueous solution prepared so that the concentration of the koji extract was 0.0003 wt% was used as Comparative Example 32.

(Comparative Example 33)
100 ml of an aqueous solution adjusted so that the concentration of the tea extract was 0.0003 wt% was used as Comparative Example 33.

(Comparative Example 34)
100 ml of an aqueous solution prepared so that the concentration of gardenia extract was 0.0003 wt% was used as Comparative Example 34.

(Comparative Example 35)
100 ml of an aqueous solution prepared so that the concentration of the armature extract was 0.0003 wt% was used as Comparative Example 35.

(Comparative Example 36)
100 ml of an aqueous solution prepared so that the concentration of Cordyceps extract was 0.0003 wt% was used as Comparative Example 36.

(Comparative Example 37)
100 ml of an aqueous solution prepared so that the concentration of licorice extract was 0.0003 wt% was used as Comparative Example 37.

(Comparative Example 38)
100 ml of an aqueous solution adjusted so that the concentration of the tamarind extract was 0.0003 wt% was used as Comparative Example 38.

(Comparative Example 39)
Comparative Example 39 was 100 ml of an aqueous solution prepared so that the concentration of iron chlorophyllin was 0.0003 wt%.

(Comparative Example 40)
Comparative Example 40 was 30 ml of an aqueous solution adjusted so that the concentration of iron chlorophyllin was 0.00003 wt%.

(Comparative Example 41)
30 ml of an aqueous solution prepared so that the concentration of the pine bark extract was 0.00003 wt% was used as Comparative Example 41.

(Comparative Example 42)
30 ml of an aqueous solution adjusted so that the concentration of the tea extract was 0.00003 wt% was used as Comparative Example 42.

(Comparative Example 43)
30 ml of water was used as Comparative Example 43.

Example 1
Preparation Examples 1 to 11 and Comparative Examples 1 to 13 were divided into 24 subjects on one day for each of five subjects suffering from bad breath, body odor, and fecal odor, and all samples were ingested in a state where the color and prescription contents were unknown. The three evaluation items of bad breath, body odor and excrement odor after ingesting the sample were evaluated with the following scores.

(Rate of bad breath after sample intake)
10 was the highest rating, and 0 was the lowest rating, and was filled in a Visual Analogue Scale (hereinafter referred to as VAS) questionnaire.

(Score of body odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

(Score of fecal odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

From the results shown in Tables 1 and 2, when the pine bark extract and iron chlorophyllin are taken in combination, the bad breath, body odor and fecal odor are significantly improved compared to the case where each is taken alone. I understood. On the other hand, when food ingredients other than pine bark extract and iron chlorophyllin are taken in combination, each food ingredient is taken alone, iron chlorophyllin is taken alone, and water alone is taken alone. The improvement of bad breath, body odor, and excrement smell was not recognized compared with the case where it did.

From the results of Example 1, a synergistic effect was observed when pine bark extract and iron chlorophyllin were taken in combination, and the bad odor, body odor, and fecal odor were significantly improved even when the amount was less than the effective amount when each was taken alone. I found out. Therefore, the following tests were conducted to examine the concentrations of pine bark extract and iron chlorophyllin, which show effectiveness.

(Example 2)
Preparation Examples 12 to 18 and Comparative Examples 1 and 13 to 27 were divided into 22 subjects each day for 5 subjects suffering from bad breath, body odor, and fecal urine odor, and all samples were unclear about color and prescription content. We had you take in state and had you evaluate with the following score about three evaluation items of halitosis, body odor, and manure odor after ingestion of sample.

(Rate of bad breath after sample intake)
10 was the highest rating, and 0 was the lowest rating.

(Score of body odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

(Score of fecal odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

From the results shown in Table 3, Table 4 and Table 5, when the pine bark extract and iron chlorophyllin were ingested in combination, if the concentration was 0.00001% by weight or more, it was compared with the case where each was ingested alone. It was found that bad breath, body odor and excrement odor were remarkably improved. On the other hand, when the concentrations of the pine bark extract and iron chlorophyllin were 15% by weight or more, the degree of improvement in bad breath, body odor, and manure odor was decreased compared to the case where the concentration was 10% by weight. In addition, when pine bark extract or iron chlorophyllin is ingested alone, if the concentration is 0.02% by weight or more, improvement in halitosis, body odor and manure odor compared to ingestion of water alone However, the improvement was not as great as when pine bark extract and iron chlorophyllin were combined.

From the results of Example 2, when the concentration is 0.00001% by weight or more, a synergistic effect is observed by ingesting a combination of pine bark extract and iron chlorophyllin, and bad breath, body odor and fecal odor are significantly improved. I understood. Therefore, in order to examine whether a further synergistic effect was observed by ingesting a combination of food ingredients with pine bark extract and iron chlorophyllin, the following test was conducted.

(Example 3)
Preparation Examples 1 and 19 to 28, and Comparative Examples 13 and 28 to 39 were divided into 24 subjects on one day for each of five subjects suffering from bad breath, body odor and fecal odor. The sample was ingested in an unknown state, and was evaluated with the following scores for the three evaluation items of bad breath, body odor and manure odor after sample intake.

(Rate of bad breath after sample intake)
10 was the highest rating, and 0 was the lowest rating.

(Score of body odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

(Score of fecal odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

From the results described in Table 6 and Table 7, when ingesting a pine bark extract and iron chlorophyllin in combination with a tea extract, when ingesting a pine bark extract, iron chlorophyllin or tea extract alone, It was also found that halitosis, body odor and manure odor were remarkably improved as compared with the case where only pine bark extract and iron chlorophyllin were taken in combination. On the other hand, when pine bark extract and iron chlorophyllin were combined with materials other than tea extract, no significant improvements were observed in halitosis, body odor and manure odor.

From Examples 1 to 3, when ingested in combination with pine bark extract and iron chlorophyllin, and when ingested in combination with pine bark extract and iron chlorophyllin with tea extract, synergistic effects are recognized and bad breath, It was found that body odor and manure odor were significantly improved. Therefore, the following test was conducted to examine whether the same effect was observed when used as an external preparation.

Example 4
Preparation Examples 29 and 30 and Comparative Examples 40 to 43 were divided into 6 subjects each day for 5 subjects suffering from body odor, and all samples were applied to the entire upper body in a state where the contents of the prescription were not known. After applying the sample, body odor was evaluated as the evaluation item with the following rating.

(Score of body odor after sample intake)
10 was the highest rating, and 0 was the lowest rating.

From the results shown in Table 8 and Table 9, when an aqueous solution combining pine bark extract and iron chlorophyllin was applied to the entire upper body, it was compared with the case where an aqueous solution containing only pine bark extract or iron chlorophyllin was applied. It was found that the body odor was remarkably improved. In addition, when an aqueous solution in which a tea extract is further combined with pine bark extract and iron chlorophyllin is applied, an aqueous solution containing pine bark extract, iron chlorophyllin or tea extract alone is applied, and pine bark extraction It was found that the body odor was remarkably improved as compared with the case of applying an aqueous solution combining only the product and iron chlorophyllin.

  The mouth odor, body odor and feces odor ameliorating agent containing pine bark extract and iron chlorophyllin of the present invention is a combination of pine bark extract and iron chlorophyllin, compared to the case where pine bark extract or iron chlorophyllin is used alone. It exhibits a much stronger bad odor such as bad breath, body odor and manure odor, and can contribute to people's comfortable daily life when used as food or cosmetics.

Claims (3)

A mouth odor, body odor and manure odor improving agent containing pine bark extract and iron chlorophyllin. Furthermore, the bad breath, body odor, and manure odor improving agent of Claim 1 containing a tea ground material or an extract. A food or cosmetic comprising the halitosis, body odor and manure odor improving agent according to claim 1 or 2.