JP2009544760A - 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用 - Google Patents

酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用 Download PDF

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JP2009544760A
JP2009544760A JP2009529458A JP2009529458A JP2009544760A JP 2009544760 A JP2009544760 A JP 2009544760A JP 2009529458 A JP2009529458 A JP 2009529458A JP 2009529458 A JP2009529458 A JP 2009529458A JP 2009544760 A JP2009544760 A JP 2009544760A
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polypeptide
pichia
cell
cells
mucin
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JP2009544760A5 (https=
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ヤン オルガーソン，
アンキ グスタフソン，
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レコファーマ アーベー
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/473—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used alpha-Glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2009529458A 2006-01-23 2007-01-23 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用 Pending JP2009544760A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76163206P 2006-01-23 2006-01-23
PCT/IB2007/004164 WO2007087420A2 (en) 2006-01-23 2007-01-23 Production of proteins carrying oligomannose or human-like glycans in yeast and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2009544760A true JP2009544760A (ja) 2009-12-17
JP2009544760A5 JP2009544760A5 (https=) 2011-01-13

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JP2009529458A Pending JP2009544760A (ja) 2006-01-23 2007-01-23 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用

Country Status (6)

Country Link
US (1) US20070184063A1 (https=)
EP (1) EP2021366A2 (https=)
JP (1) JP2009544760A (https=)
AU (1) AU2007208218A1 (https=)
CA (1) CA2637947A1 (https=)
WO (1) WO2007087420A2 (https=)

Cited By (2)

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JP2014524445A (ja) * 2011-08-17 2014-09-22 グローブイミューン，インコーポレイテッド 酵母−ｍｕｃ１免疫療法用組成物およびその使用
JP2023510260A (ja) * 2020-01-07 2023-03-13 リンマテック バイオロジクス エージー Ｌｅｉｓｈｍａｎｉａ細胞を使用する糖鎖修飾改変

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JP2009544760A (ja) * 2006-01-23 2009-12-17 レコファーマ アーベー 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
US8956834B2 (en) 2009-06-29 2015-02-17 Synthetic Genomics, Inc. Acyl-ACP thioesterase genes and uses therefor
JP5956982B2 (ja) 2010-05-27 2016-07-27 メルク・シャープ・エンド・ドーム・コーポレイション 改善された特性を有する抗体の製造方法
AU2012258907A1 (en) 2011-05-25 2013-11-07 Merck Sharp & Dohme Corp. Method for preparing Fc-containing polypeptides having improved properties
JP6454547B2 (ja) 2011-07-06 2019-01-16 ゲンマブ エー／エス 抗体重鎖のｃ末端の修飾による補体依存性細胞傷害の調節
CN104800838B (zh) * 2015-04-14 2018-01-09 深圳市中联生物科技开发有限公司 MUC1‑Fc多肽疫苗及其制备方法和应用
CN105950647A (zh) * 2016-05-16 2016-09-21 浙江理工大学 一种高效表达与制备外分泌型人源ca125的方法
US20220356234A1 (en) 2019-10-02 2022-11-10 Alexion Pharmaceuticals, Inc. Complement inhibitors for treating drug-induced complement-mediated response

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524445A (ja) * 2011-08-17 2014-09-22 グローブイミューン，インコーポレイテッド 酵母−ｍｕｃ１免疫療法用組成物およびその使用
US9533031B2 (en) 2011-08-17 2017-01-03 Globeimmune, Inc. Yeast-MUC1 immunotherapeutic compositions and uses thereof
JP2017122120A (ja) * 2011-08-17 2017-07-13 グローブイミューン，インコーポレイテッド 酵母−ｍｕｃ１免疫療法用組成物およびその使用
US10188714B2 (en) 2011-08-17 2019-01-29 Globeimmune, Inc. Yeast-MUC1 immunotherapeutic compositions and uses thereof
JP2019194261A (ja) * 2011-08-17 2019-11-07 グローブイミューン，インコーポレイテッド 酵母−ｍｕｃ１免疫療法用組成物およびその使用
US11065318B2 (en) 2011-08-17 2021-07-20 Globeimmune, Inc. Yeast-MUC1 immunotherapeutic compositions and uses thereof
JP2023510260A (ja) * 2020-01-07 2023-03-13 リンマテック バイオロジクス エージー Ｌｅｉｓｈｍａｎｉａ細胞を使用する糖鎖修飾改変
JP7684310B2 (ja) 2020-01-07 2025-05-27 リンマテック バイオロジクス エージー Ｌｅｉｓｈｍａｎｉａ細胞を使用する糖鎖修飾改変

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Publication number Publication date
WO2007087420A3 (en) 2008-12-31
WO2007087420A9 (en) 2008-11-06
US20070184063A1 (en) 2007-08-09
CA2637947A1 (en) 2007-07-23
WO2007087420A8 (en) 2008-09-25
EP2021366A2 (en) 2009-02-11
AU2007208218A1 (en) 2007-08-02
WO2007087420A2 (en) 2007-08-02

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