JP2009544611A - ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 - Google Patents
ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 Download PDFInfo
- Publication number
- JP2009544611A JP2009544611A JP2009520791A JP2009520791A JP2009544611A JP 2009544611 A JP2009544611 A JP 2009544611A JP 2009520791 A JP2009520791 A JP 2009520791A JP 2009520791 A JP2009520791 A JP 2009520791A JP 2009544611 A JP2009544611 A JP 2009544611A
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- Prior art keywords
- amino
- phenyl
- thienyl
- alkyl
- carbonyl
- Prior art date
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- 0 C/C1=C\C(\*)=C\C(\N)=C/C=C1 Chemical compound C/C1=C\C(\*)=C\C(\N)=C/C=C1 0.000 description 12
- ARZSFEURFBPUSG-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c(cc1)ccc1C(OC)=O)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c(cc1)ccc1C(OC)=O)=O)=O ARZSFEURFBPUSG-UHFFFAOYSA-N 0.000 description 1
- GFFRKRRLEPOLGO-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c1ccc(CN)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccc[s]1)c1)c1NC(c1ccc(CN)cc1)=O)=O GFFRKRRLEPOLGO-UHFFFAOYSA-N 0.000 description 1
- WQVWOYXFMKVDGD-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CN)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CN)cc1)=O)=O WQVWOYXFMKVDGD-UHFFFAOYSA-N 0.000 description 1
- UOJGNSZGYFSDBG-UHFFFAOYSA-N CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CNC(OCc(cc2)ccc2P(C)(C)=O)=O)cc1)=O)=O Chemical compound CC(C)(C)OC(Nc(ccc(-c1ccccc1)c1)c1NC(c1ccc(CNC(OCc(cc2)ccc2P(C)(C)=O)=O)cc1)=O)=O UOJGNSZGYFSDBG-UHFFFAOYSA-N 0.000 description 1
- WYXYKRCXGGKEOH-UHFFFAOYSA-N CC(C)(CO1)CO[O]1(Cc(cc1)ccc1C(OC)=O)=O Chemical compound CC(C)(CO1)CO[O]1(Cc(cc1)ccc1C(OC)=O)=O WYXYKRCXGGKEOH-UHFFFAOYSA-N 0.000 description 1
- XXVDWWBFOIDJFP-UHFFFAOYSA-N CC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)([O](C)(OC)(OC)=O)F Chemical compound CC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)([O](C)(OC)(OC)=O)F XXVDWWBFOIDJFP-UHFFFAOYSA-N 0.000 description 1
- GWXNTPAAFSGUKO-UHFFFAOYSA-N CCOP(C)(CCC(c(cc1)ccc1Br)=O)=O Chemical compound CCOP(C)(CCC(c(cc1)ccc1Br)=O)=O GWXNTPAAFSGUKO-UHFFFAOYSA-N 0.000 description 1
- XHWFEOBQYDSLRB-UHFFFAOYSA-N CCOP(C)(CCC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O)=O Chemical compound CCOP(C)(CCC(c(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O)=O XHWFEOBQYDSLRB-UHFFFAOYSA-N 0.000 description 1
- JSNJPRJEHUJINX-UHFFFAOYSA-N CCOP(C)(OCCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O Chemical compound CCOP(C)(OCCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1NC(OC(C)(C)C)=O)=O)=O JSNJPRJEHUJINX-UHFFFAOYSA-N 0.000 description 1
- IUKCEAFVFILXRT-UHFFFAOYSA-N CCOP(C)(OCCc(cc1)ccc1C(Nc1cc(-c2ccc[s]2)ccc1N)=O)=O Chemical compound CCOP(C)(OCCc(cc1)ccc1C(Nc1cc(-c2ccc[s]2)ccc1N)=O)=O IUKCEAFVFILXRT-UHFFFAOYSA-N 0.000 description 1
- ODSMDEXNXPTKGT-UHFFFAOYSA-N CN(CC1)CCP1(c(cc1)ccc1C(O)=O)=O Chemical compound CN(CC1)CCP1(c(cc1)ccc1C(O)=O)=O ODSMDEXNXPTKGT-UHFFFAOYSA-N 0.000 description 1
- BONAGWREEDYWFC-UHFFFAOYSA-N COC[O](C(c(cc1)ccc1C(OCc1ccccc1)=O)F)(OC)=O Chemical compound COC[O](C(c(cc1)ccc1C(OCc1ccccc1)=O)F)(OC)=O BONAGWREEDYWFC-UHFFFAOYSA-N 0.000 description 1
- VBTQAKVIZKHMKY-UHFFFAOYSA-N COC[O](Nc(cc1)ccc1C(OC)=O)(OC)=O Chemical compound COC[O](Nc(cc1)ccc1C(OC)=O)(OC)=O VBTQAKVIZKHMKY-UHFFFAOYSA-N 0.000 description 1
- VSUBEANUFSZOFE-UHFFFAOYSA-N COP(COC(NCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O)(OC)=O Chemical compound COP(COC(NCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O)(OC)=O VSUBEANUFSZOFE-UHFFFAOYSA-N 0.000 description 1
- MPSZFNFRFZNTPG-UHFFFAOYSA-N CP(C)(OCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O Chemical compound CP(C)(OCc(cc1)ccc1C(Nc(cc(cc1)-c2ccc[s]2)c1N)=O)=O MPSZFNFRFZNTPG-UHFFFAOYSA-N 0.000 description 1
- ZENXWFYXUDCIJW-UHFFFAOYSA-N CP(CC1)(CCN1I)=O Chemical compound CP(CC1)(CCN1I)=O ZENXWFYXUDCIJW-UHFFFAOYSA-N 0.000 description 1
- AQWBRFKCQHRFHE-UHFFFAOYSA-N CP1(OCC(CC2)(CCN2C(c(cc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)=O)CO1)=O Chemical compound CP1(OCC(CC2)(CCN2C(c(cc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)=O)CO1)=O AQWBRFKCQHRFHE-UHFFFAOYSA-N 0.000 description 1
- RXRHUVFUKNTLHO-UHFFFAOYSA-N CP1(OCC(CC2)(CCN2c(nc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)CO1)=O Chemical compound CP1(OCC(CC2)(CCN2c(nc2)ccc2C(Nc(cc(cc2)-c3ccc[s]3)c2N)=O)CO1)=O RXRHUVFUKNTLHO-UHFFFAOYSA-N 0.000 description 1
- MCNALOGTMITBJE-UHFFFAOYSA-M N[AlH]NC(c1ccccc1)=O Chemical compound N[AlH]NC(c1ccccc1)=O MCNALOGTMITBJE-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657154—Cyclic esteramides of oxyacids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83201406P | 2006-07-20 | 2006-07-20 | |
| US92054107P | 2007-03-28 | 2007-03-28 | |
| PCT/US2007/016123 WO2008010985A2 (en) | 2006-07-20 | 2007-07-16 | Phosphorus derivatives as histone deacetylase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544611A true JP2009544611A (ja) | 2009-12-17 |
| JP2009544611A5 JP2009544611A5 (US07981874-20110719-C00150.png) | 2010-08-26 |
Family
ID=38957303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520791A Withdrawn JP2009544611A (ja) | 2006-07-20 | 2007-07-16 | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
Country Status (6)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531359A (ja) * | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体 |
| JP2014516989A (ja) * | 2011-05-31 | 2014-07-17 | ニューゲン セラピューティクス， インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． | Ｃｘｃｒ２モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US8017321B2 (en) | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
| ES2537631T3 (es) | 2004-05-27 | 2015-06-10 | The Regents Of The University Of Colorado | Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer |
| WO2007100657A2 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| EP2170339B1 (en) * | 2007-06-27 | 2014-10-15 | Merck Sharp & Dohme Corp. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| AU2009285591B2 (en) | 2008-08-29 | 2015-08-27 | Treventis Corporation | Compositions and methods of treating amyloid disease |
| CA2735593C (en) | 2008-09-03 | 2017-08-15 | Repligen Corporation | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| WO2012118782A1 (en) | 2011-02-28 | 2012-09-07 | Repligen Corporation | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| WO2014018913A2 (en) * | 2012-07-27 | 2014-01-30 | University Of Connecticut | Santacruzamate a compositions and analogs and methods of use |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| EP2968565A2 (en) | 2013-03-14 | 2016-01-20 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
| AU2014228344C1 (en) | 2013-03-15 | 2019-02-07 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
| US10807944B2 (en) | 2014-04-04 | 2020-10-20 | University Of Florida Research Foundation, Inc. | HDAC inhibitor compounds and methods of treatment |
| CZ305738B6 (cs) * | 2014-12-16 | 2016-02-24 | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové | Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující |
| CN104860991B (zh) * | 2015-03-24 | 2017-10-20 | 华南理工大学 | 离子型阴极缓冲层分子型材料及其制备方法和应用 |
| JP6936796B2 (ja) | 2015-07-06 | 2021-09-22 | ロダン・セラピューティクス，インコーポレーテッド | ヒストンデアセチラーゼのヘテロハロ阻害剤 |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017127417A1 (en) * | 2016-01-19 | 2017-07-27 | Prospero Pharmaceuticals Llc | Phosphopantothenate compounds |
| CN105859774B (zh) * | 2016-04-12 | 2018-01-19 | 盘锦格林凯默科技有限公司 | 一种膦苯类化合物的制备方法 |
| FR3050732B1 (fr) * | 2016-05-02 | 2019-06-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nouveaux derives de phosphinolactones et leurs utilisations pharmaceutiques |
| US9951069B1 (en) | 2017-01-11 | 2018-04-24 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
| CN112538091B (zh) * | 2020-11-26 | 2022-09-09 | 湖北大学 | 一种双-（对-羧基苯氨基）苯基氧化膦阻燃剂的合成法 |
| CN114685559B (zh) * | 2022-05-16 | 2023-07-18 | 多氟多新材料股份有限公司 | 一种双三氟甲基磷酸锂的制备方法 |
| WO2024025862A1 (en) * | 2022-07-28 | 2024-02-01 | The Board Of Regents Of The University Of Oklahoma | Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use |
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| BE570173A (US07981874-20110719-C00150.png) | 1957-08-07 | |||
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| DE1265896B (de) | 1962-06-19 | 1968-04-11 | Ciba Geigy | Verfahren zur Herstellung von Kuepenfarbstoffen |
| US3339999A (en) | 1962-06-19 | 1967-09-05 | Ciba Ltd | Process for vat dyeing cellulosic textile materials |
| GB1491608A (en) * | 1975-05-28 | 1977-11-09 | Ici Ltd | Metal complex formazan dyestuffs and processes for their preparation |
| AU606808B2 (en) | 1988-06-29 | 1991-02-14 | Otsuka Pharmaceutical Factory, Inc. | Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same |
| US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| JP2787407B2 (ja) * | 1992-06-19 | 1998-08-20 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| JPH11335375A (ja) | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体 |
| EA007649B1 (ru) | 1999-09-08 | 2006-12-29 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение |
| AU1244001A (en) | 1999-10-27 | 2001-05-08 | Cor Therapeutics, Inc. | Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation |
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| CA2432825A1 (en) | 2000-12-15 | 2002-06-20 | Emory University | Nonpeptide agonists and antagonists of vasopressin receptors |
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| NZ534830A (en) | 2002-03-13 | 2005-08-26 | Janssen Pharmaceutica Nv | Compounds with histone deacetylase HDAC inhibiting activity and oral bioavailability useful for treating proliferative diseases |
| EP1485099B1 (en) | 2002-03-13 | 2010-07-07 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| PL376154A1 (en) | 2002-09-18 | 2005-12-27 | Ono Pharmaceutical Co, Ltd. | Triazaspiro[5.5]undecane derivatives and drugs comprising the same as the active ingredient |
| WO2004058234A2 (en) | 2002-12-27 | 2004-07-15 | Schering Aktiengesellschaft | Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors |
| CA2851462A1 (en) | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| EP1663953A1 (en) * | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| KR101258504B1 (ko) | 2004-03-26 | 2013-04-26 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
| CA2567835A1 (en) | 2004-06-10 | 2005-12-22 | Kalypsys, Inc. | Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease |
-
2007
- 2007-07-16 CA CA002657288A patent/CA2657288A1/en not_active Abandoned
- 2007-07-16 EP EP07810507A patent/EP2049124A4/en not_active Withdrawn
- 2007-07-16 US US12/309,459 patent/US7981874B2/en not_active Expired - Fee Related
- 2007-07-16 AU AU2007275743A patent/AU2007275743A1/en not_active Abandoned
- 2007-07-16 JP JP2009520791A patent/JP2009544611A/ja not_active Withdrawn
- 2007-07-16 WO PCT/US2007/016123 patent/WO2008010985A2/en active Application Filing
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531359A (ja) * | 2007-06-27 | 2010-09-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体 |
| JP2019069946A (ja) * | 2010-08-23 | 2019-05-09 | シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． | Ｃｘｃｒ２モジュレーターとしてのアミノピリジンカルボキサミドおよびアミノピリミジンカルボキサミド |
| USRE48547E1 (en) | 2010-08-23 | 2021-05-11 | Syntrix Biosystems Inc. | Aminopyrimidinecarboxamides as CXCR2 modulators |
| JP2014516989A (ja) * | 2011-05-31 | 2014-07-17 | ニューゲン セラピューティクス， インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
| US11248013B2 (en) | 2011-05-31 | 2022-02-15 | Rakovina Therapeutics Inc. | Tricyclic inhibitors of poly(ADP-ribose)polymerase |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2049124A2 (en) | 2009-04-22 |
| WO2008010985A2 (en) | 2008-01-24 |
| AU2007275743A1 (en) | 2008-01-24 |
| CA2657288A1 (en) | 2008-01-24 |
| US20090270351A1 (en) | 2009-10-29 |
| WO2008010985A3 (en) | 2008-04-03 |
| EP2049124A4 (en) | 2010-02-10 |
| US7981874B2 (en) | 2011-07-19 |
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