JP2009543874A - チアゾリジノン誘導体 - Google Patents

チアゾリジノン誘導体 Download PDF

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Publication number
JP2009543874A
JP2009543874A JP2009520840A JP2009520840A JP2009543874A JP 2009543874 A JP2009543874 A JP 2009543874A JP 2009520840 A JP2009520840 A JP 2009520840A JP 2009520840 A JP2009520840 A JP 2009520840A JP 2009543874 A JP2009543874 A JP 2009543874A
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JP
Japan
Prior art keywords
leukemia
subject
compound
cells
tdzd
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JP2009520840A
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English (en)
Japanese (ja)
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JP2009543874A5 (cg-RX-API-DMAC7.html
Inventor
クレイグ ジョーダン，
モニカ グスマン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
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University of Rochester
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Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of JP2009543874A publication Critical patent/JP2009543874A/ja
Publication of JP2009543874A5 publication Critical patent/JP2009543874A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009520840A 2006-07-18 2007-07-18 チアゾリジノン誘導体 Pending JP2009543874A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83189306P 2006-07-18 2006-07-18
PCT/US2007/016391 WO2008011113A2 (en) 2006-07-18 2007-07-18 Thiadiazolidinone derivatives

Publications (2)

Publication Number Publication Date
JP2009543874A true JP2009543874A (ja) 2009-12-10
JP2009543874A5 JP2009543874A5 (cg-RX-API-DMAC7.html) 2011-09-01

Family

ID=38957376

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009520840A Pending JP2009543874A (ja) 2006-07-18 2007-07-18 チアゾリジノン誘導体

Country Status (7)

Country Link
US (2) US9180118B2 (cg-RX-API-DMAC7.html)
EP (1) EP2043633B1 (cg-RX-API-DMAC7.html)
JP (1) JP2009543874A (cg-RX-API-DMAC7.html)
AU (1) AU2007275686B2 (cg-RX-API-DMAC7.html)
CA (1) CA2658263A1 (cg-RX-API-DMAC7.html)
NZ (1) NZ574619A (cg-RX-API-DMAC7.html)
WO (1) WO2008011113A2 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016060741A (ja) * 2014-09-12 2016-04-25 国立大学法人 鹿児島大学 成人ｔ細胞白血病治療薬
JP2017523141A (ja) * 2014-06-12 2017-08-17 シーダーズ−サイナイ メディカル センター がん治療のための組成物及び方法
JP2022169593A (ja) * 2016-07-14 2022-11-09 ミングサイト ファーマシューティカルズ，インク． 癌の処置

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007275686B2 (en) * 2006-07-18 2013-10-31 University Of Rochester Thiadiazolidinone derivatives
JP2011505336A (ja) * 2007-11-01 2011-02-24 セルジーン コーポレイション 骨髄異形成症候群治療のためのシチジンアナログ
US20090117090A1 (en) * 2007-11-01 2009-05-07 Ottawa Heart Institute Research Corporation Inhibition of glycogen synthase kinase 3 beta in arterial repair and stent re-endothelialization
WO2011151359A1 (en) * 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
EP3046560B1 (en) * 2013-09-18 2021-01-06 EpiAxis Therapeutics Pty Ltd Stem cell modulation ii
WO2016149464A1 (en) 2015-03-17 2016-09-22 Regeneron Pharmaceuticals, Inc. Amino acid acylation reagents and methods of using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11335298A (ja) * 1997-12-16 1999-12-07 Sankyo Co Ltd 白血病治療剤
JP2003532708A (ja) * 2000-05-11 2003-11-05 コンセホ・スペリオル・インヴェスティガシオンズ・シエンティフィカス グリコーゲンシンターゼキナーゼｇｓｋ−３の複素環インヒビター
WO2006024699A1 (en) * 2004-08-30 2006-03-09 Karyon-Ctt Ltd Thioxothiazolidinone compounds for use as pharmaceuticals

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999030739A1 (en) 1997-12-16 1999-06-24 Sankyo Company, Limited Leukemia remedy
AU2001248365A1 (en) 2000-03-23 2001-10-03 Mitsubishi Pharma Corporation 2-(arylalkylamino)pyrimidone derivatives and 2-(heteroarylalkylamino)pyrimidone derivatives
CA2408747C (en) 2000-05-11 2011-04-05 Consejo Superior Investigaciones Cientificas Heterocyclic inhibitors of glycogen synthase kinase gsk-3
EP1586318A1 (en) * 2004-04-05 2005-10-19 Neuropharma S.A.U. Thiadiazolidinones as GSK-3 inhibitors
WO2006045581A1 (en) * 2004-10-21 2006-05-04 Neuropharma, S.A. The use of 1, 2, 4-thiadiazolidine-3, 5-diones as ppar activators
US20060204980A1 (en) * 2004-12-28 2006-09-14 Altieri Dario C Colorectal cancer therapies
US20070196514A1 (en) * 2006-02-21 2007-08-23 Benyi Li Prostate cancer treatment with glycogen synthase kinase-3beta inhibitors
AU2007275686B2 (en) * 2006-07-18 2013-10-31 University Of Rochester Thiadiazolidinone derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11335298A (ja) * 1997-12-16 1999-12-07 Sankyo Co Ltd 白血病治療剤
JP2003532708A (ja) * 2000-05-11 2003-11-05 コンセホ・スペリオル・インヴェスティガシオンズ・シエンティフィカス グリコーゲンシンターゼキナーゼｇｓｋ−３の複素環インヒビター
WO2006024699A1 (en) * 2004-08-30 2006-03-09 Karyon-Ctt Ltd Thioxothiazolidinone compounds for use as pharmaceuticals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6012054005; Ｇｈｏｓｈ　ＪＣ　ｅｔ　ａｌ．: 'Ａｃｔｉｖａｔｉｏｎ　ｏｆ　ｐ５３-ｄｅｐｅｎｄｅｎｔ　ａｐｏｐｔｏｓｉｓ　ｂｙ　ａｃｕｔｅ　ａｂｌａｔｉｏｎ　ｏｆ　ｇｌｙｃｏｇｅｎ　ｓｙｎｔｈａｓｅ　ｋｉｎａｓｅ-３ｂｅｔａ　ｉｎ　ｃｏｌｏｒｅｃ' Ｃｌｉｎ　Ｃａｎｃｅｒ　Ｒｅｓ １１（１２）, 20050615, ４５８０-８ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017523141A (ja) * 2014-06-12 2017-08-17 シーダーズ−サイナイ メディカル センター がん治療のための組成物及び方法
JP2016060741A (ja) * 2014-09-12 2016-04-25 国立大学法人 鹿児島大学 成人ｔ細胞白血病治療薬
JP2022169593A (ja) * 2016-07-14 2022-11-09 ミングサイト ファーマシューティカルズ，インク． 癌の処置

Also Published As

Publication number Publication date
US20160058741A1 (en) 2016-03-03
CA2658263A1 (en) 2008-01-24
AU2007275686A1 (en) 2008-01-24
NZ574619A (en) 2012-03-30
AU2007275686B2 (en) 2013-10-31
WO2008011113A3 (en) 2008-02-28
WO2008011113A2 (en) 2008-01-24
US20100063109A1 (en) 2010-03-11
EP2043633A4 (en) 2009-11-25
US9180118B2 (en) 2015-11-10
EP2043633B1 (en) 2016-07-06
EP2043633A2 (en) 2009-04-08

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