JP2009543771A - 医薬化合物 - Google Patents
医薬化合物 Download PDFInfo
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- JP2009543771A JP2009543771A JP2009518968A JP2009518968A JP2009543771A JP 2009543771 A JP2009543771 A JP 2009543771A JP 2009518968 A JP2009518968 A JP 2009518968A JP 2009518968 A JP2009518968 A JP 2009518968A JP 2009543771 A JP2009543771 A JP 2009543771A
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- C—CHEMISTRY; METALLURGY
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- C07—ORGANIC CHEMISTRY
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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- C07D513/04—Ortho-condensed systems
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| PCT/GB2007/002655 WO2008007123A2 (en) | 2006-07-14 | 2007-07-13 | Pharmaceutical compounds |
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| JP2009543771A true JP2009543771A (ja) | 2009-12-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2016504395A (ja) * | 2013-01-08 | 2016-02-12 | シャンハイ フォーサン ファーマシューティカル ディベロップメント カンパニー リミテッド | 多環式置換ピラゾールキナーゼ活性阻害剤及びその用途 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ544756A (en) | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US9486441B2 (en) | 2008-04-21 | 2016-11-08 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| WO2010150245A1 (en) * | 2009-06-24 | 2010-12-29 | Tikun Olam Ltd. | Pharmaceutical and cosmeceutical compositions containing cannabis flower and seed extracts |
| ES2689177T3 (es) | 2010-04-13 | 2018-11-08 | Novartis Ag | Combinación que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (CDK4/6) y un inhibidor de mTOR para tratar cáncer |
| WO2014091265A1 (en) | 2012-12-11 | 2014-06-19 | Aurigene Discovery Technologies Limited | Pyrimidine-2,4-diamine derivatives as kinase inhibitors |
| US20140199728A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| EP3310783B1 (en) * | 2015-06-18 | 2020-11-04 | Ting Therapeutics LLC | Compositions for the prevention of hearing loss |
| CN107686477B (zh) * | 2017-09-30 | 2020-01-31 | 武汉九州钰民医药科技有限公司 | 作为cdk4/6抑制剂的新型化合物及其应用 |
| US11440912B2 (en) | 2017-10-27 | 2022-09-13 | Fresenius Kabi Oncology Ltd | Process for the preparation of ribociclib and its salts |
| CN112041307B (zh) | 2018-02-06 | 2024-02-09 | 伊利诺伊大学评议会 | 作为选择性雌激素受体降解剂的取代的苯并噻吩类似物 |
| CN108558745A (zh) * | 2018-05-17 | 2018-09-21 | 苏州莱克施德药业有限公司 | 一种帕博西林中间体的合成方法 |
| WO2020150545A1 (en) * | 2019-01-17 | 2020-07-23 | Samumed, Llc | Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway |
| US11216742B2 (en) | 2019-03-04 | 2022-01-04 | Iocurrents, Inc. | Data compression and communication using machine learning |
Family Cites Families (21)
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| US4282361A (en) * | 1978-03-16 | 1981-08-04 | Massachusetts Institute Of Technology | Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines |
| JPS6425763A (en) * | 1987-04-24 | 1989-01-27 | Mitsubishi Chem Ind | Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient |
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US5502068A (en) * | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
| US6066738A (en) * | 1996-01-30 | 2000-05-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| EP1264820A4 (en) * | 2000-03-14 | 2004-09-15 | Fujisawa Pharmaceutical Co | amide compounds |
| US6455559B1 (en) * | 2001-07-19 | 2002-09-24 | Pharmacia Italia S.P.A. | Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Il−6産生阻害剤 |
| US7169797B2 (en) * | 2003-02-14 | 2007-01-30 | Abbott Laboratories | Protein-tyrosine phosphatase inhibitors and uses thereof |
| US7320989B2 (en) * | 2003-02-28 | 2008-01-22 | Encysive Pharmaceuticals, Inc. | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists |
| NZ544756A (en) * | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| WO2006077424A1 (en) * | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| AR054425A1 (es) * | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| JP2008528469A (ja) * | 2005-01-21 | 2008-07-31 | アステックス・セラピューティクス・リミテッド | ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤 |
| US20080139620A1 (en) * | 2005-01-21 | 2008-06-12 | Astex Therapeutics Limited | Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's |
| WO2006077428A1 (en) * | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US20090142337A1 (en) * | 2006-05-08 | 2009-06-04 | Astex Therapeutics Limited | Pharmaceutical Combinations of Diazole Derivatives for Cancer Treatment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016504395A (ja) * | 2013-01-08 | 2016-02-12 | シャンハイ フォーサン ファーマシューティカル ディベロップメント カンパニー リミテッド | 多環式置換ピラゾールキナーゼ活性阻害剤及びその用途 |
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| EP2049516A2 (en) | 2009-04-22 |
| US20100004243A1 (en) | 2010-01-07 |
| WO2008007123A2 (en) | 2008-01-17 |
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| Publication | Publication Date | Title |
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