JP2009542225A5 - - Google Patents

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Publication number
JP2009542225A5
JP2009542225A5 JP2009518576A JP2009518576A JP2009542225A5 JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5 JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009518576 A JP2009518576 A JP 2009518576A JP 2009542225 A5 JP2009542225 A5 JP 2009542225A5
Authority
JP
Japan
Prior art keywords
factor viii
protein
phenylalanine
serine
substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009518576A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009542225A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/072506 external-priority patent/WO2008005847A2/en
Publication of JP2009542225A publication Critical patent/JP2009542225A/ja
Publication of JP2009542225A5 publication Critical patent/JP2009542225A5/ja
Pending legal-status Critical Current

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JP2009518576A 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法 Pending JP2009542225A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81817706P 2006-06-30 2006-06-30
PCT/US2007/072506 WO2008005847A2 (en) 2006-06-30 2007-06-29 Method of producing factor viii proteins by recombinant methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013161261A Division JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Publications (2)

Publication Number Publication Date
JP2009542225A JP2009542225A (ja) 2009-12-03
JP2009542225A5 true JP2009542225A5 (zh) 2013-09-19

Family

ID=38895363

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009518576A Pending JP2009542225A (ja) 2006-06-30 2007-06-29 組換え法によりｆｖｉｉｉタンパク質を生産する方法
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013161261A Pending JP2014000080A (ja) 2006-06-30 2013-08-02 組換え法によりｆｖｉｉｉタンパク質を生産する方法

Country Status (6)

Country Link
US (2) US20080070251A1 (zh)
EP (2) EP2035572A4 (zh)
JP (2) JP2009542225A (zh)
AU (1) AU2007269233B2 (zh)
CA (1) CA2656558A1 (zh)
WO (1) WO2008005847A2 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
US20120028900A1 (en) * 2006-06-30 2012-02-02 Kaufman Randal J Method of producing factor viii proteins by recombinant methods
EP2714909A4 (en) * 2011-06-03 2014-12-17 Univ Michigan PROCESS FOR PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT PROCESSES
WO2013057219A1 (en) 2011-10-18 2013-04-25 Csl Behring Gmbh Method for improving the stability of purified factor viii after reconstitution
CN104411323A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的药物组合物
CA2904125C (en) * 2013-03-12 2022-06-07 Cmc Icos Biologics, Inc. Improved recombinant protein expression using a hybrid chef1 promoter
CN105209488A (zh) * 2013-03-15 2015-12-30 拜耳医药保健有限公司 变体因子viii多肽及其产生和使用方法
CA2929149A1 (en) 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Improved recombinant polypeptide production methods
WO2015091130A1 (en) * 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Method for improving the recombinant production of soluble fusion polypeptides
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
MX2016012428A (es) * 2014-03-23 2017-04-27 Advantech Bioscience Farmacêutica Ltda Aumento de la expresion de proteina recombinante con cobre.
CA2944349A1 (en) 2014-04-01 2015-10-08 Advantech Bioscience Farmaceutica Ltda. Stable factor viii formulations with low sugar-glycine
AU2015240354A1 (en) 2014-04-01 2016-11-17 Advantech Bioscience Farmaceutica Ltda. Stabilization of Factor VIII without calcium as an excipient
JP6800863B2 (ja) * 2015-02-06 2020-12-16 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 最適化されたヒト凝固第ｖｉｉｉ因子遺伝子発現カセットおよびその使用
RU2020124105A (ru) 2015-06-24 2020-09-18 Ф. Хоффманн-Ля Рош Аг Антитела против трансферринового рецептора, обладающие индивидуализированной аффинностью
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
CR20180149A (es) 2015-10-02 2018-04-05 Hoffmann La Roche Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso
EP3476860A4 (en) * 2016-06-24 2020-01-22 Mogam Institute for Biomedical Research RECOMBINANT SINGLE CHAIN FVIII AND CHEMICAL CONJUGATE THEREOF
WO2024110426A1 (en) 2022-11-23 2024-05-30 F. Hoffmann-La Roche Ag Method for increasing recombinant protein expression

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ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4599308A (en) * 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US5214033A (en) * 1983-03-31 1993-05-25 Scripps Clinic & Research Foundation Factor VIII coagulant polypeptides
US4745051A (en) * 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US5045455A (en) * 1984-01-12 1991-09-03 Chiron Corporation Factor VIII:C cDNA cloning and expression
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4745057A (en) * 1984-05-18 1988-05-17 Eli Lilly And Company Method, vectors and transformants for high expression of heterologous polypeptides in yeast
US4577729A (en) * 1984-12-05 1986-03-25 Westinghouse Electric Corp. Guide rail clamping assembly
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US4761371A (en) * 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
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US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
DE3785102T2 (de) 1986-01-03 1993-07-22 Genetics Inst Verfahren zur herstellung von faktor-viii:c-typ-proteinen.
AT388079B (de) 1986-04-18 1989-04-25 Helmut Ing Koenig Backofen
US5451521A (en) 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
US5422260A (en) * 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US4877729A (en) 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1331157C (en) 1987-04-06 1994-08-02 Randal J. Kaufman Method for producing factor viii:c-type proteins
US5004803A (en) * 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US5563045A (en) * 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
US20040092442A1 (en) * 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
DE69740154D1 (de) * 1996-04-24 2011-05-05 Univ Michigan Gegen Inaktivierung resistenter Faktor VIII
US5838437A (en) * 1997-04-09 1998-11-17 Micron Optics, Inc. Reference system for optical devices including optical scanners and spectrum analyzers
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
US5888809A (en) * 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
WO1999046299A1 (en) * 1998-03-12 1999-09-16 Genetics Institute, Inc. Improved methods for producing factor viii proteins
US7041635B2 (en) * 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
CA2703948A1 (en) * 2007-11-01 2009-05-07 University Of Rochester Recombinant factor viii having increased stability

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