EP2714909A4 - Method of producing factor viii proteins by recombinant methods - Google Patents
Method of producing factor viii proteins by recombinant methodsInfo
- Publication number
- EP2714909A4 EP2714909A4 EP12796718.0A EP12796718A EP2714909A4 EP 2714909 A4 EP2714909 A4 EP 2714909A4 EP 12796718 A EP12796718 A EP 12796718A EP 2714909 A4 EP2714909 A4 EP 2714909A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- factor viii
- recombinant methods
- producing factor
- viii proteins
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/153,040 US20120028900A1 (en) | 2006-06-30 | 2011-06-03 | Method of producing factor viii proteins by recombinant methods |
PCT/US2012/040376 WO2012170289A1 (en) | 2011-06-03 | 2012-06-01 | Method of producing factor viii proteins by recombinant methods |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2714909A1 EP2714909A1 (en) | 2014-04-09 |
EP2714909A4 true EP2714909A4 (en) | 2014-12-17 |
Family
ID=47296374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12796718.0A Withdrawn EP2714909A4 (en) | 2011-06-03 | 2012-06-01 | Method of producing factor viii proteins by recombinant methods |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2714909A4 (en) |
CA (1) | CA2837995A1 (en) |
WO (1) | WO2012170289A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10370431B2 (en) | 2013-02-15 | 2019-08-06 | Bioverativ Therapeutics Inc. | Optimized factor VIII gene |
US10308705B2 (en) * | 2015-02-06 | 2019-06-04 | The University Of North Carolina At Chapel Hill | Optimized human clotting factor VIII gene expression cassettes and their use |
KR20180038448A (en) * | 2015-08-06 | 2018-04-16 | 글리코토페 게엠베하 | Heteromers including antibody domain fusion proteins |
MX2018009375A (en) | 2016-02-01 | 2018-09-05 | Bioverativ Therapeutics Inc | Optimized factor viii genes. |
US11299533B2 (en) | 2017-06-23 | 2022-04-12 | Takeda Pharmaceutical Company Limited | Purification of factor VIII subspecies |
US20220033475A1 (en) * | 2018-10-23 | 2022-02-03 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor viii function |
EP3785726A1 (en) * | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
CN114391024A (en) * | 2019-09-02 | 2022-04-22 | 生物测试股份公司 | Factor VIII proteins with increased half-life |
CN117192132B (en) * | 2023-11-03 | 2024-02-02 | 庄亚(北京)生物科技有限公司 | vWF fragment residue detection kit and method |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008005847A2 (en) * | 2006-06-30 | 2008-01-10 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
-
2012
- 2012-06-01 CA CA2837995A patent/CA2837995A1/en not_active Abandoned
- 2012-06-01 WO PCT/US2012/040376 patent/WO2012170289A1/en active Application Filing
- 2012-06-01 EP EP12796718.0A patent/EP2714909A4/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008005847A2 (en) * | 2006-06-30 | 2008-01-10 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
Non-Patent Citations (4)
Title |
---|
KERRY L. DOORISS ET AL: "Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A", HUMAN GENE THERAPY, vol. 20, no. 5, 1 May 2009 (2009-05-01), pages 465 - 478, XP055136766, ISSN: 1043-0342, DOI: 10.1089/hum.2008.150 * |
MIAO HONGZHI Z ET AL: "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 103, no. 9, 1 May 2004 (2004-05-01), pages 3412 - 3419, XP002452857, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2003-10-3591 * |
N. J. WARD ET AL: "Codon optimization of human factor VIII cDNAs leads to high-level expression", BLOOD, vol. 117, no. 3, 20 January 2011 (2011-01-20), pages 798 - 807, XP055052195, ISSN: 0006-4971, DOI: 10.1182/blood-2010-05-282707 * |
See also references of WO2012170289A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012170289A1 (en) | 2012-12-13 |
EP2714909A1 (en) | 2014-04-09 |
CA2837995A1 (en) | 2012-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20131216 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CANGENE CORPORATION Owner name: THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20141117 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 38/37 20060101ALI20141111BHEP Ipc: C07K 14/755 20060101ALI20141111BHEP Ipc: C12Q 1/68 20060101ALI20141111BHEP Ipc: A61P 7/04 20060101ALI20141111BHEP Ipc: C12N 15/12 20060101AFI20141111BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20150616 |