JP2009541288A - 放射性標識方法 - Google Patents

放射性標識方法 Download PDF

Info

Publication number
JP2009541288A
JP2009541288A JP2009515955A JP2009515955A JP2009541288A JP 2009541288 A JP2009541288 A JP 2009541288A JP 2009515955 A JP2009515955 A JP 2009515955A JP 2009515955 A JP2009515955 A JP 2009515955A JP 2009541288 A JP2009541288 A JP 2009541288A
Authority
JP
Japan
Prior art keywords
formula
compound
vector
peptide
following formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009515955A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009541288A5 (enExample
Inventor
グレイサー，マティアス・エバーハード
アースタッド，エリック
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hammersmith Imanet Ltd
Original Assignee
Hammersmith Imanet Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hammersmith Imanet Ltd filed Critical Hammersmith Imanet Ltd
Publication of JP2009541288A publication Critical patent/JP2009541288A/ja
Publication of JP2009541288A5 publication Critical patent/JP2009541288A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009515955A 2006-06-21 2007-06-20 放射性標識方法 Pending JP2009541288A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80536906P 2006-06-21 2006-06-21
PCT/GB2007/002303 WO2007148089A2 (en) 2006-06-21 2007-06-20 Radiolabelling methods

Publications (2)

Publication Number Publication Date
JP2009541288A true JP2009541288A (ja) 2009-11-26
JP2009541288A5 JP2009541288A5 (enExample) 2010-07-08

Family

ID=38457685

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009515955A Pending JP2009541288A (ja) 2006-06-21 2007-06-20 放射性標識方法

Country Status (5)

Country Link
US (3) US8211403B2 (enExample)
EP (1) EP2029179A2 (enExample)
JP (1) JP2009541288A (enExample)
CN (1) CN101472614A (enExample)
WO (1) WO2007148089A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013513578A (ja) * 2009-12-10 2013-04-22 ジーイー・ヘルスケア・リミテッド ヨウ素放射性標識法
JP2017160163A (ja) * 2016-03-09 2017-09-14 ダイキン工業株式会社 ニトリルオキシド化合物

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009109798A2 (en) 2008-03-07 2009-09-11 Universität Ulm Precursors of lipid metabolism for the diagnosis and treatment of cancer
GB0914543D0 (en) * 2009-08-20 2009-09-30 Ge Healthcare Ltd Radioiodination method
FR2951449B1 (fr) * 2009-10-15 2011-11-25 Commissariat Energie Atomique Procede de fonctionnalisation de molecules biologiques
GB0922304D0 (en) 2009-12-22 2010-02-03 Ge Healthcare Ltd Radioiodinated compounds
GB201019824D0 (en) 2010-11-23 2011-01-05 Ge Healthcare Ltd Radioiodination method
GB201021369D0 (en) 2010-12-16 2011-01-26 Ge Healthcare Ltd Radioiodinated fatty acids
GB201021517D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Radioiodinated guanidines
US20160022846A1 (en) * 2014-07-22 2016-01-28 Ge Healthcare Limited Iodine radiolabelling method
DE102014112747A1 (de) 2014-09-04 2016-03-10 Eberhard Karls Universität Tübingen Medizinische Fakultät Verwendung eines Quinoxalinderivats in einem bildgebenden Verfahren
DE102017103600A1 (de) 2017-02-22 2018-08-23 Eberhard Karls Universität Tübingen Medizinische Fakultät Radioaktiv markiertes beta-Galactosidase Substrat für PET Bildgebung der Seneszenz
DE102023106170A1 (de) 2023-03-13 2024-09-19 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Neue Generation von Seneszenz-Tracern

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004055160A2 (en) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
WO2004080492A1 (en) * 2003-03-13 2004-09-23 Amersham Health As Methods of radiofluorination of biologically active vectors
JP2005507376A (ja) * 2001-07-10 2005-03-17 アメルシャム ヘルス アクスイェ セルスカプ ペプチドベースの化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7375234B2 (en) 2002-05-30 2008-05-20 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
WO2006017619A2 (en) 2004-08-06 2006-02-16 The Regents Of The University Of California Receptor-binding cyclic peptides and methods of use
GB0428012D0 (en) * 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
KR20080000620A (ko) 2005-04-27 2008-01-02 지멘스 메디컬 솔루션즈 유에스에이, 인크. 분자 이미징 프로브를 합성하기 위한 클릭 화학 방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005507376A (ja) * 2001-07-10 2005-03-17 アメルシャム ヘルス アクスイェ セルスカプ ペプチドベースの化合物
WO2004055160A2 (en) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
WO2004080492A1 (en) * 2003-03-13 2004-09-23 Amersham Health As Methods of radiofluorination of biologically active vectors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HANSEN TV ET AL, J ORG CHEM, vol. 70, JPN6012055135, 2005, pages 7761 - 4, ISSN: 0002361838 *
HU Y ET AL, TETRAHEDRON, vol. 56, JPN6012055137, 2000, pages 8239 - 43, ISSN: 0002361840 *
PEREZ-BALDERAS F ET AL, TETRAHEDRON, vol. 61, JPN6012055136, 2005, pages 9338 - 48, ISSN: 0002361839 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013513578A (ja) * 2009-12-10 2013-04-22 ジーイー・ヘルスケア・リミテッド ヨウ素放射性標識法
JP2016028096A (ja) * 2009-12-10 2016-02-25 ジーイー・ヘルスケア・リミテッド ヨウ素放射性標識法
JP2017160163A (ja) * 2016-03-09 2017-09-14 ダイキン工業株式会社 ニトリルオキシド化合物

Also Published As

Publication number Publication date
EP2029179A2 (en) 2009-03-04
US20130224835A1 (en) 2013-08-29
US8211403B2 (en) 2012-07-03
CN101472614A (zh) 2009-07-01
WO2007148089A3 (en) 2008-03-06
US20100040550A1 (en) 2010-02-18
WO2007148089A2 (en) 2007-12-27
US20120282171A1 (en) 2012-11-08
US8409547B2 (en) 2013-04-02

Similar Documents

Publication Publication Date Title
JP5743372B2 (ja) 放射性標識法
US8409547B2 (en) Radiolabelling methods
EP2680889B1 (en) Radiolabelled octreotate analogues as pet tracers
JP5860808B2 (ja) 放射性ヨウ素化方法
AU2014225381B2 (en) Vinylsulfone-based 18f-labeling compositions and methods and uses thereof
US8216548B2 (en) Radiofluorination methods
EP4696686A1 (en) Fapi theranostic compounds assembled with tetrazine ligation
US20080213174A1 (en) Radiolabelled Insulin
AU2013204443A1 (en) Radiolabelling methods

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100518

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100518

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20100518

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20100518

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121023

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130123

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130423

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130827