JP2009537518A - ３，４−二置換クマリン及びキノロン化合物 - Google Patents

３，４−二置換クマリン及びキノロン化合物 Download PDF

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Publication number
JP2009537518A
JP2009537518A JP2009510932A JP2009510932A JP2009537518A JP 2009537518 A JP2009537518 A JP 2009537518A JP 2009510932 A JP2009510932 A JP 2009510932A JP 2009510932 A JP2009510932 A JP 2009510932A JP 2009537518 A JP2009537518 A JP 2009537518A
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alkyl
aryl
heteroaryl
cycloalkyl
aralkyl
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English (en)
Japanese (ja)
Inventor
シュ，ビン
チュウ，チャン
チョ，ヒュン−ジュン
ファティ，レザ
ヤン，チェン
サンドラサグラ，アンソニー
リュー，イーシン
Original Assignee
エックスティーエル バイオファーマシューティカルズ，リミテッド
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Publication of JP2009537518A publication Critical patent/JP2009537518A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009510932A 2006-05-15 2006-05-15 ３，４−二置換クマリン及びキノロン化合物 Pending JP2009537518A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/018857 WO2007133211A1 (en) 2006-05-15 2006-05-15 3,4-disubstituted coumarin and quinolone compounds

Publications (1)

Publication Number Publication Date
JP2009537518A true JP2009537518A (ja) 2009-10-29

Family

ID=38694184

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009510932A Pending JP2009537518A (ja) 2006-05-15 2006-05-15 ３，４−二置換クマリン及びキノロン化合物

Country Status (5)

Country Link
EP (1) EP2028938A4 (de)
JP (1) JP2009537518A (de)
AU (1) AU2006343604A1 (de)
CA (1) CA2694955A1 (de)
WO (1) WO2007133211A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090312406A1 (en) * 2008-06-12 2009-12-17 Hsing-Pang Hsieh Coumarin compounds and their use for treating viral infection
AU2014216178B2 (en) 2013-02-15 2018-06-28 KALA BIO, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
EP2958895B1 (de) 2013-02-20 2020-08-19 Kala Pharmaceuticals, Inc. Therapeutische verbindungen und verwendungen davon
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106061261B (zh) 2013-11-01 2018-04-24 卡拉制药公司 治疗化合物的结晶形式及其用途
EP3509421A4 (de) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. Kristalline formen therapeutischer verbindungen und verwendungen davon
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500739A (ja) * 1995-10-13 2000-01-25 アグレボ・ユー・ケイ・リミテツド 複素環式殺菌剤
JP2000511920A (ja) * 1996-06-11 2000-09-12 ヘキスト マリオン ルセル リボースで置換された新規な芳香族誘導体、それらの製造方法及び医薬としての利用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992017452A1 (en) * 1991-04-03 1992-10-15 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives
US7148253B2 (en) * 2002-05-14 2006-12-12 Xtl Biopharmaceuticals Ltd. 4-thio coumarins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000500739A (ja) * 1995-10-13 2000-01-25 アグレボ・ユー・ケイ・リミテツド 複素環式殺菌剤
JP2000511920A (ja) * 1996-06-11 2000-09-12 ヘキスト マリオン ルセル リボースで置換された新規な芳香族誘導体、それらの製造方法及び医薬としての利用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6012030681; ＭＡＪＵＭＤＡＲ，Ｋ．Ｃ．　ｅｔ　ａｌ: 'Ｐｈａｓｅ　ｔｒａｎｓｆｅｒ-ｃａｔａｌｙｚｅｄ　ａｌｋｙｌａｔｉｏｎ　ｏｆ　４-ｈｙｄｒｏｘｙｃｏｕｍａｒｉｎ．　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　alpha，alpha-ｄｉｓｕｂｓｔｉｔｕｔｅｄ　ｏ-ｈｙｄｒｏｘｙ' Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ，　Ｓｅｃｔｉｏｎ　Ｂ：　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ　Ｉｎｃｌｕｄｉｎｇ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２９Ｂ，　Ｎｏ．５, 1990, ｐ．４８３-４８５ *
JPN6012030682; ＥＲＭＩＬＩ，Ａ．　ｅｔ　ａｌ: 'Ｌａ　ｒｅａｚｉｏｎｅ　ｄｉ　Ｖｉｌｓｍｅｉｅｒ　-　Ｈａａｃｋ　ａｐｐｌｉｃａｔａ　ａｌｌｅ　Ｎ，Ｎ-ｄｉａｌｃｈｉｌｅｔｏｓｓｉｃａｒｂｏｎｙｌａｃｅｔａｍｍｉｄｉ．　-　Ｎｏｔａ　ＩＩＩ．　Ｄｅ' Ａｎｎａｌｉ　ｄｉ　Ｃｈｉｍｉｃａ（Ｒｏｍｅ，　Ｉｔａｌｙ） Ｖｏｌ．６２，　Ｎｏ．６, 1972, ｐ．４５８-４６８ *
JPN6012030683; ＩＴＯ，Ｋ．　ｅｔ　ａｌ: 'Ｐｈｏｔｏｒｅａｃｔｉｏｎｓ　ｏｆ　４-　ａｎｄ　３-ａｚｉｄｏｃｏｕｍａｒｉｎｓ　ｉｎ　ｔｈｅ　ｐｒｅｓｅｎｃｅ　ｏｆ　ｎｕｃｌｅｏｐｈｉｌｅｓ' Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．３５，　Ｎｏ．２, 1993, ｐ．９３７-９４７ *
JPN6012030684; ＲＯＳＳＩ，Ｅ．　ｅｔ　ａｌ: 'Ｍｅｄｒｏｘｙｐｒｏｇｅｓｔｅｒｏｎｅ　ａｃｅｔａｔｅ　（ＭＰＡ）　ｉｎ　ｈｕｍａｎ　ｐｌａｓｍａ' Ｃｈｒｏｍａｔｏｇｒａｐｈｙ　Ｓｙｍｐｏｓｉａ　Ｓｅｒｉｅｓ Ｖｏｌ．１, 1979, ｐ．９５-１０３ *

Also Published As

Publication number Publication date
WO2007133211A1 (en) 2007-11-22
EP2028938A4 (de) 2010-07-07
CA2694955A1 (en) 2007-11-22
AU2006343604A1 (en) 2007-11-22
EP2028938A1 (de) 2009-03-04

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