JP2009536967A - 高眼圧症状治療に有用なイソチアゾリジン類 - Google Patents

高眼圧症状治療に有用なイソチアゾリジン類 Download PDF

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Publication number
JP2009536967A
JP2009536967A JP2009511159A JP2009511159A JP2009536967A JP 2009536967 A JP2009536967 A JP 2009536967A JP 2009511159 A JP2009511159 A JP 2009511159A JP 2009511159 A JP2009511159 A JP 2009511159A JP 2009536967 A JP2009536967 A JP 2009536967A
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Japan
Prior art keywords
compound according
compound
carbon atoms
another embodiment
phenyl
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JP2009511159A
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English (en)
Japanese (ja)
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JP2009536967A5 (enExample
Inventor
ロバート エム バーク
ディヴィッド ダブリュー オールド
トッド エス ガック
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Allergan Inc
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Allergan Inc
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Publication of JP2009536967A publication Critical patent/JP2009536967A/ja
Publication of JP2009536967A5 publication Critical patent/JP2009536967A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009511159A 2006-05-12 2007-05-09 高眼圧症状治療に有用なイソチアゾリジン類 Pending JP2009536967A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74711506P 2006-05-12 2006-05-12
US11/745,317 US7557095B2 (en) 2006-05-12 2007-05-07 Therapeutic compounds
PCT/US2007/068518 WO2007134085A2 (en) 2006-05-12 2007-05-09 Isothiazolidines useful in the treatment of ocular hypertensive conditions

Publications (2)

Publication Number Publication Date
JP2009536967A true JP2009536967A (ja) 2009-10-22
JP2009536967A5 JP2009536967A5 (enExample) 2010-06-24

Family

ID=38606676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009511159A Pending JP2009536967A (ja) 2006-05-12 2007-05-09 高眼圧症状治療に有用なイソチアゾリジン類

Country Status (7)

Country Link
US (2) US7557095B2 (enExample)
EP (1) EP2044041A2 (enExample)
JP (1) JP2009536967A (enExample)
AU (1) AU2007249443B2 (enExample)
BR (1) BRPI0711461A2 (enExample)
CA (1) CA2652866A1 (enExample)
WO (1) WO2007134085A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
US8314250B2 (en) * 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
EP2531493B1 (en) 2010-02-01 2015-07-22 Basf Se Substituted ketonic isoxazoline compounds and derivatives for combating animal pests
JP2013540116A (ja) 2010-10-01 2013-10-31 ビーエーエスエフ ソシエタス・ヨーロピア 殺有害生物剤としてのイミン置換−２，４−ジアリール−ピロリン誘導体
AR084486A1 (es) 2010-10-01 2013-05-22 Basf Se Compuestos de imina

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09509652A (ja) * 1994-01-19 1997-09-30 アラーガン 眼圧降下剤としてのｅｐ▲下２▼受容体作動剤
JP2001523721A (ja) * 1997-11-21 2001-11-27 アラーガン・セイルズ・インコーポレイテッド 眼用神経保護剤としてのｅｐ２受容体作動剤
WO2003074483A1 (en) * 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
JP2005509632A (ja) * 2001-10-23 2005-04-14 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ プロスタグランジンｅｐ２及び／又はｅｐ４受容体のリガンドとしてのポリアゾリジノン化合物
JP2005104836A (ja) * 2003-08-08 2005-04-21 Ono Pharmaceut Co Ltd プロスタグランジン誘導体
JP2005517665A (ja) * 2001-12-20 2005-06-16 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ プロスタグランジン調節物質としてのピロリジン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519040A (en) 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
TW401408B (en) 1995-07-21 2000-08-11 Fujisawa Pharmaceutical Co Heterocyclic compounds having prostaglandin I2 agonism
US6465501B2 (en) * 2000-07-17 2002-10-15 Wyeth Azolidines as β3 adrenergic receptor agonists
US6927216B2 (en) * 2000-10-03 2005-08-09 Bristol-Myers Squibb Pharma Company Cyclic sulfonyl compounds as inhibitors of metalloproteases
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09509652A (ja) * 1994-01-19 1997-09-30 アラーガン 眼圧降下剤としてのｅｐ▲下２▼受容体作動剤
JP2001523721A (ja) * 1997-11-21 2001-11-27 アラーガン・セイルズ・インコーポレイテッド 眼用神経保護剤としてのｅｐ２受容体作動剤
JP2005509632A (ja) * 2001-10-23 2005-04-14 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ プロスタグランジンｅｐ２及び／又はｅｐ４受容体のリガンドとしてのポリアゾリジノン化合物
JP2005517665A (ja) * 2001-12-20 2005-06-16 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ プロスタグランジン調節物質としてのピロリジン誘導体
WO2003074483A1 (en) * 2002-03-05 2003-09-12 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
JP2005104836A (ja) * 2003-08-08 2005-04-21 Ono Pharmaceut Co Ltd プロスタグランジン誘導体

Also Published As

Publication number Publication date
BRPI0711461A2 (pt) 2011-11-08
AU2007249443A1 (en) 2007-11-22
AU2007249443B2 (en) 2012-09-27
CA2652866A1 (en) 2007-11-22
US7897629B2 (en) 2011-03-01
WO2007134085A2 (en) 2007-11-22
US7557095B2 (en) 2009-07-07
US20070265321A1 (en) 2007-11-15
US20090247594A1 (en) 2009-10-01
WO2007134085A3 (en) 2008-01-10
EP2044041A2 (en) 2009-04-08

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