AU2007249443B2 - Isothiazolidines useful in the treatment of ocular hypertensive conditions - Google Patents

Isothiazolidines useful in the treatment of ocular hypertensive conditions Download PDF

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Publication number
AU2007249443B2
AU2007249443B2 AU2007249443A AU2007249443A AU2007249443B2 AU 2007249443 B2 AU2007249443 B2 AU 2007249443B2 AU 2007249443 A AU2007249443 A AU 2007249443A AU 2007249443 A AU2007249443 A AU 2007249443A AU 2007249443 B2 AU2007249443 B2 AU 2007249443B2
Authority
AU
Australia
Prior art keywords
compound
compound according
carbon atoms
another embodiment
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007249443A
Other languages
English (en)
Other versions
AU2007249443A1 (en
Inventor
Robert M. Burk
Todd S. Gac
David W. Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2007249443A1 publication Critical patent/AU2007249443A1/en
Application granted granted Critical
Publication of AU2007249443B2 publication Critical patent/AU2007249443B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2007249443A 2006-05-12 2007-05-09 Isothiazolidines useful in the treatment of ocular hypertensive conditions Ceased AU2007249443B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74711506P 2006-05-12 2006-05-12
US60/747,115 2006-05-12
US11/745,317 US7557095B2 (en) 2006-05-12 2007-05-07 Therapeutic compounds
US11/745,317 2007-05-07
PCT/US2007/068518 WO2007134085A2 (en) 2006-05-12 2007-05-09 Isothiazolidines useful in the treatment of ocular hypertensive conditions

Publications (2)

Publication Number Publication Date
AU2007249443A1 AU2007249443A1 (en) 2007-11-22
AU2007249443B2 true AU2007249443B2 (en) 2012-09-27

Family

ID=38606676

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007249443A Ceased AU2007249443B2 (en) 2006-05-12 2007-05-09 Isothiazolidines useful in the treatment of ocular hypertensive conditions

Country Status (7)

Country Link
US (2) US7557095B2 (enExample)
EP (1) EP2044041A2 (enExample)
JP (1) JP2009536967A (enExample)
AU (1) AU2007249443B2 (enExample)
BR (1) BRPI0711461A2 (enExample)
CA (1) CA2652866A1 (enExample)
WO (1) WO2007134085A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
US8314250B2 (en) * 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
KR20120125332A (ko) 2010-02-01 2012-11-14 바스프 에스이 동물 해충을 퇴치하기 위한 치환된 케톤계 이속사졸린 화합물 및 유도체
KR20130143047A (ko) 2010-10-01 2013-12-30 바스프 에스이 살충제로서의 이민 치환된 2,4-디아릴-피롤린 유도체
EP2621897A1 (en) 2010-10-01 2013-08-07 Basf Se Imine compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029904A1 (en) * 1994-04-29 1995-11-09 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
WO1997003973A1 (en) * 1995-07-21 1997-02-06 Fujisawa Pharmaceutical Co., Ltd. 4,5-diaryl oxazole derivatives
US20020032222A1 (en) * 2000-07-17 2002-03-14 American Home Products Corporation Azolidines as beta-3 adrenergic receptor agonists
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462968A (en) * 1994-01-19 1995-10-31 Allergan, Inc. EP2 -receptor agonists as agents for lowering intraocular pressure
US5902726A (en) 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
US5877211A (en) * 1997-11-21 1999-03-02 Allergan EP2 receptor agonists as neuroprotective agents for the eye
US6927216B2 (en) * 2000-10-03 2005-08-09 Bristol-Myers Squibb Pharma Company Cyclic sulfonyl compounds as inhibitors of metalloproteases
AU2002340282B2 (en) * 2001-10-23 2007-08-09 Merck Serono Sa Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors
AU2002358772B2 (en) * 2001-12-20 2008-11-20 Merck Serono Sa Pyrrolidine derivatives as prostaglandin modulators
AU2003211574A1 (en) * 2002-03-05 2003-09-16 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
JP2005104836A (ja) * 2003-08-08 2005-04-21 Ono Pharmaceut Co Ltd プロスタグランジン誘導体
US7557095B2 (en) * 2006-05-12 2009-07-07 Allergan, Inc. Therapeutic compounds
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029904A1 (en) * 1994-04-29 1995-11-09 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
WO1997003973A1 (en) * 1995-07-21 1997-02-06 Fujisawa Pharmaceutical Co., Ltd. 4,5-diaryl oxazole derivatives
US20020032222A1 (en) * 2000-07-17 2002-03-14 American Home Products Corporation Azolidines as beta-3 adrenergic receptor agonists
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents

Also Published As

Publication number Publication date
BRPI0711461A2 (pt) 2011-11-08
US7557095B2 (en) 2009-07-07
AU2007249443A1 (en) 2007-11-22
US20090247594A1 (en) 2009-10-01
WO2007134085A2 (en) 2007-11-22
US7897629B2 (en) 2011-03-01
EP2044041A2 (en) 2009-04-08
WO2007134085A3 (en) 2008-01-10
JP2009536967A (ja) 2009-10-22
CA2652866A1 (en) 2007-11-22
US20070265321A1 (en) 2007-11-15

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired