JP2009536623A5 - - Google Patents
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- Publication number
- JP2009536623A5 JP2009536623A5 JP2009507924A JP2009507924A JP2009536623A5 JP 2009536623 A5 JP2009536623 A5 JP 2009536623A5 JP 2009507924 A JP2009507924 A JP 2009507924A JP 2009507924 A JP2009507924 A JP 2009507924A JP 2009536623 A5 JP2009536623 A5 JP 2009536623A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound
- compound according
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 208000010412 Glaucoma Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 206010030043 Ocular hypertension Diseases 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 230000004410 intraocular pressure Effects 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940054534 ophthalmic solution Drugs 0.000 claims 2
- 239000002997 ophthalmic solution Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- VKDUGMGFBQIQNP-UHFFFAOYSA-N 1-cyclohexyl-6-methylpiperidine-2,4-dione Chemical compound CC1CC(=O)CC(=O)N1C1CCCCC1 VKDUGMGFBQIQNP-UHFFFAOYSA-N 0.000 claims 1
- VRRQHWODKANWJS-UHFFFAOYSA-N 5-chloro-4-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene-1,3-diol Chemical compound CC(=C)C1CCC(C)=CC1C1=C(O)C=C(O)C=C1Cl VRRQHWODKANWJS-UHFFFAOYSA-N 0.000 claims 1
- GHFGFXOHQSQRKU-UHFFFAOYSA-N 5-methyl-4-(4-methyl-1-propan-2-yl-3,6-dihydro-2h-pyridin-6-yl)benzene-1,3-diol Chemical compound CC(C)N1CCC(C)=CC1C1=C(C)C=C(O)C=C1O GHFGFXOHQSQRKU-UHFFFAOYSA-N 0.000 claims 1
- 229940122459 Glutamate antagonist Drugs 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- OGLDWXZKYODSOB-SNVBAGLBSA-N alpha-phellandrene Natural products CC(C)[C@H]1CC=C(C)C=C1 OGLDWXZKYODSOB-SNVBAGLBSA-N 0.000 claims 1
- 125000003067 alpha-phellandrene group Chemical group 0.000 claims 1
- 239000003194 amino acid receptor blocking agent Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 239000000064 cholinergic agonist Substances 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/409,570 US7612101B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US11/409,871 US7618966B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| US11/409,868 US7718830B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
| PCT/US2007/067267 WO2007127711A2 (en) | 2006-04-24 | 2007-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228274A Division JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536623A JP2009536623A (ja) | 2009-10-15 |
| JP2009536623A5 true JP2009536623A5 (enExample) | 2010-06-17 |
Family
ID=38229040
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507924A Pending JP2009536623A (ja) | 2006-04-24 | 2007-04-24 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
| JP2013228274A Pending JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228274A Pending JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7968711B2 (enExample) |
| EP (2) | EP2123264A1 (enExample) |
| JP (2) | JP2009536623A (enExample) |
| AU (1) | AU2007244978B2 (enExample) |
| BR (1) | BRPI0710732A2 (enExample) |
| CA (3) | CA2823767A1 (enExample) |
| WO (1) | WO2007127711A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050282902A1 (en) * | 2004-06-22 | 2005-12-22 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US7618966B2 (en) * | 2006-04-24 | 2009-11-17 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| US20120172339A1 (en) * | 2009-07-10 | 2012-07-05 | Northeastern University | Angiogenic resorcinol derivatives |
| WO2020205867A1 (en) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
| WO2021007661A1 (en) * | 2019-07-12 | 2021-01-21 | Canopy Growth Corporation | Cannabinoid derivatives |
| WO2021046636A1 (en) * | 2019-09-09 | 2021-03-18 | Kare Chemical Technologies Inc. | Cannabinoid derivatives, precursors and uses |
| EP4628481A1 (en) * | 2022-12-02 | 2025-10-08 | Benethera (Shaoxing) Biotechnology Co., Ltd. | Compound and use thereof in treatment of treg-related diseases |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE627826A (enExample) | 1960-09-09 | |||
| US3281424A (en) | 1964-04-15 | 1966-10-25 | Geigy Chem Corp | Certain pyridobenzodiazepine derivatives |
| SE431085B (sv) * | 1977-09-13 | 1984-01-16 | Pfizer | 3-(2-hydroxi-4-(substituerade)fenyl)cykloalkanoner och -cykloalkanoder och vissa derivat derav till anvendning for farmakologiska och medicinska endamal |
| PL122835B1 (en) * | 1977-09-13 | 1982-08-31 | Process for preparing novel cycloalkanols | |
| US4529732A (en) * | 1983-03-14 | 1985-07-16 | Pfizer Inc. | 2-[2-Hydroxy-4-(substituted)phenyl]piperidines |
| GB8329531D0 (en) | 1983-11-04 | 1983-12-07 | Ici America Inc | Pyrazolopyridine cycloalkanones |
| TR22638A (tr) | 1985-07-30 | 1988-01-29 | Nissan Chemical Ind Ltd | Piridazinon tuerevleri,bunlarin ve hasarat oeldueruecue bilesiklerin hazirlanmasina mahsus usul |
| GB8711525D0 (en) | 1987-05-15 | 1987-06-17 | Shell Int Research | Oximino ether compounds |
| GB8722838D0 (en) | 1987-09-29 | 1987-11-04 | Shell Int Research | Oximino ether compounds |
| EP0492904A1 (en) | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted benzene derivatives for use in the treatment of glaucoma |
| US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6828460B2 (en) * | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
| OA11849A (en) * | 1999-03-22 | 2006-03-07 | Pfizer | Resorcinol derivatives. |
| EP1318974A2 (en) * | 2000-09-21 | 2003-06-18 | Pfizer Products Inc. | Resorcinol derivatives |
| JP2004534851A (ja) * | 2001-07-11 | 2004-11-18 | パラチン テクノロジーズ インク． | メラノコルチン受容体に特異的な線状および環状ペプチド |
| SI1490064T1 (sl) | 2002-02-14 | 2010-01-29 | Pharmacia Corp | Substituirani piridinoni kot modulatorji p38 MAP kinaze |
| US6863897B2 (en) | 2002-03-22 | 2005-03-08 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Stabilization of resorcinol derivatives in cosmetic compositions |
| AU2002326312A1 (en) * | 2002-04-25 | 2003-11-10 | Virginia Commonwealth University | Cannabinoids |
| CA2523419C (en) | 2003-04-24 | 2012-05-01 | Mallinckrodt Inc. | Process for preparation of (+)-p-mentha-2,8-diene-1-ol |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| WO2006001982A2 (en) | 2004-06-04 | 2006-01-05 | Washington University | Methods and compositions for treating neuropathies |
| US20050282902A1 (en) * | 2004-06-22 | 2005-12-22 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US20050282913A1 (en) * | 2004-06-22 | 2005-12-22 | June Chen | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US20050282912A1 (en) * | 2004-06-22 | 2005-12-22 | June Chen | Abnormal cannabidiols as neuroprotective agents for the eye |
| BRPI0512525A (pt) * | 2004-06-22 | 2008-03-11 | Allergan Inc | canabidióis anormais como agentes para diminuir a pressão intraocular e fornecer efeito neuroprotetor ao olho |
| EP1898897A2 (en) | 2005-07-07 | 2008-03-19 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| WO2007014226A2 (en) * | 2005-07-26 | 2007-02-01 | The Board Of Trustees Of The University Of Illinois | Compounds for the treatment of neurodegeneration and stroke |
| US20080282902A1 (en) | 2007-01-05 | 2008-11-20 | Dayton Douglas C | Automatic cooking appliance shutoff apparatus |
-
2007
- 2007-04-24 JP JP2009507924A patent/JP2009536623A/ja active Pending
- 2007-04-24 BR BRPI0710732-3A patent/BRPI0710732A2/pt not_active IP Right Cessation
- 2007-04-24 WO PCT/US2007/067267 patent/WO2007127711A2/en not_active Ceased
- 2007-04-24 EP EP09167706A patent/EP2123264A1/en not_active Withdrawn
- 2007-04-24 US US11/739,183 patent/US7968711B2/en active Active
- 2007-04-24 EP EP07761166A patent/EP2010165A2/en not_active Withdrawn
- 2007-04-24 CA CA2823767A patent/CA2823767A1/en not_active Abandoned
- 2007-04-24 CA CA2823724A patent/CA2823724A1/en not_active Abandoned
- 2007-04-24 AU AU2007244978A patent/AU2007244978B2/en not_active Ceased
- 2007-04-24 CA CA2648884A patent/CA2648884C/en active Active
-
2011
- 2011-06-02 US US13/151,675 patent/US20110269715A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228274A patent/JP2014058536A/ja active Pending
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