JP2009530401A - フェノールヒドラゾンマクロファージ転移阻害因子阻害剤 - Google Patents
フェノールヒドラゾンマクロファージ転移阻害因子阻害剤 Download PDFInfo
- Publication number
- JP2009530401A JP2009530401A JP2009501581A JP2009501581A JP2009530401A JP 2009530401 A JP2009530401 A JP 2009530401A JP 2009501581 A JP2009501581 A JP 2009501581A JP 2009501581 A JP2009501581 A JP 2009501581A JP 2009530401 A JP2009530401 A JP 2009530401A
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- Prior art keywords
- compound
- disease
- mammal
- sepsis
- mif
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- Ceased
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- 0 Cc1c(*)c(C=NN*)c(*)c(*)c1O Chemical compound Cc1c(*)c(C=NN*)c(*)c(*)c1O 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78583406P | 2006-03-24 | 2006-03-24 | |
| PCT/US2007/007277 WO2007112015A2 (en) | 2006-03-24 | 2007-03-23 | Phenolic hydrazone macrophage migration inhibitory factor inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009530401A true JP2009530401A (ja) | 2009-08-27 |
| JP2009530401A5 JP2009530401A5 (enExample) | 2013-03-21 |
Family
ID=38541686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501581A Ceased JP2009530401A (ja) | 2006-03-24 | 2007-03-23 | フェノールヒドラゾンマクロファージ転移阻害因子阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8193247B2 (enExample) |
| EP (1) | EP2004649B1 (enExample) |
| JP (1) | JP2009530401A (enExample) |
| AU (1) | AU2007231012B2 (enExample) |
| CA (1) | CA2647045A1 (enExample) |
| WO (1) | WO2007112015A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018534303A (ja) * | 2015-11-12 | 2018-11-22 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計 |
| WO2020067477A1 (ja) * | 2018-09-28 | 2020-04-02 | 日産化学株式会社 | パラクライン因子生産促進用培地添加剤 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5523095B2 (ja) * | 2006-03-24 | 2014-06-18 | ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ | 修飾マクロファージ遊走阻止因子阻害剤 |
| EP2287149A1 (en) * | 2009-08-20 | 2011-02-23 | Max-Delbrück-Centrum Für Molekulare Medizin | Enhancers of protein degradation |
| US8703749B2 (en) | 2009-12-07 | 2014-04-22 | Roberto Testi | Compositions and methods for treating Friedreich's Ataxia |
| US9567306B2 (en) | 2014-06-17 | 2017-02-14 | The Feinstein Institute For Medical Research | Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer |
| CN104402771B (zh) * | 2014-11-26 | 2016-09-28 | 玉林师范学院 | 对羟基苯甲醛缩氨基脲的合成及在防治植物病害中的应用 |
| EP3804706B1 (en) * | 2015-05-29 | 2023-08-23 | Emory University | 2-amino-n'-benzylideneacetohydrazides and derivatives for the management of cftr protein mediated diseases |
| US10512636B2 (en) | 2015-05-29 | 2019-12-24 | Emory University | 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compounds for the management of CFTR protein mediated diseases |
| CN111909082B (zh) * | 2019-05-07 | 2022-09-13 | 湖南大学 | 吡啶腙衍生物及其制备方法与应用 |
| CN110229081B (zh) * | 2019-07-01 | 2022-02-08 | 长沙理工大学 | 2,4-二硝基苯腙衍生物及其制备方法与应用 |
| EP4237002A4 (en) * | 2020-10-28 | 2025-02-12 | University Health Network | METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58189192A (ja) * | 1982-04-22 | 1983-11-04 | Nissan Chem Ind Ltd | 有機リン酸エステル誘導体、その製法及びこれらを含有する有害生物防除剤 |
| JPH08310122A (ja) * | 1995-05-16 | 1996-11-26 | Asahi Denka Kogyo Kk | 感熱記録材料 |
| JP2003519145A (ja) * | 1999-12-23 | 2003-06-17 | アストラゼネカ・アクチエボラーグ | 痛みの処置のための化合物および方法 |
| WO2004009596A2 (en) * | 2002-07-23 | 2004-01-29 | Smithkline Beecham Corporation | Pyrazolopyrimidines as kinase inhibitors |
| JP2004517898A (ja) * | 2000-10-23 | 2004-06-17 | ボード・オブ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | Src族のチエノピリミジン系阻害剤 |
| WO2005037779A2 (de) * | 2003-10-15 | 2005-04-28 | Imtm Gmbh | Neue dipeptidylpeptidase iv-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entzündlicher, neuronaler und anderer erkrankungen |
| WO2005037773A1 (de) * | 2003-10-09 | 2005-04-28 | Merck Patent Gmbh | Acylhydrazonderivate und ihre verwendung bei der hemmung, regulierung und/oder modulation des signaltransduktion von kinasen |
| WO2005084651A2 (en) * | 2004-03-08 | 2005-09-15 | Merck Patent Gmbh | Methods for altering insulin secretion |
| US20050239740A1 (en) * | 2004-03-30 | 2005-10-27 | Alan Verkman | Hydrazide-containing CFTR inhibitor compounds and uses thereof |
| JP2005536517A (ja) * | 2002-07-23 | 2005-12-02 | スミスクライン ビーチャム コーポレーション | キナーゼインヒビターとしてのピラゾロピリミジン |
| EP1612204A1 (en) * | 2003-03-31 | 2006-01-04 | Daiichi Pharmaceutical Co., Ltd. | Hydrazone derivative |
| WO2006014404A1 (en) * | 2004-07-02 | 2006-02-09 | Board Of Regents Of The University Of Texas System | Small molecule thienopyrimidine-based protein tyrosine kinase inhibitors |
| JP2008530104A (ja) * | 2005-02-08 | 2008-08-07 | ザ スクリプス リサーチ インスティテュート | トランスサイレチンアミロイド線維形成の阻害剤 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753652A (en) * | 1991-07-03 | 1998-05-19 | Novartis Corporation | Antiretroviral hydrazine derivatives |
| US6080407A (en) * | 1993-05-17 | 2000-06-27 | The Picower Institute For Medical Research | Diagnostic assays for MIF |
| EP0839669A1 (en) | 1996-11-05 | 1998-05-06 | Asahi Denka Kogyo Kabushiki Kaisha | Heat-sensitive recording meterial |
| DE19817262A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
| EP1228037A4 (en) * | 1999-10-29 | 2004-06-02 | Picower Inst Med Res | COMPOUNDS HAVING ANTIAGONIST ACTIVITY OF MIF |
| CA2450589C (en) | 2001-06-08 | 2011-12-20 | Cytokine Pharmasciences, Inc. | Isoxazoline compounds having mif antagonist activity |
-
2007
- 2007-03-23 CA CA002647045A patent/CA2647045A1/en not_active Abandoned
- 2007-03-23 EP EP07753868A patent/EP2004649B1/en not_active Not-in-force
- 2007-03-23 JP JP2009501581A patent/JP2009530401A/ja not_active Ceased
- 2007-03-23 AU AU2007231012A patent/AU2007231012B2/en not_active Ceased
- 2007-03-23 WO PCT/US2007/007277 patent/WO2007112015A2/en not_active Ceased
- 2007-03-23 US US12/225,572 patent/US8193247B2/en not_active Expired - Fee Related
-
2012
- 2012-03-13 US US13/418,877 patent/US8742173B2/en not_active Expired - Fee Related
Patent Citations (13)
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| JP2018534303A (ja) * | 2015-11-12 | 2018-11-22 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ポリミキシン系抗生物質に対する耐性グラム陰性細菌感染を標的にする合理的薬物設計 |
| US10925857B2 (en) | 2015-11-12 | 2021-02-23 | The Trustees Of Columbia University In The City Of New York | Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics |
| WO2020067477A1 (ja) * | 2018-09-28 | 2020-04-02 | 日産化学株式会社 | パラクライン因子生産促進用培地添加剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2004649B1 (en) | 2012-07-04 |
| CA2647045A1 (en) | 2007-10-04 |
| EP2004649A4 (en) | 2009-07-15 |
| AU2007231012A1 (en) | 2007-10-04 |
| US8193247B2 (en) | 2012-06-05 |
| US20090170951A1 (en) | 2009-07-02 |
| WO2007112015A2 (en) | 2007-10-04 |
| EP2004649A2 (en) | 2008-12-24 |
| WO2007112015A3 (en) | 2008-07-24 |
| US20120178805A1 (en) | 2012-07-12 |
| US8742173B2 (en) | 2014-06-03 |
| AU2007231012B2 (en) | 2013-07-04 |
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