JP2009530392A - タンパク質プレニルトランスフェラーゼの阻害剤 - Google Patents

タンパク質プレニルトランスフェラーゼの阻害剤 Download PDF

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Publication number
JP2009530392A
JP2009530392A JP2009501558A JP2009501558A JP2009530392A JP 2009530392 A JP2009530392 A JP 2009530392A JP 2009501558 A JP2009501558 A JP 2009501558A JP 2009501558 A JP2009501558 A JP 2009501558A JP 2009530392 A JP2009530392 A JP 2009530392A
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Japan
Prior art keywords
compound
cancer
compounds
salt
ggtase
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Japanese (ja)
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JP2009530392A5 (https=
Inventor
冬彦 玉野井
オヒュン クウォン
渡辺　　勝
ハンナ フィジー
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ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア
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Publication of JP2009530392A publication Critical patent/JP2009530392A/ja
Publication of JP2009530392A5 publication Critical patent/JP2009530392A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009501558A 2006-03-22 2007-03-22 タンパク質プレニルトランスフェラーゼの阻害剤 Pending JP2009530392A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78444306P 2006-03-22 2006-03-22
PCT/US2007/007135 WO2007111948A2 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Publications (2)

Publication Number Publication Date
JP2009530392A true JP2009530392A (ja) 2009-08-27
JP2009530392A5 JP2009530392A5 (https=) 2010-05-20

Family

ID=38541651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009501558A Pending JP2009530392A (ja) 2006-03-22 2007-03-22 タンパク質プレニルトランスフェラーゼの阻害剤

Country Status (7)

Country Link
US (1) US8093274B2 (https=)
EP (1) EP2007383A4 (https=)
JP (1) JP2009530392A (https=)
CN (1) CN101431996A (https=)
AU (1) AU2007229457A1 (https=)
CA (1) CA2647038A1 (https=)
WO (1) WO2007111948A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519308A (ja) * 2012-04-10 2015-07-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 癌治療用組成物および方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
CN101495116A (zh) 2005-03-22 2009-07-29 哈佛大学校长及研究员协会 蛋白降解病症的治疗
AU2007345292B2 (en) 2006-02-14 2013-10-31 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
CA2647038A1 (en) 2006-03-22 2007-10-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases
CA2654540C (en) * 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
WO2010014054A1 (en) 2008-07-28 2010-02-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2012097371A2 (en) * 2011-01-14 2012-07-19 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
EP2963039A1 (en) * 2011-02-24 2016-01-06 The Regents of The University of California Small molecules for endothelial cell activation
HUE045348T2 (hu) 2011-05-08 2019-12-30 Legochem Biosciences Inc Fehérje-hatóanyag konjugátumok és eljárás elõállításukra
EP3698797A1 (en) 2017-10-16 2020-08-26 Tsinghua University Mevalonic acid pathway inhibitor and pharmaceutical composition thereof
CN112574041B (zh) * 2020-12-25 2022-10-28 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

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US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
AU2003259717A1 (en) 2002-08-07 2004-02-25 Bristol-Myers Squibb Company Modulators of rabggt and methods of use thereof
MXPA05013770A (es) 2003-06-19 2006-03-08 Pfizer Prod Inc Antagonista de neuroquinina 1.
CA2647038A1 (en) 2006-03-22 2007-10-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6012048689; Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７０，　Ｎｏ．２４, 2005, ｐ．９９７５-９９８４ *
JPN6012048691; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．１２７，　Ｎｏ．３５, 2005, ｐ．１２２３４-１２２３５ *
JPN6012048694; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．６１，　Ｎｏ．２６, 2005, ｐ．６２７６-６２８２ *
JPN6012048696; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．１２５，　Ｎｏ．１６, 2003, ｐ．４７１６-４７１７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519308A (ja) * 2012-04-10 2015-07-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 癌治療用組成物および方法

Also Published As

Publication number Publication date
AU2007229457A1 (en) 2007-10-04
EP2007383A4 (en) 2010-09-15
EP2007383A2 (en) 2008-12-31
US20100063114A1 (en) 2010-03-11
WO2007111948A2 (en) 2007-10-04
US8093274B2 (en) 2012-01-10
CA2647038A1 (en) 2007-10-04
WO2007111948A3 (en) 2008-08-07
CN101431996A (zh) 2009-05-13

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