AU2007229457A1 - Inhibitors of protein prenyltransferases - Google Patents

Inhibitors of protein prenyltransferases Download PDF

Info

Publication number
AU2007229457A1
AU2007229457A1 AU2007229457A AU2007229457A AU2007229457A1 AU 2007229457 A1 AU2007229457 A1 AU 2007229457A1 AU 2007229457 A AU2007229457 A AU 2007229457A AU 2007229457 A AU2007229457 A AU 2007229457A AU 2007229457 A1 AU2007229457 A1 AU 2007229457A1
Authority
AU
Australia
Prior art keywords
compound
compounds
ggtase
salt
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007229457A
Other languages
English (en)
Inventor
Hannah Fiji
Ohyun Kwon
Fuyuhiko Tamanoi
Masaru Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of AU2007229457A1 publication Critical patent/AU2007229457A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007229457A 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases Abandoned AU2007229457A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78444306P 2006-03-22 2006-03-22
US60/784,443 2006-03-22
PCT/US2007/007135 WO2007111948A2 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Publications (1)

Publication Number Publication Date
AU2007229457A1 true AU2007229457A1 (en) 2007-10-04

Family

ID=38541651

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007229457A Abandoned AU2007229457A1 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Country Status (7)

Country Link
US (1) US8093274B2 (https=)
EP (1) EP2007383A4 (https=)
JP (1) JP2009530392A (https=)
CN (1) CN101431996A (https=)
AU (1) AU2007229457A1 (https=)
CA (1) CA2647038A1 (https=)
WO (1) WO2007111948A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
US8222423B2 (en) 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES
US8304451B2 (en) * 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
AU2009274549B2 (en) 2008-07-23 2014-05-01 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
US20110178138A1 (en) * 2008-07-28 2011-07-21 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2012097371A2 (en) * 2011-01-14 2012-07-19 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
EP2678680A4 (en) * 2011-02-24 2014-07-23 Univ California SMALL MOLECULES FOR ENDOTHELIAL CELL ACTIVATION
MX393973B (es) * 2011-05-08 2025-03-24 Legochem Biosciences Inc Conjugados de proteína-agente activo y método para su preparación.
EP2836482B1 (en) * 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
KR20200066690A (ko) 2017-10-16 2020-06-10 칭화대학교 메발로네이트 경로 억제제 및 이의 약제학적 조성물
CN112574041B (zh) * 2020-12-25 2022-10-28 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO2004015130A2 (en) 2002-08-07 2004-02-19 Exelixis Modulators of rabggt and methods of use thereof
BRPI0410630A (pt) * 2003-06-19 2006-06-13 Pfizer Prod Inc antagonista de nk1
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES

Also Published As

Publication number Publication date
CN101431996A (zh) 2009-05-13
JP2009530392A (ja) 2009-08-27
CA2647038A1 (en) 2007-10-04
US20100063114A1 (en) 2010-03-11
WO2007111948A2 (en) 2007-10-04
EP2007383A2 (en) 2008-12-31
WO2007111948A3 (en) 2008-08-07
US8093274B2 (en) 2012-01-10
EP2007383A4 (en) 2010-09-15

Similar Documents

Publication Publication Date Title
US8093274B2 (en) Inhibitors of protein prenyltransferases
US8815935B2 (en) Inhibitors of protein prenyltransferases
AU2026202278A1 (en) Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
Kaushik et al. N’-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene] 2/4-substituted hydrazides: Synthesis and anticonvulsant activity
WO2011044073A1 (en) Pyrrolidine gpr40 modulators
NO316117B1 (no) Inhibitorer for farnesyl-protein-transferase, anvendelse av dem og farmasöytiske preparater inneholdende dem
MX2008015638A (es) Acidos fenil aceticos sustituidos como antagonistas de dp-2.
AU2012345863A1 (en) Aryl dihydropyridinones and piperidinones as MGAT2 inhibitors
US20030187027A1 (en) Dioxanes and uses thereof
Mariaule et al. 3-Oxo-hexahydro-1 H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors
TR201906325T4 (tr) Tetrazolon sübstitüeli dihidropiridinon MGAT2 inhibitörleri.
Chamakuri et al. Synthesis of enantiomerically pure 6-substituted-piperazine-2-acetic acid esters as intermediates for library production
Balog et al. The synthesis and evaluation of [2.2. 1]-bicycloazahydantoins as androgen receptor antagonists
EP2334658A2 (en) Ortho-aminoanilides for the treatment of cancer
WO2009138338A1 (en) Novel n-(2-amino-phenyl)-acrylamides
Suh et al. Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)-and [(acylthio) alkanoyl] glycine derivatives
Saha et al. Novel triazole based inhibitors of Ras farnesyl transferase
US20040235798A1 (en) Compositions and methods for inhibiting prenyltransferases
Taylor Diversity-oriented synthesis of alkaloids for chemical genetic screening
Astles et al. Diamine containing VLA-4 antagonists
US7662750B2 (en) Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds
D'emilio et al. The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds
Ceusters Eight-membered cyclic amines as novel scaffolds for drug discovery
Liu Novel concepts and methodologies in pseudo natural product chemistry
JP2001172260A (ja) ウレア化合物、その製造法および用途

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period