CN101431996A - 蛋白质异戊二烯基转移酶的抑制剂 - Google Patents

蛋白质异戊二烯基转移酶的抑制剂 Download PDF

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Publication number
CN101431996A
CN101431996A CNA2007800144909A CN200780014490A CN101431996A CN 101431996 A CN101431996 A CN 101431996A CN A2007800144909 A CNA2007800144909 A CN A2007800144909A CN 200780014490 A CN200780014490 A CN 200780014490A CN 101431996 A CN101431996 A CN 101431996A
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CN
China
Prior art keywords
compound
compounds
salt
cancer
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800144909A
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English (en)
Chinese (zh)
Inventor
玉野井冬彦
权五铉
渡边胜
汉娜·斐济
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
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University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN101431996A publication Critical patent/CN101431996A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2007800144909A 2006-03-22 2007-03-22 蛋白质异戊二烯基转移酶的抑制剂 Pending CN101431996A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78444306P 2006-03-22 2006-03-22
US60/784,443 2006-03-22

Publications (1)

Publication Number Publication Date
CN101431996A true CN101431996A (zh) 2009-05-13

Family

ID=38541651

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800144909A Pending CN101431996A (zh) 2006-03-22 2007-03-22 蛋白质异戊二烯基转移酶的抑制剂

Country Status (7)

Country Link
US (1) US8093274B2 (https=)
EP (1) EP2007383A4 (https=)
JP (1) JP2009530392A (https=)
CN (1) CN101431996A (https=)
AU (1) AU2007229457A1 (https=)
CA (1) CA2647038A1 (https=)
WO (1) WO2007111948A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112574041A (zh) * 2020-12-25 2021-03-30 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US8999289B2 (en) 2005-03-22 2015-04-07 President And Fellows Of Harvard College Treatment of protein degradation disorders
US8222423B2 (en) 2006-02-14 2012-07-17 Dana-Farber Cancer Institute, Inc. Bifunctional histone deacetylase inhibitors
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES
US8304451B2 (en) * 2006-05-03 2012-11-06 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
AU2009274549B2 (en) 2008-07-23 2014-05-01 Dana-Farber Cancer Institute, Inc. Deacetylase inhibitors and uses thereof
US20110178138A1 (en) * 2008-07-28 2011-07-21 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2012097371A2 (en) * 2011-01-14 2012-07-19 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
EP2678680A4 (en) * 2011-02-24 2014-07-23 Univ California SMALL MOLECULES FOR ENDOTHELIAL CELL ACTIVATION
MX393973B (es) * 2011-05-08 2025-03-24 Legochem Biosciences Inc Conjugados de proteína-agente activo y método para su preparación.
EP2836482B1 (en) * 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
KR20200066690A (ko) 2017-10-16 2020-06-10 칭화대학교 메발로네이트 경로 억제제 및 이의 약제학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
WO2004015130A2 (en) 2002-08-07 2004-02-19 Exelixis Modulators of rabggt and methods of use thereof
BRPI0410630A (pt) * 2003-06-19 2006-06-13 Pfizer Prod Inc antagonista de nk1
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112574041A (zh) * 2020-12-25 2021-03-30 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

Also Published As

Publication number Publication date
JP2009530392A (ja) 2009-08-27
CA2647038A1 (en) 2007-10-04
US20100063114A1 (en) 2010-03-11
WO2007111948A2 (en) 2007-10-04
EP2007383A2 (en) 2008-12-31
WO2007111948A3 (en) 2008-08-07
AU2007229457A1 (en) 2007-10-04
US8093274B2 (en) 2012-01-10
EP2007383A4 (en) 2010-09-15

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Open date: 20090513