JP2009530392A - タンパク質プレニルトランスフェラーゼの阻害剤 - Google Patents

タンパク質プレニルトランスフェラーゼの阻害剤 Download PDF

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Publication number
JP2009530392A
JP2009530392A JP2009501558A JP2009501558A JP2009530392A JP 2009530392 A JP2009530392 A JP 2009530392A JP 2009501558 A JP2009501558 A JP 2009501558A JP 2009501558 A JP2009501558 A JP 2009501558A JP 2009530392 A JP2009530392 A JP 2009530392A
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Japan
Prior art keywords
compound
cancer
compounds
salt
ggtase
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Japanese (ja)
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JP2009530392A5 (enExample
Inventor
冬彦 玉野井
オヒュン クウォン
渡辺　　勝
ハンナ フィジー
Original Assignee
ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア
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Publication of JP2009530392A publication Critical patent/JP2009530392A/ja
Publication of JP2009530392A5 publication Critical patent/JP2009530392A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
JP2009501558A 2006-03-22 2007-03-22 タンパク質プレニルトランスフェラーゼの阻害剤 Pending JP2009530392A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78444306P 2006-03-22 2006-03-22
PCT/US2007/007135 WO2007111948A2 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Publications (2)

Publication Number Publication Date
JP2009530392A true JP2009530392A (ja) 2009-08-27
JP2009530392A5 JP2009530392A5 (enExample) 2010-05-20

Family

ID=38541651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009501558A Pending JP2009530392A (ja) 2006-03-22 2007-03-22 タンパク質プレニルトランスフェラーゼの阻害剤

Country Status (7)

Country Link
US (1) US8093274B2 (enExample)
EP (1) EP2007383A4 (enExample)
JP (1) JP2009530392A (enExample)
CN (1) CN101431996A (enExample)
AU (1) AU2007229457A1 (enExample)
CA (1) CA2647038A1 (enExample)
WO (1) WO2007111948A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519308A (ja) * 2012-04-10 2015-07-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 癌治療用組成物および方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
CA2647038A1 (en) 2006-03-22 2007-10-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases
WO2007130429A2 (en) * 2006-05-03 2007-11-15 The President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
EP2321264B1 (en) 2008-07-23 2016-05-04 President and Fellows of Harvard College Deacetylase inhibitors and uses thereof
WO2010014054A1 (en) 2008-07-28 2010-02-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
WO2012097371A2 (en) * 2011-01-14 2012-07-19 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
WO2012116181A2 (en) * 2011-02-24 2012-08-30 The Regents Of The University Of California Small molecules for endothelial cell activation
DK2707031T3 (da) 2011-05-08 2019-10-07 Legochem Biosciences Inc Protein-active agent conjugates and method for preparing the same
EP3698797A1 (en) 2017-10-16 2020-08-26 Tsinghua University Mevalonic acid pathway inhibitor and pharmaceutical composition thereof
CN112574041B (zh) * 2020-12-25 2022-10-28 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
AU2003259717A1 (en) 2002-08-07 2004-02-25 Bristol-Myers Squibb Company Modulators of rabggt and methods of use thereof
JP2006527756A (ja) * 2003-06-19 2006-12-07 ファイザー・プロダクツ・インク Ｎｋ１拮抗薬
CA2647038A1 (en) 2006-03-22 2007-10-04 The Regents Of The University Of California Inhibitors of protein prenyltransferases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6012048689; Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７０，　Ｎｏ．２４, 2005, ｐ．９９７５-９９８４ *
JPN6012048691; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．１２７，　Ｎｏ．３５, 2005, ｐ．１２２３４-１２２３５ *
JPN6012048694; Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．６１，　Ｎｏ．２６, 2005, ｐ．６２７６-６２８２ *
JPN6012048696; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．１２５，　Ｎｏ．１６, 2003, ｐ．４７１６-４７１７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015519308A (ja) * 2012-04-10 2015-07-09 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア 癌治療用組成物および方法

Also Published As

Publication number Publication date
WO2007111948A3 (en) 2008-08-07
US8093274B2 (en) 2012-01-10
CA2647038A1 (en) 2007-10-04
WO2007111948A2 (en) 2007-10-04
EP2007383A4 (en) 2010-09-15
US20100063114A1 (en) 2010-03-11
EP2007383A2 (en) 2008-12-31
CN101431996A (zh) 2009-05-13
AU2007229457A1 (en) 2007-10-04

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