CA2647038A1 - Inhibitors of protein prenyltransferases - Google Patents

Inhibitors of protein prenyltransferases Download PDF

Info

Publication number
CA2647038A1
CA2647038A1 CA002647038A CA2647038A CA2647038A1 CA 2647038 A1 CA2647038 A1 CA 2647038A1 CA 002647038 A CA002647038 A CA 002647038A CA 2647038 A CA2647038 A CA 2647038A CA 2647038 A1 CA2647038 A1 CA 2647038A1
Authority
CA
Canada
Prior art keywords
compound
compounds
ggtase
salt
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002647038A
Other languages
English (en)
French (fr)
Inventor
Fuyuhiko Tamanoi
Ohyun Kwon
Masaru Watanabe
Hannah Fiji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2647038A1 publication Critical patent/CA2647038A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
CA002647038A 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases Abandoned CA2647038A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78444306P 2006-03-22 2006-03-22
US60/784,443 2006-03-22
PCT/US2007/007135 WO2007111948A2 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Publications (1)

Publication Number Publication Date
CA2647038A1 true CA2647038A1 (en) 2007-10-04

Family

ID=38541651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002647038A Abandoned CA2647038A1 (en) 2006-03-22 2007-03-22 Inhibitors of protein prenyltransferases

Country Status (7)

Country Link
US (1) US8093274B2 (enExample)
EP (1) EP2007383A4 (enExample)
JP (1) JP2009530392A (enExample)
CN (1) CN101431996A (enExample)
AU (1) AU2007229457A1 (enExample)
CA (1) CA2647038A1 (enExample)
WO (1) WO2007111948A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
JP5441416B2 (ja) 2006-02-14 2014-03-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二官能性ヒストンデアセチラーゼインヒビター
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES
CA2654540C (en) * 2006-05-03 2017-01-17 President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
KR101708946B1 (ko) 2008-07-23 2017-02-21 다나-파버 캔서 인스티튜트 인크. 탈아세틸화제 억제제 및 그것의 용도
US20110178138A1 (en) * 2008-07-28 2011-07-21 The Regents Of The University Of California Inhibitors of protein prenyltransferases
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
US9084782B2 (en) 2011-01-14 2015-07-21 The Regents Of The University Of California Chemical inhibitors of cholesterol biosynthesis and venous angiogenesis
US10197557B2 (en) * 2011-02-24 2019-02-05 The Regents Of The University Of California Small molecules for endothelial cell activation
CA2835576C (en) * 2011-05-08 2021-01-05 Legochem Biosciences, Inc. Protein-active agent conjugates and method for preparing the same
EP2836482B1 (en) * 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
CN111225672B (zh) 2017-10-16 2023-09-29 清华大学 甲羟戊酸通路抑制剂及其药物组合物
CN112574041B (zh) * 2020-12-25 2022-10-28 温州大学新材料与产业技术研究院 一种手性β羟基1,3-二羰基类化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
EP1534862A4 (en) 2002-08-07 2007-10-10 Exelixis Inc RABGGT MODULATORS AND METHODS OF USE THEREOF
MXPA05013770A (es) 2003-06-19 2006-03-08 Pfizer Prod Inc Antagonista de neuroquinina 1.
EP2007383A4 (en) 2006-03-22 2010-09-15 Univ California HEMMER OF PROTEIN PRENYL TRANSFERASES

Also Published As

Publication number Publication date
EP2007383A2 (en) 2008-12-31
US20100063114A1 (en) 2010-03-11
CN101431996A (zh) 2009-05-13
EP2007383A4 (en) 2010-09-15
US8093274B2 (en) 2012-01-10
WO2007111948A2 (en) 2007-10-04
JP2009530392A (ja) 2009-08-27
AU2007229457A1 (en) 2007-10-04
WO2007111948A3 (en) 2008-08-07

Similar Documents

Publication Publication Date Title
US8093274B2 (en) Inhibitors of protein prenyltransferases
US8815935B2 (en) Inhibitors of protein prenyltransferases
Hafez et al. Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease
US20030187027A1 (en) Dioxanes and uses thereof
Carroll et al. Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
Mariaule et al. 3-Oxo-hexahydro-1 H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors
WO2011044073A1 (en) Pyrrolidine gpr40 modulators
Rodriquez et al. Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222
Marcaurelle et al. Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2
Chamakuri et al. Synthesis of enantiomerically pure 6-substituted-piperazine-2-acetic acid esters as intermediates for library production
Delong et al. Design, synthesis and evaluation of 3-arylidene azetidin-2-ones as potential antifungal agents against Alternaria solani Sorauer
Chamakuri et al. Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library
Balog et al. The synthesis and evaluation of [2.2. 1]-bicycloazahydantoins as androgen receptor antagonists
Rokosz et al. Surfing the piperazine core of tricyclic farnesyltransferase inhibitors
Saha et al. Novel triazole based inhibitors of Ras farnesyl transferase
Mai et al. New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme-and cell-based investigations
Corredor et al. Efficient synthesis of conformationally restricted apoptosis inhibitors bearing a triazole moiety
EP2280940A1 (en) Novel n-(2-amino-phenyl)-acrylamides
MX2007011072A (es) Hidroxamatos como inhibidores de la histona deacetilasa y formulaciones farmaceuticas que los contienen.
Tolomelli et al. Development of isoxazoline‐containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands
Ullah et al. Synthesis and molecular docking study of thiophene-bearing thiourea derivatives as potential acetylcholinesterase, and butyrylcholinesterase inhibitors
Mammadova et al. Synthesis, Biological Evaluation and Molecular Docking of Novel Sulfonamide Derivatives as Dual Inhibitors of Carbonic Anhydrase Isoenzymes I/II and Acetylcholinesterase
Astles et al. Diamine containing VLA-4 antagonists
Tekkam et al. Concise Synthesis of α‐Methylene‐β‐hydroxy‐γ‐carboxy‐γ‐lactams
Nepomuceno Studies Toward the Total Synthesis of a Natural Product and Exploration of the Chemical Biology of the Bacterial Cell Division Protein FtsZ

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued