JP2009526750A5 - - Google Patents

Info

Publication number

JP2009526750A5

JP2009526750A5 JP2008547703A JP2008547703A JP2009526750A5 JP 2009526750 A5 JP2009526750 A5 JP 2009526750A5 JP 2008547703 A JP2008547703 A JP 2008547703A JP 2008547703 A JP2008547703 A JP 2008547703A JP 2009526750 A5 JP2009526750 A5 JP 2009526750A5

Authority

JP

Japan

Prior art keywords

seq

glp

composition

mimetibody

animal

Prior art date

2006-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 65
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 50
• 108090000765 processed proteins & peptides Proteins 0.000 claims 45
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 44
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 44
• 229920001184 polypeptide Polymers 0.000 claims 39
• 102000004196 processed proteins & peptides Human genes 0.000 claims 39
• 241001465754 Metazoa Species 0.000 claims 34
• 210000000056 organ Anatomy 0.000 claims 33
• 210000001519 tissue Anatomy 0.000 claims 33
• 102000039446 nucleic acids Human genes 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 22
• 150000007523 nucleic acids Chemical class 0.000 claims 22
• 108060003951 Immunoglobulin Proteins 0.000 claims 20
• 102000018358 immunoglobulin Human genes 0.000 claims 20
• 239000004480 active ingredient Substances 0.000 claims 19
• 208000008589 Obesity Diseases 0.000 claims 16
• 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 claims 16
• 235000020824 obesity Nutrition 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 15
• 229940079593 drug Drugs 0.000 claims 14
• 239000003814 drug Substances 0.000 claims 14
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 8
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 8
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
• 208000030159 metabolic disease Diseases 0.000 claims 7
• 150000001413 amino acids Chemical group 0.000 claims 5
• 102000040430 polynucleotide Human genes 0.000 claims 5
• 108091033319 polynucleotide Proteins 0.000 claims 5
• 239000002157 polynucleotide Substances 0.000 claims 5
• 102000004877 Insulin Human genes 0.000 claims 4
• 108090001061 Insulin Proteins 0.000 claims 4
• 239000000556 agonist Substances 0.000 claims 4
• 230000000975 bioactive effect Effects 0.000 claims 4
• 229940125396 insulin Drugs 0.000 claims 4
• 230000002950 deficient Effects 0.000 claims 3
• 206010012601 diabetes mellitus Diseases 0.000 claims 3
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 210000003403 autonomic nervous system Anatomy 0.000 claims 2
• 210000003169 central nervous system Anatomy 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 230000002526 effect on cardiovascular system Effects 0.000 claims 2
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
• 241001260012 Bursa Species 0.000 claims 1
• 102000006395 Globulins Human genes 0.000 claims 1
• 108010044091 Globulins Proteins 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 206010020710 Hyperphagia Diseases 0.000 claims 1
• 210000001015 abdomen Anatomy 0.000 claims 1
• 230000002924 anti-infective effect Effects 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940041181 antineoplastic drug Drugs 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000010836 blood and blood product Substances 0.000 claims 1
• 229940125691 blood product Drugs 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000003792 electrolyte Substances 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• -1 hormonal drugs Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 239000002955 immunomodulating agent Substances 0.000 claims 1
• 229940121354 immunomodulator Drugs 0.000 claims 1
• 230000003914 insulin secretion Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 238000007914 intraventricular administration Methods 0.000 claims 1
• 230000004060 metabolic process Effects 0.000 claims 1
• 235000015097 nutrients Nutrition 0.000 claims 1
• 235000020830 overeating Nutrition 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 210000000664 rectum Anatomy 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 210000001215 vagina Anatomy 0.000 claims 1