JP2009526049A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009526049A5 JP2009526049A5 JP2008554254A JP2008554254A JP2009526049A5 JP 2009526049 A5 JP2009526049 A5 JP 2009526049A5 JP 2008554254 A JP2008554254 A JP 2008554254A JP 2008554254 A JP2008554254 A JP 2008554254A JP 2009526049 A5 JP2009526049 A5 JP 2009526049A5
- Authority
- JP
- Japan
- Prior art keywords
- vesicle
- atp
- biomolecule
- group
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000014113 dietary fatty acids Nutrition 0.000 claims 11
- 229930195729 fatty acid Natural products 0.000 claims 11
- 239000000194 fatty acid Substances 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 7
- 238000010521 absorption reaction Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 claims 4
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 150000003904 phospholipids Chemical class 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- IESVDEZGAHUQJU-ZLBXKVHBSA-N 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC IESVDEZGAHUQJU-ZLBXKVHBSA-N 0.000 claims 2
- IJKRDVKGCQRKBI-UHFFFAOYSA-N 11,12-methyleneoctadecanoic acid Chemical compound CCCCCCC1CC1CCCCCCCCCC(O)=O IJKRDVKGCQRKBI-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 claims 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 2
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 claims 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000700 radioactive tracer Substances 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- RQFCJASXJCIDSX-UHFFFAOYSA-N 14C-Guanosin-5'-monophosphat Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(O)=O)C(O)C1O RQFCJASXJCIDSX-UHFFFAOYSA-N 0.000 claims 1
- MNIQECRMTVGZBM-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;7h-purin-6-amine Chemical compound NC1=NC=NC2=C1NC=N2.CN1CCCC1C1=CC=CN=C1 MNIQECRMTVGZBM-UHFFFAOYSA-N 0.000 claims 1
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical group C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 claims 1
- 102000000412 Annexin Human genes 0.000 claims 1
- 108050008874 Annexin Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- ZWIADYZPOWUWEW-XVFCMESISA-N CDP Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 ZWIADYZPOWUWEW-XVFCMESISA-N 0.000 claims 1
- IERHLVCPSMICTF-XVFCMESISA-N CMP group Chemical group P(=O)(O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C(=O)N=C(N)C=C1)O)O IERHLVCPSMICTF-XVFCMESISA-N 0.000 claims 1
- PCDQPRRSZKQHHS-XVFCMESISA-N CTP Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-XVFCMESISA-N 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 102000011727 Caspases Human genes 0.000 claims 1
- 108010076667 Caspases Proteins 0.000 claims 1
- 108091006146 Channels Proteins 0.000 claims 1
- 102000010970 Connexin Human genes 0.000 claims 1
- 108050001175 Connexin Proteins 0.000 claims 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 1
- 101100347633 Drosophila melanogaster Mhc gene Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- YPZRHBJKEMOYQH-UYBVJOGSSA-L FADH2(2-) Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP([O-])(=O)OP([O-])(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(NC(=O)NC2=O)=C2NC2=C1C=C(C)C(C)=C2 YPZRHBJKEMOYQH-UYBVJOGSSA-L 0.000 claims 1
- 108010069446 Fertilins Proteins 0.000 claims 1
- 102000001133 Fertilins Human genes 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- QGWNDRXFNXRZMB-UUOKFMHZSA-K GDP(3-) Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O QGWNDRXFNXRZMB-UUOKFMHZSA-K 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 102000042092 Glucose transporter family Human genes 0.000 claims 1
- 108091052347 Glucose transporter family Proteins 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XKMLYUALXHKNFT-UUOKFMHZSA-N 0.000 claims 1
- JPXZQMKKFWMMGK-KQYNXXCUSA-K IDP(3-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])([O-])=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 JPXZQMKKFWMMGK-KQYNXXCUSA-K 0.000 claims 1
- HAEJPQIATWHALX-KQYNXXCUSA-J ITP(4-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 HAEJPQIATWHALX-KQYNXXCUSA-J 0.000 claims 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
- 229930010555 Inosine Natural products 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims 1
- 102000004390 N-Ethylmaleimide-Sensitive Proteins Human genes 0.000 claims 1
- 108010081735 N-Ethylmaleimide-Sensitive Proteins Proteins 0.000 claims 1
- 101150092843 SEC1 gene Proteins 0.000 claims 1
- CYDYNVMCEGXBEM-JXOAFFINSA-N TDP Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 CYDYNVMCEGXBEM-JXOAFFINSA-N 0.000 claims 1
- IGWHDMPTQKSDTL-JXOAFFINSA-N TMP Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IGWHDMPTQKSDTL-JXOAFFINSA-N 0.000 claims 1
- RZCIEJXAILMSQK-JXOAFFINSA-N TTP Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 RZCIEJXAILMSQK-JXOAFFINSA-N 0.000 claims 1
- XCCTYIAWTASOJW-UHFFFAOYSA-N UDP-Glc Natural products OC1C(O)C(COP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-UHFFFAOYSA-N 0.000 claims 1
- KYOBSHFOBAOFBF-UHFFFAOYSA-N UMP Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1C(O)=O KYOBSHFOBAOFBF-UHFFFAOYSA-N 0.000 claims 1
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 claims 1
- XCCTYIAWTASOJW-XVFCMESISA-N Uridine-5'-Diphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-XVFCMESISA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 150000001840 cholesterol esters Chemical class 0.000 claims 1
- -1 cyclohexyl fatty acids Chemical class 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 229960002061 ergocalciferol Drugs 0.000 claims 1
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 claims 1
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000002414 glycolytic effect Effects 0.000 claims 1
- QGWNDRXFNXRZMB-UHFFFAOYSA-N guanidine diphosphate Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O QGWNDRXFNXRZMB-UHFFFAOYSA-N 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 claims 1
- 150000002423 hopanoids Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 229960003786 inosine Drugs 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 229950007002 phosphocreatine Drugs 0.000 claims 1
- 235000019175 phylloquinone Nutrition 0.000 claims 1
- 239000011772 phylloquinone Substances 0.000 claims 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims 1
- 229960001898 phytomenadione Drugs 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- XKMLYUALXHKNFT-UHFFFAOYSA-N rGTP Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O XKMLYUALXHKNFT-UHFFFAOYSA-N 0.000 claims 1
- 229960003471 retinol Drugs 0.000 claims 1
- 235000020944 retinol Nutrition 0.000 claims 1
- 239000011607 retinol Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000000946 synaptic effect Effects 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 claims 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 claims 1
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 claims 1
- 230000019540 viral envelope fusion with host membrane Effects 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 235000001892 vitamin D2 Nutrition 0.000 claims 1
- 239000011653 vitamin D2 Substances 0.000 claims 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 235000019168 vitamin K Nutrition 0.000 claims 1
- 239000011712 vitamin K Substances 0.000 claims 1
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
- 229940045997 vitamin a Drugs 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 229940046010 vitamin k Drugs 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 125000001020 α-tocopherol group Chemical group 0.000 claims 1
- 0 [O-]P(*CC(COC(CCCCCCCCCCCCCCCl)=O)OC(CCCCCCCC=CCCCCCCCCl)=O)(O)=O Chemical compound [O-]P(*CC(COC(CCCCCCCCCCCCCCCl)=O)OC(CCCCCCCC=CCCCCCCCCl)=O)(O)=O 0.000 description 4
- KMOSYEBKRJQSQK-UHFFFAOYSA-N CC(C(COC)NC)O Chemical compound CC(C(COC)NC)O KMOSYEBKRJQSQK-UHFFFAOYSA-N 0.000 description 1
- NYDLOCKCVISJKK-WRBBJXAJSA-N CCCCCCCC/C=C\CCCCCCCC(OCC(CN(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O Chemical compound CCCCCCCC/C=C\CCCCCCCC(OCC(CN(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O NYDLOCKCVISJKK-WRBBJXAJSA-N 0.000 description 1
- FVNDTRVAUMPJCU-LNVKXUELSA-N CCCCCCCCCCCCCCCCCC(OCC(C[N-](C)(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O Chemical compound CCCCCCCCCCCCCCCCCC(OCC(C[N-](C)(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O FVNDTRVAUMPJCU-LNVKXUELSA-N 0.000 description 1
- ORTDZGFNIQBSPY-UHFFFAOYSA-N CCC[N](C)(C)C Chemical compound CCC[N](C)(C)C ORTDZGFNIQBSPY-UHFFFAOYSA-N 0.000 description 1
Claims (45)
- (a)安定小胞形成体であるリン脂質;及び
(b)少なくとも1つの不安定小胞形成部材
を含んでなり、該不安定小胞形成部材が安定小胞形成体でない極性脂質、PEG、ラフト形
成体及び融合タンパク質からなる群より選択される、小胞。 - AがHであるか、又は式(III)、(IV)、(V)、(VI)及び(VII)
からなる群より選択される構造を有し;
Lは式(VIII)、(IX)又は(X)
Eは、イソ-分枝鎖脂肪酸、アンテイソ-分枝鎖脂肪酸、15-メチル脂肪酸、トランス-不飽和若しくはシス-不飽和脂肪酸、a-ヒドロキシル脂肪酸、b-ヒドロキシル脂肪酸、a-ヒ
ドロキシル-b-メチル脂肪酸、a,b-ジヒドロキシル脂肪酸、シクロヘキシル脂肪酸、(Z,Z)-不飽和脂肪酸、a-ヒドロキシル-(bE)-エン及び2-ヘキシルシクロプロパンデカン酸からなる群より選択される細菌性脂肪酸であるか、又はEは(XII)、(XIII)、(XIV)、(XV)、(XVI)、(XVII)、(XVIII)、(XIX)、(XX)、(XXI)及び(XXII)
- 前記安定小胞形成体であるリン脂質がホスファチジルコリンである、請求項1に記載の小胞。
- 前記ホスファチジルコリンが、ダイズホスファチジルコリン、卵ホスファチジルコリン、イー.コリ抽出物ホスファチジルコリン、1,2-ジオレオイル-sn-グリセロ-3-ホスホコリン(DOPC)、1-パルミトイル-2-ドコサヘキサエノイル-sn-グリセロ-3-ホスホコリン(PDPC)、ジミリストイルホスファチジルコリン(DMPC)、ジパルミトイルホスファチジルコリン(DPPC)、ジステアロイルホスファチジルコリン(DSPC)又はこれらの混合物である、請求項4に記載の小胞。
- 前記不安定小胞形成部材が約20〜約8000繰返し単位の重量を有するPEGである請求項1
に記載の小胞。 - 前記PEGが約3000〜約4000繰返し単位の重量を有する、請求項7に記載の小胞。
- 前記PEGが約3350繰返し単位の重量を有する、請求項8に記載の小胞。
- 前記不安定小胞形成部材がコレステロール及びスフィンゴミエリンからなる群より選択されるラフト形成体である、請求項1に記載の小胞。
- 前記不安定小胞形成部材がフェルチリン、可溶性N-エチルマレイミド感受性因子付着タンパク質レセプター(SNARE)、sec1/munc18(SM)ポリペプチド、ウイルスエンベロープ融合タンパク質及びアネキシンからなる群より選択される融合タンパク質である、請求項1に記載の小胞。
- 前記小胞が生体分子を更に含んでなる、請求項1に記載の小胞。
- 前記生体分子が脂溶性生体分子である、請求項12に記載の小胞。
- 前記脂溶性生体分子がα-トコフェロール(ビタミンE)、レチノール(ビタミンA)、フ
ィロキノン(ビタミンK)、エルゴカルシフェロール(ビタミンD)、コレステロール、コレステロールエステル、ステロイド、ホパノイド、界面活性剤、脂肪酸、細菌性分枝鎖脂肪酸、イソプレノイド、長鎖アルコール、脂溶性麻酔剤、ガングリオシド、リポ多糖、ビオチン標識リン脂質、膜イオンコンダクタンスチャンネル、輸送タンパク質、グルコース輸送体、粘着タンパク質、ギャップ結合タンパク質、シナプス接合タンパク質、カスパーゼ、接着タンパク質、Gタンパク質、MHCタンパク質、補体タンパク質、脂溶性ウイルスタンパク質、細胞レセプター、脂溶性蛍光プローブ分子及び脂溶性放射性トレーサ分子からなる群より選択される、請求項13に記載の小胞。 - 前記生体分子が水溶性生体分子である、請求項12に記載の小胞。
- 前記水溶性生体分子がアミノ酸、ポリペプチド、タンパク質、単糖類、二糖類、多糖類
、ヌクレオチド、ポリヌクレオチド、水溶性ビタミン、ミネラル、高エネルギーホスフェート、解糖中間体、酸化中間体、ニコチンアデニンジヌクレオチド(NAD+/NADH)、フラビンアデニンジヌクレオチド(FAD+/FADH2)、水溶性細胞酵素、インスリン、水溶性蛍光プローブ分子、水溶性放射性トレーサ分子及び水溶性薬物からなる群より選択される、請求項15に記載の小胞。 - 前記高エネルギーホスフェートがATP、ADP、AMP、アデノシン、CTP、CDP、CMP、シトシン、UTP、UDP、UMP、ウラシル、GTP、GDP、GMP、グアノシン、TTP、TDP、TMP、チミン、ITP、IDP、IMP、イノシン及びホスホクレアチンからなる群より選択される、請求項16に記載の小胞。
- 前記高エネルギーホスフェート生体分子がATPである、請求項17に記載の小胞。
- 前記ATPがMg-ATPである、請求項18に記載の小胞。
- 前記ATPが約1M又はそれ未満の濃度で存在する、請求項18に記載の小胞。
- 前記ATPが約0.001mM〜約200mMの濃度で存在する、請求項20に記載の小胞。
- 前記ATPが約1mM〜約50mMの濃度で存在する、請求項21に記載の小胞。
- 前記小胞が少なくとも1小胞吸収/秒/細胞の吸収速度を有する、請求項1に記載の小胞。
- 前記小胞が少なくとも103小胞吸収/秒/細胞の吸収速度を有する、請求項23に記載の
小胞。 - 前記小胞が少なくとも106小胞吸収/秒/細胞の吸収速度を有する、請求項24に記載の
小胞。 - 前記小胞が1:9〜100,000:1の前記安定小胞形成部材 対 前記不安定小胞形成部材
の比を有する、請求項1に記載の小胞。 - 前記小胞が1:1〜1,000:1の前記安定小胞形成部材 対 前記不安定小胞形成部材の
比を有する、請求項26に記載の小胞。 - 前記小胞が単一ラメラ小胞である、請求項1に記載の小胞。
- 前記小胞が約20nm〜約600nmの水力学的半径を有する、請求項1に記載の小胞。
- 前記小胞が約100nm〜約300nmの水力学的半径を有する、請求項29に記載の小胞。
- 生体分子;
ダイズホスファチジルコリン;及び
DOTAP
を含んでなる小胞。 - 前記生体分子がATPである、請求項31に記載の小胞。
- 前記ATPが約0.01mM〜約200mMの濃度で存在する、請求項32に記載の小胞。
- 前記小胞が50:1のダイズホスファチジルコリン 対 DOTAPの比を有する、請求項31
に記載の小胞。 - 前記小胞が約100nm〜約300nmの水力学的半径を有する、請求項31に記載の小胞。
- 生体分子;
DOPC;及び
DOTAP
を含んでなる小胞。 - 前記生体分子がATPである、請求項36に記載の小胞。
- 前記ATPが約0.01mM〜約200mMの濃度で存在する、請求項37に記載の小胞。
- 前記小胞が50:1のDOPC 対 DOTAPの比を有する、請求項36に記載の小胞。
- 前記小胞が約100nm〜約300nmの水力学的半径を有する、請求項36に記載の小胞。
- 細胞を請求項12に記載の小胞と接触させることを含んでなる、生体分子を細胞に送達する方法。
- 前記生体分子がATPである、請求項41に記載の方法。
- 前記細胞に送達するATPの量が該細胞の代謝要求を満たすに十分である、請求項42に
記載の方法。 - 組織を請求項12に記載の小胞と接触させることを含んでなる、組織を保存する方法。
- 細胞を請求項12に記載の小胞と接触させることを含んでなる、少なくとも1つの細胞を有するバイオリアクターの生産性を向上させる方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/349,023 US20060193905A1 (en) | 2002-05-14 | 2006-02-07 | Direct cellular energy delivery system |
PCT/US2007/001948 WO2007092161A2 (en) | 2006-02-07 | 2007-01-25 | A direct cellular energy delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009526049A JP2009526049A (ja) | 2009-07-16 |
JP2009526049A5 true JP2009526049A5 (ja) | 2010-02-25 |
Family
ID=38345619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008554254A Withdrawn JP2009526049A (ja) | 2006-02-07 | 2007-01-25 | 細胞エネルギーの直接送達システム |
Country Status (9)
Country | Link |
---|---|
US (2) | US20060193905A1 (ja) |
EP (1) | EP2020991A2 (ja) |
JP (1) | JP2009526049A (ja) |
KR (1) | KR20080110589A (ja) |
CN (1) | CN101466357A (ja) |
AU (1) | AU2007212679A1 (ja) |
CA (1) | CA2641638A1 (ja) |
WO (1) | WO2007092161A2 (ja) |
ZA (1) | ZA200806831B (ja) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005027834A2 (en) * | 2003-09-12 | 2005-03-31 | Z-Medica Corporation | Partially hydrated hemostatic agent |
KR20170102377A (ko) | 2004-01-22 | 2017-09-08 | 유니버시티 오브 마이애미 | 국소용 코-엔자임 큐10 제형 및 그의 사용 방법 |
US20060178609A1 (en) | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
AU2006214371A1 (en) | 2005-02-15 | 2006-08-24 | Virginia Commonwealth University | Mineral technologies (MT) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
US8938898B2 (en) * | 2006-04-27 | 2015-01-27 | Z-Medica, Llc | Devices for the identification of medical products |
US7968114B2 (en) | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US8202532B2 (en) | 2006-05-26 | 2012-06-19 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
BRPI0809164B8 (pt) | 2007-03-22 | 2023-02-28 | Berg Llc | Composição para administração tópica e composição farmacêutica compreendendo a referida composição |
WO2008157536A2 (en) * | 2007-06-21 | 2008-12-24 | Z-Medica Corporation | Hemostatic sponge and method of making the same |
WO2009033588A2 (en) * | 2007-09-11 | 2009-03-19 | F. Hoffmann-La-Roche Ag | Self-controlled insulin delivery system |
WO2009126764A1 (en) | 2008-04-11 | 2009-10-15 | Cytotech Labs, Llc | Methods and use of inducing apoptosis in cancer cells |
WO2010132502A2 (en) | 2009-05-11 | 2010-11-18 | Cytotech Labs, Llc | Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
WO2011112900A2 (en) | 2010-03-12 | 2011-09-15 | Cytotech Labs, Llc | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
AU2012240222B2 (en) | 2011-04-04 | 2017-04-27 | Berg Llc | Methods of treating central nervous system tumors |
EA201490047A1 (ru) | 2011-06-17 | 2014-08-29 | Берг Ллк | Ингаляционные фармацевтические композиции |
US20150182542A1 (en) | 2012-02-16 | 2015-07-02 | Brightside Innovations, Inc. | Dietary and nutritional compositions and methods of use |
JP6001169B2 (ja) | 2012-06-22 | 2016-10-05 | ゼット−メディカ,エルエルシー | 止血デバイス |
WO2014168734A1 (en) | 2013-03-15 | 2014-10-16 | Cedars-Sinai Medical Center | Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof |
US10933032B2 (en) | 2013-04-08 | 2021-03-02 | Berg Llc | Methods for the treatment of cancer using coenzyme Q10 combination therapies |
EP3730131A1 (en) | 2013-09-04 | 2020-10-28 | Berg LLC | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
CA2928723A1 (en) * | 2013-10-25 | 2015-04-30 | Benesol, Inc. | Systems and methods for increased vitamin d3 production |
CA3019590A1 (en) | 2016-04-01 | 2017-10-05 | Black Light Surgical, Inc. | Systems, devices, and methods for time-resolved fluorescent spectroscopy |
JP7395355B2 (ja) | 2017-05-08 | 2023-12-11 | フラッグシップ パイオニアリング イノベーションズ ブイ, インコーポレイテッド | 膜融合を促進するための組成物およびその使用 |
CN108624597B (zh) * | 2018-05-23 | 2021-07-09 | 中山大学 | 花生AhGOS1-1基因及其在提高植物抗旱性中的应用 |
WO2022170176A1 (en) * | 2021-02-05 | 2022-08-11 | The Trustees Of Columbia University In The City Of New York | Enhanced delivery vehicle for a treating agent |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
US4704355A (en) * | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
US4783220A (en) * | 1986-12-18 | 1988-11-08 | Xerox Corporation | Vesicle ink compositions |
US5162201A (en) * | 1987-04-01 | 1992-11-10 | Toyo Jozo Co., Ltd. | Analytical method making use of monoglyceride lipase |
US6132763A (en) * | 1988-10-20 | 2000-10-17 | Polymasc Pharmaceuticals Plc | Liposomes |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5820848A (en) * | 1990-01-12 | 1998-10-13 | The Liposome Company, Inc. | Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent |
US6011020A (en) * | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
JP2599492B2 (ja) * | 1990-08-21 | 1997-04-09 | 第一製薬株式会社 | リポソーム製剤の製造法 |
WO1994018987A1 (en) * | 1993-02-19 | 1994-09-01 | Nippon Shinyaku Co., Ltd. | Drug composition containing nucleic acid copolymer |
US5863556A (en) * | 1993-08-20 | 1999-01-26 | Euro-Celtique, S.A. | Preparations for the external application of antiseptic agents and/or agents promoting the healing of wounds |
US5874075A (en) * | 1993-10-06 | 1999-02-23 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
US5540935A (en) * | 1993-12-06 | 1996-07-30 | Nof Corporation | Reactive vesicle and functional substance-fixed vesicle |
US6110666A (en) * | 1994-06-09 | 2000-08-29 | Medical Research Council | Locus control subregions conferring integration-site independent transgene expression abstract of the disclosure |
US5674528A (en) * | 1994-06-15 | 1997-10-07 | Terumo Kabushiki Kaisha | Hemoglobin-encapsulated liposome |
US5795587A (en) * | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5582839A (en) * | 1995-04-18 | 1996-12-10 | Nutrition 21 | Magnesium taurate and other mineral taurates |
US5811406A (en) * | 1995-06-07 | 1998-09-22 | Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
US6296844B1 (en) * | 1995-09-27 | 2001-10-02 | The General Hospital Corporation | Asialocytokines and treatment of liver disease |
US5783566A (en) * | 1996-05-10 | 1998-07-21 | California Institute Of Technology | Method for increasing or decreasing transfection efficiency |
AU2284697A (en) * | 1996-04-11 | 1997-10-29 | University Of British Columbia, The | Fusogenic liposomes |
CA2269631C (en) * | 1996-10-25 | 2008-03-25 | Monsanto Company | Composition and method for treating plants with exogenous chemicals |
US5965542A (en) * | 1997-03-18 | 1999-10-12 | Inex Pharmaceuticals Corp. | Use of temperature to control the size of cationic liposome/plasmid DNA complexes |
DE19925519A1 (de) * | 1999-06-04 | 2000-12-07 | Lohmann Therapie Syst Lts | Wundauflage zur gesteuerten Abgabe von Wirkstoff an Wunden und Verfahren zu ihrer Herstellung |
US7056529B2 (en) * | 2002-05-14 | 2006-06-06 | University Of Louisville Research Foundation, Inc. | Direct cellular energy delivery system |
-
2006
- 2006-02-07 US US11/349,023 patent/US20060193905A1/en not_active Abandoned
-
2007
- 2007-01-25 JP JP2008554254A patent/JP2009526049A/ja not_active Withdrawn
- 2007-01-25 AU AU2007212679A patent/AU2007212679A1/en not_active Abandoned
- 2007-01-25 CN CNA2007800115376A patent/CN101466357A/zh active Pending
- 2007-01-25 WO PCT/US2007/001948 patent/WO2007092161A2/en active Application Filing
- 2007-01-25 EP EP07763550A patent/EP2020991A2/en not_active Withdrawn
- 2007-01-25 CA CA002641638A patent/CA2641638A1/en not_active Abandoned
- 2007-01-25 KR KR1020087021814A patent/KR20080110589A/ko not_active Application Discontinuation
-
2008
- 2008-08-07 ZA ZA200806831A patent/ZA200806831B/xx unknown
-
2011
- 2011-06-17 US US13/163,546 patent/US9066866B2/en not_active Expired - Lifetime
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2009526049A5 (ja) | ||
Mayhew et al. | Inhibition of Tumor Cell Growth in vitro and in vivo by 1-β-D-arabinofuranosylcytosine Entrapped within Phospholipid Vesicles | |
US9066866B2 (en) | Direct cellular energy delivery system | |
New | Liposomes | |
Bar et al. | Surface area of human erythrocyte lipids: reinvestigation of experiments on plasma membrane | |
Andreoli | On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes | |
Shohet | Hemolysis and changes in erythrocyte membrane lipids | |
Papahadjopoulos et al. | Fusion of mammalian cells by unilamellar lipid vesicles: influence of lipid surface charge, fluidity and cholesterol | |
US5194654A (en) | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use | |
CA1315684C (en) | Anti-retroviral agents and delivery system for the same | |
US4619794A (en) | Spontaneous preparation of small unilamellar liposomes | |
WO1990014074A1 (en) | Improved liposomal formulations of nucleotides and nucleotide analogues | |
AU2526188A (en) | Liposomal nucleoside analogues for treating aids | |
WO2006022325A1 (ja) | ガラクトース誘導体、薬物担体及び医薬組成物 | |
EP2003140A9 (en) | Galactose derivative, drug carrier and medicinal composition | |
Vanderkooi et al. | Sarcoplasmic Reticulum. XVI: the permeability of phosphatidyl choline vesicles for calcium | |
WO2006102533A2 (en) | Pharmaceutically active lipid-based formulation of nucleoside-lipid conjugates | |
CA2377422A1 (en) | Periodic structures comprising lipids, polyelectrolytes, and structure- inducing soluble oligovalent linkers, and biological use thereof | |
NAKANISHI et al. | Mechanism of the enhancement of rectal permeability of drugs by nonsteroidal anti-inflammatory drugs | |
US20130085146A1 (en) | Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues | |
JP2006513189A5 (ja) | ||
Gregoriadis et al. | Possible implications in the use of exogenous phospholipids | |
JPH04356421A (ja) | プロスタグランジン類含有脂肪小体組成物 | |
Mizuma et al. | Intestinal absorption of acyclovir β-glucoside: Comparative study with acyclovir, guanosine, and kinetin β-glucoside | |
Tep et al. | Formulation and evaluation of ATP-containing liposomes including lactosylated ASGPr ligand |