JP2009524424A5 - - Google Patents
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- Publication number
- JP2009524424A5 JP2009524424A5 JP2008551877A JP2008551877A JP2009524424A5 JP 2009524424 A5 JP2009524424 A5 JP 2009524424A5 JP 2008551877 A JP2008551877 A JP 2008551877A JP 2008551877 A JP2008551877 A JP 2008551877A JP 2009524424 A5 JP2009524424 A5 JP 2009524424A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- amino acids
- cells
- production profile
- consumption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 20
- 235000001014 amino acid Nutrition 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 11
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 210000002257 embryonic structure Anatomy 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 239000001963 growth medium Substances 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 241000282887 Suidae Species 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000003855 balanced salt solution Substances 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 238000001212 derivatisation Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 229940116871 l-lactate Drugs 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0601746.1 | 2006-01-27 | ||
| GBGB0601746.1A GB0601746D0 (en) | 2006-01-27 | 2006-01-27 | Cryopreservation method |
| PCT/GB2007/000277 WO2007085851A1 (en) | 2006-01-27 | 2007-01-26 | Method op assessing the viability of thawed cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524424A JP2009524424A (ja) | 2009-07-02 |
| JP2009524424A5 true JP2009524424A5 (https=) | 2010-03-04 |
| JP5452808B2 JP5452808B2 (ja) | 2014-03-26 |
Family
ID=36061050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551877A Expired - Fee Related JP5452808B2 (ja) | 2006-01-27 | 2007-01-26 | 解凍細胞の生存率を評価する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8143060B2 (https=) |
| EP (1) | EP1984489A1 (https=) |
| JP (1) | JP5452808B2 (https=) |
| CN (2) | CN103529218A (https=) |
| AU (1) | AU2007209144B2 (https=) |
| CA (1) | CA2640116A1 (https=) |
| GB (1) | GB0601746D0 (https=) |
| NO (1) | NO20083274L (https=) |
| WO (1) | WO2007085851A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070162992A1 (en) | 2006-01-09 | 2007-07-12 | Mcgill University | Metabolomic determination in assisted reproductive technology |
| ES2498674T3 (es) * | 2007-11-09 | 2014-09-25 | Genzyme Corporation | Métodos para medir la viabilidad celular sin usar células de control |
| US9700038B2 (en) | 2009-02-25 | 2017-07-11 | Genea Limited | Cryopreservation of biological cells and tissues |
| WO2011008932A1 (en) * | 2009-07-16 | 2011-01-20 | Molecular Biometrics, Inc. | Methods of assessing embryo outcome |
| CN103179852B (zh) | 2010-05-28 | 2015-04-08 | 格尼亚有限公司 | 改良的显微操作和储存装置以及方法 |
| US10271876B2 (en) | 2011-11-23 | 2019-04-30 | Mezadata Medical Ip Holding Llc | Method of in vitro fertilization with delay of embryo transfer and use of peripheral blood mononuclear cells |
| EP2917738A1 (de) * | 2012-11-12 | 2015-09-16 | BIOCRATES Life Sciences AG | Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben |
| JP2014193145A (ja) * | 2013-03-01 | 2014-10-09 | Naoki Yamashita | 胚盤胞培養液中のノルエピネフリン量によるヒト胚盤胞の評価方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202395B2 (en) * | 2000-01-19 | 2007-04-10 | The University Of York | Assessment method |
-
2006
- 2006-01-27 GB GBGB0601746.1A patent/GB0601746D0/en not_active Ceased
-
2007
- 2007-01-26 CN CN201310225929.XA patent/CN103529218A/zh active Pending
- 2007-01-26 US US12/162,284 patent/US8143060B2/en not_active Expired - Fee Related
- 2007-01-26 EP EP07705045A patent/EP1984489A1/en not_active Withdrawn
- 2007-01-26 WO PCT/GB2007/000277 patent/WO2007085851A1/en not_active Ceased
- 2007-01-26 CA CA002640116A patent/CA2640116A1/en not_active Abandoned
- 2007-01-26 AU AU2007209144A patent/AU2007209144B2/en not_active Ceased
- 2007-01-26 JP JP2008551877A patent/JP5452808B2/ja not_active Expired - Fee Related
- 2007-01-26 CN CNA2007800102713A patent/CN101405387A/zh active Pending
-
2008
- 2008-07-24 NO NO20083274A patent/NO20083274L/no not_active Application Discontinuation
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