JP2009523732A5 - - Google Patents
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- Publication number
- JP2009523732A5 JP2009523732A5 JP2008550455A JP2008550455A JP2009523732A5 JP 2009523732 A5 JP2009523732 A5 JP 2009523732A5 JP 2008550455 A JP2008550455 A JP 2008550455A JP 2008550455 A JP2008550455 A JP 2008550455A JP 2009523732 A5 JP2009523732 A5 JP 2009523732A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- defined above
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000003118 aryl group Chemical group 0.000 claims 88
- 150000002367 halogens Chemical group 0.000 claims 84
- 229910052736 halogen Chemical group 0.000 claims 81
- 125000003545 alkoxy group Chemical group 0.000 claims 79
- 229910052739 hydrogen Inorganic materials 0.000 claims 78
- 239000001257 hydrogen Substances 0.000 claims 78
- 125000001188 haloalkyl group Chemical group 0.000 claims 42
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 40
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 37
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 35
- 150000002431 hydrogen Chemical class 0.000 claims 32
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000000623 heterocyclic group Chemical group 0.000 claims 25
- 125000004438 haloalkoxy group Chemical group 0.000 claims 24
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 22
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 20
- 125000004663 dialkyl amino group Chemical group 0.000 claims 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 17
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 14
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 12
- IYYZUPMFVPLQIF-UHFFFAOYSA-N dibenzothiophene Chemical compound C1=CC=C2C3=CC=CC=C3SC2=C1 IYYZUPMFVPLQIF-UHFFFAOYSA-N 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 9
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- TXCDCPKCNAJMEE-UHFFFAOYSA-N dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001345 alkine derivatives Chemical group 0.000 claims 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002475 indoles Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 0 C*1C=C2OCOC2=CC=C1 Chemical compound C*1C=C2OCOC2=CC=C1 0.000 description 3
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75852706P | 2006-01-13 | 2006-01-13 | |
US11/331,180 US7868037B2 (en) | 2004-07-14 | 2006-01-13 | Methods for treating hepatitis C |
US92148307P | 2007-01-13 | 2007-01-13 | |
PCT/US2007/000996 WO2007084435A2 (en) | 2006-01-13 | 2007-01-16 | Methods for treating hepatitis c |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009523732A JP2009523732A (ja) | 2009-06-25 |
JP2009523732A5 true JP2009523732A5 (zh) | 2010-03-04 |
Family
ID=38283923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008550455A Withdrawn JP2009523732A (ja) | 2006-01-13 | 2007-01-16 | C型肝炎の治療方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2009523732A (zh) |
WO (1) | WO2007084435A2 (zh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE543808T1 (de) | 2006-12-22 | 2012-02-15 | Schering Corp | 5,6-ring-annelierte indolderivate und ihre verwendung |
AU2007339386B8 (en) | 2006-12-22 | 2013-12-05 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
BRPI0720625A2 (pt) | 2006-12-22 | 2014-03-25 | Schering Corp | Derivados de indol de 4,5-anel anulados e métodos de uso dos mesmos |
EP2408761B1 (en) | 2007-08-29 | 2014-01-01 | Merck Sharp & Dohme Corp. | Substituted indole derivatives and methods of use thereof |
CN101842353A (zh) | 2007-08-29 | 2010-09-22 | 先灵公司 | 用于治疗病毒感染的2,3-取代的吲哚衍生物 |
CA2697500A1 (en) * | 2007-08-29 | 2009-03-12 | Schering Corporation | 2,3-substituted azaindole derivatives for treating viral infections |
CA2705586A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
AR072088A1 (es) | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
EP2545050B1 (en) * | 2010-03-10 | 2014-08-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis c |
EP3188730B1 (en) | 2014-09-05 | 2019-05-01 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
EP3188732B1 (en) | 2014-09-05 | 2019-07-24 | Merck Sharp & Dohme Corp. | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
EP3188731B1 (en) | 2014-09-05 | 2019-04-03 | Merck Sharp & Dohme Corp. | Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2 |
JP2020502058A (ja) | 2016-11-18 | 2020-01-23 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ジアシルグリセリドo−アシルトランスフェラーゼ2の阻害薬として有用なインダゾール誘導体 |
MA46859A (fr) | 2016-11-18 | 2019-09-25 | Merck Sharp & Dohme | Dérivés d'indole utiles en tant qu'inhibiteurs de la diacylglycéride o-acyltransférase 2 |
RS65335B1 (sr) | 2018-10-05 | 2024-04-30 | Annapurna Bio Inc | Jedinjenja i kompozicije za lečenje stanja povezanih sa aktivnošću receptora apj |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US20050215614A1 (en) * | 2002-10-15 | 2005-09-29 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
GB0323845D0 (en) * | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
JP2008506702A (ja) * | 2004-07-14 | 2008-03-06 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎を治療するための方法 |
-
2007
- 2007-01-16 JP JP2008550455A patent/JP2009523732A/ja not_active Withdrawn
- 2007-01-16 WO PCT/US2007/000996 patent/WO2007084435A2/en active Application Filing
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