JP2009522218A5 - - Google Patents
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- Publication number
- JP2009522218A5 JP2009522218A5 JP2008547886A JP2008547886A JP2009522218A5 JP 2009522218 A5 JP2009522218 A5 JP 2009522218A5 JP 2008547886 A JP2008547886 A JP 2008547886A JP 2008547886 A JP2008547886 A JP 2008547886A JP 2009522218 A5 JP2009522218 A5 JP 2009522218A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- salt
- kda
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims description 17
- 229920002674 hyaluronan Polymers 0.000 claims description 12
- 229960003160 hyaluronic acid Drugs 0.000 claims description 12
- 229940010747 Sodium Hyaluronate Drugs 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 201000008482 osteoarthritis Diseases 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 12
- 239000011780 sodium chloride Substances 0.000 claims 12
- 229960002286 Clodronic Acid Drugs 0.000 claims 5
- ACSIXWWBWUQEHA-UHFFFAOYSA-N Clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 5
- HJKBJIYDJLVSAO-UHFFFAOYSA-L clodronic acid disodium salt Chemical compound [Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O HJKBJIYDJLVSAO-UHFFFAOYSA-L 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000000845 Cartilage Anatomy 0.000 description 2
- 241000219061 Rheum Species 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010003246 Arthritis Diseases 0.000 description 1
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108010074224 Hyaluronoglucosaminidase Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- 210000002540 Macrophages Anatomy 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 description 1
- 230000002491 angiogenic Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003412 degenerative Effects 0.000 description 1
- 230000004059 degradation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001627 detrimental Effects 0.000 description 1
- 230000002757 inflammatory Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000002482 oligosaccharides Polymers 0.000 description 1
- 230000004936 stimulating Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002515A ITMI20052515A1 (it) | 2005-12-29 | 2005-12-29 | Formulazione farmaceutica per il trattamento della osteoartrite |
| PCT/EP2006/012367 WO2007073921A1 (en) | 2005-12-29 | 2006-12-21 | Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009522218A JP2009522218A (ja) | 2009-06-11 |
| JP2009522218A5 true JP2009522218A5 (zh) | 2010-02-04 |
Family
ID=36648609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008547886A Pending JP2009522218A (ja) | 2005-12-29 | 2006-12-21 | 変形性骨関節炎の治療のための医薬処方物 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20090042833A1 (zh) |
| EP (1) | EP1976538B1 (zh) |
| JP (1) | JP2009522218A (zh) |
| KR (2) | KR20140107651A (zh) |
| AT (1) | ATE446763T1 (zh) |
| AU (1) | AU2006331019B2 (zh) |
| CA (1) | CA2646974C (zh) |
| CY (1) | CY1109541T1 (zh) |
| DE (1) | DE602006010111D1 (zh) |
| DK (1) | DK1976538T3 (zh) |
| ES (1) | ES2333615T3 (zh) |
| HK (1) | HK1123986A1 (zh) |
| IT (1) | ITMI20052515A1 (zh) |
| NO (1) | NO340794B1 (zh) |
| NZ (1) | NZ569420A (zh) |
| PL (1) | PL1976538T3 (zh) |
| PT (1) | PT1976538E (zh) |
| RU (1) | RU2414908C2 (zh) |
| SI (1) | SI1976538T1 (zh) |
| WO (1) | WO2007073921A1 (zh) |
| ZA (1) | ZA200805598B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7184792B2 (ja) | 2016-12-06 | 2022-12-06 | アビオジェン ファルマ ソシエタ ペル アチオニ | 変形性関節症の治療のための組成物 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6091415B2 (ja) * | 2010-10-07 | 2017-03-08 | ナショナル チェン クン ユニバーシティー | 糖尿病における虚血肢の血流の促進のためのヒアルロナンの使用 |
| CN111773173B (zh) | 2014-11-07 | 2024-03-22 | 胞外体干细胞株式会社 | 用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物 |
| KR101706642B1 (ko) | 2015-02-04 | 2017-02-17 | 주식회사 엑소스템텍 | 연골세포로 분화되고 있는 줄기세포로부터 추출된 엑소좀을 포함하는 연골세포 분화 유도 또는 연골조직 재생용 조성물 |
| IT202100023894A1 (it) * | 2021-09-16 | 2023-03-16 | Professional Derma Sa | Composizione per utilizzo in campo ortopedico |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1187828B (it) | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| JP2001253827A (ja) * | 2000-02-15 | 2001-09-18 | Pfizer Prod Inc | 骨粗鬆症を治療するための組成物および方法 |
| CA2407747C (en) * | 2000-05-05 | 2008-03-11 | F. Hoffmann-La Roche Ag | Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts |
| NZ536478A (en) * | 2002-05-17 | 2008-02-29 | Wyeth Corp | Injectable or implantable solid, rod- shaped compositions for intraosseous delivery of osteogenic proteins |
| KR100648515B1 (ko) * | 2004-05-04 | 2006-11-27 | (주)아모레퍼시픽 | 비스포스포네이트-함유 고분자 미립구를 포함하는 골-관련질환 치료 또는 예방용 서방 효과를 갖는 주사제 |
-
2005
- 2005-12-29 IT IT002515A patent/ITMI20052515A1/it unknown
-
2006
- 2006-12-21 DK DK06841087T patent/DK1976538T3/da active
- 2006-12-21 PL PL06841087T patent/PL1976538T3/pl unknown
- 2006-12-21 PT PT06841087T patent/PT1976538E/pt unknown
- 2006-12-21 AT AT06841087T patent/ATE446763T1/de active
- 2006-12-21 US US12/159,222 patent/US20090042833A1/en not_active Abandoned
- 2006-12-21 AU AU2006331019A patent/AU2006331019B2/en active Active
- 2006-12-21 EP EP06841087A patent/EP1976538B1/en active Active
- 2006-12-21 DE DE602006010111T patent/DE602006010111D1/de active Active
- 2006-12-21 ES ES06841087T patent/ES2333615T3/es active Active
- 2006-12-21 SI SI200630473T patent/SI1976538T1/sl unknown
- 2006-12-21 JP JP2008547886A patent/JP2009522218A/ja active Pending
- 2006-12-21 RU RU2008126108/15A patent/RU2414908C2/ru active
- 2006-12-21 KR KR1020147021224A patent/KR20140107651A/ko active IP Right Grant
- 2006-12-21 NZ NZ569420A patent/NZ569420A/en unknown
- 2006-12-21 ZA ZA200805598A patent/ZA200805598B/xx unknown
- 2006-12-21 WO PCT/EP2006/012367 patent/WO2007073921A1/en active Application Filing
- 2006-12-21 CA CA2646974A patent/CA2646974C/en active Active
-
2008
- 2008-06-26 NO NO20082848A patent/NO340794B1/no unknown
- 2008-06-26 KR KR1020087015583A patent/KR101470608B1/ko active IP Right Grant
-
2009
- 2009-04-03 HK HK09103213.6A patent/HK1123986A1/xx unknown
- 2009-12-03 CY CY20091101271T patent/CY1109541T1/el unknown
-
2014
- 2014-09-03 US US14/476,521 patent/US9943540B2/en active Active
-
2018
- 2018-02-28 US US15/907,300 patent/US20180185407A1/en not_active Abandoned
-
2019
- 2019-12-27 US US16/728,378 patent/US20200147126A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7184792B2 (ja) | 2016-12-06 | 2022-12-06 | アビオジェン ファルマ ソシエタ ペル アチオニ | 変形性関節症の治療のための組成物 |
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