JP2009521928A5 - - Google Patents
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- Publication number
- JP2009521928A5 JP2009521928A5 JP2008548723A JP2008548723A JP2009521928A5 JP 2009521928 A5 JP2009521928 A5 JP 2009521928A5 JP 2008548723 A JP2008548723 A JP 2008548723A JP 2008548723 A JP2008548723 A JP 2008548723A JP 2009521928 A5 JP2009521928 A5 JP 2009521928A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- cycloalkyl
- aryl
- heterocycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- -1 amino, imino Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 7
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000001589 carboacyl group Chemical group 0.000 claims 5
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 102000013446 GTP Phosphohydrolases Human genes 0.000 claims 3
- 108091006109 GTPases Proteins 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 101100356682 Caenorhabditis elegans rho-1 gene Proteins 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 101150111584 RHOA gene Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75533705P | 2005-12-30 | 2005-12-30 | |
| PCT/US2006/049424 WO2007079141A2 (en) | 2005-12-30 | 2006-12-28 | Method of identifying compounds useful to treat neuronal degenerative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009521928A JP2009521928A (ja) | 2009-06-11 |
| JP2009521928A5 true JP2009521928A5 (enExample) | 2010-02-18 |
Family
ID=38134984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548723A Pending JP2009521928A (ja) | 2005-12-30 | 2006-12-28 | 神経細胞変性疾患の治療に有用な化合物を特定する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20070265350A1 (enExample) |
| EP (1) | EP1971867A2 (enExample) |
| JP (1) | JP2009521928A (enExample) |
| AU (1) | AU2006332728A1 (enExample) |
| CA (1) | CA2634670A1 (enExample) |
| WO (1) | WO2007079141A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8241622B2 (en) | 2001-07-13 | 2012-08-14 | University Of Iowa Research Foundation | Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences |
| EP1971867A2 (en) * | 2005-12-30 | 2008-09-24 | University of Iowa Research Foundation | Method of identifying compounds useful to treat neuronal degenerative diseases |
| EP2970873A4 (en) * | 2013-03-14 | 2017-02-22 | President and Fellows of Harvard College | Methods for selecting microbes from a genetically modified library to detect and optimize the production of metabolites |
| WO2017139381A1 (en) | 2016-02-08 | 2017-08-17 | University Of Iowa Research Foundation | Methods to produce chimeric adeno-associated virus/bocavirus parvovirus |
| WO2017155973A1 (en) | 2016-03-07 | 2017-09-14 | University Of Iowa Research Foundation | Aav-mediated expression using a synthetic promoter and enhancer |
| US12173305B2 (en) | 2016-05-26 | 2024-12-24 | University Of Iowa Research Foundation | cis and trans requirements for terminal resolution of human bocavirus 1 |
| US11142775B2 (en) | 2017-01-13 | 2021-10-12 | University Of Iowa Research Foundation | Bocaparvovirus small noncoding RNA and uses thereof |
| KR20200088856A (ko) * | 2017-11-15 | 2020-07-23 | 벤더르빌트 유니버시티 | 리소좀 기능의 개선 및 퇴행성 신경 질환의 치료를 위한 방법 및 조성물 |
| EP4724816A2 (en) * | 2023-06-06 | 2026-04-15 | Mclaughlin Research Institute for Biomedical Sciences | Methods for detecting the presence of at least one misfolded form of sod1 in a biological sample |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083713A (en) * | 1992-08-31 | 2000-07-04 | Bristol-Myers Squibb Company | Cloning and expression of βAPP-C100 receptor (C100-R) |
| US5939460A (en) * | 1996-07-08 | 1999-08-17 | Idun Pharmaceuticals, Inc. | Method of inhibiting NADPH oxidase |
| IL128017A0 (en) * | 1998-07-22 | 1999-11-30 | Technion Res & Dev Foundation | Method for detecting protein-protein interactions and a kit therefor |
| ES2140354B1 (es) * | 1998-08-03 | 2000-11-01 | S A L V A T Lab Sa | Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2. |
| EP1131425A2 (en) * | 1998-11-18 | 2001-09-12 | Incyte Pharmaceuticals, Inc. | Inflammation-associated genes |
| CA2270795A1 (en) | 1999-05-05 | 2000-11-05 | Gestilab Inc. | Neuroprotective compositions and uses thereof |
| US6492429B1 (en) * | 2000-07-10 | 2002-12-10 | N.V. Nutricia | Composition for the treatment of osteoarthritis |
| US6485950B1 (en) * | 2000-07-14 | 2002-11-26 | Council Of Scientific And Industrial Research | Isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD in cosmetic, food and pharmaceutical compositions |
| WO2003006614A2 (en) * | 2001-07-12 | 2003-01-23 | Exelixis, Inc. | UBE2s AS MODIFIERS OF THE p21 PATHWAY AND METHODS OF USE |
| JP2003201255A (ja) * | 2001-11-05 | 2003-07-18 | Otsuka Pharmaceut Factory Inc | アルツハイマー病予防および治療剤 |
| WO2003087399A1 (en) * | 2002-04-17 | 2003-10-23 | Glucox Ab | Nad)p)h oxidase inhibitors for increased glucose uptake and treatment of type ii diabetes |
| WO2004047772A2 (en) * | 2002-11-26 | 2004-06-10 | Florida Atlantic University | Catalytic antioxidants and methods of use |
| KR100522188B1 (ko) | 2003-01-20 | 2005-10-18 | 주식회사 뉴로테크 | 뉴로트로핀에 의해 유도되는 세포괴사 억제 방법 |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| EP1602926A1 (en) * | 2004-06-04 | 2005-12-07 | University of Geneva | Novel means and methods for the treatment of hearing loss and phantom hearing |
| US20060002913A1 (en) * | 2004-06-22 | 2006-01-05 | Gehlsen Kurt R | Use of histamine and related compounds to treat disorders affecting muscle function |
| EP1971867A2 (en) * | 2005-12-30 | 2008-09-24 | University of Iowa Research Foundation | Method of identifying compounds useful to treat neuronal degenerative diseases |
-
2006
- 2006-12-28 EP EP06849005A patent/EP1971867A2/en not_active Withdrawn
- 2006-12-28 WO PCT/US2006/049424 patent/WO2007079141A2/en not_active Ceased
- 2006-12-28 AU AU2006332728A patent/AU2006332728A1/en not_active Abandoned
- 2006-12-28 JP JP2008548723A patent/JP2009521928A/ja active Pending
- 2006-12-28 CA CA002634670A patent/CA2634670A1/en not_active Abandoned
- 2006-12-28 US US11/617,491 patent/US20070265350A1/en not_active Abandoned
-
2007
- 2007-08-07 US US11/890,779 patent/US20080206792A1/en not_active Abandoned
- 2007-08-07 US US11/890,775 patent/US20090239243A1/en not_active Abandoned
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