JP2009520711A - 炎症性疾患の治療に使用する、抗コリン作用薬類、β2−アドレナリン受容体のアゴニスト類、抗ロイコトリエン(ロイコトリエン受容体のアンタゴニスト)類、グルココルチコイド類および/またはPDE4阻害剤類の新規配合薬 - Google Patents
炎症性疾患の治療に使用する、抗コリン作用薬類、β2−アドレナリン受容体のアゴニスト類、抗ロイコトリエン(ロイコトリエン受容体のアンタゴニスト)類、グルココルチコイド類および/またはPDE4阻害剤類の新規配合薬 Download PDFInfo
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Abstract
Description
B:PDE4阻害剤類:1:ロリプラム、2:ロフルミラスト、3:シロミラスト、4:AWD−12−281
C:グルココルチコイド類:1:ブデソニド、2:フルチカゾン、3:モメタゾン、4:ベクロメタゾン、5:シクレソニド、6:トリアムシノロン、7:ロテプレドノール、8:エチプレドノール、9:フルニソリド
D:β2−アドレナリン受容体のアゴニスト類:1:サルブタモール、2:テルブタリン、3:サルメテロール、4:ホルモテロール、5:インダカテロール、6:フェノテロール、7:レプロテロール、8:ピルブテロール、9:ビトルテロール
E:ロイコトリエン受容体のアンタゴニスト類:1:プランルカスト、2:モンテルカスト、3:ザフィルルカスト
抗コリン作用薬類、PDE4阻害剤類およびβ2−アドレナリン受容体のアゴニスト類
抗コリン作用薬類、PDE4阻害剤類およびロイコトリエン受容体のアンタゴニスト類
抗コリン作用薬類、グルココルチコイド類およびβ2−アドレナリン受容体のアゴニスト類
抗コリン作用薬類、グルココルチコイド類およびロイコトリエン受容体のアンタゴニスト類
PDE4阻害剤、グルココルチコイド類およびβ2−アドレナリン受容体のアゴニスト類
PDE4阻害剤、β2−アドレナリン受容体のアゴニスト類およびロイコトリエン受容体のアンタゴニスト類
グルココルチコイド類、β2−アドレナリン受容体のアゴニスト類およびロイコトリエン受容体のアンタゴニスト類
R,R−グリコピロラート、PDE4阻害剤類およびβ2−アドレナリン受容体のアゴニスト類
R,R−グリコピロラート、PDE4阻害剤類およびロイコトリエン受容体のアンタゴニスト類
R,R−グリコピロラート、グルココルチコイド類およびβ2−アドレナリン受容体のアゴニスト類
R,R−グリコピロラート、グルココルチコイド類およびロイコトリエン受容体のアンタゴニスト類
単一化合物とその各種配合薬および三種配合薬の、TNFの分泌に対する影響を、ヒトの単球を使って試験した。その試験は、the International Declarations of Helsinki and Tokyoに従って本発明者らのinstitutional Ethics Commitee によって認可された。
10μMまでの濃度のβ2−アドレナリン受容体のアゴニストのホルモテロールは、LPSで刺激されたTNFαの放出に影響しなかった。
Claims (20)
- 炎症性疾患を治療するための、抗コリン作用薬類、PDE4阻害剤類、グルココルチコイド類、β2−アドレナリン受容体のアゴニスト類およびロイコトリエン受容体のアンタゴニスト類からなる群から選択される少なくとも3つの異なる、薬剤として活性の物質またはそれらの生理的に許容できる塩類の配合薬。
- 前記抗コリン作用薬が、ラセミ体のグリコピロラート、そのエナンチオマー類の内の一つ、そのジアステレオマー類の内の一つ、またはそれらの生理的に許容できる塩類もしくはそれらの混合物である請求項1に記載の配合薬。
- 前記PDE4阻害剤が、ロリプラム、ロフルミラスト、シロミラスト、AWD−12−281またはそれらの生理的に許容できる塩類を含む群から選択される請求項1に記載の配合薬。
- 前記グルココルチコイドが、ブデソニド、フルチカゾン、モメタゾン、ベクロメタゾン、シクレソニド、トリアムシノロン、ロテプレドノール、エチプレドノール、フルニソリドまたはそれらの生理的に許容できる塩類を含む群から選択される請求項1に記載の配合薬。
- 前記β2−アドレナリン受容体のアゴニストが、サルブタモール、テルブタリン、サルメテロール、ホルモテロール、インダカテロール、フェノテロール、レプロテロール、ピルブテロール、ビトルテロール、またはそれらの生理的に許容できる塩類を含む群から選択される請求項1に記載の配合薬。
- 前記ロイコトリエン受容体のアンタゴニストが、プランルカスト、モンテルカスト、ザフィルルカストまたはそれらの生理的に許容できる塩類を含む群から選択される請求項1に記載の配合薬。
- 前記炎症性疾患が、呼吸器疾患、リウマチまたは自己免疫疾患である請求項1〜6のいずれか一項に記載の配合薬。
- 前記呼吸器疾患が喘息またはCOPDである請求項7に記載の配合薬。
- 前記自己免疫疾患が、リウマチ様関節炎、糸球体腎炎、多発性硬化症、クローン病、潰瘍性大腸炎、全身性エリエマトーデスまたは乾癬である請求項7に記載の配合薬。
- R,R−グリコピロラート、ホルモテロールおよびブデソニドまたはそれらの生理的に許容される塩類を含む請求項1〜9のいずれか一項に記載の配合薬。
- R,R−グリコピロラート、ロリプラムおよびブデソニドまたはそれらの生理的に許容される塩類を含む請求項1〜9のいずれか一項に記載の配合薬。
- 抗コリン作用薬類、PDE4阻害剤類、グルココルチコイド類、β2−アドレナリン受容体のアゴニスト類およびロイコトリエン受容体のアンタゴニスト類からなる群から選択される少なくとも3つの異なる、薬剤として活性の物質またはそれらの生理的に許容できる塩類を含有する、炎症性疾患を治療するための薬剤。
- 抗コリン作用薬がR,R−グリコピロラートまたはそれらの生理的に許容される塩類である請求項12に記載の薬剤。
- 噴射剤ありまたは噴射剤なしで吸入可能なエーロゾルであることを特徴とする、請求項12に記載の薬剤。
- 吸入可能な乾燥粉末であることを特徴とする、請求項12に記載の薬剤。
- 吸入可能な懸濁液または溶液であることを特徴とする、請求項12に記載の薬剤。
- 吸入器で提供される請求項12〜16のいずれか一項に記載の薬剤。
- 活性物質が、吸入で利用するのに適した薬剤形状で、通常の賦形剤、補助薬および添加剤とともに同時に、連続してまたは別個に投与するために固定または自由な組み合わせで存在していることを特徴とする、請求項14〜17のいずれか一項に記載の薬剤。
- R,R−グリコピロラート、ホルモテロールおよびブデソニドまたはそれらの生理的に許容される塩類を含む請求項12〜18のいずれか一項に記載の薬剤。
- R,R−グリコピロラート、ロリプラムおよびブデソニドまたはそれらの生理的に許容される塩類を含む請求項12〜18のいずれか一項に記載の薬剤。
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PCT/EP2006/011536 WO2007071313A2 (en) | 2005-12-21 | 2006-12-01 | Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
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EP (2) | EP1971369B1 (ja) |
JP (1) | JP5107933B2 (ja) |
CN (1) | CN101321539B (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2008021237A1 (en) * | 2006-08-10 | 2008-02-21 | Arubor Corporation | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
EP1894568A1 (en) * | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
US9623000B2 (en) | 2008-07-31 | 2017-04-18 | Dekel Pharmaceuticals Ltd | Compositions and methods for treating inflammatory disorders |
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KR20180028563A (ko) * | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
WO2012107364A1 (en) * | 2011-02-07 | 2012-08-16 | Scipharm Sàrl | Novel composition for the treatment of cystic fibrosis |
CN102247380A (zh) * | 2011-08-19 | 2011-11-23 | 北京阜康仁生物制药科技有限公司 | 一种以布地奈德与茚达特罗为活性成分的复方制剂 |
EP2968152B2 (en) | 2013-03-15 | 2022-06-22 | Pearl Therapeutics, Inc. | Methods and systems for conditioning of particulate crystalline materials |
US10058661B2 (en) | 2014-12-04 | 2018-08-28 | Norton (Waterford) Limited | Inhalation monitoring system and method |
WO2019060595A1 (en) | 2017-09-20 | 2019-03-28 | Teva Branded Pharmaceutical Products R&D, Inc. | INHALABLE DRY POWDER MEDICINAL PRODUCT COMPRISING GLYCOPYRRONIUM |
CN111228257A (zh) * | 2020-03-03 | 2020-06-05 | 中国人民解放军南部战区总医院 | 咯利普兰在制备治疗脓毒症心功能障碍的药物中的应用 |
EP4209219A1 (en) * | 2022-01-07 | 2023-07-12 | MetrioPharm AG | Combination of budesonide and 5-amino-2,3-dihydro-1,4-phtalazinedione |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001504459A (ja) * | 1996-11-11 | 2001-04-03 | ノエ・クリスティアン・エル | 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法 |
JP2003506405A (ja) * | 1999-08-09 | 2003-02-18 | アラキス リミテッド | 抗ムスカリン薬の局所的使用 |
JP2004519436A (ja) * | 2000-12-07 | 2004-07-02 | アラキス リミテッド | 抗ムスカリン剤とカルシウムチャンネル遮断剤の併用 |
WO2004075896A1 (en) * | 2003-02-27 | 2004-09-10 | Chiesi Farmaceutici S.P.A. | Medicament comprising a highly potent long-lasting beta2-agonist in combination with other active ingredients |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100331255B1 (ko) * | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
US6204285B1 (en) | 1996-07-01 | 2001-03-20 | Sepracor Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (R,R)-glycopyrrolate |
US6384038B1 (en) * | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
AU7455498A (en) * | 1998-05-29 | 1999-12-20 | Citizen Watch Co. Ltd. | Method of subjecting ink jet printer to preuse treatment |
US6475467B1 (en) | 1998-08-04 | 2002-11-05 | Jago Research Ag | Medicinal aerosol formulations |
HU226164B1 (en) * | 1998-11-13 | 2008-05-28 | Jagotec Ag | Use of magnesium stearate in dry powder compositions suitable for inhalation and compositions suitable for inhalation |
US6745467B1 (en) * | 1999-02-10 | 2004-06-08 | Canon Kabushiki Kaisha | Method of producing a liquid discharge head |
DE19921693A1 (de) * | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
US6086914A (en) * | 1999-03-12 | 2000-07-11 | Weinstein; Robert E. | Nonsedating formulations for allergic rhinitis which possess antihistaminic and anticholinergic activity |
US20040002548A1 (en) * | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
US20040028958A1 (en) | 2002-06-18 | 2004-02-12 | Total Innovative Manufacturing Llc | Recyclable fire-resistant moldable batt and panels formed therefrom |
DE19961300A1 (de) * | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
GB0009584D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
GB0009583D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Respiratory formulations |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
DE10110772A1 (de) | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
CZ301676B6 (cs) | 2001-03-30 | 2010-05-19 | Jagotec Ag | Farmaceutický suspenzní aerosolový prípravek pro inhalaci a použití soli karboxylové kyseliny |
US20030055026A1 (en) * | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
US6667344B2 (en) * | 2001-04-17 | 2003-12-23 | Dey, L.P. | Bronchodilating compositions and methods |
MXPA03010162A (es) | 2001-05-25 | 2004-03-10 | Pfizer | Un inhibidor de pde4 y un agente anticolinergico en combinacion para tratar enfermedades obstructivas de vias respiratorias. |
DE60216588T2 (de) | 2001-05-25 | 2007-09-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen |
DE10130371A1 (de) * | 2001-06-23 | 2003-01-02 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika |
GB0118373D0 (en) | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
US7258118B2 (en) * | 2002-01-24 | 2007-08-21 | Sofotec Gmbh & Co, Kg | Pharmaceutical powder cartridge, and inhaler equipped with same |
GB0207906D0 (en) * | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
US20050107420A1 (en) * | 2002-05-23 | 2005-05-19 | Boehringe Ingelheim Pharma Gmbh & Co. Kg | Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases |
US20040038958A1 (en) * | 2002-07-11 | 2004-02-26 | Chris Rundfeldt | Topical treatment of skin diseases |
UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
JP2005539046A (ja) * | 2002-08-29 | 2005-12-22 | シプラ・リミテッド | 特異的な抗コリン作用薬、β−2アゴニスト、および副腎皮質ステロイドを含む、治療薬および組成物 |
US20040053902A1 (en) * | 2002-09-13 | 2004-03-18 | Smith C. Steven | Novel composition and method for treatment of upper respiratory conditions |
ATE384529T1 (de) * | 2003-03-28 | 2008-02-15 | Nycomed Gmbh | Synergistische kombination enthaltend roflumilast und einen anticholinergischen wirkstoff ausgewählt aus tiotropiumsalzen für die behandlung von atemwegserkrankungen |
US20060189642A1 (en) | 2003-03-28 | 2006-08-24 | Altana Pharma Ag | Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases |
EP1646881A1 (en) | 2003-07-11 | 2006-04-19 | Philips Intellectual Property & Standards GmbH | Improved frequency determination |
WO2005065435A2 (en) * | 2003-12-31 | 2005-07-21 | Cydex, Inc. Et Al. | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
ES2413011T3 (es) * | 2004-02-06 | 2013-07-15 | Meda Pharma Gmbh & Co. Kg | Combinación de anticolinérgicos y glucocorticoides para el tratamiento a largo plazo de asma y EPOC |
DK1718336T3 (da) * | 2004-02-06 | 2008-10-20 | Meda Pharma Gmbh & Co Kg | Ny kombination af anticholinergikum og beta-mimetika til behandling af luftvejssygdomme |
CN1913882A (zh) * | 2004-02-06 | 2007-02-14 | Meda制药有限及两合公司 | 用抗胆碱能药单独或联合抗组胺药、磷酸二酯酶4抑制剂或皮质类固醇来治疗鼻炎 |
EP1720577A2 (en) * | 2004-02-27 | 2006-11-15 | Altana Pharma AG | Ciclesonide and glycopyrronium combination |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
DE102004056579A1 (de) * | 2004-11-23 | 2006-05-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Arzneimittel enthaltend ein neues Anticholinergikum, Salmeterol und ein Steroid |
CA2603433A1 (en) * | 2005-03-30 | 2006-10-05 | Schering Corporation | Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist |
EP1894568A1 (en) * | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
-
2006
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- 2006-12-01 SI SI200631387T patent/SI2098248T1/sl unknown
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-
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-
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- 2009-02-10 HK HK09101175.6A patent/HK1123497A1/xx not_active IP Right Cessation
- 2009-09-21 HR HR20090498T patent/HRP20090498T1/xx unknown
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-
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-
2012
- 2012-08-30 CY CY20121100780T patent/CY1113080T1/el unknown
- 2012-09-06 HR HRP20120708TT patent/HRP20120708T1/hr unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001504459A (ja) * | 1996-11-11 | 2001-04-03 | ノエ・クリスティアン・エル | 対掌体純粋な、塩基性アリール―シクロアルキル―ヒドロキシカルボン酸エステル、その製造方法及びこれを薬剤に使用する方法 |
JP2003506405A (ja) * | 1999-08-09 | 2003-02-18 | アラキス リミテッド | 抗ムスカリン薬の局所的使用 |
JP2004519436A (ja) * | 2000-12-07 | 2004-07-02 | アラキス リミテッド | 抗ムスカリン剤とカルシウムチャンネル遮断剤の併用 |
WO2004075896A1 (en) * | 2003-02-27 | 2004-09-10 | Chiesi Farmaceutici S.P.A. | Medicament comprising a highly potent long-lasting beta2-agonist in combination with other active ingredients |
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US10159645B2 (en) | 2009-12-23 | 2018-12-25 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
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