JP2009519328A - 筋萎縮に対する可溶性食物繊維の使用 - Google Patents
筋萎縮に対する可溶性食物繊維の使用 Download PDFInfo
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Abstract
【選択図】 なし
Description
物質および方法
雄のCD2F1マウス(BALB/c×DBA/2, Harlan, the Netherlands)を使用し、腫瘍を有する群(TB)においてカヘキシーを誘発するためにC-26腺癌細胞を使用し、一方、対照マウス(C)には偽の注射を行った。実験1において、食物は、51%ガラクトオリゴ糖(GOS)およびフルクト多糖類(9:1)、19%マルトデキストリン、16%ラクトースならびに14%グルコースで構成された。実験2において、FOSは付加的なGOSで置換された。トランス-ガラクトオリゴ糖のGOS噴霧乾燥粉末はある程度の重合度(dp)3-8を有し(Vivinal GOS, Borculo Domo, Zwolle, NL)、FOSは高い重合度を有していた(Raftiline HP, Orafti, Wijchen, NL; 平均dp >23)。腫瘍細胞の接種の後、腫瘍量および骨格筋(長指伸筋(EDL)およびヒラメ筋)を分析し、重さを量った。
-対照マウス =C
-腫瘍を有するマウス =TB
-腫瘍を有する+GOS/FOS =TB-Gos Fos
実験2
-対照マウス =C
-腫瘍を有するマウス =TB
-腫瘍を有する+GOS =TB-Gos
結果
以下の表は、実験1および2の筋肉量(mg、+Cに対する%減少)を示す。
液体製剤は、慢性的な筋萎縮に罹患している患者のために調製された。100ml当り以下を含む:
エネルギー 658kJ(157kcal)
タンパク質[8.2gカゼインおよびホエイ、1.8g Leu] 10.0g
脂質[魚油、植物] 5.3g
a. EPA 0.56g
b. DHA 0.27g
糖質 17.4g
a. ショ糖 4.21g
b. マルトデキストリン 8.42g
c. トレハロース 4.21g
d. ラクトース 0.59g
繊維 2.05g
a. インスリンDP>20 0.1g
b. 加水分解されたインスリンDP<20 0.08g
c. GOS 1.53g
d. 耐性デンプン 0.05g
e. セルロース 0.31g。
液体製剤は、慢性的な筋萎縮に罹患している患者のために調製された。前記製剤は、100ml当り以下を含む:
エネルギー 662kJ(158kcal)
タンパク質[カゼイン、ホエイ+1g Leu、0.5g Met、0.5g Arg] 10.0g
脂質[魚油、植物] 5.3g
糖質[糖類ブレンド] 17.5g
繊維[GOS+ポリフルクトース9:1] 2.1g
灰分 1.2g。
液体製剤は、慢性的な筋萎縮に罹患している患者のために調製された。前記製剤は、100ml当り以下を含む:
エネルギー 587kJ(140kcal)
タンパク質[カゼイン+0.9g Leu、0.5 Ile、0.2g Val] 9g
脂質 5.0g
糖質(10重量%遊離リボース) 15g
繊維[加水分解されたグアー+GOS比3:7] 1.5g
ミネラル/微量成分/60μgの葉酸を含むビタミン 2.0g。
慢性的な筋萎縮に罹患している患者のための液体製剤は、100ml当り以下を含む:
タンパク質[カゼイン6.1+ホエイ2.9+遊離Leu 1.1] 10.1g
脂質[EPA 0.6、DHA 0.29、ω-3/ω-6=1.16、
PUFA’s 2.5;MUFA 1.5;飽和0.76] 5.6g
消化可能な糖質[ショ糖3.92、ラクトース0.7、
マルトデキストリン7.84、トレハロース3.92] 16.4g
繊維[加水分解されたインスリンDP<20 0.2+GOS 1.8] 2.0g
ミネラル/微量成分/ビタミン。
Claims (15)
- 筋萎縮および/または慢性的な筋萎縮および/または筋肉減少症の発生の治療または減少のための栄養組成物または医薬組成物を調製するための可溶性食物繊維の使用であって、前記食物繊維は、少なくとも30重量%の3〜10無水モノース単位の鎖長を有するオリゴ糖を含んでなる使用。
- 請求項1に記載の使用であって、前記食物繊維は少なくとも30重量%のオリゴ糖を含んでなり、前記無水モノース単位は、ガラクトース、マンノース、キシロース、それらのデオキシ形態、アミノ形態およびN-アシルアミノ形態の群から選択される多数の無水ピラノース単位を有する使用。
- 請求項1または2に記載の使用であって、前記食物繊維は、前記無水モノース単位が多数の無水ガラクトース単位を有する30〜96重量%のオリゴ糖ならびに前記無水モノース単位が多数の無水フルクトース単位を有する4〜50重量%のオリゴ糖および/または多糖類を含んでなる使用。
- 請求項1〜3のいずれか1項に記載の使用であって、前記食物繊維は、50〜100重量%、好ましくは70〜98重量%の前記オリゴ糖を含んでなる使用。
- 請求項1〜4のいずれか1項に記載の使用であって、前記筋萎縮は、腫瘍、手術、心的外傷または炎症と関連する使用。
- 請求項5に記載の使用であって、前記腫瘍は、肝臓、膵臓、肺、皮膚、食道、脳、頭および頸部における腫瘍である使用。
- 請求項1〜6のいずれか1項に記載の使用であって、前記組成物は、消化可能な糖質、脂質およびタンパク質を含んでなる栄養組成物である使用。
- 請求項7に記載の使用であって、前記栄養組成物は、100sec−1のせん断速度、20℃において、35Mpa.s未満の粘度を有する液体組成物である使用。
- 請求項7または8に記載の使用であって、前記栄養組成物は、5.0〜16.8kJ/ml(1.2〜4.0kcal/ml)、好ましくは5.4〜8.4kJ/ml(1.3〜2.0kcal/ml)のエネルギー密度を有する使用。
- 請求項1〜9のいずれか1項に記載の使用であって、前記組成物は、ヌクレオチド合成および葉酸代謝を補助する成分、特に繊維組成物1g当り50〜1000μgの量の葉酸をさらに含んでなる使用。
- 請求項1〜10のいずれか1項に記載の使用であって、前記組成物は、グルコースの血糖指数の70%未満の血糖指数を有する糖質画分をさらに含んでなる使用。
- 10〜90重量%の請求項1〜4のいずれか1項で定義された可溶性繊維組成物および90〜10重量%のリボースを含有する食品補助剤。
- 3〜40重量%の請求項1〜4のいずれか1項で定義された可溶性繊維組成物、3〜40重量%のリボース、5〜40重量%のラクトースおよび20〜80重量%の他の消化可能な糖質を含有する糖質組成物。
- 10〜95重量%の請求項1〜4のいずれか1項で定義された可溶性繊維組成物、および5〜90重量%のω-3脂肪酸を含有する食品補助剤であって、前記可溶性繊維はガラクトオリゴ糖を含んでなる食品補助剤。
- 請求項1〜4のいずれか1項で定義された可溶性繊維組成物およびタンパク質画分を含有する栄養組成物であって、前記繊維組成物と前記タンパク質画分との重量比は5:95〜75:25であり、前記タンパク質画分は少なくとも48重量%の必須アミノ酸を含有し、前記可溶性繊維はガラクトオリゴ糖を含んでなる栄養組成物。
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JPH11508282A (ja) * | 1996-04-25 | 1999-07-21 | アボツト・ラボラトリーズ | 悪液質および食欲不振の予防および治療方法 |
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JP2007222128A (ja) * | 2006-02-27 | 2007-09-06 | Pola Chem Ind Inc | 食品組成物 |
JP4610499B2 (ja) * | 2006-02-27 | 2011-01-12 | ポーラ化成工業株式会社 | 食品組成物 |
Also Published As
Publication number | Publication date |
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ATE441333T1 (de) | 2009-09-15 |
IL192219A (en) | 2011-08-31 |
NZ569169A (en) | 2012-01-12 |
EP1965669A1 (en) | 2008-09-10 |
CN101374426A (zh) | 2009-02-25 |
AU2006325591B2 (en) | 2012-07-12 |
CN102948659A (zh) | 2013-03-06 |
CA2633292A1 (en) | 2007-06-21 |
CA2633292C (en) | 2015-04-28 |
ZA200805905B (en) | 2009-10-28 |
RU2450815C2 (ru) | 2012-05-20 |
WO2007069900A1 (en) | 2007-06-21 |
BRPI0619947A2 (pt) | 2011-10-25 |
EP1965669B1 (en) | 2009-09-02 |
CN101374426B (zh) | 2012-11-28 |
CN102948659B (zh) | 2014-04-23 |
US8143235B2 (en) | 2012-03-27 |
US9555059B2 (en) | 2017-01-31 |
PL1965669T3 (pl) | 2010-02-26 |
US20090203573A1 (en) | 2009-08-13 |
BRPI0619947B1 (pt) | 2023-10-10 |
IL192219A0 (en) | 2008-12-29 |
DK1965669T3 (da) | 2009-10-05 |
US20120165243A1 (en) | 2012-06-28 |
RU2008129102A (ru) | 2010-01-27 |
ES2332149T3 (es) | 2010-01-27 |
DE602006008985D1 (de) | 2009-10-15 |
AU2006325591A1 (en) | 2007-06-21 |
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