JP2009517695A - バイオセンサー表面上での抗原のリアルタイム結合解析 - Google Patents

バイオセンサー表面上での抗原のリアルタイム結合解析 Download PDF

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Publication number
JP2009517695A
JP2009517695A JP2008543421A JP2008543421A JP2009517695A JP 2009517695 A JP2009517695 A JP 2009517695A JP 2008543421 A JP2008543421 A JP 2008543421A JP 2008543421 A JP2008543421 A JP 2008543421A JP 2009517695 A JP2009517695 A JP 2009517695A
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phage
biosensor
antibody
binding
protein
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Japanese (ja)
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JP2009517695A5 (https=
Inventor
マディソン,ララ
ガストンメイヤー,ジョン
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エス アール ユー バイオシステムズ,インコーポレイテッド
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Publication of JP2009517695A publication Critical patent/JP2009517695A/ja
Publication of JP2009517695A5 publication Critical patent/JP2009517695A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G01N33/567Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds utilising isolate of tissue or organ as binding agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2008543421A 2005-11-30 2006-11-29 バイオセンサー表面上での抗原のリアルタイム結合解析 Pending JP2009517695A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/290,036 US7524625B2 (en) 2000-10-30 2005-11-30 Real time binding analysis of antigens on a biosensor surface
PCT/US2006/045684 WO2007064702A1 (en) 2005-11-30 2006-11-29 Real time binding analysis of antigens on a biosensor surface

Publications (2)

Publication Number Publication Date
JP2009517695A true JP2009517695A (ja) 2009-04-30
JP2009517695A5 JP2009517695A5 (https=) 2010-01-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008543421A Pending JP2009517695A (ja) 2005-11-30 2006-11-29 バイオセンサー表面上での抗原のリアルタイム結合解析

Country Status (8)

Country Link
US (2) US7524625B2 (https=)
EP (2) EP2383580A1 (https=)
JP (1) JP2009517695A (https=)
CN (1) CN101336376A (https=)
AU (1) AU2006320660A1 (https=)
CA (1) CA2632055A1 (https=)
NZ (1) NZ569311A (https=)
WO (1) WO2007064702A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013128614A1 (ja) * 2012-03-01 2013-09-06 日本精工株式会社 標的物質検出装置及び標的物質検出方法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) * 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7524625B2 (en) * 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
AU2006236090B2 (en) * 2000-10-30 2008-01-03 Sru Biosystems, Inc. A label-free high-throughput optical technique for detecting biomolecular interactions
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
JP2008523383A (ja) * 2004-12-10 2008-07-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マルチスポット調査装置
NZ562794A (en) * 2005-04-12 2010-07-30 Sru Biosystems Inc Proteolipid membrane & lipid membrane biosensor using a titanium surface
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
CN101802611A (zh) 2007-07-11 2010-08-11 Sru生物系统公司 鉴别离子通道调节剂的方法
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
CN102149327A (zh) * 2008-07-11 2011-08-10 Sru生物系统公司 鉴定离子通道调节剂的方法
KR101165720B1 (ko) * 2008-11-18 2012-07-18 한국전자통신연구원 휴대용 광바이오 센서 측정 장치 및 그 측정 방법
KR101123641B1 (ko) 2008-12-31 2012-03-20 키스트 유럽 에프게엠베하 검출 물질에 특이적으로 반응할 수 있는 분자 인지 물질이 진열된 박테리오파아지의 제조 방법 및 상기 제조 방법으로제조된 박테리오파아지를 미량 검출물을 검출하는데 활용하는 방법 및 상기 박테리오파아지를 이용한 질량 분석장치
KR101123640B1 (ko) 2008-12-31 2012-04-19 키스트 유럽 에프게엠베하 전기 전도성을 지니게 하는 박테리오파아지의 제조 방법 및상기 제조 방법으로 제조된 박테리오파아지 및 상기 박테리오파아지를 분자 인지 센서로 이용하는 방법 및 상기박테리오파아지를 이용한 분자 인지 센서
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
CA2761114A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of changes in cell populations and mixed cell populations
US8525237B1 (en) * 2010-10-04 2013-09-03 The Regents Of The University Of California Electrically conductive polymer nanowires with incorporated viruses
CN103728447B (zh) * 2014-01-03 2016-07-13 北京纳晶生物科技有限公司 可控量子点位点特异性桥接偶联的抗体标记方法及其应用
US9903816B2 (en) 2014-12-02 2018-02-27 Infineon Technologies Ag Photonic crystal sensor structure and a method for manufacturing the same
WO2017136187A2 (en) * 2016-02-01 2017-08-10 Micro Detect, Inc. Uv solid state detection and methods therefor
US11740399B2 (en) * 2018-02-06 2023-08-29 Raytheon Company Low cost dispersive optical elements
EP4310184A3 (en) * 2018-02-23 2024-05-01 Meso Scale Technologies, LLC. Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule
CN108956983B (zh) * 2018-05-07 2021-05-07 西北工业大学 一种以烟草花叶病毒为模板的微传感器可控阵列化制备方法
WO2023039342A1 (en) * 2021-09-08 2023-03-16 Arizona Board Of Regents On Behalf Of Arizona State University Charge-sensitive optical detection of binding kinetics between phage displayed peptide ligands and protein targets

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05211871A (ja) * 1992-01-31 1993-08-24 Rikagaku Kenkyusho 領域指定突然変異導入法
WO2001079559A1 (en) * 2000-04-18 2001-10-25 Wayne State University System to detect protein-protein interactions
JP2002526111A (ja) * 1998-10-07 2002-08-20 ストライカー・コーポレーション 形態形成タンパク質を含むTGF−βスーパーファミリー変異体メンバー
WO2004036177A2 (en) * 2002-10-15 2004-04-29 Regents Of The University Of Minnesota Assays to detect or quantify bacterial or viral pathogens and contaminants
US20040229215A1 (en) * 2003-03-04 2004-11-18 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
WO2005001475A2 (en) * 2003-04-10 2005-01-06 Kent Voorhees Apparatus and method for detecting microscopic living organisms using bacteriophage
JP2005535870A (ja) * 2001-11-07 2005-11-24 オーバーン ユニバーシティ ファージリガンドセンサーデバイスおよびその使用

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
WO1986007149A1 (de) * 1985-05-29 1986-12-04 Kurt Tiefenthaler Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahländerungen in messubstanzen
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE8902043L (sv) * 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
US5216680A (en) * 1991-07-11 1993-06-01 Board Of Regents, The University Of Texas System Optical guided-mode resonance filter
GB9314991D0 (en) * 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
WO1996038726A1 (en) 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
GB9602542D0 (en) * 1996-02-08 1996-04-10 Fisons Plc Analytical device
US5666197A (en) * 1996-08-21 1997-09-09 Polaroid Corporation Apparatus and methods employing phase control and analysis of evanescent illumination for imaging and metrology of subwavelength lateral surface topography
AU4207897A (en) * 1996-08-29 1998-03-19 Novartis Ag Optical chemical / biochemical sensor
DE59811600D1 (de) * 1997-09-10 2004-07-29 Artificial Sensing Instr Asi A Optischer sensor und optisches verfahren zur charakterisierung einer chemischen und/oder biochemischen substanz
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
US6684007B2 (en) * 1998-10-09 2004-01-27 Fujitsu Limited Optical coupling structures and the fabrication processes
DE69933193T2 (de) 1999-02-25 2007-08-02 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A. Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
KR100883079B1 (ko) 1999-07-05 2009-02-10 노파르티스 아게 플랫폼, 플랫폼을 가지는 장치, 및 플랫폼을 사용하는 방법
EP1085315B1 (en) 1999-09-15 2003-07-09 CSEM Centre Suisse d'Electronique et de Microtechnique SA Integrated-optical sensor
US6541071B1 (en) * 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
WO2001092870A2 (de) 2000-06-02 2001-12-06 Zeptosens Ag Kit und verfahren zur multianalytbestimmung
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7094595B2 (en) * 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
JP4183505B2 (ja) 2000-10-30 2008-11-19 エイティーオー・フィンドレー・インコーポレーテッド 制御可能な変色速度を有するホットメルト湿り度指示薬接着剤組成物
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US6951715B2 (en) 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
CA2453528C (en) * 2001-08-01 2011-07-26 Cellomics, Inc. Novel fusion proteins and assays for molecular binding
US7927822B2 (en) * 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7863052B2 (en) * 2005-08-11 2011-01-04 Sru Biosystems, Inc. Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
US20040091397A1 (en) * 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
US7309614B1 (en) * 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) * 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
JP2007510928A (ja) * 2003-11-06 2007-04-26 エス アール ユー バイオシステムズ,インコーポレイテッド 高密度アミン機能化表面
US6990259B2 (en) * 2004-03-29 2006-01-24 Sru Biosystems, Inc. Photonic crystal defect cavity biosensor
EP1769230A2 (en) * 2004-06-28 2007-04-04 SRU Biosystems, Inc. Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules
DE102004052510A1 (de) * 2004-10-21 2006-04-27 Wilhelm Stahlecker Gmbh Luftdüsenspinnmaschine
US7803619B2 (en) * 2004-11-24 2010-09-28 Geneprotech, Inc. Embryoid body-based screen
NZ562794A (en) * 2005-04-12 2010-07-30 Sru Biosystems Inc Proteolipid membrane & lipid membrane biosensor using a titanium surface
US7197198B2 (en) * 2005-06-23 2007-03-27 Sru Biosystems, Inc. Biosensor substrate structure for reducing the effects of optical interference
US7162125B1 (en) * 2005-06-23 2007-01-09 Sru Biosystems, Inc. Optimized grating based biosensor and substrate combination
US7521769B2 (en) * 2005-07-08 2009-04-21 Sru Biosystems, Inc. Photonic crystal biosensor structure and fabrication method
US7479404B2 (en) * 2005-07-08 2009-01-20 The Board Of Trustees Of The University Of Illinois Photonic crystal biosensor structure and fabrication method
US7483127B1 (en) * 2005-08-08 2009-01-27 Sru Biosystems, Inc. Method and apparatus for generating an image of biomolecular sensor target area
US7790406B2 (en) * 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
EP2041554A2 (en) * 2006-07-07 2009-04-01 The Board of Trustees of the University of Illinois Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio
JP2010508520A (ja) * 2006-10-31 2010-03-18 エス アール ユー バイオシステムズ,インコーポレイテッド 官能基が付与された表面上の非特異的タンパク質結合をブロッキングする方法
AU2007319975B2 (en) * 2006-11-09 2011-03-03 Sru Biosystems, Inc. Photonic crystal sensors with integrated fluid containment structure
US7628085B2 (en) * 2006-11-17 2009-12-08 Sru Biosystems, Inc. Simultaneous aspirator and dispenser for multiwell plates and similar devices
US20080240543A1 (en) * 2007-03-30 2008-10-02 Wolfgang Ernst Gustav Budach Calibration and normalization method for biosensors
AU2008242664B2 (en) * 2007-04-19 2011-10-20 Sru Biosystems, Inc. Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
US9134307B2 (en) * 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
CN101802611A (zh) 2007-07-11 2010-08-11 Sru生物系统公司 鉴别离子通道调节剂的方法
US8268637B2 (en) * 2008-01-11 2012-09-18 The Board Of Trustees Of The University Of Illinois Label-free biosensors based upon distributed feedback laser
US20090213910A1 (en) * 2008-02-25 2009-08-27 Grant Stephen J Code Power Estimation for MIMO Signals
US20090227469A1 (en) * 2008-03-10 2009-09-10 Conklin Bruce R Cells and assays for use in detecting long qt syndrome
US8257936B2 (en) * 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
EP2304500A1 (en) * 2008-06-04 2011-04-06 SRU Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
US20100008826A1 (en) * 2008-07-10 2010-01-14 Sru Biosystems, Inc. Biosensors featuring confinement of deposited material and intra-well self-referencing
CN102149327A (zh) 2008-07-11 2011-08-10 Sru生物系统公司 鉴定离子通道调节剂的方法
WO2010087806A1 (en) * 2009-02-02 2010-08-05 Sru Biosystems, Inc Efficient optical arrangement for illumination and detection of label-free biosensors and method to reduce interference fringes in label-free imaging
CA2761114A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of changes in cell populations and mixed cell populations

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05211871A (ja) * 1992-01-31 1993-08-24 Rikagaku Kenkyusho 領域指定突然変異導入法
JP2002526111A (ja) * 1998-10-07 2002-08-20 ストライカー・コーポレーション 形態形成タンパク質を含むTGF−βスーパーファミリー変異体メンバー
WO2001079559A1 (en) * 2000-04-18 2001-10-25 Wayne State University System to detect protein-protein interactions
JP2005535870A (ja) * 2001-11-07 2005-11-24 オーバーン ユニバーシティ ファージリガンドセンサーデバイスおよびその使用
WO2004036177A2 (en) * 2002-10-15 2004-04-29 Regents Of The University Of Minnesota Assays to detect or quantify bacterial or viral pathogens and contaminants
US20040229215A1 (en) * 2003-03-04 2004-11-18 Auburn University Methods of forming monolayers of phage-derived products and uses thereof
WO2005001475A2 (en) * 2003-04-10 2005-01-06 Kent Voorhees Apparatus and method for detecting microscopic living organisms using bacteriophage

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5008020027; CEKAITE LINA: PROTEOMICS V4 N9, 200409, P2572-2582 *
JPN5008020028; SUN W: JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY V25 N5, 200011, P273-275 *
JPN5008020029; WAN JIEHUI: PROCEEDINGS OF THE FOURTH IEEE CONFERENCE ON SENSORS V2005, 20051103, P1308-1311 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013128614A1 (ja) * 2012-03-01 2013-09-06 日本精工株式会社 標的物質検出装置及び標的物質検出方法

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