JP2009515844A5 - - Google Patents
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- Publication number
- JP2009515844A5 JP2009515844A5 JP2008539361A JP2008539361A JP2009515844A5 JP 2009515844 A5 JP2009515844 A5 JP 2009515844A5 JP 2008539361 A JP2008539361 A JP 2008539361A JP 2008539361 A JP2008539361 A JP 2008539361A JP 2009515844 A5 JP2009515844 A5 JP 2009515844A5
- Authority
- JP
- Japan
- Prior art keywords
- oxy
- methyl
- difluoro
- diene
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 1-ethyl-2-methylpropyl Chemical group 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- ZQCAOHVYAHPGEW-SCZYCMLPSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-3h-cyclopenta[a]phenanthrene-17-carboxylic acid Chemical compound C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)C(O)=O)[C@@H]4[C@@H]3CCC2=C1 ZQCAOHVYAHPGEW-SCZYCMLPSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001602 bicycloalkyls Chemical group 0.000 claims 2
- 125000003113 cycloheptyloxy group Chemical group C1(CCCCCC1)O* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000004410 cyclooctyloxy group Chemical group C1(CCCCCCC1)O* 0.000 claims 2
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000005919 1,2,2-trimethylpropyl group Chemical group 0.000 claims 1
- 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 125000001887 cyclopentyloxy group Chemical group C1(CCCC1)O* 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0523251.7A GB0523251D0 (en) | 2005-11-15 | 2005-11-15 | Novel compounds |
| PCT/EP2006/010894 WO2007057152A1 (en) | 2005-11-15 | 2006-11-13 | 17.beta.-fluoromethoxycarbonyl-androst-4-en-3-one compounds with a 17.alpha.-carbonate substituent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515844A JP2009515844A (ja) | 2009-04-16 |
| JP2009515844A5 true JP2009515844A5 (https=) | 2010-01-07 |
Family
ID=35516957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539361A Pending JP2009515844A (ja) | 2005-11-15 | 2006-11-13 | １７アルファ−カルボネート置換基を有する１７ベータ−フルオロメトキシカルボニル−アンドロスタ−４−エン−３−オン化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080249077A1 (https=) |
| EP (1) | EP1957512A1 (https=) |
| JP (1) | JP2009515844A (https=) |
| GB (1) | GB0523251D0 (https=) |
| WO (1) | WO2007057152A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012056201A2 (en) | 2010-10-27 | 2012-05-03 | Hovione Inter Limited | Electrophilic reagents for monohalomethylation,their preparation and their uses |
| WO2024149093A1 (zh) * | 2023-01-10 | 2024-07-18 | 四川科伦博泰生物医药股份有限公司 | 糖皮质激素受体激动剂及其偶联物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA814440B (en) * | 1980-07-10 | 1982-10-27 | Otsuka Pharma Co Ltd | Soft steroids having anti-inflammatory activity |
| US4996335A (en) * | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
| JPS6041607A (ja) * | 1983-08-12 | 1985-03-05 | Otsuka Pharmaceut Co Ltd | 軟膏基剤 |
| DE4025342A1 (de) * | 1990-08-10 | 1992-02-13 | Hoechst Ag | In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| WO2005000317A1 (en) * | 2003-06-19 | 2005-01-06 | Bodor Nicholas S | Enhancement of activity and/or duration of action of soft anti-inflammatory steroids for topical or other local application |
| US20090124588A1 (en) * | 2005-01-10 | 2009-05-14 | Glaxo Group Limited | Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions |
| EP1841780B1 (en) * | 2005-01-10 | 2011-07-27 | Glaxo Group Limited | Androstane 17-alpha-carbonate derivatives for use in the treatment of allergic and inflammatory conditions |
-
2005
- 2005-11-15 GB GBGB0523251.7A patent/GB0523251D0/en not_active Ceased
-
2006
- 2006-11-13 EP EP06818517A patent/EP1957512A1/en not_active Withdrawn
- 2006-11-13 JP JP2008539361A patent/JP2009515844A/ja active Pending
- 2006-11-13 US US12/093,613 patent/US20080249077A1/en not_active Abandoned
- 2006-11-13 WO PCT/EP2006/010894 patent/WO2007057152A1/en not_active Ceased
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