JP2009514525A5 - - Google Patents
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- Publication number
- JP2009514525A5 JP2009514525A5 JP2008538854A JP2008538854A JP2009514525A5 JP 2009514525 A5 JP2009514525 A5 JP 2009514525A5 JP 2008538854 A JP2008538854 A JP 2008538854A JP 2008538854 A JP2008538854 A JP 2008538854A JP 2009514525 A5 JP2009514525 A5 JP 2009514525A5
- Authority
- JP
- Japan
- Prior art keywords
- klh
- adjuvant
- immunogenic
- immunostimulatory
- furoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Description
免疫刺激性オリゴヌクレオチドまたは免疫刺激性オリゴヌクレオチド接合体、あるいはワクチンのいずれか、あるいは両方は、キーホールリンペットヘモシアニン(KLH)、コレラ毒素Ｂサブユニット、または任意の他の免疫原性担体タンパク質などの、免疫原性タンパク質へと随意に結合してもよい。フロイント完全アジュバント、KLH、モノホスホリル脂質A(MPL)、ミョウバン、あるいはQS-21、イミキモド、R848、またはその組み合わせを含むサポニンを限定なく含む任意の過剰のアジュバントを用いてもよい。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/040215 WO2007055682A2 (en) | 2005-11-07 | 2005-11-07 | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011227910A Division JP2012051921A (ja) | 2011-10-17 | 2011-10-17 | 修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514525A JP2009514525A (ja) | 2009-04-09 |
| JP2009514525A5 true JP2009514525A5 (ja) | 2011-12-08 |
Family
ID=38023708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538854A Pending JP2009514525A (ja) | 2005-11-07 | 2005-11-07 | 修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1945653A4 (ja) |
| JP (1) | JP2009514525A (ja) |
| CN (1) | CN101351469A (ja) |
| AU (1) | AU2005338050B2 (ja) |
| CA (1) | CA2630118A1 (ja) |
| MX (1) | MX2008006004A (ja) |
| WO (1) | WO2007055682A2 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| US7354907B2 (en) * | 2003-02-07 | 2008-04-08 | Idera Pharmaceuticals, Inc. | Short immunomodulatory oligonucleotides |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| US11866700B2 (en) | 2016-05-06 | 2024-01-09 | Exicure Operating Company | Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7785610B2 (en) * | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
| WO2003035836A2 (en) * | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| JP4726630B2 (ja) * | 2003-01-16 | 2011-07-20 | イデラ ファーマシューティカルズ インコーポレイテッド | 修飾された免疫賦活性ジヌクレオチドを用いることによるオリゴヌクレオチドに基づく化合物の免疫賦活特性の調節 |
| CA2549173A1 (en) * | 2003-12-08 | 2005-07-07 | Hybridon, Inc. | Modulation of immunostimulatory properties by small oligonucleotide-based compounds |
-
2005
- 2005-11-07 CN CNA2005800524839A patent/CN101351469A/zh active Pending
- 2005-11-07 JP JP2008538854A patent/JP2009514525A/ja active Pending
- 2005-11-07 CA CA002630118A patent/CA2630118A1/en not_active Abandoned
- 2005-11-07 EP EP05851389A patent/EP1945653A4/en not_active Withdrawn
- 2005-11-07 WO PCT/US2005/040215 patent/WO2007055682A2/en active Application Filing
- 2005-11-07 AU AU2005338050A patent/AU2005338050B2/en not_active Ceased
- 2005-11-07 MX MX2008006004A patent/MX2008006004A/es active IP Right Grant
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