JP2009514525A - 修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性 - Google Patents

修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性 Download PDF

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JP2009514525A
JP2009514525A JP2008538854A JP2008538854A JP2009514525A JP 2009514525 A JP2009514525 A JP 2009514525A JP 2008538854 A JP2008538854 A JP 2008538854A JP 2008538854 A JP2008538854 A JP 2008538854A JP 2009514525 A JP2009514525 A JP 2009514525A
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immunostimulatory oligonucleotide
administering
oligonucleotide
immunostimulatory
tctgtr
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アグラワル,サディール
ユ,ドン
カンディマラ,エカンバー,アール.
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Aceragen Inc
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Idera Pharmaceuticals Inc
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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JP2008538854A 2005-11-07 2005-11-07 修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性 Pending JP2009514525A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/040215 WO2007055682A2 (en) 2005-11-07 2005-11-07 Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides

Related Child Applications (1)

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JP2011227910A Division JP2012051921A (ja) 2011-10-17 2011-10-17 修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性

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JP2009514525A true JP2009514525A (ja) 2009-04-09
JP2009514525A5 JP2009514525A5 (https=) 2011-12-08

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EP (1) EP1945653A4 (https=)
JP (1) JP2009514525A (https=)
CN (1) CN101351469A (https=)
AU (1) AU2005338050B2 (https=)
CA (1) CA2630118A1 (https=)
MX (1) MX2008006004A (https=)
WO (1) WO2007055682A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
US7354907B2 (en) * 2003-02-07 2008-04-08 Idera Pharmaceuticals, Inc. Short immunomodulatory oligonucleotides
US7470674B2 (en) * 2005-11-07 2008-12-30 Idera Pharmaceuticals, Inc. Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
EP3452598A4 (en) 2016-05-06 2020-04-29 Exicure, Inc. LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225016A1 (en) * 2001-06-21 2003-12-04 Fearon Karen L. Chimeric immunomodulatory compounds and methods of using the same - III
WO2004064782A2 (en) * 2003-01-16 2004-08-05 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
JP2005518402A (ja) * 2001-10-24 2005-06-23 ハイブリドン・インコーポレイテッド 5’末端の至適表示によるオリゴヌクレオチド化合物の免疫賦活性調節

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2549173A1 (en) * 2003-12-08 2005-07-07 Hybridon, Inc. Modulation of immunostimulatory properties by small oligonucleotide-based compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225016A1 (en) * 2001-06-21 2003-12-04 Fearon Karen L. Chimeric immunomodulatory compounds and methods of using the same - III
JP2005518402A (ja) * 2001-10-24 2005-06-23 ハイブリドン・インコーポレイテッド 5’末端の至適表示によるオリゴヌクレオチド化合物の免疫賦活性調節
WO2004064782A2 (en) * 2003-01-16 2004-08-05 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN6011023764; Nucleic Acids Res., 2002年, 第30巻, 4460-4469ページ *
JPN6011023766; Proc Natl Acad Sci USA., 2003年, 第100巻, 14303-14308ページ *
JPN6011023768; Proc Natl Acad Sci USA., 2005年5月, 第102巻, 6925-6930ページ *
JPN6011023770; Vaccine, 2005年4月, 第23巻, 2614-2622ページ *
JPN6011023772; Cell Immunol., 2010年, 第263巻, 105-113ページ *
JPN6011023773; 村松正實 他編 「分子細胞生物学辞典」, 東京化学同人, 2002年, 158ページ *
JPN6011023775; 八杉龍一 他編 「岩波生物学辞典 第4版」, 岩波書店, 1997年, 170ページ *

Also Published As

Publication number Publication date
AU2005338050B2 (en) 2012-02-02
WO2007055682A8 (en) 2007-08-02
EP1945653A4 (en) 2012-03-14
AU2005338050A1 (en) 2007-05-18
MX2008006004A (es) 2008-10-01
AU2005338050A8 (en) 2008-07-03
WO2007055682A2 (en) 2007-05-18
CN101351469A (zh) 2009-01-21
CA2630118A1 (en) 2007-05-18
EP1945653A2 (en) 2008-07-23

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