JP2009510084A - 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 - Google Patents
自己免疫及び神経変性疾患及び障害のためのエストリオール療法 Download PDFInfo
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- JP2009510084A JP2009510084A JP2008533586A JP2008533586A JP2009510084A JP 2009510084 A JP2009510084 A JP 2009510084A JP 2008533586 A JP2008533586 A JP 2008533586A JP 2008533586 A JP2008533586 A JP 2008533586A JP 2009510084 A JP2009510084 A JP 2009510084A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72097205P | 2005-09-26 | 2005-09-26 | |
| US83352706P | 2006-07-26 | 2006-07-26 | |
| PCT/US2006/037752 WO2007038636A2 (en) | 2005-09-26 | 2006-09-26 | Estriol therapy for autoimmune and neurodegenerataive diseases and disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009510084A true JP2009510084A (ja) | 2009-03-12 |
| JP2009510084A5 JP2009510084A5 (https=) | 2011-01-27 |
Family
ID=37900442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533586A Pending JP2009510084A (ja) | 2005-09-26 | 2006-09-26 | 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (3) | EP2698167A3 (https=) |
| JP (1) | JP2009510084A (https=) |
| AU (1) | AU2006294662A1 (https=) |
| CA (1) | CA2623839C (https=) |
| WO (1) | WO2007038636A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009510070A (ja) * | 2005-09-26 | 2009-03-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 |
| JP2014508809A (ja) * | 2011-03-22 | 2014-04-10 | ザ・ポピュレイション・カウンシル,インコーポレイテッド | アンドロゲンを用いたミエリン再生 |
| JPWO2015199195A1 (ja) * | 2014-06-27 | 2017-04-20 | 国立大学法人名古屋大学 | 標本作製用包埋剤、硬化性基材非浸透標本の作製方法、硬化性基材浸透標本の作製方法、硬化性基材非浸透標本、凍結包埋剤の薄切性改善剤、及び凍結包埋剤 |
| JP2019526612A (ja) * | 2016-09-12 | 2019-09-19 | スティーブン・ホフマン | 認知症を治療するための組成物 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130203722A1 (en) | 2006-09-26 | 2013-08-08 | Rhonda R. Voskuhl | Estriol therapy for autoimmune and neurodegenerative disease and disorders |
| US20120328566A9 (en) * | 2001-04-25 | 2012-12-27 | Rhonda R Voskuhl | Estrogen receptor ligand treatment for neurodegenerative diseases |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| US8658627B2 (en) | 2001-04-25 | 2014-02-25 | The Regents Of The University Of California | Pregnancy hormone combination for treatment of autoimmune diseases |
| US20100239528A1 (en) * | 2007-07-20 | 2010-09-23 | Stem Cell Therapeutics Corp. | Treating or Ameliorating a Neuroinflammatory or Demyelinating Disorder with Prolactin and Interferon-Beta |
| JP5476587B2 (ja) | 2007-10-26 | 2014-04-23 | アカディア ファーマシューティカルズ,インコーポレーテッド | エストロゲン受容体に対して活性を有する縮合化合物 |
| HUP0800414A2 (en) * | 2008-07-04 | 2010-10-28 | Pecsi Tudomanyegyetem | Pharmaceutical combination |
| US9808470B2 (en) | 2012-04-19 | 2017-11-07 | Universite De Liege | Estrogenic components for use in the treatment of neurological disorders |
| EP2653163A1 (en) * | 2012-04-19 | 2013-10-23 | Université de Liège | Estrogenic components for use in the treatment of neurological disorders |
| EP3137087B1 (en) | 2014-04-28 | 2023-09-06 | The Regents of the University of California | Estrogen combination for treatment of multiple sclerosis |
| ES2959603T3 (es) | 2014-04-28 | 2024-02-27 | Univ California | Envase farmacéutico para terapia con estriol para el tratamiento de la esclerosis múltiple |
| EP3189026B1 (en) * | 2014-09-02 | 2020-07-22 | The Regents of The University of California | Estrogen receptor ligand treatment for neurodegenerative diseases |
| WO2016036719A1 (en) | 2014-09-02 | 2016-03-10 | The Regents Of The University Of California | Estrogen therapy for brain gray matter atrophy and associated disability |
| ES2957543T3 (es) | 2014-09-29 | 2024-01-22 | Univ California | Composiciones y métodos para mantener la función cognitiva |
| WO2016160832A1 (en) | 2015-03-30 | 2016-10-06 | The Regents Of The University Of California | Methods of monitoring estriol therapy |
| CN110337265B (zh) * | 2016-11-15 | 2023-02-21 | 加利福尼亚大学董事会 | 用于改善外周神经功能的方法和装置 |
| CA3098602A1 (en) | 2018-05-02 | 2019-11-07 | Pantarhei Oncology B.V. | Treatment of advanced estrogen receptor positive breast cancer |
| TW202124418A (zh) * | 2019-12-20 | 2021-07-01 | 比利時商埃斯特拉有限責任公司 | 壞死性凋亡調節劑、篩選方法及醫藥組成物 |
| CN113243332B (zh) * | 2020-02-07 | 2023-07-28 | 上海市东方医院(同济大学附属东方医院) | 一种广泛脑区神经元树突发育障碍动物模型的制备与应用 |
| WO2022173871A1 (en) | 2021-02-09 | 2022-08-18 | The Regents Of The University Of California | Methods and apparatuses for treating stroke using low-frequency stimulation |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11514327A (ja) * | 1993-11-05 | 1999-12-07 | ユニバーシティ・オブ・フロリダ・リサーチ・ファウンデーション・インコーポレーテッド | エストロゲン組成物及び神経保護の方法 |
| US20010016325A1 (en) * | 1999-12-01 | 2001-08-23 | Mobley William C. | Activation of novel estrogen receptor supports and neuronal viability and function |
| WO2002085374A1 (en) * | 2001-04-25 | 2002-10-31 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| US20020164314A1 (en) * | 2001-03-02 | 2002-11-07 | Neurostasis, Inc. | Ovarian hormone induced neural stem cell increase |
| JP2003522737A (ja) * | 1999-11-05 | 2003-07-29 | ワイエス | アミロイド阻害化合物を同定しそして使用するための方法 |
| JP2003246736A (ja) * | 2002-02-25 | 2003-09-02 | Noritake Co Ltd | 自己免疫疾患発病抑制薬 |
| JP2009510070A (ja) * | 2005-09-26 | 2009-03-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9502921D0 (sv) | 1995-08-23 | 1995-08-23 | Astra Ab | New compounds |
| US6734211B1 (en) * | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
| US20050209208A1 (en) * | 2001-04-25 | 2005-09-22 | The Regents Of The University Of California | Use of estriol and other estranes, estrogens and estrogen receptor active compositions in the treatment of psoriasis and other autoimmune disorders |
| EP1358881A1 (en) * | 2002-04-30 | 2003-11-05 | Schering Aktiengesellschaft | Use of biogenic estriol diester prodrugs for the treatment of autoimmune diseases |
-
2006
- 2006-09-26 EP EP13005320.0A patent/EP2698167A3/en not_active Withdrawn
- 2006-09-26 EP EP16000349.7A patent/EP3045177A1/en not_active Withdrawn
- 2006-09-26 EP EP06815626A patent/EP1929291A4/en not_active Ceased
- 2006-09-26 JP JP2008533586A patent/JP2009510084A/ja active Pending
- 2006-09-26 CA CA2623839A patent/CA2623839C/en not_active Expired - Fee Related
- 2006-09-26 WO PCT/US2006/037752 patent/WO2007038636A2/en not_active Ceased
- 2006-09-26 AU AU2006294662A patent/AU2006294662A1/en not_active Abandoned
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11514327A (ja) * | 1993-11-05 | 1999-12-07 | ユニバーシティ・オブ・フロリダ・リサーチ・ファウンデーション・インコーポレーテッド | エストロゲン組成物及び神経保護の方法 |
| JP2003522737A (ja) * | 1999-11-05 | 2003-07-29 | ワイエス | アミロイド阻害化合物を同定しそして使用するための方法 |
| US20010016325A1 (en) * | 1999-12-01 | 2001-08-23 | Mobley William C. | Activation of novel estrogen receptor supports and neuronal viability and function |
| US20020164314A1 (en) * | 2001-03-02 | 2002-11-07 | Neurostasis, Inc. | Ovarian hormone induced neural stem cell increase |
| WO2002085374A1 (en) * | 2001-04-25 | 2002-10-31 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| JP2003246736A (ja) * | 2002-02-25 | 2003-09-02 | Noritake Co Ltd | 自己免疫疾患発病抑制薬 |
| JP2009510070A (ja) * | 2005-09-26 | 2009-03-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 |
Non-Patent Citations (8)
| Title |
|---|
| JPN5007024041; KIM S: NEUROLOGY Vol.52 No.1, 19990412, pp.1230-1238, LIPPINCOTT WILLIAMS & WILKINS * |
| JPN5008015192; SOLDAN: THE JOURNAL OF IMMUNOLOGY Vol.171 No.11, 200312, pp.6267-6274 * |
| JPN6012025498; Offner H: 'Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelit' J Neurosci Res. Vol.78 No.5, 20041201, pp.603-624 * |
| JPN6012025501; Kurman RJ et al.: 'Norethindrone acetate and estradiol-induced endometrial hyperplasia.' Obstet Gynecol. Vol.96 No.3, 200009, pp.373-379 * |
| JPN6012025504; メルクマニュアル日本語版 第17版, 19991210, pp.1477-1479, 日経BP社 * |
| JPN6012025507; Kuiper GG et al.: 'Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor' Endocrinology Vol.138 No.3, 199703, pp.863-870 * |
| JPN6013005494; Harrington WR et al.: 'Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gen' Mol Cell Endocrinol. Vol.206 No.1-2, 20030829, pp.13-22 * |
| JPN6013005495; Carswell HV et al.: 'Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia.' Am J Physiol Heart Circ Physiol. Vol.287 No.4, 20040520, pp.1501-1504 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009510070A (ja) * | 2005-09-26 | 2009-03-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自己免疫及び神経変性疾患及び障害のためのエストリオール療法 |
| JP2014508809A (ja) * | 2011-03-22 | 2014-04-10 | ザ・ポピュレイション・カウンシル,インコーポレイテッド | アンドロゲンを用いたミエリン再生 |
| US9364488B2 (en) | 2011-03-22 | 2016-06-14 | The Population Council, Inc. | Myelin regeneration with androgens |
| JPWO2015199195A1 (ja) * | 2014-06-27 | 2017-04-20 | 国立大学法人名古屋大学 | 標本作製用包埋剤、硬化性基材非浸透標本の作製方法、硬化性基材浸透標本の作製方法、硬化性基材非浸透標本、凍結包埋剤の薄切性改善剤、及び凍結包埋剤 |
| JP2019526612A (ja) * | 2016-09-12 | 2019-09-19 | スティーブン・ホフマン | 認知症を治療するための組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3045177A1 (en) | 2016-07-20 |
| WO2007038636A3 (en) | 2007-12-27 |
| CA2623839C (en) | 2013-12-17 |
| EP2698167A2 (en) | 2014-02-19 |
| EP1929291A2 (en) | 2008-06-11 |
| EP2698167A3 (en) | 2014-03-05 |
| EP1929291A4 (en) | 2010-12-22 |
| CA2623839A1 (en) | 2007-04-05 |
| WO2007038636A2 (en) | 2007-04-05 |
| AU2006294662A1 (en) | 2007-04-05 |
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