JP2009510080A5 - - Google Patents
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- Publication number
- JP2009510080A5 JP2009510080A5 JP2008533575A JP2008533575A JP2009510080A5 JP 2009510080 A5 JP2009510080 A5 JP 2009510080A5 JP 2008533575 A JP2008533575 A JP 2008533575A JP 2008533575 A JP2008533575 A JP 2008533575A JP 2009510080 A5 JP2009510080 A5 JP 2009510080A5
- Authority
- JP
- Japan
- Prior art keywords
- milnacipran
- administered
- medicament according
- dose
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 18
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims 14
- 229960000600 milnacipran Drugs 0.000 claims 14
- 208000001640 Fibromyalgia Diseases 0.000 claims 7
- 208000002193 Pain Diseases 0.000 claims 7
- 208000024891 symptom Diseases 0.000 claims 7
- 238000011866 long-term treatment Methods 0.000 claims 6
- 239000003775 serotonin noradrenalin reuptake inhibitor Substances 0.000 claims 6
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 4
- 208000005298 acute pain Diseases 0.000 claims 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 3
- METKIMKYRPQLGS-GFCCVEGCSA-N (R)-atenolol Chemical compound CC(C)NC[C@@H](O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-GFCCVEGCSA-N 0.000 claims 2
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 claims 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 2
- QSQQPMHPCBLLGX-UHFFFAOYSA-N N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine Chemical compound CNCCCCOC1=CC=CC=C1CC1=CC=CC=C1 QSQQPMHPCBLLGX-UHFFFAOYSA-N 0.000 claims 2
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 claims 2
- 229940123445 Tricyclic antidepressant Drugs 0.000 claims 2
- 229940025084 amphetamine Drugs 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 239000002830 appetite depressant Substances 0.000 claims 2
- 229960002274 atenolol Drugs 0.000 claims 2
- 229910052788 barium Inorganic materials 0.000 claims 2
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 2
- 239000002876 beta blocker Substances 0.000 claims 2
- 229940097320 beta blocking agent Drugs 0.000 claims 2
- 229960004933 bifemelane Drugs 0.000 claims 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- 229960000623 carbamazepine Drugs 0.000 claims 2
- 229960002896 clonidine Drugs 0.000 claims 2
- 229960004126 codeine Drugs 0.000 claims 2
- 229960002870 gabapentin Drugs 0.000 claims 2
- TZDUHAJSIBHXDL-UHFFFAOYSA-N gabapentin enacarbil Chemical compound CC(C)C(=O)OC(C)OC(=O)NCC1(CC(O)=O)CCCCC1 TZDUHAJSIBHXDL-UHFFFAOYSA-N 0.000 claims 2
- 229960002359 gabapentin enacarbil Drugs 0.000 claims 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 2
- 239000003326 hypnotic agent Substances 0.000 claims 2
- 230000000147 hypnotic effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960001165 modafinil Drugs 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 229940035363 muscle relaxants Drugs 0.000 claims 2
- 239000003158 myorelaxant agent Substances 0.000 claims 2
- 229960003642 nicergoline Drugs 0.000 claims 2
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 2
- 229960003089 pramipexole Drugs 0.000 claims 2
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 2
- 229960001233 pregabalin Drugs 0.000 claims 2
- 229960003712 propranolol Drugs 0.000 claims 2
- 239000000932 sedative agent Substances 0.000 claims 2
- 229940125723 sedative agent Drugs 0.000 claims 2
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 2
- 229960004425 sibutramine Drugs 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 claims 2
- 229960000488 tizanidine Drugs 0.000 claims 2
- 229960004380 tramadol Drugs 0.000 claims 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 2
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 claims 2
- 229960003991 trazodone Drugs 0.000 claims 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72172205P | 2005-09-28 | 2005-09-28 | |
| PCT/US2006/037714 WO2007038620A2 (en) | 2005-09-28 | 2006-09-27 | Milnacipran for the long-term treatment of fibromyalgia syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012159397A Division JP5922515B2 (ja) | 2005-09-28 | 2012-07-18 | 線維筋痛症候群の長期治療のためのミルナシプラン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009510080A JP2009510080A (ja) | 2009-03-12 |
| JP2009510080A5 true JP2009510080A5 (https=) | 2009-11-12 |
Family
ID=37900431
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533575A Pending JP2009510080A (ja) | 2005-09-28 | 2006-09-27 | 線維筋痛症候群の長期治療のためのミルナシプラン |
| JP2012159397A Expired - Fee Related JP5922515B2 (ja) | 2005-09-28 | 2012-07-18 | 線維筋痛症候群の長期治療のためのミルナシプラン |
| JP2015063053A Expired - Fee Related JP6014702B2 (ja) | 2005-09-28 | 2015-03-25 | 線維筋痛症候群の長期治療のためのミルナシプラン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012159397A Expired - Fee Related JP5922515B2 (ja) | 2005-09-28 | 2012-07-18 | 線維筋痛症候群の長期治療のためのミルナシプラン |
| JP2015063053A Expired - Fee Related JP6014702B2 (ja) | 2005-09-28 | 2015-03-25 | 線維筋痛症候群の長期治療のためのミルナシプラン |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7994220B2 (https=) |
| EP (2) | EP2682114B1 (https=) |
| JP (3) | JP2009510080A (https=) |
| KR (1) | KR20080055967A (https=) |
| CN (1) | CN101355930A (https=) |
| AU (1) | AU2006294645B2 (https=) |
| BR (1) | BRPI0617541A2 (https=) |
| CA (1) | CA2624018A1 (https=) |
| CR (1) | CR9882A (https=) |
| EC (1) | ECSP088407A (https=) |
| GE (1) | GEP20125595B (https=) |
| IL (2) | IL190284A (https=) |
| MA (1) | MA31720B1 (https=) |
| MY (1) | MY145340A (https=) |
| NI (1) | NI200800099A (https=) |
| NO (1) | NO20081951L (https=) |
| NZ (2) | NZ567271A (https=) |
| RU (1) | RU2437661C2 (https=) |
| SG (3) | SG10201807899PA (https=) |
| SV (1) | SV2008002855A (https=) |
| TN (1) | TNSN08129A1 (https=) |
| UA (1) | UA94721C2 (https=) |
| WO (1) | WO2007038620A2 (https=) |
| ZA (1) | ZA200803469B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| CA2479350A1 (en) * | 2002-03-15 | 2003-09-25 | Cypress Bioscience, Inc. | Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes |
| EP1558231A4 (en) * | 2002-10-03 | 2010-09-08 | Cypress Bioscience Inc | DOSAGE CLIMBING AND FRICTIONAL DAILY DOSE OF ANTIDEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS |
| US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| TW200911225A (en) * | 2007-05-22 | 2009-03-16 | Cypress Bioscience Inc | Methods for improving physical function in fibromyalgia |
| JPWO2009025091A1 (ja) * | 2007-08-23 | 2010-11-18 | Ｍｐｏ株式会社 | 線維筋痛症治療用医薬組成物 |
| JP5274071B2 (ja) * | 2008-03-28 | 2013-08-28 | 旭化成ファーマ株式会社 | 線維筋痛症治療剤 |
| CN102099033B (zh) * | 2008-05-16 | 2012-10-24 | 阿克西斯股份有限公司 | 用于治疗纤维肌痛症的药物组合物 |
| ES2589915T3 (es) | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
| US20100197797A1 (en) * | 2009-02-05 | 2010-08-05 | Rao Srinivas G | Methods of managing fibromyalgia using milnacipran |
| EP2406243B1 (en) | 2009-03-10 | 2014-05-07 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
| US20100286260A1 (en) * | 2009-05-05 | 2010-11-11 | Forest Laboratories Holdings Ltd. | Milnacipran formulations |
| SMT201700578T1 (it) | 2009-11-20 | 2018-01-11 | Tonix Pharma Holdings Ltd | Metodo e composizioni per trattare i sintomi associati al disturbo da stress post-traumatico usando ciclobenzaprina |
| US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| US11998516B2 (en) * | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| FR2978350B1 (fr) | 2011-07-28 | 2013-11-08 | Pf Medicament | Medicament a base de levomilnacipran pour la rehabilitation fonctionnelle apres accident neurologique aigu |
| MX365525B (es) * | 2011-09-06 | 2019-06-06 | Curna Inc | Compuestos que regulan la expresión de subunidades alfa de canales de sodio regulados por voltaje en enfermedades relacionadas con epilepsia mioclónica severa de la infancia. |
| SMT202400324T1 (it) | 2013-03-15 | 2024-11-15 | Tonix Pharma Ltd | Formulazioni eutettiche di ciclobenzaprina cloridrato e mannitolo |
| MY186047A (en) | 2014-09-18 | 2021-06-17 | Tonix Pharma Holdings Ltd | Eutectic formulations of cyclobenzaprine hydrochloride |
| MX2020006140A (es) | 2017-12-11 | 2020-08-13 | Tonix Pharma Holdings Ltd | Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas. |
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- 2006-09-27 EP EP13187396.0A patent/EP2682114B1/en not_active Not-in-force
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- 2006-09-27 AU AU2006294645A patent/AU2006294645B2/en not_active Ceased
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- 2006-09-27 EP EP06804211A patent/EP1928446A4/en not_active Withdrawn
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- 2006-09-27 CA CA002624018A patent/CA2624018A1/en not_active Abandoned
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