JP2009509538A5 - - Google Patents
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- Publication number
- JP2009509538A5 JP2009509538A5 JP2008533581A JP2008533581A JP2009509538A5 JP 2009509538 A5 JP2009509538 A5 JP 2009509538A5 JP 2008533581 A JP2008533581 A JP 2008533581A JP 2008533581 A JP2008533581 A JP 2008533581A JP 2009509538 A5 JP2009509538 A5 JP 2009509538A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 27
- 102000036639 antigens Human genes 0.000 claims 27
- 108091007433 antigens Proteins 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 claims 5
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 210000004180 plasmocyte Anatomy 0.000 claims 2
- 241001137251 Corvidae Species 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72152505P | 2005-09-29 | 2005-09-29 | |
| US60/721,525 | 2005-09-29 | ||
| PCT/US2006/037724 WO2007041171A2 (en) | 2005-09-29 | 2006-09-28 | Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013005541A Division JP2013126984A (ja) | 2005-09-29 | 2013-01-16 | 膜Ｉｇ特異的抗体を同定する方法および免疫グロブリンを生成する前駆体細胞を標的化するための使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009509538A JP2009509538A (ja) | 2009-03-12 |
| JP2009509538A5 true JP2009509538A5 (https=) | 2009-10-15 |
| JP5389442B2 JP5389442B2 (ja) | 2014-01-15 |
Family
ID=37906692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533581A Active JP5389442B2 (ja) | 2005-09-29 | 2006-09-28 | 膜Ｉｇ特異的抗体を同定する方法および免疫グロブリンを生成する前駆体細胞を標的化するための使用 |
| JP2013005541A Pending JP2013126984A (ja) | 2005-09-29 | 2013-01-16 | 膜Ｉｇ特異的抗体を同定する方法および免疫グロブリンを生成する前駆体細胞を標的化するための使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013005541A Pending JP2013126984A (ja) | 2005-09-29 | 2013-01-16 | 膜Ｉｇ特異的抗体を同定する方法および免疫グロブリンを生成する前駆体細胞を標的化するための使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8137670B2 (https=) |
| EP (1) | EP1941275B1 (https=) |
| JP (2) | JP5389442B2 (https=) |
| AU (1) | AU2006297304B2 (https=) |
| CA (1) | CA2624081C (https=) |
| WO (1) | WO2007041171A2 (https=) |
Families Citing this family (26)
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|---|---|---|---|---|
| US7468418B2 (en) * | 2003-04-29 | 2008-12-23 | Avi Biopharma., Inc. | Compositions for enhancing transport of molecules into cells |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8168181B2 (en) * | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CA2822302A1 (en) * | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| SI2132230T1 (sl) * | 2007-03-22 | 2014-07-31 | Genentech, Inc. | Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| EP2401300B1 (en) | 2009-02-25 | 2018-01-10 | Academia Sinica | ANTI-C[epsilon]mX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES |
| CA3090304A1 (en) * | 2010-05-13 | 2011-11-17 | Sarepta Therapeutics, Inc. | Antisense modulation of interleukins 17 and 23 signaling |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2013158274A1 (en) * | 2012-04-20 | 2013-10-24 | Academia Sinica | ANTI-MIGE ANTIBODIES THAT BIND TO THE JUNCTION BETWEEN CH4 AND CεMX DOMAINS |
| HK1210192A1 (en) | 2012-07-19 | 2016-04-15 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| WO2015084736A2 (en) * | 2013-12-03 | 2015-06-11 | Welt Bio-Molecular Pharmaceutical, Llc | Antibodies targeting b-cell receptor complex membrane bound igm and uses thereof |
| JP6316966B2 (ja) * | 2013-12-05 | 2018-04-25 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | ｍＩｇＡ−Ｂリンパ球の溶解及びＩｇＡ生産の減少が可能な抗ヒトｍＩｇＡ抗体 |
| EP3080158A4 (en) | 2013-12-09 | 2018-03-21 | Adimab, LLC | Polyclonal mixtures of antibodies, and methods of making and using them |
| IL250404B (en) * | 2014-08-06 | 2022-07-01 | Astellas Pharma Inc | Novel anti-human igbeta antibody |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| US20180186896A1 (en) * | 2015-07-07 | 2018-07-05 | Affiris Ag | Vaccines for the treatment and prevention of ige mediated diseases |
| CN108883173B (zh) * | 2015-12-02 | 2022-09-06 | 阿吉纳斯公司 | 抗体和其使用方法 |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| KR102810425B1 (ko) | 2016-12-19 | 2025-05-21 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체 |
| WO2019085902A1 (en) | 2017-10-31 | 2019-05-09 | Fountain Biopharma Inc. | Treating ige-mediated allergic diseases |
| AU2018362747B2 (en) * | 2017-11-07 | 2025-08-14 | Hubit Genomix, Inc. | Method for primary prevention of allergic disorders during infancy through IgE-class-specific immunosuppression |
| US12497464B1 (en) | 2018-08-03 | 2025-12-16 | Berkeley Therapeutics, Inc. | Antibody, antibody fragments or peptide for treating cancer and methods of formation and administration |
| EP4006546A1 (en) * | 2020-11-30 | 2022-06-01 | Medizinische Hochschule Hannover | Application of stem-cell derived monocytes in a monocyte activation test (mat) for the assessment of pyrogenicity and inflammatory potential |
| KR20260042217A (ko) | 2023-07-13 | 2026-03-30 | 인히브릭스 바이오사이언스, 인크. | IgE 결합 단백질 및 이의 용도 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449760A (en) | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
| US5252467A (en) | 1987-12-31 | 1993-10-12 | Tanox Biosystems, Inc. | Method of making antibodies to antigenic epitopes of IGE present on B cells but not basophil cell surface or secreted, soluble IGE |
| US5089603A (en) | 1989-06-21 | 1992-02-18 | Tanox Biosystems, Inc. | Antigenic epitopes present on membrane-bound but not secreted iga |
| US5091313A (en) * | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
| US5422258A (en) | 1987-12-31 | 1995-06-06 | Tanox Biosystems, Inc. | Methods for producing high affinity anti-human IgE-monoclonal antibodies which binds to IgE on IgEabearing B cells but not basophils |
| US5342924A (en) * | 1987-12-31 | 1994-08-30 | Tanox Biosystems, Inc. | Extracellular segments of human ε immunoglobulin anchoring peptides and antibodies specific therefor |
| AU618317B2 (en) | 1987-12-31 | 1991-12-19 | Tanox Biosystems, Inc. | Unique antigenic epitopes on ige-bearing b lymphocytes |
| US5514776A (en) | 1987-12-31 | 1996-05-07 | Tanox Biosystems, Inc. | Peptides representing antigenic epitopes of dog IgE present on B cell but not basophil surface |
| US5428133A (en) | 1987-12-31 | 1995-06-27 | Tanox Biosystems, Inc. | Chimeric anti-human IgE-monoclonal antibody which binds to secreted IgE and membrane-bound IgE expressed by IgE-expressing B cells but notto IgE bound to FC receptors on basophils |
| US5254671A (en) | 1990-04-27 | 1993-10-19 | Tanox Biosystems, Inc. | Extracellular segments of human e immunoglobulin anchoring peptides and antibodies specific therefor |
| US5231026A (en) | 1987-12-31 | 1993-07-27 | Tanox Biosystems, Inc. | DNA encoding murine-human chimeric antibodies specific for antigenic epitopes of IgE present on the extracellular segment of the membrane domain of membrane-bound IgE |
| US5614611A (en) | 1987-12-31 | 1997-03-25 | Tanox Biosystems, Inc. | Humanized monoclonal antibodies binding to IgE-bearing B cells but not basophils |
| US5079344A (en) | 1989-06-21 | 1992-01-07 | Tanox Biosystems, Inc. | Antigenic epitopes present on membrane-bound but not secreted IgA |
| US5274075A (en) | 1987-12-31 | 1993-12-28 | Tanox Biosystems, Inc. | Newly identified human epsilon immunoglobulin peptides and related products |
| US5260416A (en) | 1987-12-31 | 1993-11-09 | Tanox Biosystems, Inc. | Antigenic epitopes present on membrane-bound but not secreted IgE |
| US5362643A (en) | 1989-06-21 | 1994-11-08 | Tanox Biosystems | Antibodies to epitopes present on membrane-bound but not secreted IGA |
| US5484907A (en) | 1989-06-21 | 1996-01-16 | Tanox Biosystems, Inc. | Nucleotides coding for the extracellular membrane-bound segment of IgA |
| US5690934A (en) | 1987-12-31 | 1997-11-25 | Tanox Biosystems, Inc. | Peptides relating to the extracellular membrane-bound segment of human alpha chain |
| US5292867A (en) | 1988-11-16 | 1994-03-08 | Tanox Biosystems, Inc. | Chimeric monoclonal antibodies which bind to the extracellular segment of the membrane-bound domain of a human membrane-bound immunoglobulin |
| US5310875A (en) | 1989-06-21 | 1994-05-10 | Tanox Biosystems, Inc. | Peptides corresponding to membrane-bound IgA |
| ES2100892T3 (es) | 1989-09-15 | 1997-07-01 | Tanox Biosystems Inc | Tratamiento de enfermedades autoinmunitarias. |
| CA2074089C (en) * | 1990-01-23 | 2001-04-10 | Tse-Wen Chang | Extracellular segments of human e immunoglobulin anchoring peptides and antibodies specific therefor |
| US5281699A (en) * | 1990-06-01 | 1994-01-25 | Tanox Biosystems, Inc. | Treating B cell lymphoma or leukemia by targeting specific epitopes on B cell bound immunoglobulins |
| US5298420A (en) | 1990-08-03 | 1994-03-29 | Tanox Biosystems, Inc. | Antibodies specific for isotype specific domains of human IgM and human IgG expressed or the B cell surface |
| AU9016591A (en) | 1990-10-25 | 1992-05-26 | Tanox Biosystems, Inc. | Glycoproteins associated with membrane-bound immunoglobulins as antibody targets on B cells |
| US6685939B2 (en) * | 1991-08-14 | 2004-02-03 | Genentech, Inc. | Method of preventing the onset of allergic disorders |
| DK1621554T4 (da) * | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
| US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
| JP2638436B2 (ja) * | 1992-10-12 | 1997-08-06 | 日本電気株式会社 | スイッチングレギュレータ |
| US5499760A (en) * | 1994-05-05 | 1996-03-19 | Pielocik; William P. | Interconvertible backpack and chair apparatus |
| AU4012095A (en) * | 1994-10-25 | 1996-05-15 | United Biomedical Inc. | Synthetic ige membrane anchor peptide immunogens for the treatment of allergy |
| US6037453A (en) * | 1995-03-15 | 2000-03-14 | Genentech, Inc. | Immunoglobulin variants |
| AU3515597A (en) | 1997-05-30 | 1998-12-30 | Tanox Biosystems, Inc. | Inhibition of antigen-specific ige production by antigen coupled to membrane igepetide |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| EP1155038A1 (en) | 1999-02-25 | 2001-11-21 | SMITHKLINE BEECHAM BIOLOGICALS (S.A.), formerly SMITHKLINE BIOLOGICALS (S.A.) | Epitopes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of ige, antagonists thereof, and their therapeutic uses |
| US20030147906A1 (en) | 1999-07-21 | 2003-08-07 | Smithkline Beecham Biologicals, S.A. | Epitopes or mimotopes derived from the C-epsilon-3 or C-epsilon-4 domains of lgE, antagonists thereof, and their therapeutic uses |
| FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| IL154219A0 (en) | 2000-09-06 | 2003-07-31 | Pharmexa As | Method for down-regulating ige |
| SE0101093D0 (sv) | 2001-03-28 | 2001-03-28 | Pharmacia Diagnostics Ab | Novel compound for treatment of allergy and asthma |
| JP4213586B2 (ja) * | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| WO2004000217A2 (en) | 2002-06-20 | 2003-12-31 | The Trustees Of The University Of Pennsylvania | Vaccines for suppressing ige-mediated allergic disease and methods for using the same |
| EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| WO2004070011A2 (en) * | 2003-02-01 | 2004-08-19 | Tanox, Inc. | HIGH AFFINITY ANTI-HUMAN IgE ANTIBODIES |
| SI2132230T1 (sl) | 2007-03-22 | 2014-07-31 | Genentech, Inc. | Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE |
| EP1972640A1 (en) | 2007-03-23 | 2008-09-24 | Biomay AG | Apoptosis inducing antibodies |
| JP2010532158A (ja) | 2007-04-02 | 2010-10-07 | アムジェン フレモント インク． | 抗ＩｇＥ抗体 |
-
2006
- 2006-09-28 EP EP06815598.5A patent/EP1941275B1/en not_active Not-in-force
- 2006-09-28 CA CA2624081A patent/CA2624081C/en not_active Expired - Fee Related
- 2006-09-28 JP JP2008533581A patent/JP5389442B2/ja active Active
- 2006-09-28 US US12/067,396 patent/US8137670B2/en active Active
- 2006-09-28 WO PCT/US2006/037724 patent/WO2007041171A2/en not_active Ceased
- 2006-09-28 AU AU2006297304A patent/AU2006297304B2/en not_active Ceased
-
2012
- 2012-02-13 US US13/372,170 patent/US8404236B2/en active Active
-
2013
- 2013-01-16 JP JP2013005541A patent/JP2013126984A/ja active Pending
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