JP2009506054A5 - - Google Patents
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- Publication number
- JP2009506054A5 JP2009506054A5 JP2008528124A JP2008528124A JP2009506054A5 JP 2009506054 A5 JP2009506054 A5 JP 2009506054A5 JP 2008528124 A JP2008528124 A JP 2008528124A JP 2008528124 A JP2008528124 A JP 2008528124A JP 2009506054 A5 JP2009506054 A5 JP 2009506054A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hedgehog
- cancer
- pathway activity
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000001340 Gmelina philippensis Species 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 7
- 230000037361 pathway Effects 0.000 claims 7
- 230000003042 antagnostic Effects 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 210000004027 cells Anatomy 0.000 claims 5
- IAKHMKGGTNLKSZ-INIZCTEOSA-N Colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- VHVPQPYKVGDNFY-TUJWMRSMSA-N 2-[(2S)-butan-2-yl]-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-TUJWMRSMSA-N 0.000 claims 2
- 229960001338 colchicine Drugs 0.000 claims 2
- 229960004130 itraconazole Drugs 0.000 claims 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 210000003445 Biliary Tract Anatomy 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 210000001900 Endoderm Anatomy 0.000 claims 1
- 210000003238 Esophagus Anatomy 0.000 claims 1
- 206010020112 Hirsutism Diseases 0.000 claims 1
- 206010061289 Metastatic neoplasm Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 1
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 210000000496 Pancreas Anatomy 0.000 claims 1
- 208000000587 Small Cell Lung Carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 210000002784 Stomach Anatomy 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000002280 anti-androgenic Effects 0.000 claims 1
- 230000000118 anti-eoplastic Effects 0.000 claims 1
- 239000000051 antiandrogen Substances 0.000 claims 1
- 201000001531 bladder carcinoma Diseases 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 201000009030 carcinoma Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001394 metastastic Effects 0.000 claims 1
- 230000001613 neoplastic Effects 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000000699 topical Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71011705P | 2005-08-22 | 2005-08-22 | |
| US60/710,117 | 2005-08-22 | ||
| PCT/US2006/032952 WO2007024971A2 (en) | 2005-08-22 | 2006-08-22 | Hedgehog pathway antagonists to treat disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009506054A JP2009506054A (ja) | 2009-02-12 |
| JP2009506054A5 true JP2009506054A5 (US20070167479A1-20070719-C00034.png) | 2010-08-26 |
| JP5435946B2 JP5435946B2 (ja) | 2014-03-05 |
Family
ID=37772335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528124A Active JP5435946B2 (ja) | 2005-08-22 | 2006-08-22 | 疾患を処置するためのヘッジホッグ経路アンタゴニスト |
Country Status (7)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| CN102144163A (zh) * | 2008-04-10 | 2011-08-03 | 麻省理工学院 | 关于鉴定和使用靶向癌症干细胞的试剂的方法 |
| US9072660B2 (en) | 2011-09-09 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Topical itraconazole formulations and uses thereof |
| WO2013130625A1 (en) * | 2012-02-27 | 2013-09-06 | Basil Rigas | Phospho-ester derivatives and uses thereof |
| US10106778B2 (en) | 2012-11-08 | 2018-10-23 | Whitehead Institute For Biomedical Research | Selective targeting of cancer stem cells |
| US9192609B2 (en) * | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
| ITRM20130366A1 (it) * | 2013-06-25 | 2014-12-26 | Univ Roma La Sapienza | Multitarget hedgehog pathway inhibitors and uses thereof |
| WO2015116947A1 (en) | 2014-02-01 | 2015-08-06 | University Of Connecticut | Itraconazole analogues and methods of use thereof |
| US10398672B2 (en) | 2014-04-29 | 2019-09-03 | Whitehead Institute For Biomedical Research | Methods and compositions for targeting cancer stem cells |
| US10512641B2 (en) * | 2015-06-01 | 2019-12-24 | University Of Kentucky Research Foundation | Chloroquine induction par-4 and treatment of cancer |
| JP6796638B2 (ja) | 2015-06-04 | 2020-12-09 | ペレファーム, インク.Pellepharm, Inc. | ヘッジホッグ阻害性化合物の送達のための局所的製剤及びその使用 |
| US20180193335A1 (en) * | 2015-10-12 | 2018-07-12 | Vikash J. BHAGWANDIN | Compositions, formulations, packaged pharmaceuticals, and methods of using hedgehog pathway modulators for the sensitization of resistant tumors |
| KR20200059188A (ko) * | 2017-04-12 | 2020-05-28 | 비카쉬 제이. 바그완딘 | 내성 종양의 민감화를 위해 포사코나졸을 사용한 조성물, 패키징된 약제, 및 방법 |
| EP3624798A1 (en) | 2017-05-18 | 2020-03-25 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of mast cell diseases |
| WO2019040363A1 (en) | 2017-08-20 | 2019-02-28 | University Of Connecticut | AZOLE-TYPE COMPOUND ANALOGUES AND METHODS OF USE |
| CN110279696A (zh) * | 2019-07-31 | 2019-09-27 | 中国医学科学院皮肤病医院 | 伊曲康唑在制备抑制肿瘤转移药物中的应用 |
| CN113521071A (zh) * | 2021-07-22 | 2021-10-22 | 广州医科大学 | 氯喹那多的新应用 |
| CN114081883B (zh) * | 2021-11-04 | 2023-02-28 | 武汉科技大学 | 氯喹那多在制备抗肿瘤药物中的应用 |
| WO2024040175A1 (en) | 2022-08-18 | 2024-02-22 | Pulmatrix Operating Company, Inc. | Methods for treating cancer using inhaled angiogenesis inhibitor |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4824829A (en) | 1984-08-15 | 1989-04-25 | American Cyanamid Company | Non-dusting antibiotic, anticoccidial premix compositions and a process for their manufacture |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| US4916134A (en) | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| EP0631578B1 (en) | 1992-03-18 | 2001-05-23 | Janssen Pharmaceutica N.V. | Itraconazole and saperconazole stereoisomers |
| JPH0782162A (ja) | 1993-09-10 | 1995-03-28 | Pola Chem Ind Inc | 皮膚外用剤 |
| JPH0782163A (ja) | 1993-09-10 | 1995-03-28 | Pola Chem Ind Inc | 肝障害治療剤及びこれを含有する組成物 |
| CA2179029C (en) | 1993-12-30 | 2009-02-24 | Philip W. Ingham | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| AUPN033894A0 (en) * | 1994-12-29 | 1995-01-27 | Rowe, J.B. | Prevention of adverse behaviour in humans and animals |
| FR2738741B1 (fr) * | 1995-09-19 | 1997-12-05 | Oreal | Composition pour la teinture des fibres keratiniques, contenant un antagoniste de substance p |
| EP0904060B1 (en) | 1996-05-20 | 2003-12-10 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
| WO1999033467A1 (en) | 1997-12-31 | 1999-07-08 | Choongwae Pharma Corporation | Method and composition of an oral preparation of itraconazole |
| US6277566B1 (en) | 1998-02-13 | 2001-08-21 | Phillip A. Beachy | Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor |
| EP1067939B1 (en) * | 1998-04-09 | 2015-09-16 | The Johns Hopkins University | Use of steroidal alkaloid derivatives as inhibitors of hedgehog protein signaling pathways |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
| ES2157731B1 (es) | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
| US6552026B2 (en) | 1999-06-14 | 2003-04-22 | Basf Aktiengesellschaft | 6-phenyl-pyrazolopyrimidines |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| DE19963052A1 (de) * | 1999-12-24 | 2001-06-28 | Bayer Ag | Verwendung von Azolen zur Prävention von Hautkrebs |
| US20040060568A1 (en) | 2000-10-13 | 2004-04-01 | Henryk Dudek | Hedgehog antagonists, methods and uses related thereto |
| AU2002217911A1 (en) * | 2000-11-28 | 2002-06-11 | Curis, Inc. | Basal cell carcinoma cultures, methods related thereto and their use |
| WO2002078703A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
| US6946137B2 (en) | 2001-10-19 | 2005-09-20 | Idexx Laboratories, Inc. | Methods for the controlled delivery of pharmacologically active compounds |
| US20070179152A1 (en) * | 2003-05-23 | 2007-08-02 | Lee Margaret S | Combination therapy for the treatment of neoplasms |
| WO2005000208A2 (en) | 2003-05-30 | 2005-01-06 | Combinatorx, Inc. | Combination therapy for the treatment of neoplasms |
| US20050049207A1 (en) * | 2003-09-03 | 2005-03-03 | Kaufmann Doug A. | Method of treating and preventing cancer |
| WO2006004795A2 (en) | 2004-06-25 | 2006-01-12 | The Johns Hopkins University | Angiogenesis inhibitors |
-
2006
- 2006-08-22 EP EP06802186A patent/EP1919480B1/en active Active
- 2006-08-22 JP JP2008528124A patent/JP5435946B2/ja active Active
- 2006-08-22 ES ES06802186T patent/ES2403006T3/es active Active
- 2006-08-22 WO PCT/US2006/032952 patent/WO2007024971A2/en active Application Filing
- 2006-08-22 AU AU2006283040A patent/AU2006283040B2/en active Active
- 2006-08-22 EP EP20110184350 patent/EP2404602A1/en not_active Ceased
- 2006-08-22 US US11/990,729 patent/US8653083B2/en active Active
- 2006-08-22 CA CA2619889A patent/CA2619889C/en active Active
