JP2009503083A5 - - Google Patents

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Publication number

JP2009503083A5

JP2009503083A5 JP2008525073A JP2008525073A JP2009503083A5 JP 2009503083 A5 JP2009503083 A5 JP 2009503083A5 JP 2008525073 A JP2008525073 A JP 2008525073A JP 2008525073 A JP2008525073 A JP 2008525073A JP 2009503083 A5 JP2009503083 A5 JP 2009503083A5

Authority

JP

Japan

Prior art keywords

alkyl

methyl

aryl

oxo

hydrogen

Prior art date

2006-07-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 125000000217 alkyl group Chemical group 0.000 claims 52
• 229910052739 hydrogen Inorganic materials 0.000 claims 33
• 239000001257 hydrogen Substances 0.000 claims 33
• 125000003118 aryl group Chemical group 0.000 claims 32
• 125000000623 heterocyclic group Chemical group 0.000 claims 21
• 150000002431 hydrogen Chemical class 0.000 claims 19
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 12
• 229910052736 halogen Inorganic materials 0.000 claims 12
• 150000002367 halogens Chemical class 0.000 claims 12
• -1 {2-[({7-[(4-Fluorophenyl) methyl] -4-hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridin-3-yl} carbonyl) amino] ethyl} phosphonic acid Chemical compound 0.000 claims 12
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 9
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 9
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
• 125000000304 alkynyl group Chemical group 0.000 claims 8
• 125000003710 aryl alkyl group Chemical group 0.000 claims 8
• 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 7
• 125000001424 substituent group Chemical group 0.000 claims 7
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
• 125000003545 alkoxy group Chemical group 0.000 claims 5
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
• 125000005842 heteroatom Chemical group 0.000 claims 5
• 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 1
• ZPSJPGHVLDDZQL-UHFFFAOYSA-N 2-[[7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,5-naphthyridine-3-carbonyl]amino]ethylphosphonic acid Chemical compound C=1N=C2C(O)=C(C(=O)NCCP(O)(O)=O)C(=O)N(C)C2=CC=1CC1=CC=C(F)C=C1 ZPSJPGHVLDDZQL-UHFFFAOYSA-N 0.000 claims 1
• MJMVUVWSSYDFPO-UHFFFAOYSA-N 3-[[7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,5-naphthyridine-3-carbonyl]amino]propylphosphonic acid Chemical compound C=1N=C2C(O)=C(C(=O)NCCCP(O)(O)=O)C(=O)N(C)C2=CC=1CC1=CC=C(F)C=C1 MJMVUVWSSYDFPO-UHFFFAOYSA-N 0.000 claims 1
• QRVYMDVCVWYGAU-UHFFFAOYSA-N 4-[2-[7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-3-(phosphonomethylcarbamoyl)-1,5-naphthyridin-1-yl]ethylamino]butanoic acid Chemical compound C=1N=C2C(O)=C(C(=O)NCP(O)(O)=O)C(=O)N(CCNCCCC(=O)O)C2=CC=1CC1=CC=C(F)C=C1 QRVYMDVCVWYGAU-UHFFFAOYSA-N 0.000 claims 1
• NIPVCGHZPVBSPW-UHFFFAOYSA-N 4-[[7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,5-naphthyridine-3-carbonyl]amino]butylphosphonic acid Chemical compound C=1N=C2C(O)=C(C(=O)NCCCCP(O)(O)=O)C(=O)N(C)C2=CC=1CC1=CC=C(F)C=C1 NIPVCGHZPVBSPW-UHFFFAOYSA-N 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• PTQIMVFKAJIPCV-UHFFFAOYSA-N [[7-[(4-fluorophenyl)methyl]-4-hydroxy-1-methyl-2-oxo-1,5-naphthyridine-3-carbonyl]amino]methylphosphonic acid Chemical compound C=1N=C2C(O)=C(C(=O)NCP(O)(O)=O)C(=O)N(C)C2=CC=1CC1=CC=C(F)C=C1 PTQIMVFKAJIPCV-UHFFFAOYSA-N 0.000 claims 1
• GUNLZIOBCDJRJM-UHFFFAOYSA-N [[7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxopyrrolidin-1-yl)ethyl]-1,5-naphthyridine-3-carbonyl]amino]methylphosphonic acid Chemical compound C12=CC(CC=3C=CC(F)=CC=3)=CN=C2C(O)=C(C(=O)NCP(O)(O)=O)C(=O)N1CCN1CCCC1=O GUNLZIOBCDJRJM-UHFFFAOYSA-N 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000002651 drug therapy Methods 0.000 claims 1
• 125000001188 haloalkyl group Chemical group 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000005541 phosphonamide group Chemical group 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1