JP2009502775A5 - - Google Patents
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- Publication number
- JP2009502775A5 JP2009502775A5 JP2008522168A JP2008522168A JP2009502775A5 JP 2009502775 A5 JP2009502775 A5 JP 2009502775A5 JP 2008522168 A JP2008522168 A JP 2008522168A JP 2008522168 A JP2008522168 A JP 2008522168A JP 2009502775 A5 JP2009502775 A5 JP 2009502775A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- tumors
- compound
- carbon atoms
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 16
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- 125000001931 aliphatic group Chemical group 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 5
- -1 —CF 3 or —CF 2 CF 3 Chemical group 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000037976 chronic inflammation Diseases 0.000 claims 3
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- YVFQBLJLBDEBDA-UHFFFAOYSA-N 2-hydroxy-4-piperazin-1-ylbenzoic acid Chemical compound C1=C(O)C(C(=O)O)=CC=C1N1CCNCC1 YVFQBLJLBDEBDA-UHFFFAOYSA-N 0.000 claims 1
- DTDDTFSVLBUSRQ-UHFFFAOYSA-N 4-[di(propan-2-yl)amino]-2-hydroxybenzoic acid Chemical compound CC(C)N(C(C)C)C1=CC=C(C(O)=O)C(O)=C1 DTDDTFSVLBUSRQ-UHFFFAOYSA-N 0.000 claims 1
- KKDAZKGSLSSFFB-UHFFFAOYSA-N 5-[di(propan-2-yl)amino]-2-hydroxybenzoic acid Chemical compound CC(C)N(C(C)C)C1=CC=C(O)C(C(O)=O)=C1 KKDAZKGSLSSFFB-UHFFFAOYSA-N 0.000 claims 1
- LAAHHSIHJWHOGY-UHFFFAOYSA-N 5-amino-2-ethoxy-n-hydroxybenzamide Chemical compound CCOC1=CC=C(N)C=C1C(=O)NO LAAHHSIHJWHOGY-UHFFFAOYSA-N 0.000 claims 1
- XKDHOKGLFLSGFL-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline-5-carboxylic acid Chemical compound N1CCCC2=C(C(O)=O)C(OC)=CC=C21 XKDHOKGLFLSGFL-UHFFFAOYSA-N 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- IBGRXJLNYHYVQR-UHFFFAOYSA-N CN(C=1C=C(C(C(=O)O)=CC1)O)C.C(C)OC1=C(C(=O)O)C=C(C=C1)N.C(C)OC1=C(C(=O)O)C=CC(=C1)N Chemical compound CN(C=1C=C(C(C(=O)O)=CC1)O)C.C(C)OC1=C(C(=O)O)C=C(C=C1)N.C(C)OC1=C(C(=O)O)C=CC(=C1)N IBGRXJLNYHYVQR-UHFFFAOYSA-N 0.000 claims 1
- BLMSHJMTUFDGSL-UHFFFAOYSA-N COc1ccc(N)cc1C(=O)NO.COc1cc(N)ccc1C(=O)NO.Nc1cc2CCOc2c(c1)C(O)=O Chemical compound COc1ccc(N)cc1C(=O)NO.COc1cc(N)ccc1C(=O)NO.Nc1cc2CCOc2c(c1)C(O)=O BLMSHJMTUFDGSL-UHFFFAOYSA-N 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000025402 neoplasm of esophagus Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- OMBVEVHRIQULKW-DNQXCXABSA-M (3r,5r)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-propan-2-yl-5,6-dihydro-4h-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoate Chemical compound O=C1C=2N(C(C)C)C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C=3C=CC(F)=CC=3)C=2CCCN1C1=CC=CC=C1 OMBVEVHRIQULKW-DNQXCXABSA-M 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940126540 compound 41 Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000390A ITRM20050390A1 (it) | 2005-07-22 | 2005-07-22 | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| ITRM2005A000390 | 2005-07-22 | ||
| PCT/IE2006/000076 WO2007010514A2 (en) | 2005-07-22 | 2006-07-24 | Compounds and their salts specific to the ppar receptors and the egf receptors and their use in the medical field |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502775A JP2009502775A (ja) | 2009-01-29 |
| JP2009502775A5 true JP2009502775A5 (OSRAM) | 2009-09-03 |
| JP5193862B2 JP5193862B2 (ja) | 2013-05-08 |
Family
ID=37574984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522168A Expired - Fee Related JP5193862B2 (ja) | 2005-07-22 | 2006-07-24 | Ｐｐａｒ受容体及びｅｇｆ受容体に特異的な化合物及びそれらの塩並びに医療分野におけるそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8138357B2 (OSRAM) |
| EP (1) | EP1910275B1 (OSRAM) |
| JP (1) | JP5193862B2 (OSRAM) |
| CN (1) | CN101243043B (OSRAM) |
| AU (1) | AU2006271163B2 (OSRAM) |
| BR (1) | BRPI0613398A2 (OSRAM) |
| CA (1) | CA2615978A1 (OSRAM) |
| IT (1) | ITRM20050390A1 (OSRAM) |
| NO (1) | NO20080323L (OSRAM) |
| NZ (1) | NZ566044A (OSRAM) |
| WO (1) | WO2007010514A2 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20050389A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| ITRM20050390A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| IE20070129A1 (en) | 2007-02-28 | 2008-12-24 | Giuliani Int Ltd | Ppar-gamma agonists stimulate enteric defensin expression |
| ITMI20072429A1 (it) * | 2007-12-24 | 2009-06-25 | Giuliani Int Ltd | Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca |
| UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
| PT2396081T (pt) | 2009-02-16 | 2017-07-11 | Nogra Pharma Ltd | Compostos alquilamido e suas utilizações |
| EP2811993B1 (en) | 2012-02-09 | 2019-10-09 | Nogra Pharma Limited | Methods of treating fibrosis |
| IN2014DN08157A (OSRAM) | 2012-04-18 | 2015-05-01 | Nogra Pharma Ltd | |
| WO2017040963A1 (en) | 2015-09-03 | 2017-03-09 | Forma Therapeutics, Inc. | [6,6] fused bicyclic hdac8 inhibitors |
| WO2020152350A1 (en) | 2019-01-25 | 2020-07-30 | Nogra Pharma Limited | Compositions for use in preventing acne |
| SI3921299T1 (sl) * | 2019-02-08 | 2025-03-31 | Nogra Pharma Limited | Postopek izdelave 3-(4'-aminofenil)-2-metoksipropionske kisline in njenih analogov in vmesnih proizvodov |
| WO2025132838A1 (en) | 2023-12-20 | 2025-06-26 | Nogra Pharma Limited | Acne topical formulations |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB767788A (en) | 1953-12-28 | 1957-02-06 | Schering Corp | Polyiodinated phenyl fatty acid compounds and process for their manufacture |
| US3211610A (en) * | 1961-09-29 | 1965-10-12 | Merck & Co Inc | Benzoic acid ester derivatives for treating coccidiosis and method of using same |
| US3444232A (en) * | 1966-05-18 | 1969-05-13 | Squibb & Sons Inc | O-alkyl or phenylalkyl benzohydroxamic acids |
| US4036951A (en) * | 1973-03-12 | 1977-07-19 | Synergistics, Inc. | Ultra-violet filtration with certain aminosalicylic acid esters |
| GB1561350A (en) * | 1976-11-05 | 1980-02-20 | May & Baker Ltd | Benzamide derivatives |
| DE3164618D1 (en) | 1980-12-22 | 1984-08-09 | Schering Ag | 3-substituted 2,4,6-trihalogenobenzamides and their salts, their preparation and their use as substitutes for natural sweetening agents, and sweeteners containing them |
| IL69282A (en) * | 1982-09-02 | 1988-06-30 | Euro Celtique Sa | Method for the carboxylation of potassium phenoxide with carbon dioxide |
| AU1388388A (en) | 1987-04-01 | 1988-10-06 | Dak-Laboratoriet A/S | Benzoic acid derivatives and use thereof |
| ES2065980T3 (es) | 1988-05-05 | 1995-03-01 | Tillotts Pharma Ag | Uso del acido 5-aminosalicilico en el tratamiento de alteraciones dermatologicas. |
| US5519014A (en) * | 1990-10-22 | 1996-05-21 | Borody; Thomas J. | Treatment of non-inflammatory and non-infectious bowel disorders |
| US5262549A (en) * | 1991-05-30 | 1993-11-16 | Polaroid Corporation | Benzpyrylium dyes, and processes for their preparation and use |
| US5302751A (en) * | 1992-01-21 | 1994-04-12 | Ethyl Corporation | Profen resolution |
| EP0604641B1 (en) | 1992-06-30 | 2002-03-20 | SHAPIRO, Howard, K. | Use of a combination containing an amine or amine-related derivative of benzoic acid and an amino-polysaccharide in the manufacture of a medicament for the treatment of inflammatory diseases |
| ES2137996T3 (es) * | 1992-07-17 | 2000-01-01 | Janssen Pharmaceutica Nv | 4-amino-n-(4-metil-4-piperidinil)-2-metoxibenzamidas, su preparacion y su empleo como antagonistas 5-ht2. |
| US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| WO1995031194A1 (en) | 1994-05-11 | 1995-11-23 | Shapiro Howard K | Compositions for treatment of chronic inflammatory diseases |
| US5939442A (en) * | 1995-06-07 | 1999-08-17 | The Salk Institute For Biological Studies | Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof |
| GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| GB9617001D0 (en) | 1996-08-13 | 1996-09-25 | Tillotts Pharma Ag | Oral composition |
| DE19647582A1 (de) * | 1996-11-18 | 1998-05-20 | Hoechst Ag | Verfahren zur Herstellung von aromatischen Olefinen mittels Katalyse durch Palladaphosphacyclobutane |
| AU6773598A (en) | 1997-03-26 | 1998-10-20 | Institut Pasteur | Treatment of gastrointestinal disease with ppar modulators |
| US7098025B1 (en) * | 1997-07-25 | 2006-08-29 | Ligand Pharmaceuticals Incorporated | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor |
| AU9002798A (en) * | 1997-09-19 | 1999-04-12 | Ono Pharmaceutical Co. Ltd. | Fused or nonfused benzene compounds |
| US6326364B1 (en) * | 1999-02-08 | 2001-12-04 | Cedars-Sinai Medical Center | Use of 5-aminosalicylates as antimicrobial agents |
| FR2791671B1 (fr) | 1999-04-01 | 2001-05-11 | Oreal | Nouveaux composes derives d'esters d'acide benzoique, composition les comprenant et utilisation |
| US20040034067A1 (en) * | 1999-04-15 | 2004-02-19 | Macphee Colin Houston | Novel method of treatment |
| GB9914371D0 (en) * | 1999-06-18 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| AU2000241494B2 (en) | 2000-04-19 | 2005-03-17 | Gnt Pharma Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| PT1285908E (pt) | 2000-05-29 | 2008-12-04 | Kyorin Seiyaku Kk | Derivados do ácido fenilpropiónico substituídos |
| CA2420576C (en) | 2000-08-29 | 2005-06-14 | Nobex Corporation | Immunoregulatory compounds, derivatives thereof and their use |
| JPWO2002046161A1 (ja) | 2000-12-05 | 2004-04-08 | 杏林製薬株式会社 | 置換カルボン酸誘導体 |
| FR2822955B1 (fr) * | 2001-03-27 | 2003-10-03 | Chru Lille | Methode de diagnostic de maladies inflammatoires chroniques de l'intestin |
| CA2354921A1 (en) | 2001-05-24 | 2002-11-24 | Yasuo Konishi | Drug evolution: drug design at hot spots |
| EP1436268A1 (en) | 2001-10-16 | 2004-07-14 | Dr. Reddy's Laboratories Ltd. | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them |
| GB0127916D0 (en) * | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
| UA82835C2 (en) * | 2001-12-03 | 2008-05-26 | Reddys Lab Ltd Dr | ?-aryl-?-oxysubstituted propionuc acid derivatives and pharmaceutical composition based thereon |
| US20030113815A1 (en) * | 2001-12-19 | 2003-06-19 | Pfizer Inc. | Canine peroxisome proliferator activated receptor gamma |
| US20030220374A1 (en) | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
| US20040115127A1 (en) * | 2002-04-12 | 2004-06-17 | Wright Samuel D. | Ppar-alpha-gamma ligands or agonists for the treatment of inflammation |
| GB0303609D0 (en) | 2003-02-17 | 2003-03-19 | Glaxo Group Ltd | Novel therapeutic method and compositions |
| WO2004082715A1 (ja) * | 2003-03-20 | 2004-09-30 | Eisai Co., Ltd. | 炎症性腸疾患治療剤としての併用医薬 |
| EP1654247B1 (en) * | 2003-07-21 | 2010-01-20 | Merck Serono SA | Alkynyl aryl carboxamides |
| JP2006528157A (ja) * | 2003-07-21 | 2006-12-14 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | アリールジカルボキシアミド |
| US7417037B2 (en) | 2004-01-20 | 2008-08-26 | The Board Of Regents Of The University Of Oklahoma | Compositions and methods of treatment for inflammatory diseases |
| WO2005084658A1 (en) | 2004-03-04 | 2005-09-15 | Arakis Ltd. | Derivatives of actarit and their therapeutic use |
| US20060286046A1 (en) | 2005-01-05 | 2006-12-21 | Haber C Andrew | Skin care compositions |
| US20060270635A1 (en) * | 2005-05-27 | 2006-11-30 | Wallace John L | Derivatives of 4- or 5-aminosalicylic acid |
| ITRM20050390A1 (it) | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| ITRM20050389A1 (it) * | 2005-07-22 | 2007-01-23 | Giuliani Spa | Composti e loro sali specifici per i recettori ppar ed i recettori per l'egf e loro uso in campo medico. |
| DE102005061472A1 (de) * | 2005-12-22 | 2007-07-05 | Saltigo Gmbh | Verfahren zur Herstellung von enantiomerenangereicherten 2-Alkoxy-3-phenylpropionsäuren |
| IE20070129A1 (en) | 2007-02-28 | 2008-12-24 | Giuliani Int Ltd | Ppar-gamma agonists stimulate enteric defensin expression |
| ITMI20072429A1 (it) | 2007-12-24 | 2009-06-25 | Giuliani Int Ltd | Composti per il trattamento selettivo della componente immuno-infiammatoria intestinale della malattia celiaca |
| UA107562C2 (uk) | 2008-12-05 | 2015-01-26 | Спосіб лікування псоріазу | |
| PT2396081T (pt) | 2009-02-16 | 2017-07-11 | Nogra Pharma Ltd | Compostos alquilamido e suas utilizações |
-
2005
- 2005-07-22 IT IT000390A patent/ITRM20050390A1/it unknown
-
2006
- 2006-07-24 CN CN2006800300279A patent/CN101243043B/zh not_active Expired - Fee Related
- 2006-07-24 JP JP2008522168A patent/JP5193862B2/ja not_active Expired - Fee Related
- 2006-07-24 WO PCT/IE2006/000076 patent/WO2007010514A2/en not_active Ceased
- 2006-07-24 EP EP06766083A patent/EP1910275B1/en active Active
- 2006-07-24 US US11/989,033 patent/US8138357B2/en not_active Expired - Fee Related
- 2006-07-24 BR BRPI0613398-3A patent/BRPI0613398A2/pt not_active IP Right Cessation
- 2006-07-24 NZ NZ566044A patent/NZ566044A/en not_active IP Right Cessation
- 2006-07-24 AU AU2006271163A patent/AU2006271163B2/en not_active Ceased
- 2006-07-24 CA CA002615978A patent/CA2615978A1/en not_active Abandoned
-
2008
- 2008-01-18 NO NO20080323A patent/NO20080323L/no not_active Application Discontinuation
-
2012
- 2012-02-15 US US13/397,245 patent/US8450506B2/en not_active Expired - Fee Related
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